GREMLIN Database
Q97UG3 - Maltose ABC transporter, permease
UniProt: Q97UG3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 323 (252)
Sequences: 28523 (17848)
Seq/√Len: 1124.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
174_V201_I2.7761.00
111_S171_R2.7221.00
177_I182_Y2.4601.00
187_R193_S2.4581.00
195_R199_N2.4411.00
191_E195_R2.3951.00
80_T229_F2.3911.00
87_S155_V2.3811.00
99_I114_I2.3401.00
177_I180_R2.3361.00
49_F55_P2.2981.00
194_W198_F2.2651.00
192_K195_R2.2601.00
91_L159_A2.2371.00
181_D184_I2.0981.00
73_V243_M2.0431.00
183_I201_I2.0411.00
49_F52_S2.0091.00
183_I196_I1.9931.00
214_L279_N1.9491.00
57_S60_I1.9431.00
101_L174_V1.9401.00
102_F106_Y1.8901.00
106_Y193_S1.8791.00
106_Y110_I1.8721.00
94_I98_L1.8591.00
69_D72_S1.8461.00
64_D68_H1.8191.00
242_T251_G1.7991.00
166_G216_G1.7911.00
52_S55_P1.7701.00
109_K113_V1.7571.00
182_Y204_S1.7551.00
34_G78_T1.7041.00
105_Y193_S1.6971.00
177_I205_I1.6931.00
104_G174_V1.6821.00
61_L263_G1.6721.00
66_F73_V1.6521.00
71_L75_M1.6451.00
95_I163_W1.6341.00
70_V263_G1.6211.00
110_I114_I1.6161.00
178_S201_I1.6131.00
95_I98_L1.6111.00
102_F110_I1.5801.00
28_L32_A1.5651.00
92_I162_S1.5501.00
83_I87_S1.5461.00
114_I167_A1.5421.00
59_H69_D1.5361.00
105_Y197_I1.5291.00
155_V159_A1.5241.00
93_A213_F1.4941.00
76_A79_L1.4861.00
173_Q176_S1.4781.00
89_G213_F1.4741.00
49_F53_L1.4741.00
20_I281_G1.4641.00
118_L167_A1.4621.00
68_H72_S1.4381.00
36_V39_F1.4151.00
244_L264_A1.4101.00
96_S166_G1.4081.00
47_E50_G1.4011.00
50_G53_L1.3961.00
176_S180_R1.3901.00
100_G104_G1.3801.00
96_S170_I1.3761.00
54_P58_A1.3671.00
211_A283_D1.3661.00
116_D119_T1.3651.00
185_A189_I1.3551.00
171_R175_L1.3381.00
129_I133_I1.3341.00
50_G54_P1.3311.00
23_G274_G1.3261.00
109_K112_G1.3201.00
100_G170_I1.3141.00
80_T83_I1.2831.00
177_I183_I1.2801.00
99_I167_A1.2671.00
159_A163_W1.2531.00
136_A141_A1.2521.00
61_L71_L1.2511.00
177_I201_I1.2401.00
104_G178_S1.2381.00
101_L197_I1.2361.00
30_D269_M1.2351.00
218_L272_G1.2301.00
169_Q212_Q1.2281.00
134_I157_G1.2261.00
103_G114_I1.2241.00
152_I156_I1.2231.00
258_W262_L1.2191.00
186_S200_Q1.2171.00
21_L25_V1.2161.00
32_A36_V1.2111.00
283_D287_D1.2101.00
282_I285_F1.2041.00
56_S61_L1.1921.00
74_M267_P1.1891.00
210_V286_I1.1881.00
53_L56_S1.1681.00
68_H73_V1.1601.00
107_G178_S1.1351.00
122_A164_A1.1291.00
18_K21_L1.1291.00
174_V205_I1.1291.00
186_S196_I1.1221.00
250_N254_L1.1191.00
101_L202_L1.1191.00
84_V224_L1.1021.00
68_H76_A1.1001.00
281_G285_F1.0871.00
157_G161_T1.0821.00
186_S191_E1.0791.00
61_L74_M1.0731.00
170_I209_T1.0701.00
264_A268_I1.0681.00
47_E55_P1.0671.00
97_T170_I1.0531.00
112_G116_D1.0501.00
184_I187_R1.0481.00
98_L101_L1.0471.00
170_I174_V1.0371.00
125_I130_L1.0361.00
195_R198_F1.0351.00
30_D271_L1.0291.00
173_Q177_I1.0271.00
243_M260_W1.0271.00
117_I122_A1.0231.00
29_V33_I1.0221.00
131_L157_G1.0221.00
37_G76_A1.0201.00
63_T69_D1.0191.00
27_I270_V1.0151.00
163_W167_A1.0141.00
111_S115_I1.0091.00
23_G281_G1.0081.00
189_I200_Q1.0071.00
70_V260_W1.0041.00
70_V243_M1.0011.00
108_G111_S0.9951.00
25_V28_L0.9931.00
115_I167_A0.9881.00
41_T72_S0.9871.00
152_I155_V0.9851.00
83_I151_Y0.9841.00
137_Y141_A0.9791.00
187_R196_I0.9781.00
77_S243_M0.9771.00
25_V29_V0.9721.00
22_A25_V0.9691.00
27_I274_G0.9681.00
79_L83_I0.9651.00
88_V159_A0.9621.00
107_G179_K0.9621.00
73_V260_W0.9601.00
186_S189_I0.9581.00
263_G266_I0.9521.00
113_V117_I0.9471.00
72_S76_A0.9431.00
274_G278_L0.9421.00
207_P283_D0.9371.00
26_I274_G0.9291.00
49_F54_P0.9261.00
110_I113_V0.9241.00
111_S175_L0.9231.00
23_G273_A0.9161.00
170_I205_I0.9151.00
88_V158_L0.9151.00
56_S59_H0.9131.00
88_V92_I0.9131.00
217_V275_L0.9091.00
35_I39_F0.8991.00
100_G174_V0.8941.00
259_W263_G0.8931.00
191_E196_I0.8931.00
51_I55_P0.8871.00
83_I86_I0.8851.00
51_I54_P0.8831.00
74_M263_G0.8821.00
193_S196_I0.8721.00
23_G277_I0.8721.00
112_G115_I0.8681.00
275_L279_N0.8661.00
56_S60_I0.8611.00
24_I28_L0.8581.00
43_Y72_S0.8571.00
93_A97_T0.8571.00
127_G223_S0.8561.00
73_V76_A0.8541.00
97_T209_T0.8481.00
253_Y256_N0.8471.00
24_I278_L0.8441.00
205_I208_L0.8431.00
108_G112_G0.8401.00
26_I270_V0.8391.00
212_Q216_G0.8371.00
31_F49_F0.8171.00
118_L164_A0.8151.00
33_I75_M0.8151.00
156_I159_A0.8111.00
94_I97_T0.8111.00
151_Y155_V0.8101.00
210_V279_N0.8071.00
75_M79_L0.8071.00
172_A175_L0.8031.00
63_T67_G0.7991.00
243_M264_A0.7981.00
59_H63_T0.7961.00
193_S197_I0.7951.00
127_G131_L0.7941.00
43_Y58_A0.7891.00
158_L223_S0.7881.00
198_F201_I0.7871.00
88_V220_G0.7871.00
138_F153_I0.7791.00
141_A153_I0.7741.00
93_A98_L0.7741.00
174_V178_S0.7731.00
191_E200_Q0.7691.00
180_R184_I0.7671.00
20_I24_I0.7661.00
39_F258_W0.7661.00
93_A166_G0.7651.00
72_S75_M0.7651.00
98_L102_F0.7611.00
20_I277_I0.7601.00
50_G59_H0.7591.00
104_G175_L0.7581.00
48_T55_P0.7561.00
78_T271_L0.7551.00
81_S85_G0.7551.00
99_I163_W0.7541.00
184_I188_L0.7521.00
87_S229_F0.7521.00
262_L266_I0.7461.00
42_P72_S0.7421.00
48_T52_S0.7401.00
177_I204_S0.7391.00
60_I71_L0.7391.00
48_T51_I0.7381.00
153_I156_I0.7371.00
103_G111_S0.7351.00
64_D257_Q0.7331.00
263_G267_P0.7321.00
47_E51_I0.7311.00
91_L155_V0.7311.00
251_G255_S0.7281.00
86_I90_A0.7271.00
283_D290_L0.7261.00
50_G55_P0.7261.00
87_S90_A0.7221.00
56_S266_I0.7211.00
134_I153_I0.7201.00
19_F23_G0.7171.00
31_F266_I0.7101.00
284_E290_L0.7061.00
268_I272_G0.7061.00
33_I78_T0.7061.00
250_N260_W0.7001.00
218_L275_L0.6931.00
22_A26_I0.6921.00
170_I173_Q0.6911.00
33_I37_G0.6891.00
36_V40_W0.6861.00
43_Y59_H0.6841.00
250_N253_Y0.6801.00
173_Q208_L0.6741.00
52_S257_Q0.6731.00
194_W197_I0.6731.00
95_I159_A0.6711.00
92_I159_A0.6691.00
123_L164_A0.6691.00
42_P71_L0.6671.00
173_Q205_I0.6661.00
75_M78_T0.6651.00
96_S100_G0.6611.00
196_I201_I0.6611.00
270_V274_G0.6561.00
74_M264_A0.6551.00
278_L282_I0.6541.00
262_L265_I0.6471.00
43_Y46_S0.6441.00
32_A49_F0.6441.00
60_I69_D0.6421.00
224_L228_E0.6421.00
113_V116_D0.6351.00
222_L225_I0.6291.00
166_G170_I0.6281.00
95_I99_I0.6271.00
162_S165_F0.6271.00
21_L24_I0.6271.00
161_T164_A0.6271.00
105_Y178_S0.6261.00
251_G254_L0.6231.00
214_L275_L0.6231.00
23_G26_I0.6201.00
107_G111_S0.6201.00
139_R153_I0.6161.00
272_G276_G0.6151.00
103_G115_I0.6131.00
54_P259_W0.6081.00
115_I118_L0.6081.00
127_G130_L0.6051.00
191_E194_W0.6041.00
107_G175_L0.6031.00
261_I265_I0.6021.00
89_G217_V0.6011.00
114_I118_L0.5991.00
30_D270_V0.5991.00
27_I275_L0.5951.00
85_G220_G0.5911.00
105_Y198_F0.5911.00
90_A94_I0.5891.00
166_G212_Q0.5851.00
31_F35_I0.5851.00
26_I30_D0.5841.00
175_L178_S0.5811.00
223_S226_T0.5801.00
225_I242_T0.5781.00
118_L163_W0.5781.00
37_G40_W0.5771.00
154_V224_L0.5771.00
165_F216_G0.5741.00
222_L226_T0.5711.00
55_P259_W0.5701.00
38_A79_L0.5691.00
96_S167_A0.5681.00
277_I281_G0.5671.00
89_G216_G0.5661.00
250_N261_I0.5661.00
82_L86_I0.5661.00
93_A209_T0.5661.00
106_Y197_I0.5661.00
43_Y256_N0.5581.00
130_L161_T0.5551.00
103_G171_R0.5541.00
44_P47_E0.5541.00
284_E291_K0.5531.00
78_T82_L0.5521.00
220_G223_S0.5481.00
87_S152_I0.5461.00
211_A214_L0.5441.00
48_T53_L0.5391.00
164_A167_A0.5381.00
23_G27_I0.5381.00
183_I187_R0.5371.00
115_I119_T0.5371.00
192_K196_I0.5351.00
41_T76_A0.5341.00
127_G160_I0.5321.00
221_I225_I0.5301.00
79_L82_L0.5291.00
116_D120_I0.5281.00
160_I163_W0.5281.00
225_I250_N0.5271.00
119_T123_L0.5261.00
73_V77_S0.5251.00
34_G265_I0.5221.00
280_I283_D0.5221.00
244_L268_I0.5201.00
65_E255_S0.5191.00
198_F203_P0.5191.00
153_I157_G0.5181.00
133_I137_Y0.5181.00
27_I278_L0.5171.00
156_I160_I0.5151.00
169_Q173_Q0.5151.00
38_A76_A0.5121.00
89_G93_A0.5121.00
259_W262_L0.5061.00
104_G111_S0.5041.00
162_S216_G0.5011.00
122_A163_W0.5001.00
101_L170_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4tquM 1 0.808 99.9 0.646 Contact Map
3tuiA 2 0.6471 99.9 0.684 Contact Map
3rlfF 1 0.8111 99.9 0.688 Contact Map
3d31C 2 0.743 99.9 0.695 Contact Map
2onkC 2 0.7554 99.9 0.701 Contact Map
4tquN 1 0.8111 99.9 0.701 Contact Map
4ymuD 2 0.6656 99.8 0.71 Contact Map
3rlfG 1 0.8297 99.8 0.711 Contact Map
3j9pD 4 0.774 74.7 0.94 Contact Map
3rvyA 3 0.6316 73.5 0.94 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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