GREMLIN Database
Q97UG4 - Maltose ABC transporter, permease
UniProt: Q97UG4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 322 (293)
Sequences: 15264 (9759)
Seq/√Len: 570.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
61_A65_V3.5211.00
61_A69_H3.4201.00
16_R66_Q3.3651.00
72_Q76_T2.9761.00
68_A72_Q2.8981.00
54_A59_T2.7731.00
8_I67_Y2.6781.00
46_A50_S2.6441.00
21_S53_E2.5981.00
210_M236_V2.5691.00
107_V191_I2.5231.00
100_W268_T2.4541.00
231_R234_K2.4221.00
9_T67_Y2.3531.00
273_F277_L2.2981.00
223_E229_H2.2821.00
64_Y68_A2.2511.00
219_V236_V2.2361.00
93_I274_F2.0741.00
7_V295_A2.0661.00
49_V53_E2.0411.00
85_Y93_I2.0061.00
89_P92_S1.9671.00
249_A305_V1.9421.00
48_E51_Q1.9321.00
214_I236_V1.9231.00
213_T218_Y1.9191.00
165_F188_T1.9161.00
165_F185_R1.8841.00
51_Q55_A1.8451.00
228_D231_R1.8441.00
126_N129_S1.8251.00
245_I312_L1.8201.00
45_I48_E1.8191.00
111_I195_M1.7971.00
65_V69_H1.7781.00
114_F118_Y1.7521.00
221_Y225_L1.7481.00
88_T92_S1.7371.00
213_T216_D1.7331.00
159_S167_I1.7031.00
73_G78_N1.6891.00
50_S53_E1.6841.00
4_F296_I1.6771.00
90_V289_G1.6701.00
50_S54_A1.6441.00
119_L135_I1.6381.00
219_V232_I1.6251.00
125_F233_R1.6151.00
69_H72_Q1.6131.00
5_F9_T1.5811.00
74_I79_L1.5701.00
122_I126_N1.5641.00
156_M161_Q1.5621.00
246_T309_Y1.5601.00
130_R134_V1.5541.00
157_W161_Q1.5511.00
170_P268_T1.5431.00
181_M185_R1.5411.00
132_D207_R1.5401.00
91_L95_L1.5161.00
5_F67_Y1.5161.00
154_L193_A1.5121.00
122_I131_K1.5071.00
275_F290_I1.4891.00
308_I311_I1.4871.00
88_T96_S1.4611.00
131_K135_I1.4571.00
115_L118_Y1.4391.00
278_A286_L1.4361.00
69_H73_G1.4301.00
225_L235_M1.4251.00
191_I195_M1.4221.00
23_L49_V1.4201.00
149_V153_Y1.4191.00
93_I286_L1.4171.00
126_N131_K1.4091.00
100_W170_P1.3981.00
124_G210_M1.3981.00
274_F286_L1.3871.00
112_A198_S1.3871.00
103_F170_P1.3771.00
52_L55_A1.3731.00
115_L199_L1.3651.00
227_L231_R1.3571.00
52_L56_F1.3551.00
121_S210_M1.3551.00
218_Y239_N1.3411.00
195_M199_L1.3331.00
57_G61_A1.3321.00
213_T219_V1.3261.00
157_W162_H1.3261.00
62_P65_V1.3161.00
8_I70_Y1.2991.00
213_T240_S1.2751.00
242_L309_Y1.2651.00
57_G69_H1.2631.00
172_K182_A1.2541.00
113_F248_F1.2461.00
128_R132_D1.2441.00
65_V68_A1.2421.00
81_A89_P1.2371.00
9_T13_I1.2331.00
145_L150_I1.2311.00
24_A49_V1.2211.00
116_G206_M1.2211.00
206_M244_N1.2191.00
103_F183_L1.2181.00
82_S283_D1.2071.00
120_G124_G1.2041.00
182_A186_F1.1991.00
109_A248_F1.1951.00
217_N220_T1.1941.00
153_Y157_W1.1891.00
5_F71_I1.1801.00
88_T93_I1.1461.00
84_T281_S1.1371.00
79_L289_G1.1341.00
9_T63_W1.1291.00
124_G211_L1.1281.00
120_G206_M1.1231.00
154_L189_L1.1231.00
165_F189_L1.1211.00
142_L200_S1.1081.00
307_A311_I1.1001.00
96_S99_P1.0981.00
21_S24_A1.0981.00
290_I294_I1.0961.00
184_S188_T1.0941.00
4_F299_I1.0931.00
158_L162_H1.0931.00
100_W103_F1.0911.00
8_I292_L1.0891.00
207_R211_L1.0861.00
229_H232_I1.0821.00
20_G282_K1.0721.00
276_G280_T1.0701.00
92_S96_S1.0671.00
116_G202_F1.0661.00
93_I96_S1.0641.00
193_A197_T1.0621.00
79_L91_L1.0621.00
61_A64_Y1.0571.00
301_S305_V1.0531.00
135_I203_V1.0531.00
172_K186_F1.0521.00
277_L281_S1.0511.00
171_S186_F1.0501.00
111_I191_I1.0491.00
16_R63_W1.0481.00
103_F187_Y1.0441.00
51_Q54_A1.0431.00
158_L165_F1.0401.00
95_L99_P1.0321.00
27_I52_L1.0311.00
103_F107_V1.0301.00
67_Y71_I1.0261.00
119_L203_V1.0181.00
74_I292_L1.0161.00
151_L265_L1.0121.00
304_I308_I1.0121.00
151_L193_A1.0071.00
147_S262_V1.0011.00
123_A135_I1.0001.00
188_T192_I0.9981.00
187_Y191_I0.9841.00
92_S95_L0.9821.00
54_A61_A0.9781.00
227_L232_I0.9761.00
205_G247_A0.9711.00
105_V255_A0.9621.00
13_I16_R0.9611.00
139_T203_V0.9551.00
252_L301_S0.9531.00
124_G214_I0.9511.00
213_T236_V0.9451.00
72_Q75_F0.9381.00
128_R133_L0.9361.00
264_G273_F0.9341.00
182_A185_R0.9311.00
73_G76_T0.9291.00
23_L27_I0.9261.00
209_N240_S0.9241.00
106_V110_I0.9211.00
245_I305_V0.9201.00
6_V10_V0.9161.00
132_D211_L0.9161.00
253_G298_L0.9151.00
127_R215_R0.9141.00
223_E232_I0.9131.00
47_L51_Q0.9121.00
109_A252_L0.9111.00
83_I285_P0.9101.00
259_S262_V0.9081.00
202_F251_I0.8981.00
97_G274_F0.8981.00
41_G44_A0.8931.00
118_Y121_S0.8931.00
70_Y74_I0.8901.00
206_M210_M0.8881.00
310_T316_A0.8881.00
307_A310_T0.8831.00
108_G195_M0.8751.00
150_I196_F0.8721.00
23_L53_E0.8721.00
81_A87_P0.8711.00
13_I63_W0.8701.00
232_I236_V0.8691.00
130_R133_L0.8681.00
274_F278_A0.8621.00
27_I44_A0.8481.00
181_M184_S0.8381.00
106_V252_L0.8381.00
121_S233_R0.8341.00
300_L304_I0.8341.00
12_F16_R0.8321.00
99_P102_L0.8311.00
125_F229_H0.8291.00
68_A71_I0.8291.00
85_Y88_T0.8261.00
94_I290_I0.8261.00
94_I289_G0.8251.00
118_Y122_I0.8241.00
101_T105_V0.8201.00
107_V268_T0.8171.00
127_R211_L0.8151.00
138_I142_L0.8091.00
170_P183_L0.8081.00
142_L196_F0.8061.00
116_G203_V0.8051.00
46_A49_V0.8041.00
16_R284_L0.8011.00
47_L50_S0.8011.00
11_N291_F0.8011.00
116_G120_G0.7981.00
108_G194_L0.7981.00
9_T64_Y0.7971.00
134_V138_I0.7961.00
158_L164_I0.7931.00
171_S182_A0.7921.00
108_G112_A0.7921.00
3_T299_I0.7911.00
222_A232_I0.7891.00
170_P187_Y0.7851.00
120_G210_M0.7851.00
72_Q77_L0.7831.00
113_F118_Y0.7811.00
133_L136_L0.7801.00
136_L203_V0.7791.00
296_I300_L0.7771.00
309_Y316_A0.7741.00
147_S196_F0.7731.00
119_L199_L0.7681.00
107_V187_Y0.7681.00
185_R188_T0.7681.00
193_A262_V0.7671.00
117_S206_M0.7671.00
154_L192_I0.7671.00
277_L280_T0.7631.00
103_F106_V0.7621.00
229_H233_R0.7621.00
192_I195_M0.7561.00
172_K183_L0.7541.00
222_A227_L0.7521.00
44_A49_V0.7491.00
102_L106_V0.7451.00
245_I308_I0.7431.00
71_I75_F0.7391.00
240_S243_P0.7381.00
23_L52_L0.7371.00
274_F290_I0.7371.00
112_A195_M0.7321.00
183_L186_F0.7321.00
188_T191_I0.7261.00
131_K134_V0.7261.00
155_E167_I0.7251.00
278_A287_L0.7251.00
264_G276_G0.7221.00
222_A225_L0.7201.00
50_S59_T0.7191.00
206_M237_Y0.7171.00
23_L56_F0.7171.00
107_V184_S0.7171.00
206_M240_S0.7171.00
169_F186_F0.7151.00
199_L203_V0.7101.00
269_P273_F0.7081.00
284_L288_Q0.7051.00
156_M160_V0.7031.00
194_L259_S0.6981.00
253_G301_S0.6981.00
101_T259_S0.6981.00
115_L195_M0.6961.00
166_L186_F0.6931.00
264_G277_L0.6921.00
111_I192_I0.6891.00
107_V188_T0.6881.00
260_L276_G0.6831.00
71_I74_I0.6831.00
161_Q164_I0.6831.00
121_S237_Y0.6821.00
107_V111_I0.6801.00
104_L191_I0.6801.00
168_S267_T0.6771.00
233_R236_V0.6761.00
26_V52_L0.6751.00
310_T317_R0.6721.00
135_I139_T0.6711.00
288_Q291_F0.6701.00
98_L102_L0.6701.00
16_R288_Q0.6671.00
314_P317_R0.6671.00
15_P287_L0.6591.00
171_S183_L0.6591.00
13_I17_L0.6571.00
115_L119_L0.6541.00
218_Y222_A0.6531.00
53_E59_T0.6511.00
94_I271_V0.6491.00
22_A284_L0.6471.00
123_A132_D0.6471.00
206_M209_N0.6441.00
275_F294_I0.6431.00
134_V137_I0.6431.00
97_G273_F0.6411.00
105_V109_A0.6361.00
158_L189_L0.6361.00
289_G293_F0.6331.00
297_M301_S0.6321.00
145_L149_V0.6311.00
147_S197_T0.6291.00
149_V152_M0.6281.00
6_V9_T0.6261.00
48_E52_L0.6231.00
286_L290_I0.6231.00
117_S244_N0.6221.00
242_L316_A0.6171.00
99_P103_F0.6141.00
303_A307_A0.6141.00
93_I97_G0.6131.00
158_L161_Q0.6121.00
305_V309_Y0.6121.00
198_S201_G0.6101.00
129_S133_L0.6081.00
222_A235_M0.6061.00
23_L41_G0.6051.00
298_L302_I0.6031.00
299_I302_I0.6001.00
249_A301_S0.6001.00
294_I298_L0.5981.00
105_V252_L0.5971.00
241_L244_N0.5971.00
209_N213_T0.5971.00
202_F247_A0.5971.00
129_S132_D0.5961.00
287_L291_F0.5951.00
112_A202_F0.5931.00
308_I312_L0.5911.00
184_S191_I0.5901.00
241_L245_I0.5901.00
126_N132_D0.5901.00
137_I141_I0.5891.00
109_A113_F0.5891.00
121_S125_F0.5881.00
263_E270_G0.5881.00
55_A87_P0.5871.00
202_F248_F0.5871.00
103_F268_T0.5871.00
143_A200_S0.5861.00
44_A48_E0.5861.00
295_A299_I0.5861.00
228_D232_I0.5851.00
159_S163_G0.5851.00
279_L287_L0.5841.00
8_I71_I0.5831.00
23_L26_V0.5811.00
194_L262_V0.5781.00
9_T12_F0.5751.00
184_S187_Y0.5751.00
95_L98_L0.5731.00
110_I114_F0.5731.00
227_L235_M0.5721.00
202_F244_N0.5721.00
8_I12_F0.5670.99
202_F206_M0.5650.99
260_L264_G0.5640.99
201_G205_G0.5630.99
63_W66_Q0.5610.99
124_G132_D0.5540.99
195_M198_S0.5510.99
156_M159_S0.5510.99
253_G297_M0.5500.99
275_F278_A0.5500.99
210_M240_S0.5500.99
65_V72_Q0.5490.99
201_G247_A0.5470.99
132_D136_L0.5470.99
129_S134_V0.5470.99
113_F202_F0.5450.99
22_A25_V0.5410.99
139_T200_S0.5370.99
5_F8_I0.5360.99
105_V259_S0.5350.99
251_I254_L0.5310.99
260_L275_F0.5300.99
192_I196_F0.5290.99
310_T318_V0.5270.99
200_S203_V0.5270.99
217_N221_Y0.5260.99
23_L44_A0.5260.99
123_A207_R0.5250.99
172_K185_R0.5240.99
9_T71_I0.5220.99
201_G251_I0.5210.99
11_N16_R0.5210.99
213_T239_N0.5200.99
127_R130_R0.5200.99
104_L268_T0.5180.99
216_D221_Y0.5160.99
114_F117_S0.5150.99
12_F19_P0.5150.99
205_G209_N0.5130.99
67_Y70_Y0.5130.99
9_T16_R0.5100.99
90_V286_L0.5100.99
140_S144_A0.5100.99
147_S150_I0.5090.99
102_L256_I0.5080.99
155_E159_S0.5070.99
166_L169_F0.5060.99
241_L312_L0.5060.99
159_S165_F0.5040.99
187_Y268_T0.5030.99
285_P288_Q0.5030.99
55_A81_A0.5030.99
11_N15_P0.5020.99
219_V223_E0.5010.99
12_F67_Y0.5010.99
198_S251_I0.5000.99
77_L81_A0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tuiA 2 0.646 99.9 0.706 Contact Map
3rlfF 1 0.8323 99.8 0.723 Contact Map
4tquM 1 0.8106 99.8 0.734 Contact Map
2onkC 2 0.7298 99.8 0.735 Contact Map
4ymuD 2 0.6491 99.8 0.737 Contact Map
3d31C 2 0.7205 99.7 0.75 Contact Map
4tquN 1 0.7733 99.6 0.77 Contact Map
3rlfG 1 0.8478 99.5 0.786 Contact Map
4lz6A 1 0.264 13.4 0.962 Contact Map
2yevC 1 0.0994 12.7 0.963 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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