GREMLIN Database
Q97UF7 - Transposase ISC1229
UniProt: Q97UF7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 355 (312)
Sequences: 3713 (2767)
Seq/√Len: 156.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
76_V129_V3.9241.00
203_E225_M3.2531.00
52_S122_A2.9611.00
154_E216_Q2.9431.00
169_S175_N2.8781.00
266_F339_A2.7421.00
207_I218_K2.7091.00
321_H324_R2.7021.00
254_V266_F2.6201.00
270_C296_L2.4941.00
210_K218_K2.4101.00
322_R327_G2.3811.00
325_L329_K2.3151.00
235_V351_P2.3071.00
153_M156_K2.2811.00
238_T351_P2.2641.00
261_P265_S2.2081.00
161_L212_L2.1871.00
76_V125_L2.1611.00
153_M160_R2.1301.00
250_I342_V2.0461.00
315_L319_E2.0241.00
51_T67_I1.9951.00
154_E219_L1.9881.00
288_I332_T1.9851.00
214_E218_K1.9781.00
326_H329_K1.9741.00
242_V247_A1.9721.00
147_Y223_K1.9651.00
262_K265_S1.9551.00
117_T276_V1.9531.00
75_I96_I1.9451.00
236_L342_V1.9111.00
148_L298_S1.8731.00
153_M211_A1.8421.00
60_N63_G1.8351.00
225_M228_S1.8301.00
161_L205_V1.8111.00
169_S173_K1.8091.00
90_Y93_E1.8081.00
272_L335_A1.8041.00
151_K219_L1.7971.00
211_A218_K1.7921.00
278_R283_V1.7691.00
106_L125_L1.7491.00
150_L219_L1.7451.00
42_I49_L1.7431.00
169_S172_D1.7361.00
350_K353_E1.6991.00
172_D175_N1.6781.00
260_F269_Y1.6741.00
40_L53_R1.6591.00
147_Y151_K1.6581.00
336_R340_K1.6461.00
145_T253_V1.6421.00
239_I345_V1.6401.00
246_A299_L1.6381.00
220_K223_K1.6341.00
308_C318_Y1.6261.00
232_E346_W1.6251.00
249_I299_L1.6251.00
210_K217_E1.6071.00
239_I342_V1.6071.00
235_V238_T1.5871.00
154_E212_L1.5861.00
155_V159_N1.5851.00
302_F305_Q1.5731.00
209_A213_F1.5591.00
318_Y334_L1.5531.00
320_S324_R1.5271.00
345_V351_P1.5121.00
127_N131_K1.4961.00
236_L247_A1.4891.00
54_G126_E1.4861.00
298_S302_F1.4811.00
180_E187_F1.4781.00
210_K214_E1.4761.00
343_W347_Y1.4711.00
211_A214_E1.4611.00
207_I221_E1.4551.00
231_P349_N1.4511.00
344_S348_N1.4441.00
169_S174_I1.3991.00
270_C339_A1.3781.00
304_A338_L1.3751.00
75_I91_F1.3741.00
59_N67_I1.3741.00
48_N56_K1.3691.00
89_Q138_N1.3641.00
151_K154_E1.3551.00
235_V345_V1.3441.00
267_V336_R1.3421.00
45_S50_I1.3391.00
41_G126_E1.3331.00
304_A335_A1.3281.00
90_Y94_K1.3281.00
144_V295_Y1.2971.00
179_L182_L1.2781.00
314_L341_V1.2651.00
52_S123_E1.2611.00
152_D156_K1.2581.00
45_S48_N1.2561.00
171_N175_N1.2511.00
59_N64_Y1.2491.00
42_I87_P1.2451.00
303_L338_L1.2441.00
149_F160_R1.2331.00
143_L222_V1.2211.00
279_S283_V1.2011.00
184_S213_F1.1971.00
182_L186_D1.1931.00
192_L195_L1.1891.00
139_V198_T1.1881.00
212_L216_Q1.1851.00
317_F337_K1.1821.00
239_I338_L1.1801.00
321_H325_L1.1791.00
253_V293_N1.1741.00
180_E183_A1.1731.00
153_M157_Q1.1691.00
62_K66_K1.1611.00
179_L186_D1.1561.00
54_G130_D1.1521.00
74_T97_R1.1471.00
187_F191_V1.1371.00
146_L150_L1.1341.00
46_K166_F1.1341.00
42_I51_T1.1281.00
74_T99_L1.1181.00
67_I70_M1.1151.00
344_S347_Y1.1111.00
50_I56_K1.1101.00
184_S187_F1.1081.00
148_L295_Y1.1071.00
301_Y335_A1.1030.99
216_Q220_K1.0900.99
246_A303_L1.0900.99
236_L346_W1.0830.99
321_H330_L1.0830.99
214_E217_E1.0790.99
173_K176_K1.0770.99
305_Q327_G1.0740.99
301_Y332_T1.0730.99
47_D281_K1.0720.99
257_I346_W1.0700.99
223_K227_E1.0660.99
57_Y70_M1.0620.99
157_Q161_L1.0570.99
317_F333_A1.0550.99
250_I296_L1.0550.99
317_F321_H1.0530.99
144_V226_I1.0460.99
115_K276_V1.0440.99
232_E349_N1.0360.99
217_E221_E1.0330.99
63_G66_K1.0310.99
187_F192_L1.0230.99
227_E244_K1.0230.99
231_P235_V1.0180.99
181_R185_G1.0170.99
262_K343_W1.0120.99
187_F193_Y1.0090.99
317_F334_L1.0030.99
237_L244_K1.0010.99
158_K212_L0.9960.99
141_R253_V0.9960.99
123_E127_N0.9960.99
300_F339_A0.9930.99
341_V345_V0.9920.99
327_G331_Y0.9890.99
179_L183_A0.9850.99
191_V195_L0.9830.99
76_V101_V0.9820.99
290_R297_R0.9740.99
345_V350_K0.9700.99
77_L98_V0.9690.99
63_G67_I0.9660.99
147_Y219_L0.9650.99
305_Q328_R0.9630.99
193_Y197_Y0.9620.99
301_Y305_Q0.9600.99
242_V342_V0.9580.99
52_S126_E0.9540.99
207_I225_M0.9530.99
42_I64_Y0.9510.98
328_R331_Y0.9470.98
154_E158_K0.9460.98
151_K155_V0.9430.98
180_E213_F0.9380.98
66_K69_D0.9380.98
51_T57_Y0.9340.98
202_L206_K0.9310.98
61_L65_E0.9300.98
170_D173_K0.9180.98
199_P225_M0.9170.98
180_E184_S0.9160.98
156_K159_N0.9140.98
157_Q211_A0.9120.98
148_L152_D0.9070.98
84_S100_Q0.9030.98
157_Q212_L0.9020.98
157_Q215_T0.9000.98
80_T83_Y0.9000.98
314_L334_L0.8920.98
305_Q308_C0.8860.98
79_P103_P0.8860.98
82_V166_F0.8850.98
242_V246_A0.8830.98
230_V251_I0.8800.98
178_R186_D0.8760.97
268_A273_D0.8720.97
312_P315_L0.8710.97
191_V194_Q0.8690.97
144_V248_G0.8650.97
118_D279_S0.8620.97
242_V303_L0.8620.97
242_V338_L0.8620.97
58_E63_G0.8600.97
104_N108_R0.8580.97
232_E235_V0.8550.97
41_G122_A0.8540.97
147_Y245_L0.8530.97
87_P91_F0.8500.97
157_Q208_L0.8490.97
265_S268_A0.8460.97
50_I279_S0.8430.97
304_A334_L0.8420.97
150_L222_V0.8400.97
320_S323_N0.8380.97
173_K177_E0.8360.97
314_L338_L0.8300.96
273_D289_S0.8290.96
142_E164_A0.8290.96
305_Q331_Y0.8290.96
304_A331_Y0.8260.96
288_I297_R0.8250.96
307_N310_K0.8250.96
218_K221_E0.8240.96
186_D193_Y0.8220.96
239_I242_V0.8210.96
68_L91_F0.8200.96
319_E323_N0.8180.96
182_L185_G0.8160.96
267_V273_D0.8160.96
318_Y327_G0.8130.96
316_R320_S0.8120.96
182_L187_F0.8110.96
178_R181_R0.8110.96
223_K245_L0.8100.96
40_L75_I0.8100.96
203_E206_K0.8080.96
275_V289_S0.8070.96
65_E94_K0.8060.96
256_D259_R0.8010.96
77_L88_S0.7970.96
215_T219_L0.7950.95
116_K121_D0.7920.95
150_L215_T0.7910.95
151_K223_K0.7880.95
102_S105_V0.7860.95
263_P343_W0.7700.95
170_D175_N0.7700.95
40_L73_C0.7700.95
65_E90_Y0.7670.95
114_E291_R0.7660.94
206_K210_K0.7660.94
40_L51_T0.7610.94
68_L94_K0.7610.94
109_E128_M0.7590.94
180_E186_D0.7590.94
103_P253_V0.7570.94
223_K226_I0.7550.94
326_H330_L0.7530.94
253_V295_Y0.7530.94
88_S132_A0.7520.94
221_E225_M0.7500.94
276_V283_V0.7480.94
50_I119_F0.7470.94
144_V249_I0.7470.94
186_D196_E0.7440.94
113_R268_A0.7440.94
273_D297_R0.7430.94
249_I295_Y0.7420.93
183_A186_D0.7380.93
213_F217_E0.7360.93
40_L91_F0.7350.93
181_R184_S0.7330.93
45_S280_G0.7320.93
223_K244_K0.7260.93
224_E228_S0.7240.93
41_G91_F0.7240.93
101_V106_L0.7220.93
39_V130_D0.7220.93
42_I77_L0.7210.93
254_V257_I0.7200.92
200_I225_M0.7190.92
300_F335_A0.7170.92
249_I253_V0.7170.92
68_L96_I0.7170.92
44_V77_L0.7170.92
288_I333_A0.7140.92
88_S98_V0.7140.92
45_S87_P0.7100.92
107_S112_F0.7100.92
140_L226_I0.7070.92
145_T293_N0.7050.92
172_D176_K0.7030.92
227_E237_L0.7000.91
59_N68_L0.6980.91
64_Y91_F0.6970.91
312_P316_R0.6960.91
186_D195_L0.6960.91
204_E207_I0.6890.91
319_E322_R0.6880.91
150_L218_K0.6870.91
68_L90_Y0.6870.91
273_D276_V0.6870.91
257_I266_F0.6840.90
272_L300_F0.6830.90
42_I67_I0.6810.90
222_V226_I0.6790.90
142_E204_E0.6770.90
258_R347_Y0.6730.90
305_Q335_A0.6730.90
146_L222_V0.6720.90
317_F320_S0.6710.90
329_K333_A0.6710.90
192_L197_Y0.6670.89
186_D192_L0.6660.89
147_Y164_A0.6620.89
289_S297_R0.6590.89
58_E61_L0.6570.89
306_M310_K0.6550.88
109_E127_N0.6530.88
180_E216_Q0.6520.88
60_N68_L0.6500.88
142_E201_V0.6490.88
203_E207_I0.6470.88
134_E137_Y0.6470.88
207_I211_A0.6460.88
191_V202_L0.6450.88
149_F153_M0.6440.88
146_L207_I0.6430.88
216_Q219_L0.6430.88
208_L211_A0.6420.87
198_T201_V0.6420.87
311_N352_Y0.6420.87
169_S182_L0.6410.87
299_L303_L0.6400.87
115_K289_S0.6400.87
171_N179_L0.6370.87
178_R185_G0.6360.87
46_K281_K0.6350.87
178_R182_L0.6340.87
271_G297_R0.6320.87
169_S186_D0.6300.86
57_Y64_Y0.6300.86
161_L208_L0.6300.86
232_E251_I0.6270.86
99_L129_V0.6250.86
164_A205_V0.6250.86
49_L59_N0.6250.86
272_L336_R0.6220.86
250_I254_V0.6200.86
340_K343_W0.6200.86
211_A215_T0.6190.85
49_L57_Y0.6180.85
305_Q309_S0.6180.85
191_V197_Y0.6160.85
314_L318_Y0.6160.85
159_N163_R0.6150.85
179_L187_F0.6100.85
224_E227_E0.6090.85
200_I203_E0.6060.84
103_P106_L0.6060.84
233_D251_I0.6060.84
300_F342_V0.6050.84
213_F216_Q0.6030.84
308_C334_L0.6020.84
87_P303_L0.5970.83
77_L125_L0.5970.83
92_K296_L0.5970.83
321_H333_A0.5960.83
72_P96_I0.5960.83
114_E275_V0.5940.83
63_G69_D0.5910.83
163_R167_L0.5900.83
264_E336_R0.5890.83
194_Q197_Y0.5890.83
171_N177_E0.5880.82
72_P97_R0.5880.82
113_R273_D0.5870.82
302_F328_R0.5850.82
104_N291_R0.5840.82
301_Y328_R0.5840.82
101_V109_E0.5810.82
143_L225_M0.5770.81
101_V105_V0.5770.81
157_Q160_R0.5760.81
250_I266_F0.5760.81
154_E215_T0.5760.81
239_I341_V0.5750.81
145_T295_Y0.5730.81
292_G297_R0.5680.80
61_L67_I0.5650.80
150_L160_R0.5640.80
45_S279_S0.5610.79
175_N182_L0.5610.79
179_L184_S0.5600.79
182_L191_V0.5590.79
187_F195_L0.5580.79
206_K221_E0.5570.79
88_S100_Q0.5550.79
347_Y350_K0.5530.78
312_P319_E0.5510.78
267_V340_K0.5510.78
235_V240_P0.5500.78
304_A307_N0.5490.78
226_I248_G0.5490.78
203_E221_E0.5480.78
55_G129_V0.5470.78
91_F338_L0.5460.78
37_V73_C0.5460.78
158_K243_G0.5450.77
221_E224_E0.5430.77
146_L208_L0.5420.77
235_V349_N0.5410.77
93_E210_K0.5400.77
272_L297_R0.5390.77
62_K68_L0.5360.76
171_N174_I0.5360.76
158_K176_K0.5310.76
44_V83_Y0.5280.75
62_K65_E0.5280.75
64_Y68_L0.5280.75
83_Y102_S0.5270.75
161_L209_A0.5270.75
295_Y298_S0.5270.75
142_E168_V0.5260.75
298_S301_Y0.5240.75
314_L319_E0.5240.75
185_G195_L0.5230.75
51_T70_M0.5220.74
199_P228_S0.5200.74
160_R208_L0.5190.74
221_E319_E0.5190.74
74_T129_V0.5190.74
146_L160_R0.5180.74
115_K120_Y0.5170.74
160_R163_R0.5160.74
338_L342_V0.5150.73
251_I342_V0.5130.73
179_L185_G0.5130.73
57_Y67_I0.5130.73
139_V200_I0.5120.73
138_N141_R0.5110.73
140_L248_G0.5110.73
84_S88_S0.5110.73
210_K221_E0.5110.73
146_L204_E0.5100.73
316_R319_E0.5090.73
179_L331_Y0.5090.73
175_N178_R0.5050.72
232_E236_L0.5040.72
117_T205_V0.5030.72
155_V349_N0.5010.71
207_I222_V0.5000.71
217_E220_K0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1keaA 2 0.5549 95.5 0.931 Contact Map
1pu6A 1 0.5408 93.6 0.938 Contact Map
1hjrA 2 0.2845 92.9 0.939 Contact Map
1kg2A 1 0.5944 90.3 0.943 Contact Map
3fhfA 1 0.5634 89.2 0.945 Contact Map
4b21A 2 0.5183 88.9 0.945 Contact Map
2abkA 1 0.5606 88.3 0.946 Contact Map
3n0uA 1 0.5549 86.9 0.947 Contact Map
1ornA 1 0.5493 86.4 0.947 Contact Map
4ofaA 1 0.3718 84.4 0.949 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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