Q97UG6 - SULSO - GREMLIN Contacts

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Q97UG6 - Oxidoreductase

UniProt:	Q97UG6	Sequences: MAKLLYLWYQTYKMCNKMEYMKFGNSGLKVSKFCLGTWHLPPSKERDSYGVYKVDEEESKKTIVKAIDLGVNFFDTANVYHGVMQGPDVFHVGNAERILGEAIKGYDRESLVLATKVRGKMAEHANGEGLSRKHIMWQVRESLKRLNTDYIDIYLMHRPDPDTPIEETMETFHDLVRQGKIHYIGESYFDPTDIPYLVKIAKDLHVPFIAMQEPYNFLERDIEKDKFILAKTYGLGIMAYIPLAQGVLTGKYLNTTPDMSRATYVPEISNRYFTKENFEVLREFHEIAKELGVTDTQLALAWIFKIQEINQITIVPIIGVTKINQLEENIESLNVKISNDTYKKLDEISKRVKVNWEIKYNKIIKRFE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	368 (306)
Sequences:	20459 (13018)
Seq/√Len:	744.2

ECOLI - GPR YAJO YDJG TAS YDHF YEAE YDBC DKGA DKGB
BACSU - GS69 IOLS YRPG YCCK YQKF YCSN YTBE GR
HALSA - Q9HPH9 Q9HQU7 Q9HNN3 Q9HSE6 Q9HS02 Q9HQT1
SULSO - Q97UG6 Q97UJ7 Q97ZZ1 Q97UV9 Q97V56 Q97U17

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
65_K	327_E	3.731	1.00
56_E	101_E	3.643	1.00
104_K	147_N	3.081	1.00
291_L	341_T	3.023	1.00
140_R	180_K	2.957	1.00
290_E	344_K	2.721	1.00
65_K	69_L	2.660	1.00
136_M	178_Q	2.561	1.00
173_H	177_R	2.551	1.00
338_S	341_T	2.521	1.00
22_K	29_K	2.504	1.00
139_V	175_L	2.379	1.00
94_N	97_R	2.353	1.00
21_M	32_K	2.287	1.00
136_M	174_D	2.227	1.00
115_T	151_I	2.211	1.00
150_Y	182_H	2.186	1.00
285_H	289_K	2.179	1.00
34_C	73_F	2.149	1.00
55_D	58_E	2.109	1.00
69_L	327_E	2.099	1.00
339_N	343_K	2.097	1.00
155_L	210_A	2.085	1.00
132_R	174_D	2.039	1.00
283_E	286_E	1.957	1.00
117_V	135_I	1.951	1.00
174_D	177_R	1.947	1.00
155_L	238_M	1.891	1.00
305_K	342_Y	1.863	1.00
139_V	151_I	1.825	1.00
37_T	74_F	1.821	1.00
139_V	154_Y	1.815	1.00
69_L	330_I	1.812	1.00
173_H	206_V	1.810	1.00
343_K	347_E	1.809	1.00
132_R	136_M	1.808	1.00
331_E	334_N	1.805	1.00
290_E	341_T	1.751	1.00
60_K	102_A	1.741	1.00
19_E	32_K	1.713	1.00
293_V	335_V	1.712	1.00
137_W	141_E	1.706	1.00
66_A	71_V	1.691	1.00
114_A	155_L	1.685	1.00
20_Y	29_K	1.684	1.00
286_E	344_K	1.672	1.00
225_D	228_I	1.667	1.00
65_K	323_I	1.656	1.00
63_I	102_A	1.648	1.00
229_L	233_Y	1.644	1.00
174_D	178_Q	1.599	1.00
56_E	60_K	1.597	1.00
117_V	154_Y	1.597	1.00
181_I	184_I	1.597	1.00
294_T	328_E	1.592	1.00
195_P	232_T	1.587	1.00
113_L	148_T	1.578	1.00
78_N	138_Q	1.575	1.00
301_A	335_V	1.565	1.00
28_L	112_V	1.562	1.00
293_V	297_Q	1.556	1.00
64_V	106_Y	1.531	1.00
58_E	61_K	1.528	1.00
60_K	64_V	1.528	1.00
171_T	174_D	1.515	1.00
202_K	207_P	1.510	1.00
195_P	199_K	1.495	1.00
115_T	142_S	1.494	1.00
67_I	111_L	1.494	1.00
231_K	307_Q	1.490	1.00
190_D	193_D	1.489	1.00
323_I	327_E	1.474	1.00
60_K	101_E	1.467	1.00
22_K	27_G	1.453	1.00
230_A	237_I	1.451	1.00
156_M	172_F	1.450	1.00
294_T	297_Q	1.432	1.00
306_I	346_D	1.418	1.00
159_P	193_D	1.415	1.00
97_R	145_R	1.410	1.00
344_K	347_E	1.397	1.00
141_E	144_K	1.374	1.00
231_K	308_E	1.373	1.00
72_N	112_V	1.368	1.00
286_E	290_E	1.365	1.00
74_F	99_L	1.356	1.00
191_P	229_L	1.349	1.00
151_I	181_I	1.342	1.00
136_M	171_T	1.330	1.00
175_L	181_I	1.329	1.00
293_V	298_L	1.322	1.00
62_T	326_L	1.314	1.00
283_E	344_K	1.314	1.00
141_E	145_R	1.306	1.00
108_R	148_T	1.295	1.00
101_E	147_N	1.291	1.00
324_N	327_E	1.286	1.00
97_R	144_K	1.282	1.00
285_H	295_D	1.280	1.00
214_P	219_E	1.273	1.00
136_M	140_R	1.267	1.00
64_V	68_D	1.257	1.00
61_K	323_I	1.250	1.00
253_L	285_H	1.246	1.00
184_I	208_F	1.243	1.00
63_I	74_F	1.241	1.00
172_F	184_I	1.239	1.00
303_I	316_P	1.220	1.00
195_P	229_L	1.218	1.00
217_F	345_L	1.218	1.00
78_N	134_H	1.215	1.00
198_V	233_Y	1.213	1.00
282_R	285_H	1.206	1.00
198_V	229_L	1.194	1.00
73_F	114_A	1.190	1.00
170_E	174_D	1.190	1.00
297_Q	331_E	1.186	1.00
57_E	61_K	1.183	1.00
32_K	304_F	1.182	1.00
32_K	333_L	1.182	1.00
186_E	208_F	1.177	1.00
19_E	336_K	1.173	1.00
97_R	101_E	1.171	1.00
297_Q	328_E	1.166	1.00
327_E	331_E	1.158	1.00
213_E	237_I	1.157	1.00
103_I	111_L	1.151	1.00
120_K	129_G	1.150	1.00
37_T	99_L	1.145	1.00
275_K	279_E	1.138	1.00
100_G	147_N	1.132	1.00
65_K	68_D	1.128	1.00
140_R	178_Q	1.124	1.00
287_I	298_L	1.123	1.00
153_I	210_A	1.122	1.00
188_Y	240_Y	1.120	1.00
183_Y	209_I	1.119	1.00
64_V	102_A	1.118	1.00
28_L	183_Y	1.117	1.00
108_R	150_Y	1.117	1.00
132_R	170_E	1.112	1.00
112_V	153_I	1.109	1.00
306_I	342_Y	1.104	1.00
194_I	235_L	1.090	1.00
69_L	331_E	1.087	1.00
222_I	237_I	1.086	1.00
196_Y	199_K	1.083	1.00
236_G	314_I	1.078	1.00
26_S	209_I	1.074	1.00
136_M	175_L	1.073	1.00
282_R	286_E	1.071	1.00
31_S	71_V	1.064	1.00
258_D	263_T	1.061	1.00
236_G	315_V	1.059	1.00
326_L	330_I	1.050	1.00
301_A	305_K	1.049	1.00
227_F	237_I	1.037	1.00
217_F	299_A	1.035	1.00
132_R	167_E	1.035	1.00
253_L	282_R	1.033	1.00
286_E	289_K	1.033	1.00
37_T	95_A	1.032	1.00
133_K	137_W	1.031	1.00
73_F	238_M	1.031	1.00
136_M	139_V	1.030	1.00
278_F	282_R	1.016	1.00
283_E	348_I	1.011	1.00
340_D	343_K	1.007	1.00
320_V	326_L	1.007	1.00
96_E	142_S	1.004	1.00
166_E	200_I	0.996	1.00
165_I	200_I	0.995	1.00
284_F	295_D	0.992	1.00
20_Y	72_N	0.990	1.00
260_S	263_T	0.989	1.00
220_R	223_E	0.980	1.00
239_A	316_P	0.977	1.00
140_R	144_K	0.968	1.00
138_Q	141_E	0.966	1.00
175_L	180_K	0.959	1.00
35_L	66_A	0.956	1.00
176_V	206_V	0.955	1.00
63_I	99_L	0.955	1.00
254_N	282_R	0.955	1.00
58_E	323_I	0.952	1.00
61_K	65_K	0.952	1.00
279_E	282_R	0.946	1.00
31_S	72_N	0.939	1.00
56_E	94_N	0.933	1.00
321_T	325_Q	0.931	1.00
34_C	315_V	0.929	1.00
170_E	173_H	0.928	1.00
166_E	196_Y	0.927	1.00
169_M	197_L	0.920	1.00
210_A	238_M	0.918	1.00
279_E	283_E	0.917	1.00
259_M	263_T	0.917	1.00
62_T	323_I	0.917	1.00
195_P	233_Y	0.909	1.00
109_E	150_Y	0.904	1.00
33_F	304_F	0.904	1.00
158_R	188_Y	0.904	1.00
114_A	153_I	0.899	1.00
152_D	182_H	0.898	1.00
320_V	325_Q	0.895	1.00
175_L	178_Q	0.890	1.00
228_I	232_T	0.886	1.00
173_H	176_V	0.886	1.00
134_H	137_W	0.885	1.00
337_I	342_Y	0.883	1.00
242_P	318_I	0.871	1.00
64_V	105_G	0.871	1.00
130_L	156_M	0.869	1.00
135_I	175_L	0.868	1.00
122_A	127_G	0.868	1.00
171_T	175_L	0.865	1.00
71_V	330_I	0.864	1.00
34_C	318_I	0.858	1.00
304_F	332_S	0.856	1.00
132_R	171_T	0.854	1.00
298_L	335_V	0.854	1.00
40_L	59_S	0.853	1.00
218_L	247_V	0.852	1.00
215_Y	306_I	0.850	1.00
287_I	348_I	0.850	1.00
271_R	275_K	0.848	1.00
59_S	98_I	0.844	1.00
63_I	67_I	0.843	1.00
217_F	349_S	0.840	1.00
146_L	151_I	0.839	1.00
165_I	168_T	0.839	1.00
40_L	62_T	0.835	1.00
287_I	341_T	0.834	1.00
247_V	281_L	0.832	1.00
168_T	171_T	0.831	1.00
56_E	98_I	0.830	1.00
76_T	99_L	0.826	1.00
224_K	228_I	0.820	1.00
287_I	291_L	0.820	1.00
278_F	281_L	0.818	1.00
67_I	110_S	0.815	1.00
143_L	180_K	0.809	1.00
19_E	334_N	0.808	1.00
176_V	181_I	0.808	1.00
25_N	234_G	0.807	1.00
328_E	331_E	0.804	1.00
186_E	189_F	0.804	1.00
296_T	328_E	0.803	1.00
35_L	40_L	0.802	1.00
298_L	345_L	0.801	1.00
305_K	339_N	0.797	1.00
322_K	325_Q	0.796	1.00
343_K	346_D	0.795	1.00
167_E	170_E	0.791	1.00
261_R	265_V	0.790	1.00
340_D	344_K	0.788	1.00
67_I	106_Y	0.786	1.00
117_V	130_L	0.786	1.00
176_V	209_I	0.783	1.00
258_D	262_A	0.781	1.00
66_A	74_F	0.779	1.00
196_Y	232_T	0.776	1.00
23_F	236_G	0.770	1.00
222_I	227_F	0.768	1.00
106_Y	110_S	0.765	1.00
324_N	328_E	0.764	1.00
198_V	235_L	0.759	1.00
61_K	64_V	0.758	1.00
281_L	285_H	0.754	1.00
215_Y	303_I	0.753	1.00
288_A	298_L	0.752	1.00
229_L	232_T	0.751	1.00
230_A	235_L	0.750	1.00
186_E	194_I	0.749	1.00
137_W	140_R	0.741	1.00
304_F	316_P	0.740	1.00
172_F	176_V	0.737	1.00
30_V	73_F	0.736	1.00
220_R	346_D	0.735	1.00
239_A	309_I	0.734	1.00
215_Y	223_E	0.734	1.00
287_I	344_K	0.732	1.00
253_L	256_T	0.731	1.00
223_E	228_I	0.731	1.00
78_N	145_R	0.731	1.00
94_N	98_I	0.726	1.00
156_M	168_T	0.723	1.00
54_V	59_S	0.722	1.00
20_Y	31_S	0.722	1.00
159_P	189_F	0.721	1.00
325_Q	328_E	0.716	1.00
76_T	95_A	0.715	1.00
254_N	275_K	0.715	1.00
169_M	208_F	0.712	1.00
215_Y	220_R	0.711	1.00
57_E	60_K	0.708	1.00
291_L	338_S	0.707	1.00
60_K	105_G	0.703	1.00
139_V	171_T	0.702	1.00
135_I	168_T	0.701	1.00
191_P	225_D	0.699	1.00
337_I	341_T	0.696	1.00
239_A	242_P	0.694	1.00
155_L	185_G	0.694	1.00
129_G	134_H	0.693	1.00
75_D	212_Q	0.690	1.00
176_V	184_I	0.688	1.00
257_P	260_S	0.688	1.00
270_N	273_F	0.687	1.00
93_G	145_R	0.685	1.00
169_M	184_I	0.683	1.00
309_I	315_V	0.683	1.00
31_S	73_F	0.679	1.00
120_K	128_E	0.679	1.00
289_K	292_G	0.677	1.00
199_K	233_Y	0.674	1.00
34_C	317_I	0.673	1.00
247_V	277_N	0.672	1.00
276_E	279_E	0.670	1.00
291_L	298_L	0.666	1.00
194_I	226_K	0.663	1.00
41_P	95_A	0.660	1.00
134_H	138_Q	0.659	1.00
297_Q	335_V	0.658	1.00
67_I	72_N	0.657	1.00
154_Y	181_I	0.652	1.00
96_E	115_T	0.648	1.00
79_V	119_G	0.648	1.00
169_M	201_A	0.646	1.00
186_E	211_M	0.645	1.00
196_Y	200_I	0.644	1.00
191_P	195_P	0.643	1.00
35_L	62_T	0.639	1.00
153_I	185_G	0.638	1.00
165_I	197_L	0.635	1.00
78_N	141_E	0.634	1.00
305_K	336_K	0.634	1.00
131_S	134_H	0.634	1.00
135_I	171_T	0.633	1.00
300_L	329_N	0.632	1.00
185_G	210_A	0.632	1.00
151_I	154_Y	0.630	1.00
189_F	194_I	0.629	1.00
198_V	207_P	0.629	1.00
119_G	158_R	0.627	1.00
130_L	168_T	0.625	1.00
74_F	111_L	0.620	1.00
291_L	335_V	0.618	1.00
38_W	241_I	0.617	1.00
258_D	261_R	0.616	1.00
242_P	300_L	0.616	1.00
242_P	303_I	0.614	1.00
298_L	337_I	0.614	1.00
323_I	326_L	0.613	1.00
74_F	103_I	0.612	1.00
116_K	157_H	0.610	1.00
63_I	103_I	0.609	1.00
67_I	102_A	0.608	1.00
192_T	195_P	0.607	1.00
211_M	230_A	0.606	1.00
301_A	336_K	0.606	1.00
103_I	106_Y	0.605	1.00
259_M	262_A	0.604	1.00
228_I	231_K	0.603	1.00
270_N	275_K	0.603	1.00
222_I	225_D	0.602	1.00
269_S	272_Y	0.602	1.00
227_F	231_K	0.602	1.00
73_F	112_V	0.599	1.00
103_I	113_L	0.598	1.00
192_T	225_D	0.598	1.00
254_N	278_F	0.598	1.00
184_I	206_V	0.597	1.00
173_H	184_I	0.595	1.00
290_E	338_S	0.592	1.00
293_V	331_E	0.591	1.00
67_I	74_F	0.590	1.00
226_K	230_A	0.589	1.00
293_V	301_A	0.588	1.00
299_A	303_I	0.582	1.00
201_A	208_F	0.580	1.00
221_D	224_K	0.580	1.00
238_M	315_V	0.580	1.00
320_V	329_N	0.580	1.00
26_S	183_Y	0.579	1.00
142_S	154_Y	0.578	1.00
346_D	350_K	0.577	1.00
58_E	324_N	0.575	1.00
56_E	59_S	0.575	1.00
62_T	320_V	0.575	1.00
222_I	226_K	0.574	1.00
194_I	211_M	0.574	1.00
284_F	345_L	0.573	1.00
115_T	157_H	0.573	1.00
161_P	193_D	0.569	1.00
298_L	341_T	0.568	1.00
30_V	315_V	0.564	1.00
300_L	332_S	0.563	1.00
284_F	299_A	0.561	1.00
117_V	138_Q	0.560	1.00
136_M	180_K	0.559	1.00
34_C	238_M	0.558	1.00
65_K	330_I	0.555	1.00
251_K	325_Q	0.555	1.00
160_D	163_T	0.553	1.00
291_L	344_K	0.553	1.00
143_L	149_D	0.553	1.00
254_N	279_E	0.553	1.00
120_K	127_G	0.553	1.00
30_V	112_V	0.552	1.00
139_V	143_L	0.552	1.00
280_V	348_I	0.551	1.00
118_R	130_L	0.551	1.00
54_V	321_T	0.549	1.00
164_P	168_T	0.548	1.00
201_A	206_V	0.548	1.00
192_T	232_T	0.547	1.00
266_P	270_N	0.547	1.00
66_A	326_L	0.544	1.00
275_K	278_F	0.543	1.00
24_G	30_V	0.542	1.00
227_F	308_E	0.542	1.00
284_F	298_L	0.541	1.00
341_T	344_K	0.540	1.00
140_R	175_L	0.539	1.00
97_R	147_N	0.539	1.00
265_V	269_S	0.538	1.00
60_K	98_I	0.537	1.00
301_A	332_S	0.535	1.00
208_F	235_L	0.533	1.00
55_D	59_S	0.532	1.00
68_D	106_Y	0.531	1.00
81_H	94_N	0.529	1.00
54_V	58_E	0.527	1.00
213_E	226_K	0.524	1.00
257_P	261_R	0.524	1.00
213_E	239_A	0.524	1.00
80_Y	116_K	0.522	1.00
33_F	318_I	0.521	1.00
196_Y	233_Y	0.518	1.00
197_L	208_F	0.518	1.00
35_L	320_V	0.518	1.00
191_P	226_K	0.518	1.00
24_G	236_G	0.517	1.00
266_P	269_S	0.514	1.00
33_F	333_L	0.514	1.00
77_A	157_H	0.511	1.00
269_S	273_F	0.510	1.00
178_Q	181_I	0.509	1.00
309_I	314_I	0.506	1.00
249_T	296_T	0.505	1.00
229_L	235_L	0.504	1.00
101_E	104_K	0.503	1.00
42_P	94_N	0.503	1.00
193_D	196_Y	0.502	1.00
176_V	207_P	0.502	1.00
215_Y	227_F	0.501	1.00
239_A	303_I	0.501	1.00
300_L	318_I	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1pyfA	1	0.8397	100	0.198	Contact Map
3v0sA	1	0.7364	100	0.201	Contact Map
3erpA	6	0.8288	100	0.206	Contact Map
1pz1A	1	0.8804	100	0.206	Contact Map
3n6qA	5	0.837	100	0.206	Contact Map
4xk2A	5	0.837	100	0.207	Contact Map
3eauA	3	0.8533	100	0.218	Contact Map
3n2tA	1	0.8668	100	0.218	Contact Map
1lqaA	2	0.875	100	0.221	Contact Map
3lutA	3	0.8533	100	0.221	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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