GREMLIN Database
Q97UG9 - Uncharacterized protein
UniProt: Q97UG9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 237 (214)
Sequences: 13877 (9994)
Seq/√Len: 683.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
79_R108_L3.0971.00
145_G172_H3.0511.00
25_K59_N3.0251.00
194_D197_G2.8851.00
53_I57_K2.8271.00
83_D112_Y2.5981.00
165_N201_K2.5731.00
34_Y210_P2.5491.00
99_E139_N2.4441.00
21_E55_L2.3211.00
115_K145_G2.2751.00
19_T22_N2.2421.00
178_D189_G2.2381.00
83_D108_L2.2301.00
54_N58_E2.2091.00
117_A172_H2.1821.00
115_K172_H2.1561.00
86_N112_Y2.1071.00
134_Y166_T2.0021.00
56_H63_V1.8831.00
135_E139_N1.8801.00
201_K204_E1.8571.00
25_K29_E1.8471.00
75_K104_L1.8261.00
55_L59_N1.8071.00
106_S144_V1.7941.00
92_V117_A1.7871.00
110_K143_R1.7591.00
55_L58_E1.7561.00
165_N204_E1.7491.00
159_N162_E1.7381.00
82_F112_Y1.7311.00
49_V87_K1.6991.00
50_K87_K1.6981.00
196_K200_G1.6661.00
108_L111_E1.6511.00
48_S51_D1.6391.00
117_A147_C1.6351.00
174_I202_V1.5881.00
161_I197_G1.5811.00
108_L112_Y1.5481.00
221_N224_P1.5351.00
82_F109_V1.5201.00
178_D191_G1.5181.00
72_K76_K1.5091.00
21_E58_E1.4871.00
99_E103_N1.4761.00
107_D111_E1.4691.00
85_A90_I1.4641.00
28_S59_N1.4461.00
134_Y138_K1.4221.00
24_L59_N1.4191.00
200_G204_E1.4041.00
76_K80_S1.3991.00
162_E166_T1.3901.00
26_V29_E1.3621.00
129_S132_K1.3601.00
51_D54_N1.3541.00
106_S140_L1.3541.00
82_F108_L1.3541.00
100_D103_N1.3521.00
201_K205_L1.3421.00
80_S83_D1.3371.00
25_K55_L1.3361.00
22_N25_K1.3351.00
145_G170_R1.3261.00
26_V223_L1.3241.00
190_S228_K1.3201.00
150_L198_V1.3001.00
75_K79_R1.2971.00
168_R205_L1.2971.00
92_V115_K1.2861.00
76_K79_R1.2841.00
53_I87_K1.2751.00
131_K166_T1.2661.00
79_R104_L1.2531.00
99_E140_L1.2511.00
138_K170_R1.2451.00
224_P228_K1.2441.00
109_V116_V1.2301.00
134_Y170_R1.2221.00
133_I146_M1.2031.00
104_L107_D1.1851.00
51_D55_L1.1711.00
24_L56_H1.1681.00
128_G132_K1.1651.00
113_D143_R1.1621.00
54_N57_K1.1621.00
197_G201_K1.1551.00
28_S60_G1.1491.00
79_R111_E1.1481.00
79_R83_D1.1471.00
110_K142_Y1.1461.00
34_Y64_I1.1401.00
26_V30_L1.1331.00
187_I190_S1.1211.00
135_E138_K1.1181.00
32_I213_I1.1071.00
165_N205_L1.1061.00
82_F114_I1.1001.00
49_V84_F1.0951.00
202_V205_L1.0891.00
34_Y62_K1.0891.00
21_E51_D1.0761.00
27_M35_V1.0761.00
162_E165_N1.0691.00
37_A63_V1.0691.00
107_D110_K1.0621.00
46_S87_K1.0561.00
103_N140_L1.0521.00
72_K104_L1.0491.00
10_I27_M1.0491.00
50_K54_N1.0481.00
134_Y167_L1.0371.00
24_L55_L1.0341.00
56_H61_V1.0251.00
161_I165_N1.0201.00
223_L227_V1.0141.00
164_V205_L1.0031.00
163_A167_L1.0031.00
103_N107_D0.9951.00
148_L153_L0.9921.00
78_L105_M0.9901.00
91_E115_K0.9641.00
106_S143_R0.9611.00
49_V53_I0.9601.00
92_V172_H0.9541.00
29_E223_L0.9481.00
193_L198_V0.9461.00
83_D86_N0.9401.00
66_H85_A0.9381.00
83_D87_K0.9161.00
75_K101_C0.9141.00
120_N153_L0.9121.00
36_E173_D0.9111.00
21_E25_K0.9101.00
119_H214_E0.9081.00
149_D214_E0.9031.00
102_L144_V0.9011.00
164_V201_K0.8951.00
79_R112_Y0.8941.00
176_V195_V0.8881.00
85_A93_I0.8871.00
56_H59_N0.8851.00
161_I201_K0.8841.00
73_S76_K0.8831.00
28_S33_S0.8801.00
43_P46_S0.8801.00
131_K135_E0.8731.00
25_K58_E0.8711.00
49_V88_V0.8691.00
224_P227_V0.8681.00
36_E65_A0.8681.00
103_N141_D0.8611.00
64_I210_P0.8601.00
32_I226_I0.8591.00
151_A177_K0.8551.00
115_K143_R0.8501.00
177_K216_E0.8501.00
140_L144_V0.8471.00
152_H177_K0.8231.00
146_M167_L0.8211.00
199_I211_L0.8191.00
199_I203_K0.8171.00
86_N114_I0.8151.00
77_E80_S0.8121.00
50_K53_I0.8121.00
197_G200_G0.8081.00
105_M116_V0.8041.00
180_N192_I0.7991.00
181_N192_I0.7981.00
130_Y158_E0.7931.00
103_N139_N0.7891.00
84_F88_V0.7801.00
63_V90_I0.7781.00
62_K91_E0.7761.00
176_V211_L0.7751.00
132_K135_E0.7691.00
225_G228_K0.7631.00
33_S62_K0.7631.00
137_T170_R0.7611.00
154_F192_I0.7601.00
195_V199_I0.7601.00
47_N51_D0.7601.00
24_L35_V0.7591.00
100_D104_L0.7571.00
13_Y16_R0.7571.00
36_E212_M0.7531.00
220_E224_P0.7521.00
137_T146_M0.7511.00
150_L195_V0.7491.00
106_S110_K0.7461.00
164_V171_I0.7461.00
94_T121_H0.7451.00
206_N209_I0.7441.00
21_E59_N0.7371.00
95_A116_V0.7311.00
24_L61_V0.7301.00
151_A179_V0.7171.00
62_K210_P0.7171.00
222_P225_G0.7171.00
104_L108_L0.7111.00
180_N186_V0.7111.00
148_L164_V0.7091.00
148_L163_A0.7091.00
177_K185_D0.7081.00
75_K105_M0.7071.00
18_L26_V0.6981.00
173_D212_M0.6971.00
101_C104_L0.6971.00
22_N26_V0.6931.00
154_F160_P0.6921.00
123_P156_Y0.6911.00
120_N127_W0.6881.00
28_S61_V0.6821.00
137_T141_D0.6821.00
130_Y166_T0.6731.00
94_T147_C0.6721.00
120_N133_I0.6711.00
130_Y134_Y0.6671.00
74_D77_E0.6651.00
80_S84_F0.6611.00
23_A27_M0.6591.00
168_R171_I0.6551.00
164_V168_R0.6551.00
107_D143_R0.6551.00
153_L163_A0.6501.00
93_I109_V0.6501.00
10_I226_I0.6471.00
220_E228_K0.6461.00
75_K108_L0.6391.00
92_V173_D0.6321.00
119_H175_H0.6321.00
121_H177_K0.6311.00
53_I89_E0.6301.00
174_I211_L0.6291.00
203_K211_L0.6291.00
186_V190_S0.6251.00
75_K78_L0.6241.00
25_K28_S0.6221.00
185_D188_V0.6211.00
127_W133_I0.6191.00
187_I225_G0.6191.00
164_V167_L0.6171.00
15_L26_V0.6171.00
24_L52_I0.6161.00
167_L171_I0.6151.00
78_L82_F0.6141.00
73_S77_E0.6121.00
169_D205_L0.6111.00
164_V198_V0.6111.00
56_H60_G0.6101.00
168_R201_K0.6081.00
99_E136_F0.6081.00
147_C173_D0.6061.00
27_M32_I0.6021.00
148_L171_I0.6021.00
30_L227_V0.5951.00
175_H212_M0.5911.00
102_L106_S0.5901.00
188_V191_G0.5901.00
66_H90_I0.5901.00
149_D177_K0.5891.00
57_K87_K0.5861.00
68_V71_L0.5841.00
15_L18_L0.5821.00
109_V114_I0.5771.00
203_K206_N0.5701.00
68_V81_I0.5701.00
122_G155_R0.5651.00
102_L136_F0.5651.00
10_I15_L0.5641.00
81_I93_I0.5611.00
154_F193_L0.5601.00
89_E114_I0.5601.00
119_H152_H0.5601.00
215_Y225_G0.5551.00
173_D207_L0.5541.00
141_D170_R0.5521.00
136_F140_L0.5501.00
43_P80_S0.5491.00
86_N113_D0.5491.00
37_A52_I0.5491.00
134_Y137_T0.5471.00
65_A94_T0.5451.00
64_I212_M0.5441.00
146_M171_I0.5431.00
85_A114_I0.5411.00
46_S50_K0.5401.00
127_W136_F0.5401.00
174_I198_V0.5361.00
164_V202_V0.5361.00
95_A102_L0.5351.00
57_K89_E0.5351.00
150_L176_V0.5281.00
138_K166_T0.5271.00
24_L28_S0.5271.00
63_V66_H0.5241.00
52_I55_L0.5231.00
67_G70_H0.5211.00
12_S15_L0.5200.99
221_N225_G0.5190.99
117_A145_G0.5170.99
155_R179_V0.5170.99
12_S17_K0.5140.99
106_S116_V0.5130.99
15_L223_L0.5130.99
29_E227_V0.5100.99
77_E81_I0.5100.99
20_Y52_I0.5080.99
53_I88_V0.5080.99
153_L158_E0.5050.99
133_I137_T0.5040.99
119_H149_D0.5030.99
154_F158_E0.5020.99
202_V207_L0.5020.99
174_I207_L0.5020.99
10_I14_S0.5020.99
121_H216_E0.5010.99
133_I153_L0.5010.99
109_V112_Y0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3lmzA 2 0.9958 100 0.218 Contact Map
4kw2A 5 0.9578 100 0.22 Contact Map
3p6lA 2 0.9958 100 0.221 Contact Map
2zdsA 5 0.9747 100 0.233 Contact Map
1i60A 1 0.9705 100 0.245 Contact Map
3cnyA 1 0.9705 100 0.25 Contact Map
3u0hA 3 0.9789 100 0.257 Contact Map
3dx5A 2 0.9536 100 0.259 Contact Map
3cqjA 2 0.9747 100 0.26 Contact Map
2q02A 2 0.9789 100 0.261 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0092 seconds.