GREMLIN Database
Q97UG6 - Oxidoreductase
UniProt: Q97UG6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 368 (306)
Sequences: 20459 (13018)
Seq/√Len: 744.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
65_K327_E3.7311.00
56_E101_E3.6431.00
104_K147_N3.0811.00
291_L341_T3.0231.00
140_R180_K2.9571.00
290_E344_K2.7211.00
65_K69_L2.6601.00
136_M178_Q2.5611.00
173_H177_R2.5511.00
338_S341_T2.5211.00
22_K29_K2.5041.00
139_V175_L2.3791.00
94_N97_R2.3531.00
21_M32_K2.2871.00
136_M174_D2.2271.00
115_T151_I2.2111.00
150_Y182_H2.1861.00
285_H289_K2.1791.00
34_C73_F2.1491.00
55_D58_E2.1091.00
69_L327_E2.0991.00
339_N343_K2.0971.00
155_L210_A2.0851.00
132_R174_D2.0391.00
283_E286_E1.9571.00
117_V135_I1.9511.00
174_D177_R1.9471.00
155_L238_M1.8911.00
305_K342_Y1.8631.00
139_V151_I1.8251.00
37_T74_F1.8211.00
139_V154_Y1.8151.00
69_L330_I1.8121.00
173_H206_V1.8101.00
343_K347_E1.8091.00
132_R136_M1.8081.00
331_E334_N1.8051.00
290_E341_T1.7511.00
60_K102_A1.7411.00
19_E32_K1.7131.00
293_V335_V1.7121.00
137_W141_E1.7061.00
66_A71_V1.6911.00
114_A155_L1.6851.00
20_Y29_K1.6841.00
286_E344_K1.6721.00
225_D228_I1.6671.00
65_K323_I1.6561.00
63_I102_A1.6481.00
229_L233_Y1.6441.00
174_D178_Q1.5991.00
56_E60_K1.5971.00
117_V154_Y1.5971.00
181_I184_I1.5971.00
294_T328_E1.5921.00
195_P232_T1.5871.00
113_L148_T1.5781.00
78_N138_Q1.5751.00
301_A335_V1.5651.00
28_L112_V1.5621.00
293_V297_Q1.5561.00
64_V106_Y1.5311.00
58_E61_K1.5281.00
60_K64_V1.5281.00
171_T174_D1.5151.00
202_K207_P1.5101.00
195_P199_K1.4951.00
115_T142_S1.4941.00
67_I111_L1.4941.00
231_K307_Q1.4901.00
190_D193_D1.4891.00
323_I327_E1.4741.00
60_K101_E1.4671.00
22_K27_G1.4531.00
230_A237_I1.4511.00
156_M172_F1.4501.00
294_T297_Q1.4321.00
306_I346_D1.4181.00
159_P193_D1.4151.00
97_R145_R1.4101.00
344_K347_E1.3971.00
141_E144_K1.3741.00
231_K308_E1.3731.00
72_N112_V1.3681.00
286_E290_E1.3651.00
74_F99_L1.3561.00
191_P229_L1.3491.00
151_I181_I1.3421.00
136_M171_T1.3301.00
175_L181_I1.3291.00
293_V298_L1.3221.00
62_T326_L1.3141.00
283_E344_K1.3141.00
141_E145_R1.3061.00
108_R148_T1.2951.00
101_E147_N1.2911.00
324_N327_E1.2861.00
97_R144_K1.2821.00
285_H295_D1.2801.00
214_P219_E1.2731.00
136_M140_R1.2671.00
64_V68_D1.2571.00
61_K323_I1.2501.00
253_L285_H1.2461.00
184_I208_F1.2431.00
63_I74_F1.2411.00
172_F184_I1.2391.00
303_I316_P1.2201.00
195_P229_L1.2181.00
217_F345_L1.2181.00
78_N134_H1.2151.00
198_V233_Y1.2131.00
282_R285_H1.2061.00
198_V229_L1.1941.00
73_F114_A1.1901.00
170_E174_D1.1901.00
297_Q331_E1.1861.00
57_E61_K1.1831.00
32_K304_F1.1821.00
32_K333_L1.1821.00
186_E208_F1.1771.00
19_E336_K1.1731.00
97_R101_E1.1711.00
297_Q328_E1.1661.00
327_E331_E1.1581.00
213_E237_I1.1571.00
103_I111_L1.1511.00
120_K129_G1.1501.00
37_T99_L1.1451.00
275_K279_E1.1381.00
100_G147_N1.1321.00
65_K68_D1.1281.00
140_R178_Q1.1241.00
287_I298_L1.1231.00
153_I210_A1.1221.00
188_Y240_Y1.1201.00
183_Y209_I1.1191.00
64_V102_A1.1181.00
28_L183_Y1.1171.00
108_R150_Y1.1171.00
132_R170_E1.1121.00
112_V153_I1.1091.00
306_I342_Y1.1041.00
194_I235_L1.0901.00
69_L331_E1.0871.00
222_I237_I1.0861.00
196_Y199_K1.0831.00
236_G314_I1.0781.00
26_S209_I1.0741.00
136_M175_L1.0731.00
282_R286_E1.0711.00
31_S71_V1.0641.00
258_D263_T1.0611.00
236_G315_V1.0591.00
326_L330_I1.0501.00
301_A305_K1.0491.00
227_F237_I1.0371.00
217_F299_A1.0351.00
132_R167_E1.0351.00
253_L282_R1.0331.00
286_E289_K1.0331.00
37_T95_A1.0321.00
133_K137_W1.0311.00
73_F238_M1.0311.00
136_M139_V1.0301.00
278_F282_R1.0161.00
283_E348_I1.0111.00
340_D343_K1.0071.00
320_V326_L1.0071.00
96_E142_S1.0041.00
166_E200_I0.9961.00
165_I200_I0.9951.00
284_F295_D0.9921.00
20_Y72_N0.9901.00
260_S263_T0.9891.00
220_R223_E0.9801.00
239_A316_P0.9771.00
140_R144_K0.9681.00
138_Q141_E0.9661.00
175_L180_K0.9591.00
35_L66_A0.9561.00
176_V206_V0.9551.00
63_I99_L0.9551.00
254_N282_R0.9551.00
58_E323_I0.9521.00
61_K65_K0.9521.00
279_E282_R0.9461.00
31_S72_N0.9391.00
56_E94_N0.9331.00
321_T325_Q0.9311.00
34_C315_V0.9291.00
170_E173_H0.9281.00
166_E196_Y0.9271.00
169_M197_L0.9201.00
210_A238_M0.9181.00
279_E283_E0.9171.00
259_M263_T0.9171.00
62_T323_I0.9171.00
195_P233_Y0.9091.00
109_E150_Y0.9041.00
33_F304_F0.9041.00
158_R188_Y0.9041.00
114_A153_I0.8991.00
152_D182_H0.8981.00
320_V325_Q0.8951.00
175_L178_Q0.8901.00
228_I232_T0.8861.00
173_H176_V0.8861.00
134_H137_W0.8851.00
337_I342_Y0.8831.00
242_P318_I0.8711.00
64_V105_G0.8711.00
130_L156_M0.8691.00
135_I175_L0.8681.00
122_A127_G0.8681.00
171_T175_L0.8651.00
71_V330_I0.8641.00
34_C318_I0.8581.00
304_F332_S0.8561.00
132_R171_T0.8541.00
298_L335_V0.8541.00
40_L59_S0.8531.00
218_L247_V0.8521.00
215_Y306_I0.8501.00
287_I348_I0.8501.00
271_R275_K0.8481.00
59_S98_I0.8441.00
63_I67_I0.8431.00
217_F349_S0.8401.00
146_L151_I0.8391.00
165_I168_T0.8391.00
40_L62_T0.8351.00
287_I341_T0.8341.00
247_V281_L0.8321.00
168_T171_T0.8311.00
56_E98_I0.8301.00
76_T99_L0.8261.00
224_K228_I0.8201.00
287_I291_L0.8201.00
278_F281_L0.8181.00
67_I110_S0.8151.00
143_L180_K0.8091.00
19_E334_N0.8081.00
176_V181_I0.8081.00
25_N234_G0.8071.00
328_E331_E0.8041.00
186_E189_F0.8041.00
296_T328_E0.8031.00
35_L40_L0.8021.00
298_L345_L0.8011.00
305_K339_N0.7971.00
322_K325_Q0.7961.00
343_K346_D0.7951.00
167_E170_E0.7911.00
261_R265_V0.7901.00
340_D344_K0.7881.00
67_I106_Y0.7861.00
117_V130_L0.7861.00
176_V209_I0.7831.00
258_D262_A0.7811.00
66_A74_F0.7791.00
196_Y232_T0.7761.00
23_F236_G0.7701.00
222_I227_F0.7681.00
106_Y110_S0.7651.00
324_N328_E0.7641.00
198_V235_L0.7591.00
61_K64_V0.7581.00
281_L285_H0.7541.00
215_Y303_I0.7531.00
288_A298_L0.7521.00
229_L232_T0.7511.00
230_A235_L0.7501.00
186_E194_I0.7491.00
137_W140_R0.7411.00
304_F316_P0.7401.00
172_F176_V0.7371.00
30_V73_F0.7361.00
220_R346_D0.7351.00
239_A309_I0.7341.00
215_Y223_E0.7341.00
287_I344_K0.7321.00
253_L256_T0.7311.00
223_E228_I0.7311.00
78_N145_R0.7311.00
94_N98_I0.7261.00
156_M168_T0.7231.00
54_V59_S0.7221.00
20_Y31_S0.7221.00
159_P189_F0.7211.00
325_Q328_E0.7161.00
76_T95_A0.7151.00
254_N275_K0.7151.00
169_M208_F0.7121.00
215_Y220_R0.7111.00
57_E60_K0.7081.00
291_L338_S0.7071.00
60_K105_G0.7031.00
139_V171_T0.7021.00
135_I168_T0.7011.00
191_P225_D0.6991.00
337_I341_T0.6961.00
239_A242_P0.6941.00
155_L185_G0.6941.00
129_G134_H0.6931.00
75_D212_Q0.6901.00
176_V184_I0.6881.00
257_P260_S0.6881.00
270_N273_F0.6871.00
93_G145_R0.6851.00
169_M184_I0.6831.00
309_I315_V0.6831.00
31_S73_F0.6791.00
120_K128_E0.6791.00
289_K292_G0.6771.00
199_K233_Y0.6741.00
34_C317_I0.6731.00
247_V277_N0.6721.00
276_E279_E0.6701.00
291_L298_L0.6661.00
194_I226_K0.6631.00
41_P95_A0.6601.00
134_H138_Q0.6591.00
297_Q335_V0.6581.00
67_I72_N0.6571.00
154_Y181_I0.6521.00
96_E115_T0.6481.00
79_V119_G0.6481.00
169_M201_A0.6461.00
186_E211_M0.6451.00
196_Y200_I0.6441.00
191_P195_P0.6431.00
35_L62_T0.6391.00
153_I185_G0.6381.00
165_I197_L0.6351.00
78_N141_E0.6341.00
305_K336_K0.6341.00
131_S134_H0.6341.00
135_I171_T0.6331.00
300_L329_N0.6321.00
185_G210_A0.6321.00
151_I154_Y0.6301.00
189_F194_I0.6291.00
198_V207_P0.6291.00
119_G158_R0.6271.00
130_L168_T0.6251.00
74_F111_L0.6201.00
291_L335_V0.6181.00
38_W241_I0.6171.00
258_D261_R0.6161.00
242_P300_L0.6161.00
242_P303_I0.6141.00
298_L337_I0.6141.00
323_I326_L0.6131.00
74_F103_I0.6121.00
116_K157_H0.6101.00
63_I103_I0.6091.00
67_I102_A0.6081.00
192_T195_P0.6071.00
211_M230_A0.6061.00
301_A336_K0.6061.00
103_I106_Y0.6051.00
259_M262_A0.6041.00
228_I231_K0.6031.00
270_N275_K0.6031.00
222_I225_D0.6021.00
269_S272_Y0.6021.00
227_F231_K0.6021.00
73_F112_V0.5991.00
103_I113_L0.5981.00
192_T225_D0.5981.00
254_N278_F0.5981.00
184_I206_V0.5971.00
173_H184_I0.5951.00
290_E338_S0.5921.00
293_V331_E0.5911.00
67_I74_F0.5901.00
226_K230_A0.5891.00
293_V301_A0.5881.00
299_A303_I0.5821.00
201_A208_F0.5801.00
221_D224_K0.5801.00
238_M315_V0.5801.00
320_V329_N0.5801.00
26_S183_Y0.5791.00
142_S154_Y0.5781.00
346_D350_K0.5771.00
58_E324_N0.5751.00
56_E59_S0.5751.00
62_T320_V0.5751.00
222_I226_K0.5741.00
194_I211_M0.5741.00
284_F345_L0.5731.00
115_T157_H0.5731.00
161_P193_D0.5691.00
298_L341_T0.5681.00
30_V315_V0.5641.00
300_L332_S0.5631.00
284_F299_A0.5611.00
117_V138_Q0.5601.00
136_M180_K0.5591.00
34_C238_M0.5581.00
65_K330_I0.5551.00
251_K325_Q0.5551.00
160_D163_T0.5531.00
291_L344_K0.5531.00
143_L149_D0.5531.00
254_N279_E0.5531.00
120_K127_G0.5531.00
30_V112_V0.5521.00
139_V143_L0.5521.00
280_V348_I0.5511.00
118_R130_L0.5511.00
54_V321_T0.5491.00
164_P168_T0.5481.00
201_A206_V0.5481.00
192_T232_T0.5471.00
266_P270_N0.5471.00
66_A326_L0.5441.00
275_K278_F0.5431.00
24_G30_V0.5421.00
227_F308_E0.5421.00
284_F298_L0.5411.00
341_T344_K0.5401.00
140_R175_L0.5391.00
97_R147_N0.5391.00
265_V269_S0.5381.00
60_K98_I0.5371.00
301_A332_S0.5351.00
208_F235_L0.5331.00
55_D59_S0.5321.00
68_D106_Y0.5311.00
81_H94_N0.5291.00
54_V58_E0.5271.00
213_E226_K0.5241.00
257_P261_R0.5241.00
213_E239_A0.5241.00
80_Y116_K0.5221.00
33_F318_I0.5211.00
196_Y233_Y0.5181.00
197_L208_F0.5181.00
35_L320_V0.5181.00
191_P226_K0.5181.00
24_G236_G0.5171.00
266_P269_S0.5141.00
33_F333_L0.5141.00
77_A157_H0.5111.00
269_S273_F0.5101.00
178_Q181_I0.5091.00
309_I314_I0.5061.00
249_T296_T0.5051.00
229_L235_L0.5041.00
101_E104_K0.5031.00
42_P94_N0.5031.00
193_D196_Y0.5021.00
176_V207_P0.5021.00
215_Y227_F0.5011.00
239_A303_I0.5011.00
300_L318_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pyfA 1 0.8397 100 0.198 Contact Map
3v0sA 1 0.7364 100 0.201 Contact Map
3erpA 6 0.8288 100 0.206 Contact Map
1pz1A 1 0.8804 100 0.206 Contact Map
3n6qA 5 0.837 100 0.206 Contact Map
4xk2A 5 0.837 100 0.207 Contact Map
3eauA 3 0.8533 100 0.218 Contact Map
3n2tA 1 0.8668 100 0.218 Contact Map
1lqaA 2 0.875 100 0.221 Contact Map
3lutA 3 0.8533 100 0.221 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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