GREMLIN Database
Q97UG2 - Alpha-fucosidase C-terminal (FucA1)
UniProt: Q97UG2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 403 (334)
Sequences: 2669 (2011)
Seq/√Len: 110.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
10_Y65_G4.7191.00
14_K66_Q4.5191.00
41_Y133_L4.2051.00
57_R61_E4.0681.00
53_R58_E4.0621.00
18_K272_L3.9301.00
10_Y62_A3.4911.00
60_K70_F3.3971.00
17_K66_Q3.2051.00
8_D11_E3.1161.00
26_L56_V2.9401.00
10_Y66_Q2.9071.00
9_P62_A2.8541.00
258_K262_T2.8391.00
13_A63_V2.7141.00
265_E269_R2.6771.00
6_N260_D2.6301.00
234_P273_D2.6271.00
278_L282_G2.5531.00
284_A336_I2.5341.00
237_I274_V2.4541.00
14_K18_K2.4461.00
161_Y164_A2.4421.00
35_A42_T2.4081.00
26_L36_L2.3941.00
60_K64_E2.3881.00
373_L384_I2.2221.00
325_D331_R2.2081.00
25_V71_G2.1921.00
365_S399_I2.1871.00
18_K279_N2.1141.00
15_V268_K2.0951.00
6_N262_T2.0161.00
40_N141_K2.0151.00
39_S45_C2.0101.00
332_H399_I2.0021.00
234_P270_I1.9361.00
180_P183_I1.9001.00
243_D247_K1.8861.00
346_L367_L1.8691.00
275_G279_N1.8621.00
129_M133_L1.8611.00
15_V263_I1.8571.00
384_I398_V1.8501.00
283_E399_I1.7991.00
24_V63_V1.7951.00
11_E268_K1.7911.00
233_L236_V1.7901.00
321_Y346_L1.7791.00
270_I273_D1.7621.00
69_I145_W1.7291.00
212_W249_G1.7231.00
183_I186_Q1.7131.00
43_R48_K1.7111.00
56_V72_I1.6961.00
45_C48_K1.6931.00
9_P58_E1.6681.00
240_H251_F1.6641.00
23_F250_V1.6371.00
269_R273_D1.6221.00
74_Y131_W1.5971.00
218_I237_I1.5951.00
245_V285_I1.5851.00
364_V398_V1.5811.00
15_V272_L1.5761.00
167_S171_N1.5581.00
268_K272_L1.5491.00
57_R141_K1.5491.00
59_L70_F1.5281.00
180_P185_K1.5111.00
24_V59_L1.4991.00
263_I268_K1.4851.00
28_A72_I1.4831.00
336_I395_V1.4771.00
282_G286_F1.4631.00
7_W58_E1.4611.00
38_E47_T1.4571.00
139_V144_P1.4521.00
232_K236_V1.4511.00
13_A24_V1.4501.00
335_A400_L1.4231.00
321_Y335_A1.3951.00
180_P186_Q1.3911.00
282_G285_I1.3871.00
22_K286_F1.3661.00
125_D129_M1.3661.00
13_A66_Q1.3621.00
25_V252_L1.3441.00
16_F19_S1.3421.00
38_E45_C1.3371.00
136_V168_Y1.3301.00
39_S133_L1.3241.00
238_L242_G1.3170.99
139_V147_V1.3130.99
201_R217_S1.2770.99
291_W321_Y1.2670.99
195_I198_L1.2660.99
258_K264_P1.2610.99
60_K72_I1.2480.99
255_I271_L1.2300.99
14_K17_K1.2260.99
16_F21_A1.2260.99
61_E65_G1.2220.99
62_A66_Q1.2100.99
242_G336_I1.2090.99
219_D267_A1.2090.99
278_L286_F1.2080.99
215_D251_F1.2040.99
12_W263_I1.2000.99
54_D141_K1.1990.99
5_E260_D1.1950.99
84_D126_E1.1940.99
13_A62_A1.1850.99
217_S254_N1.1810.99
243_D320_R1.1770.99
166_A182_I1.1730.99
135_I147_V1.1720.99
18_K276_D1.1690.99
298_P319_V1.1630.99
275_G278_L1.1560.99
39_S130_D1.1560.99
136_V171_N1.1530.99
241_L251_F1.1500.99
283_E334_Y1.1430.99
56_V138_A1.1400.99
215_D223_W1.1390.98
36_L55_I1.1320.98
34_F46_A1.1300.98
221_K230_E1.1290.98
275_G286_F1.1260.98
284_A397_R1.1180.98
78_E151_W1.1110.98
287_G324_K1.1110.98
335_A346_L1.1100.98
140_E168_Y1.1040.98
131_W149_F1.1020.98
47_T51_P1.0920.98
233_L270_I1.0870.98
41_Y130_D1.0840.98
26_L59_L1.0840.98
136_V140_E1.0800.98
7_W55_I1.0770.98
168_Y171_N1.0760.98
29_E75_H1.0760.98
378_S383_K1.0760.98
63_V70_F1.0700.98
37_W56_V1.0700.98
29_E35_A1.0640.98
242_G395_V1.0610.98
246_S320_R1.0610.98
234_P238_L1.0490.97
23_F145_W1.0480.97
231_Y267_A1.0460.97
363_D372_K1.0420.97
128_L132_L1.0380.97
364_V400_L1.0280.97
364_V375_W1.0250.97
38_E141_K1.0240.97
28_A138_A1.0240.97
340_K390_I1.0240.97
38_E48_K1.0160.97
320_R323_V1.0030.97
54_D142_Y0.9970.96
15_V18_K0.9950.96
201_R216_T0.9940.96
265_E268_K0.9890.96
135_I165_F0.9850.96
70_F145_W0.9810.96
264_P267_A0.9800.96
71_G146_L0.9770.96
217_S256_G0.9700.96
31_H75_H0.9690.96
74_Y134_R0.9660.96
258_K265_E0.9660.96
46_A51_P0.9610.96
345_T381_G0.9550.96
170_Y174_Y0.9490.95
266_E270_I0.9480.95
46_A55_I0.9460.95
130_D134_R0.9440.95
215_D252_L0.9420.95
374_E385_K0.9400.95
288_S324_K0.9390.95
285_I288_S0.9360.95
179_E365_S0.9290.95
168_Y172_R0.9190.94
319_V324_K0.9140.94
34_F49_I0.9060.94
216_T240_H0.9050.94
241_L274_V0.9030.94
348_S388_E0.9030.94
85_Q153_I0.8990.94
47_T50_G0.8980.94
72_I138_A0.8960.94
235_S239_S0.8890.93
259_A262_T0.8880.93
12_W16_F0.8870.93
16_F24_V0.8870.93
50_G53_R0.8860.93
182_I248_N0.8850.93
386_I398_V0.8820.93
169_Y173_S0.8780.93
234_P274_V0.8750.93
242_G335_A0.8740.93
56_V70_F0.8610.92
23_F213_L0.8590.92
349_F364_V0.8560.92
61_E64_E0.8550.92
128_L161_Y0.8540.92
126_E133_L0.8510.92
74_Y138_A0.8490.92
130_D133_L0.8490.92
238_L394_L0.8450.92
132_L164_A0.8440.92
42_T130_D0.8410.91
295_G298_P0.8380.91
248_N290_P0.8340.91
16_F255_I0.8330.91
137_E141_K0.8330.91
58_E62_A0.8290.91
76_R162_L0.8210.90
63_V66_Q0.8210.90
136_V172_R0.8180.90
237_I270_I0.8170.90
350_M385_K0.8170.90
11_E262_T0.8160.90
195_I200_E0.8150.90
132_L136_V0.8150.90
345_T383_K0.8110.90
82_F130_D0.8070.90
19_S271_L0.8060.90
253_L274_V0.8060.90
384_I387_E0.8040.89
392_A396_I0.8030.89
148_Y213_L0.7980.89
376_S383_K0.7970.89
163_K167_S0.7940.89
160_P164_A0.7930.89
281_N285_I0.7920.89
17_K67_G0.7900.89
294_Y297_G0.7900.89
238_L277_W0.7850.88
216_T251_F0.7790.88
214_A249_G0.7790.88
324_K331_R0.7770.88
76_R152_W0.7770.88
81_W86_G0.7760.88
167_S170_Y0.7710.87
198_L213_L0.7690.87
162_L188_A0.7680.87
28_A70_F0.7650.87
216_T223_W0.7640.87
255_I258_K0.7620.87
29_E33_G0.7620.87
320_R324_K0.7600.87
12_W257_P0.7600.87
241_L245_V0.7600.87
139_V169_Y0.7590.87
82_F85_Q0.7560.86
224_G256_G0.7560.86
139_V172_R0.7560.86
40_N137_E0.7550.86
164_A168_Y0.7550.86
239_S395_V0.7550.86
166_A170_Y0.7540.86
25_V146_L0.7530.86
197_D210_S0.7480.86
143_R172_R0.7480.86
42_T45_C0.7420.85
337_L398_V0.7400.85
29_E134_R0.7390.85
319_V337_L0.7380.85
276_D279_N0.7380.85
56_V59_L0.7380.85
48_K51_P0.7360.85
323_V331_R0.7360.85
203_T244_V0.7340.85
218_I254_N0.7340.85
364_V382_L0.7310.85
319_V325_D0.7290.84
46_A50_G0.7230.84
13_A68_L0.7220.84
273_D276_D0.7210.84
185_K190_G0.7210.84
281_N367_L0.7120.83
7_W59_L0.7120.83
239_S338_F0.7110.83
75_H134_R0.7100.83
143_R179_E0.7080.83
169_Y212_W0.7070.83
217_S223_W0.7020.82
37_W138_A0.7020.82
132_L165_F0.7010.82
218_I270_I0.7010.82
378_S381_G0.6990.82
266_E269_R0.6980.82
85_Q154_A0.6960.82
8_D14_K0.6950.81
194_A197_D0.6920.81
170_Y173_S0.6910.81
379_D382_L0.6900.81
291_W320_R0.6890.81
157_S162_L0.6890.81
15_V19_S0.6880.81
280_V392_A0.6840.80
134_R137_E0.6830.80
366_R387_E0.6750.80
28_A56_V0.6740.79
274_V278_L0.6710.79
78_E130_D0.6710.79
350_M387_E0.6700.79
340_K391_R0.6690.79
272_L276_D0.6690.79
26_L55_I0.6660.79
77_A85_Q0.6640.78
64_E143_R0.6620.78
62_A65_G0.6620.78
21_A271_L0.6620.78
159_Q163_K0.6620.78
337_L344_I0.6610.78
71_G145_W0.6600.78
255_I262_T0.6590.78
119_D122_Q0.6590.78
136_V141_K0.6570.78
57_R142_Y0.6560.78
41_Y137_E0.6550.77
29_E78_E0.6540.77
228_D264_P0.6530.77
338_F395_V0.6520.77
173_S180_P0.6520.77
218_I267_A0.6520.77
77_A151_W0.6510.77
64_E145_W0.6500.77
174_Y179_E0.6490.77
83_F88_K0.6490.77
239_S243_D0.6480.77
385_K388_E0.6460.76
39_S137_E0.6430.76
38_E43_R0.6420.76
124_N127_F0.6400.76
291_W295_G0.6400.76
169_Y180_P0.6390.76
386_I389_V0.6380.76
44_W81_W0.6370.75
193_T197_D0.6360.75
295_G320_R0.6360.75
34_F44_W0.6350.75
4_G46_A0.6330.75
26_L72_I0.6320.75
135_I169_Y0.6310.75
159_Q162_L0.6300.75
123_P127_F0.6290.75
37_W137_E0.6260.74
219_D230_E0.6260.74
218_I256_G0.6250.74
139_V165_F0.6240.74
84_D87_M0.6230.74
7_W12_W0.6230.74
140_E172_R0.6220.74
207_V248_N0.6210.74
35_A134_R0.6210.74
29_E73_S0.6200.74
140_E144_P0.6190.73
341_P344_I0.6180.73
360_V379_D0.6170.73
85_Q151_W0.6150.73
269_R272_L0.6150.73
84_D130_D0.6130.73
296_E321_Y0.6130.73
219_D228_D0.6130.73
366_R369_G0.6120.73
16_F68_L0.6120.73
241_L253_L0.6090.72
148_Y252_L0.6070.72
81_W85_Q0.6050.72
179_E186_Q0.6050.72
76_R131_W0.6030.71
277_W281_N0.6030.71
13_A59_L0.6030.71
339_G369_G0.6030.71
361_I382_L0.6020.71
196_P199_A0.6020.71
333_I349_F0.5970.71
64_E70_F0.5960.71
199_A202_G0.5960.71
273_D394_L0.5960.71
214_A244_V0.5950.70
162_L165_F0.5950.70
63_V68_L0.5930.70
21_A263_I0.5930.70
288_S291_W0.5930.70
280_V368_D0.5920.70
339_G370_K0.5920.70
284_A367_L0.5920.70
157_S160_P0.5920.70
35_A41_Y0.5910.70
232_K237_I0.5900.70
76_R151_W0.5880.70
168_Y174_Y0.5870.69
201_R215_D0.5870.69
225_Y259_A0.5850.69
334_Y399_I0.5830.69
134_R138_A0.5820.69
364_V373_L0.5810.69
225_Y255_I0.5800.69
222_S226_I0.5790.68
45_C51_P0.5790.68
391_R396_I0.5780.68
82_F88_K0.5770.68
219_D222_S0.5760.68
27_V73_S0.5760.68
43_R81_W0.5730.68
77_A153_I0.5720.67
201_R223_W0.5710.67
70_F144_P0.5660.67
373_L398_V0.5660.67
257_P271_L0.5660.67
348_S387_E0.5650.67
74_Y135_I0.5640.66
135_I149_F0.5620.66
46_A53_R0.5590.66
225_Y264_P0.5560.65
17_K68_L0.5560.65
346_L349_F0.5540.65
25_V148_Y0.5530.65
58_E61_E0.5520.65
231_Y266_E0.5520.65
283_E324_K0.5490.64
276_D393_P0.5490.64
27_V33_G0.5480.64
46_A49_I0.5470.64
349_F373_L0.5470.64
296_E320_R0.5460.64
33_G257_P0.5460.64
87_M126_E0.5450.64
364_V384_I0.5450.64
291_W296_E0.5450.64
201_R231_Y0.5420.63
285_I336_I0.5420.63
82_F86_G0.5410.63
157_S161_Y0.5390.63
347_R388_E0.5390.63
71_G213_L0.5380.63
204_I208_Y0.5370.63
351_K384_I0.5370.63
208_Y248_N0.5370.63
387_E391_R0.5350.62
158_F161_Y0.5350.62
285_I322_T0.5350.62
332_H365_S0.5340.62
332_H378_S0.5330.62
14_K268_K0.5330.62
119_D123_P0.5330.62
318_D322_T0.5320.62
118_L121_V0.5320.62
161_Y165_F0.5320.62
360_V363_D0.5320.62
211_T250_V0.5310.62
196_P210_S0.5310.62
242_G282_G0.5300.62
256_G264_P0.5300.62
122_Q125_D0.5290.61
389_V393_P0.5280.61
200_E204_I0.5270.61
217_S221_K0.5260.61
45_C50_G0.5260.61
127_F130_D0.5240.61
85_Q88_K0.5240.61
334_Y377_L0.5220.60
174_Y182_I0.5220.60
213_L252_L0.5210.60
12_W24_V0.5200.60
194_A200_E0.5200.60
234_P277_W0.5190.60
294_Y298_P0.5190.60
216_T232_K0.5180.60
78_E85_Q0.5180.60
263_I272_L0.5170.60
361_I375_W0.5170.60
133_L136_V0.5170.60
132_L168_Y0.5150.59
193_T196_P0.5150.59
73_S213_L0.5150.59
3_T7_W0.5150.59
365_S370_K0.5150.59
256_G267_A0.5130.59
194_A199_A0.5120.59
378_S384_I0.5110.59
361_I377_L0.5110.59
160_P165_F0.5100.59
247_K320_R0.5100.59
10_Y14_K0.5090.59
243_D246_S0.5080.58
383_K388_E0.5050.58
245_V278_L0.5050.58
29_E213_L0.5030.58
179_E185_K0.5030.58
35_A39_S0.5020.58
158_F162_L0.5000.57
245_V282_G0.5000.57
337_L397_R0.5000.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zxdA 4 0.8462 100 0.201 Contact Map
4psrA 1 0.9355 100 0.21 Contact Map
4j27A 1 0.8412 100 0.213 Contact Map
3gzaA 2 0.8586 100 0.278 Contact Map
3uesA 2 0.8809 100 0.315 Contact Map
4zrxA 1 0.8362 100 0.316 Contact Map
3eypA 1 0.8834 100 0.318 Contact Map
4fnqA 4 0.8437 99.9 0.811 Contact Map
2yfoA 4 0.8387 99.9 0.813 Contact Map
3mi6A 4 0.8536 99.7 0.847 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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