GREMLIN Database
Q97UG8 - Uncharacterized protein
UniProt: Q97UG8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 210 (178)
Sequences: 10540 (7771)
Seq/√Len: 582.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
127_T166_Y3.5141.00
108_R162_F3.2871.00
112_K162_F3.1921.00
104_Y157_L3.1141.00
63_L83_I2.8381.00
108_R161_E2.7161.00
60_V106_N2.7031.00
79_I114_T2.6211.00
11_F17_T2.5191.00
58_N66_R2.3871.00
68_D113_Y2.2121.00
159_S166_Y2.1361.00
79_I121_V2.0801.00
9_I80_S2.0551.00
108_R112_K2.0021.00
104_Y154_K1.9041.00
64_I109_R1.8591.00
8_V49_T1.7781.00
18_D56_S1.7701.00
128_P152_I1.7331.00
122_N165_T1.7251.00
168_D171_D1.7091.00
199_V202_L1.7041.00
115_R162_F1.6841.00
38_L205_L1.6311.00
34_L198_M1.6251.00
198_M202_L1.6171.00
12_A63_L1.6081.00
192_P200_I1.6011.00
111_L125_L1.6001.00
11_F80_S1.5901.00
125_L159_S1.5501.00
58_N62_D1.5471.00
154_K157_L1.5461.00
16_I192_P1.5421.00
203_K206_E1.5341.00
126_M204_L1.5331.00
99_N102_N1.5131.00
127_T168_D1.4801.00
156_R166_Y1.4761.00
127_T156_R1.4471.00
23_N194_F1.4241.00
169_L200_I1.4191.00
29_Y194_F1.4091.00
158_L162_F1.4021.00
111_L164_A1.4011.00
17_T54_G1.3701.00
64_I106_N1.3651.00
103_Y151_Y1.3601.00
20_E56_S1.3491.00
195_T198_M1.3451.00
113_Y117_V1.2911.00
38_L202_L1.2811.00
60_V103_Y1.2801.00
172_T203_K1.2761.00
104_Y108_R1.2731.00
109_R113_Y1.2671.00
167_I207_A1.2661.00
60_V107_L1.2601.00
153_E157_L1.2521.00
111_L158_L1.2311.00
114_T121_V1.2271.00
78_W124_I1.2261.00
11_F32_V1.2131.00
16_I85_I1.2061.00
22_S194_F1.2031.00
60_V110_L1.1761.00
156_R160_N1.1741.00
64_I113_Y1.1721.00
125_L155_V1.1671.00
61_I102_N1.1671.00
7_D48_I1.1641.00
80_S124_I1.1571.00
10_V76_P1.1441.00
108_R158_L1.1301.00
111_L162_F1.1241.00
7_D77_N1.1191.00
107_L155_V1.0941.00
104_Y161_E1.0681.00
66_R70_D1.0621.00
67_W114_T1.0551.00
98_F102_N1.0341.00
100_P150_Q1.0331.00
8_V51_I1.0321.00
102_N105_E1.0311.00
17_T82_L1.0271.00
59_T62_D1.0261.00
81_I110_L1.0231.00
148_L152_I1.0211.00
112_K116_K1.0211.00
124_I167_I1.0181.00
85_I190_V1.0181.00
129_F192_P1.0171.00
8_V77_N1.0141.00
80_S126_M1.0141.00
89_H190_V1.0091.00
107_L111_L0.9751.00
105_E108_R0.9741.00
34_L38_L0.9711.00
199_V203_K0.9651.00
117_V121_V0.9651.00
60_V83_I0.9611.00
103_Y155_V0.9581.00
72_L117_V0.9581.00
152_I155_V0.9531.00
103_Y154_K0.9491.00
105_E109_R0.9441.00
170_H174_K0.9421.00
34_L37_N0.9401.00
82_L129_F0.9391.00
201_A205_L0.9351.00
78_W122_N0.9201.00
10_V53_S0.9181.00
147_L150_Q0.9121.00
70_D73_S0.9101.00
61_I106_N0.9061.00
76_P121_V0.9021.00
197_H200_I0.9011.00
31_Y197_H0.8911.00
111_L123_F0.8821.00
171_D174_K0.8811.00
157_L161_E0.8771.00
113_Y116_K0.8701.00
30_G33_N0.8651.00
67_W110_L0.8611.00
82_L126_M0.8571.00
106_N110_L0.8441.00
102_N106_N0.8431.00
36_Y40_L0.8431.00
85_I131_I0.8391.00
38_L201_A0.8341.00
61_I65_D0.8311.00
69_D72_L0.8191.00
66_R69_D0.8181.00
125_L158_L0.8141.00
149_P153_E0.8121.00
172_T175_K0.8101.00
87_D106_N0.8081.00
60_V64_I0.8021.00
23_N27_L0.7981.00
67_W70_D0.7891.00
203_K207_A0.7891.00
88_L131_I0.7881.00
146_E150_Q0.7861.00
38_L198_M0.7811.00
34_L201_A0.7781.00
158_L161_E0.7781.00
114_T123_F0.7771.00
100_P104_Y0.7741.00
53_S74_Y0.7721.00
171_D175_K0.7711.00
150_Q154_K0.7701.00
33_N36_Y0.7701.00
153_E156_R0.7671.00
31_Y204_L0.7661.00
100_P154_K0.7651.00
40_L47_K0.7631.00
150_Q153_E0.7631.00
126_M169_L0.7611.00
11_F35_F0.7611.00
17_T80_S0.7581.00
101_E154_K0.7521.00
101_E105_E0.7491.00
104_Y158_L0.7431.00
159_S164_A0.7431.00
35_F205_L0.7401.00
63_L110_L0.7391.00
107_L125_L0.7381.00
152_I156_R0.7381.00
68_D72_L0.7381.00
35_F201_A0.7361.00
109_R112_K0.7201.00
156_R168_D0.7161.00
111_L115_R0.7151.00
23_N29_Y0.7141.00
85_I128_P0.7131.00
39_M48_I0.7101.00
14_D84_G0.7051.00
80_S204_L0.7041.00
82_L85_I0.7031.00
145_L149_P0.7021.00
22_S30_G0.6941.00
55_I66_R0.6931.00
48_I78_W0.6861.00
32_V36_Y0.6781.00
55_I58_N0.6781.00
126_M200_I0.6771.00
123_F164_A0.6761.00
68_D73_S0.6721.00
195_T199_V0.6701.00
167_I204_L0.6681.00
62_D65_D0.6661.00
9_I78_W0.6621.00
103_Y107_L0.6611.00
145_L148_L0.6591.00
158_L164_A0.6551.00
112_K115_R0.6541.00
129_F173_F0.6491.00
98_F103_Y0.6461.00
135_K138_G0.6341.00
8_V74_Y0.6321.00
107_L158_L0.6291.00
130_Y173_F0.6291.00
101_E104_Y0.6271.00
34_L197_H0.6241.00
33_N37_N0.6221.00
127_T155_V0.6221.00
48_I77_N0.6141.00
29_Y37_N0.6101.00
68_D71_V0.6081.00
151_Y155_V0.6081.00
106_N109_R0.6071.00
9_I50_V0.6061.00
14_D82_L0.6051.00
88_L147_L0.5981.00
162_F165_T0.5981.00
36_Y50_V0.5971.00
29_Y34_L0.5951.00
185_Y199_V0.5931.00
15_S191_H0.5931.00
64_I110_L0.5921.00
53_S70_D0.5911.00
120_N123_F0.5901.00
35_F38_L0.5851.00
172_T199_V0.5771.00
192_P197_H0.5741.00
124_I165_T0.5731.00
11_F50_V0.5731.00
86_N191_H0.5731.00
22_S197_H0.5671.00
16_I129_F0.5671.00
64_I68_D0.5661.00
185_Y189_P0.5661.00
53_S71_V0.5650.99
51_I74_Y0.5620.99
124_I207_A0.5580.99
155_V166_Y0.5570.99
110_L113_Y0.5560.99
148_L151_Y0.5550.99
64_I105_E0.5550.99
155_V158_L0.5540.99
6_G49_T0.5520.99
144_V147_L0.5480.99
85_I89_H0.5460.99
167_I203_K0.5430.99
115_R123_F0.5420.99
183_N195_T0.5400.99
16_I82_L0.5380.99
12_A83_I0.5380.99
6_G47_K0.5330.99
79_I123_F0.5310.99
88_L148_L0.5270.99
152_I170_H0.5260.99
131_I144_V0.5240.99
19_R30_G0.5220.99
7_D78_W0.5180.99
19_R197_H0.5160.99
129_F152_I0.5140.99
101_E150_Q0.5110.99
159_S162_F0.5110.99
88_L103_Y0.5100.99
28_G33_N0.5100.99
12_A53_S0.5100.99
11_F54_G0.5060.99
194_F198_M0.5040.99
10_V74_Y0.5010.99
157_L160_N0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4q9aA 2 0.9905 100 0.208 Contact Map
4jhlA 5 0.9667 100 0.229 Contact Map
3rjtA 2 0.9667 100 0.242 Contact Map
4rw0A 1 0.8571 100 0.281 Contact Map
3dc7A 3 0.9333 100 0.286 Contact Map
2o14A 1 0.9381 100 0.286 Contact Map
1k7cA 1 0.8952 100 0.288 Contact Map
2q0qA 5 0.8905 100 0.291 Contact Map
4q7qA 1 0.9524 100 0.292 Contact Map
3bzwA 4 0.9571 100 0.293 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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