Q97UF7 - SULSO - GREMLIN Contacts

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Q97UF7 - Transposase ISC1229

UniProt:	Q97UF7	Sequences: MVGSISEAKSSVSGVTDPYCRTEHCEKIHPYRCDKEVGVLGIDVSKDNLITSRGGKYENNLKGYEKILDMKPCTIVLEPTGVYSIKPSQYFKEKGIRVLQVSPNVLSREKDFREKKTDFYDAEKLENMVDKAKEYEYNVLRELVTLYLFLKDMEVKQKNRLKRALFLVSDNDKINKERLERLASGDFAQEVLYQLEYTPIVLEEVKILAKALFETQEKLKEVKEMIESQVPEDHVLLTIPGVGKLAAGIIIGVVGDIRRFPKPESFVAYCGLDPVVERSGKAVVSKGISRRGNKYLRSLFYFLAQMNCSKNPTLLRFYESHRNRLHGRKLYTALARKLAKVVWSVWYNNKPYEPK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	355 (312)
Sequences:	3713 (2767)
Seq/√Len:	156.7

SULSO - Q97UF7 Q97X29 Q97X12 Q97UQ6 Q97WZ5 Q97X07 Q97XK2 Q97WC0 Q97Y59 Q97VS0 Q97ZN4 Q97X26 Q97YE1 Q97Y06 Q97XM7 Q97VB2 Q97UU8 Q97Z62

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
76_V	129_V	3.924	1.00
203_E	225_M	3.253	1.00
52_S	122_A	2.961	1.00
154_E	216_Q	2.943	1.00
169_S	175_N	2.878	1.00
266_F	339_A	2.742	1.00
207_I	218_K	2.709	1.00
321_H	324_R	2.702	1.00
254_V	266_F	2.620	1.00
270_C	296_L	2.494	1.00
210_K	218_K	2.410	1.00
322_R	327_G	2.381	1.00
325_L	329_K	2.315	1.00
235_V	351_P	2.307	1.00
153_M	156_K	2.281	1.00
238_T	351_P	2.264	1.00
261_P	265_S	2.208	1.00
161_L	212_L	2.187	1.00
76_V	125_L	2.161	1.00
153_M	160_R	2.130	1.00
250_I	342_V	2.046	1.00
315_L	319_E	2.024	1.00
51_T	67_I	1.995	1.00
154_E	219_L	1.988	1.00
288_I	332_T	1.985	1.00
214_E	218_K	1.978	1.00
326_H	329_K	1.974	1.00
242_V	247_A	1.972	1.00
147_Y	223_K	1.965	1.00
262_K	265_S	1.955	1.00
117_T	276_V	1.953	1.00
75_I	96_I	1.945	1.00
236_L	342_V	1.911	1.00
148_L	298_S	1.873	1.00
153_M	211_A	1.842	1.00
60_N	63_G	1.835	1.00
225_M	228_S	1.830	1.00
161_L	205_V	1.811	1.00
169_S	173_K	1.809	1.00
90_Y	93_E	1.808	1.00
272_L	335_A	1.804	1.00
151_K	219_L	1.797	1.00
211_A	218_K	1.792	1.00
278_R	283_V	1.769	1.00
106_L	125_L	1.749	1.00
150_L	219_L	1.745	1.00
42_I	49_L	1.743	1.00
169_S	172_D	1.736	1.00
350_K	353_E	1.699	1.00
172_D	175_N	1.678	1.00
260_F	269_Y	1.674	1.00
40_L	53_R	1.659	1.00
147_Y	151_K	1.658	1.00
336_R	340_K	1.646	1.00
145_T	253_V	1.642	1.00
239_I	345_V	1.640	1.00
246_A	299_L	1.638	1.00
220_K	223_K	1.634	1.00
308_C	318_Y	1.626	1.00
232_E	346_W	1.625	1.00
249_I	299_L	1.625	1.00
210_K	217_E	1.607	1.00
239_I	342_V	1.607	1.00
235_V	238_T	1.587	1.00
154_E	212_L	1.586	1.00
155_V	159_N	1.585	1.00
302_F	305_Q	1.573	1.00
209_A	213_F	1.559	1.00
318_Y	334_L	1.553	1.00
320_S	324_R	1.527	1.00
345_V	351_P	1.512	1.00
127_N	131_K	1.496	1.00
236_L	247_A	1.489	1.00
54_G	126_E	1.486	1.00
298_S	302_F	1.481	1.00
180_E	187_F	1.478	1.00
210_K	214_E	1.476	1.00
343_W	347_Y	1.471	1.00
211_A	214_E	1.461	1.00
207_I	221_E	1.455	1.00
231_P	349_N	1.451	1.00
344_S	348_N	1.444	1.00
169_S	174_I	1.399	1.00
270_C	339_A	1.378	1.00
304_A	338_L	1.375	1.00
75_I	91_F	1.374	1.00
59_N	67_I	1.374	1.00
48_N	56_K	1.369	1.00
89_Q	138_N	1.364	1.00
151_K	154_E	1.355	1.00
235_V	345_V	1.344	1.00
267_V	336_R	1.342	1.00
45_S	50_I	1.339	1.00
41_G	126_E	1.333	1.00
304_A	335_A	1.328	1.00
90_Y	94_K	1.328	1.00
144_V	295_Y	1.297	1.00
179_L	182_L	1.278	1.00
314_L	341_V	1.265	1.00
52_S	123_E	1.261	1.00
152_D	156_K	1.258	1.00
45_S	48_N	1.256	1.00
171_N	175_N	1.251	1.00
59_N	64_Y	1.249	1.00
42_I	87_P	1.245	1.00
303_L	338_L	1.244	1.00
149_F	160_R	1.233	1.00
143_L	222_V	1.221	1.00
279_S	283_V	1.201	1.00
184_S	213_F	1.197	1.00
182_L	186_D	1.193	1.00
192_L	195_L	1.189	1.00
139_V	198_T	1.188	1.00
212_L	216_Q	1.185	1.00
317_F	337_K	1.182	1.00
239_I	338_L	1.180	1.00
321_H	325_L	1.179	1.00
253_V	293_N	1.174	1.00
180_E	183_A	1.173	1.00
153_M	157_Q	1.169	1.00
62_K	66_K	1.161	1.00
179_L	186_D	1.156	1.00
54_G	130_D	1.152	1.00
74_T	97_R	1.147	1.00
187_F	191_V	1.137	1.00
146_L	150_L	1.134	1.00
46_K	166_F	1.134	1.00
42_I	51_T	1.128	1.00
74_T	99_L	1.118	1.00
67_I	70_M	1.115	1.00
344_S	347_Y	1.111	1.00
50_I	56_K	1.110	1.00
184_S	187_F	1.108	1.00
148_L	295_Y	1.107	1.00
301_Y	335_A	1.103	0.99
216_Q	220_K	1.090	0.99
246_A	303_L	1.090	0.99
236_L	346_W	1.083	0.99
321_H	330_L	1.083	0.99
214_E	217_E	1.079	0.99
173_K	176_K	1.077	0.99
305_Q	327_G	1.074	0.99
301_Y	332_T	1.073	0.99
47_D	281_K	1.072	0.99
257_I	346_W	1.070	0.99
223_K	227_E	1.066	0.99
57_Y	70_M	1.062	0.99
157_Q	161_L	1.057	0.99
317_F	333_A	1.055	0.99
250_I	296_L	1.055	0.99
317_F	321_H	1.053	0.99
144_V	226_I	1.046	0.99
115_K	276_V	1.044	0.99
232_E	349_N	1.036	0.99
217_E	221_E	1.033	0.99
63_G	66_K	1.031	0.99
187_F	192_L	1.023	0.99
227_E	244_K	1.023	0.99
231_P	235_V	1.018	0.99
181_R	185_G	1.017	0.99
262_K	343_W	1.012	0.99
187_F	193_Y	1.009	0.99
317_F	334_L	1.003	0.99
237_L	244_K	1.001	0.99
158_K	212_L	0.996	0.99
141_R	253_V	0.996	0.99
123_E	127_N	0.996	0.99
300_F	339_A	0.993	0.99
341_V	345_V	0.992	0.99
327_G	331_Y	0.989	0.99
179_L	183_A	0.985	0.99
191_V	195_L	0.983	0.99
76_V	101_V	0.982	0.99
290_R	297_R	0.974	0.99
345_V	350_K	0.970	0.99
77_L	98_V	0.969	0.99
63_G	67_I	0.966	0.99
147_Y	219_L	0.965	0.99
305_Q	328_R	0.963	0.99
193_Y	197_Y	0.962	0.99
301_Y	305_Q	0.960	0.99
242_V	342_V	0.958	0.99
52_S	126_E	0.954	0.99
207_I	225_M	0.953	0.99
42_I	64_Y	0.951	0.98
328_R	331_Y	0.947	0.98
154_E	158_K	0.946	0.98
151_K	155_V	0.943	0.98
180_E	213_F	0.938	0.98
66_K	69_D	0.938	0.98
51_T	57_Y	0.934	0.98
202_L	206_K	0.931	0.98
61_L	65_E	0.930	0.98
170_D	173_K	0.918	0.98
199_P	225_M	0.917	0.98
180_E	184_S	0.916	0.98
156_K	159_N	0.914	0.98
157_Q	211_A	0.912	0.98
148_L	152_D	0.907	0.98
84_S	100_Q	0.903	0.98
157_Q	212_L	0.902	0.98
157_Q	215_T	0.900	0.98
80_T	83_Y	0.900	0.98
314_L	334_L	0.892	0.98
305_Q	308_C	0.886	0.98
79_P	103_P	0.886	0.98
82_V	166_F	0.885	0.98
242_V	246_A	0.883	0.98
230_V	251_I	0.880	0.98
178_R	186_D	0.876	0.97
268_A	273_D	0.872	0.97
312_P	315_L	0.871	0.97
191_V	194_Q	0.869	0.97
144_V	248_G	0.865	0.97
118_D	279_S	0.862	0.97
242_V	303_L	0.862	0.97
242_V	338_L	0.862	0.97
58_E	63_G	0.860	0.97
104_N	108_R	0.858	0.97
232_E	235_V	0.855	0.97
41_G	122_A	0.854	0.97
147_Y	245_L	0.853	0.97
87_P	91_F	0.850	0.97
157_Q	208_L	0.849	0.97
265_S	268_A	0.846	0.97
50_I	279_S	0.843	0.97
304_A	334_L	0.842	0.97
150_L	222_V	0.840	0.97
320_S	323_N	0.838	0.97
173_K	177_E	0.836	0.97
314_L	338_L	0.830	0.96
273_D	289_S	0.829	0.96
142_E	164_A	0.829	0.96
305_Q	331_Y	0.829	0.96
304_A	331_Y	0.826	0.96
288_I	297_R	0.825	0.96
307_N	310_K	0.825	0.96
218_K	221_E	0.824	0.96
186_D	193_Y	0.822	0.96
239_I	242_V	0.821	0.96
68_L	91_F	0.820	0.96
319_E	323_N	0.818	0.96
182_L	185_G	0.816	0.96
267_V	273_D	0.816	0.96
318_Y	327_G	0.813	0.96
316_R	320_S	0.812	0.96
182_L	187_F	0.811	0.96
178_R	181_R	0.811	0.96
223_K	245_L	0.810	0.96
40_L	75_I	0.810	0.96
203_E	206_K	0.808	0.96
275_V	289_S	0.807	0.96
65_E	94_K	0.806	0.96
256_D	259_R	0.801	0.96
77_L	88_S	0.797	0.96
215_T	219_L	0.795	0.95
116_K	121_D	0.792	0.95
150_L	215_T	0.791	0.95
151_K	223_K	0.788	0.95
102_S	105_V	0.786	0.95
263_P	343_W	0.770	0.95
170_D	175_N	0.770	0.95
40_L	73_C	0.770	0.95
65_E	90_Y	0.767	0.95
114_E	291_R	0.766	0.94
206_K	210_K	0.766	0.94
40_L	51_T	0.761	0.94
68_L	94_K	0.761	0.94
109_E	128_M	0.759	0.94
180_E	186_D	0.759	0.94
103_P	253_V	0.757	0.94
223_K	226_I	0.755	0.94
326_H	330_L	0.753	0.94
253_V	295_Y	0.753	0.94
88_S	132_A	0.752	0.94
221_E	225_M	0.750	0.94
276_V	283_V	0.748	0.94
50_I	119_F	0.747	0.94
144_V	249_I	0.747	0.94
186_D	196_E	0.744	0.94
113_R	268_A	0.744	0.94
273_D	297_R	0.743	0.94
249_I	295_Y	0.742	0.93
183_A	186_D	0.738	0.93
213_F	217_E	0.736	0.93
40_L	91_F	0.735	0.93
181_R	184_S	0.733	0.93
45_S	280_G	0.732	0.93
223_K	244_K	0.726	0.93
224_E	228_S	0.724	0.93
41_G	91_F	0.724	0.93
101_V	106_L	0.722	0.93
39_V	130_D	0.722	0.93
42_I	77_L	0.721	0.93
254_V	257_I	0.720	0.92
200_I	225_M	0.719	0.92
300_F	335_A	0.717	0.92
249_I	253_V	0.717	0.92
68_L	96_I	0.717	0.92
44_V	77_L	0.717	0.92
288_I	333_A	0.714	0.92
88_S	98_V	0.714	0.92
45_S	87_P	0.710	0.92
107_S	112_F	0.710	0.92
140_L	226_I	0.707	0.92
145_T	293_N	0.705	0.92
172_D	176_K	0.703	0.92
227_E	237_L	0.700	0.91
59_N	68_L	0.698	0.91
64_Y	91_F	0.697	0.91
312_P	316_R	0.696	0.91
186_D	195_L	0.696	0.91
204_E	207_I	0.689	0.91
319_E	322_R	0.688	0.91
150_L	218_K	0.687	0.91
68_L	90_Y	0.687	0.91
273_D	276_V	0.687	0.91
257_I	266_F	0.684	0.90
272_L	300_F	0.683	0.90
42_I	67_I	0.681	0.90
222_V	226_I	0.679	0.90
142_E	204_E	0.677	0.90
258_R	347_Y	0.673	0.90
305_Q	335_A	0.673	0.90
146_L	222_V	0.672	0.90
317_F	320_S	0.671	0.90
329_K	333_A	0.671	0.90
192_L	197_Y	0.667	0.89
186_D	192_L	0.666	0.89
147_Y	164_A	0.662	0.89
289_S	297_R	0.659	0.89
58_E	61_L	0.657	0.89
306_M	310_K	0.655	0.88
109_E	127_N	0.653	0.88
180_E	216_Q	0.652	0.88
60_N	68_L	0.650	0.88
142_E	201_V	0.649	0.88
203_E	207_I	0.647	0.88
134_E	137_Y	0.647	0.88
207_I	211_A	0.646	0.88
191_V	202_L	0.645	0.88
149_F	153_M	0.644	0.88
146_L	207_I	0.643	0.88
216_Q	219_L	0.643	0.88
208_L	211_A	0.642	0.87
198_T	201_V	0.642	0.87
311_N	352_Y	0.642	0.87
169_S	182_L	0.641	0.87
299_L	303_L	0.640	0.87
115_K	289_S	0.640	0.87
171_N	179_L	0.637	0.87
178_R	185_G	0.636	0.87
46_K	281_K	0.635	0.87
178_R	182_L	0.634	0.87
271_G	297_R	0.632	0.87
169_S	186_D	0.630	0.86
57_Y	64_Y	0.630	0.86
161_L	208_L	0.630	0.86
232_E	251_I	0.627	0.86
99_L	129_V	0.625	0.86
164_A	205_V	0.625	0.86
49_L	59_N	0.625	0.86
272_L	336_R	0.622	0.86
250_I	254_V	0.620	0.86
340_K	343_W	0.620	0.86
211_A	215_T	0.619	0.85
49_L	57_Y	0.618	0.85
305_Q	309_S	0.618	0.85
191_V	197_Y	0.616	0.85
314_L	318_Y	0.616	0.85
159_N	163_R	0.615	0.85
179_L	187_F	0.610	0.85
224_E	227_E	0.609	0.85
200_I	203_E	0.606	0.84
103_P	106_L	0.606	0.84
233_D	251_I	0.606	0.84
300_F	342_V	0.605	0.84
213_F	216_Q	0.603	0.84
308_C	334_L	0.602	0.84
87_P	303_L	0.597	0.83
77_L	125_L	0.597	0.83
92_K	296_L	0.597	0.83
321_H	333_A	0.596	0.83
72_P	96_I	0.596	0.83
114_E	275_V	0.594	0.83
63_G	69_D	0.591	0.83
163_R	167_L	0.590	0.83
264_E	336_R	0.589	0.83
194_Q	197_Y	0.589	0.83
171_N	177_E	0.588	0.82
72_P	97_R	0.588	0.82
113_R	273_D	0.587	0.82
302_F	328_R	0.585	0.82
104_N	291_R	0.584	0.82
301_Y	328_R	0.584	0.82
101_V	109_E	0.581	0.82
143_L	225_M	0.577	0.81
101_V	105_V	0.577	0.81
157_Q	160_R	0.576	0.81
250_I	266_F	0.576	0.81
154_E	215_T	0.576	0.81
239_I	341_V	0.575	0.81
145_T	295_Y	0.573	0.81
292_G	297_R	0.568	0.80
61_L	67_I	0.565	0.80
150_L	160_R	0.564	0.80
45_S	279_S	0.561	0.79
175_N	182_L	0.561	0.79
179_L	184_S	0.560	0.79
182_L	191_V	0.559	0.79
187_F	195_L	0.558	0.79
206_K	221_E	0.557	0.79
88_S	100_Q	0.555	0.79
347_Y	350_K	0.553	0.78
312_P	319_E	0.551	0.78
267_V	340_K	0.551	0.78
235_V	240_P	0.550	0.78
304_A	307_N	0.549	0.78
226_I	248_G	0.549	0.78
203_E	221_E	0.548	0.78
55_G	129_V	0.547	0.78
91_F	338_L	0.546	0.78
37_V	73_C	0.546	0.78
158_K	243_G	0.545	0.77
221_E	224_E	0.543	0.77
146_L	208_L	0.542	0.77
235_V	349_N	0.541	0.77
93_E	210_K	0.540	0.77
272_L	297_R	0.539	0.77
62_K	68_L	0.536	0.76
171_N	174_I	0.536	0.76
158_K	176_K	0.531	0.76
44_V	83_Y	0.528	0.75
62_K	65_E	0.528	0.75
64_Y	68_L	0.528	0.75
83_Y	102_S	0.527	0.75
161_L	209_A	0.527	0.75
295_Y	298_S	0.527	0.75
142_E	168_V	0.526	0.75
298_S	301_Y	0.524	0.75
314_L	319_E	0.524	0.75
185_G	195_L	0.523	0.75
51_T	70_M	0.522	0.74
199_P	228_S	0.520	0.74
160_R	208_L	0.519	0.74
221_E	319_E	0.519	0.74
74_T	129_V	0.519	0.74
146_L	160_R	0.518	0.74
115_K	120_Y	0.517	0.74
160_R	163_R	0.516	0.74
338_L	342_V	0.515	0.73
251_I	342_V	0.513	0.73
179_L	185_G	0.513	0.73
57_Y	67_I	0.513	0.73
139_V	200_I	0.512	0.73
138_N	141_R	0.511	0.73
140_L	248_G	0.511	0.73
84_S	88_S	0.511	0.73
210_K	221_E	0.511	0.73
146_L	204_E	0.510	0.73
316_R	319_E	0.509	0.73
179_L	331_Y	0.509	0.73
175_N	178_R	0.505	0.72
232_E	236_L	0.504	0.72
117_T	205_V	0.503	0.72
155_V	349_N	0.501	0.71
207_I	222_V	0.500	0.71
217_E	220_K	0.500	0.71

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1keaA	2	0.5549	95.5	0.931	Contact Map
1pu6A	1	0.5408	93.6	0.938	Contact Map
1hjrA	2	0.2845	92.9	0.939	Contact Map
1kg2A	1	0.5944	90.3	0.943	Contact Map
3fhfA	1	0.5634	89.2	0.945	Contact Map
4b21A	2	0.5183	88.9	0.945	Contact Map
2abkA	1	0.5606	88.3	0.946	Contact Map
3n0uA	1	0.5549	86.9	0.947	Contact Map
1ornA	1	0.5493	86.4	0.947	Contact Map
4ofaA	1	0.3718	84.4	0.949	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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