GREMLIN Database
Q97UF8 - Uncharacterized protein
UniProt: Q97UF8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 123 (117)
Sequences: 3116 (2163)
Seq/√Len: 200.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
51_K59_E3.7611.00
55_D85_K3.5431.00
16_S81_L2.5961.00
62_E86_Y2.3741.00
62_E92_C2.2811.00
13_I56_A2.2571.00
13_I49_Q2.1961.00
72_A79_L2.0141.00
83_Y90_T2.0071.00
72_A98_I1.9841.00
59_E63_T1.9791.00
56_A60_L1.9601.00
69_E97_Y1.9481.00
58_T86_Y1.9181.00
62_E88_R1.8911.00
67_V94_H1.8731.00
72_A76_L1.7491.00
98_I117_F1.7481.00
61_C68_L1.6791.00
22_K122_M1.6211.00
82_A86_Y1.5931.00
52_H55_D1.5901.00
69_E95_H1.5791.00
60_L63_T1.5311.00
102_T105_G1.5291.00
18_R84_L1.4971.00
58_T89_L1.4861.00
61_C92_C1.4611.00
34_G37_G1.4511.00
52_H85_K1.4301.00
58_T82_A1.4251.00
110_T113_A1.4151.00
32_G35_G1.4071.00
65_F92_C1.3921.00
76_L98_I1.3911.00
100_G117_F1.3781.00
31_H35_G1.3691.00
115_Y119_V1.3611.00
64_Y67_V1.3581.00
79_L96_L1.3451.00
86_Y89_L1.3431.00
34_G40_I1.3371.00
46_L49_Q1.3181.00
21_V122_M1.3061.00
82_A89_L1.2881.00
75_P119_V1.2831.00
20_L80_A1.2561.00
70_F93_I1.2551.00
57_I82_A1.2441.00
61_C93_I1.1931.00
58_T62_E1.1731.00
14_S48_A1.1551.00
61_C89_L1.1211.00
54_F85_K1.1191.00
34_G38_N1.1081.00
25_K118_W1.0931.00
13_I51_K1.0691.00
88_R91_E1.0581.00
55_D59_E1.0521.00
53_A78_N1.0461.00
76_L117_F1.0461.00
81_L84_L1.0431.00
113_A118_W1.0341.00
91_E94_H1.0271.00
61_C82_A1.0241.00
29_D109_I1.0091.00
57_I89_L1.0001.00
57_I79_L0.9901.00
61_C64_Y0.9811.00
32_G37_G0.9670.99
33_K38_N0.9670.99
69_E94_H0.9650.99
70_F79_L0.9530.99
54_F82_A0.9210.99
73_I98_I0.9120.99
34_G41_V0.9110.99
60_L68_L0.9100.99
14_S17_K0.9050.99
109_I118_W0.8700.99
16_S77_T0.8590.99
20_L81_L0.8550.99
57_I61_C0.8550.99
24_F119_V0.8510.99
27_V30_V0.8490.99
56_A59_E0.8410.99
107_G113_A0.8260.98
61_C90_T0.8200.98
21_V84_L0.8180.98
102_T106_R0.8050.98
70_F96_L0.7980.98
110_T118_W0.7950.98
67_V92_C0.7890.98
54_F81_L0.7880.98
72_A96_L0.7860.98
34_G39_E0.7790.98
30_V115_Y0.7790.98
16_S52_H0.7760.97
26_T119_V0.7480.97
20_L84_L0.7450.97
31_H36_V0.7260.96
18_R23_S0.7250.96
90_T93_I0.7160.96
7_K10_Y0.7130.96
71_L122_M0.7100.96
83_Y93_I0.7030.96
11_S49_Q0.6990.95
55_D58_T0.6860.95
112_I118_W0.6760.94
61_C86_Y0.6720.94
57_I70_F0.6700.94
64_Y68_L0.6680.94
30_V38_N0.6600.94
27_V115_Y0.6570.94
45_R48_A0.6560.94
31_H37_G0.6550.94
106_R112_I0.6400.93
52_H81_L0.6380.93
14_S52_H0.6350.92
60_L64_Y0.6300.92
103_I106_R0.6290.92
65_F68_L0.6280.92
58_T88_R0.6170.91
64_Y92_C0.6140.91
6_S9_R0.6130.91
35_G38_N0.6130.91
17_K84_L0.6090.91
108_N113_A0.6060.91
66_K92_C0.6040.90
58_T85_K0.6000.90
79_L93_I0.6000.90
66_K94_H0.6000.90
22_K25_K0.5970.90
16_S78_N0.5960.90
63_T66_K0.5840.89
28_E33_K0.5830.89
83_Y89_L0.5830.89
56_A115_Y0.5790.89
89_L92_C0.5760.88
11_S56_A0.5680.88
67_V83_Y0.5670.88
8_Y11_S0.5640.87
86_Y92_C0.5640.87
18_R25_K0.5600.87
19_P22_K0.5560.87
36_V39_E0.5550.86
72_A78_N0.5530.86
91_E95_H0.5480.86
71_L97_Y0.5480.86
55_D86_Y0.5480.86
22_K118_W0.5470.86
24_F30_V0.5450.85
38_N115_Y0.5440.85
41_V44_I0.5410.85
9_R46_L0.5370.85
76_L79_L0.5350.84
51_K55_D0.5340.84
44_I48_A0.5330.84
78_N82_A0.5320.84
8_Y46_L0.5320.84
81_L85_K0.5280.84
21_V81_L0.5280.84
37_G109_I0.5250.83
77_T81_L0.5250.83
102_T114_E0.5220.83
109_I119_V0.5180.82
102_T107_G0.5160.82
71_L104_Y0.5160.82
16_S20_L0.5150.82
53_A82_A0.5130.82
47_K50_S0.5130.82
18_R24_F0.5100.81
20_L77_T0.5060.81
49_Q59_E0.5040.81
105_G112_I0.5030.81
68_L95_H0.5010.80
27_V31_H0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4kpnA 2 1 100 0.117 Contact Map
3t8jA 3 0.9919 100 0.119 Contact Map
4kpoA 2 1 100 0.121 Contact Map
4wr2A 4 0.9106 100 0.124 Contact Map
3t8iA 3 0.9919 100 0.129 Contact Map
2masA 3 0.9919 100 0.13 Contact Map
1q8fA 4 0.9837 100 0.137 Contact Map
3fz0A 3 0.9837 100 0.153 Contact Map
4kl0A 1 0.9431 100 0.177 Contact Map
2c40A 2 0.9431 100 0.222 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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