GREMLIN Database
Q97UF1 - Uncharacterized protein
UniProt: Q97UF1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 243 (210)
Sequences: 3800 (2684)
Seq/√Len: 185.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
24_F227_V3.3381.00
222_A237_F3.3231.00
69_L77_S2.7061.00
88_G121_V2.6861.00
39_E54_T2.6431.00
76_E195_D2.5561.00
118_E156_K2.4491.00
22_D227_V2.3921.00
106_S110_K2.3191.00
90_G217_A2.3011.00
150_D190_K2.2981.00
123_M161_G2.2081.00
22_D225_K2.2031.00
161_G202_V2.1941.00
151_Y155_K2.1781.00
106_S147_N2.1441.00
224_L232_G2.1301.00
18_D235_R2.1151.00
121_V159_A2.1091.00
96_S125_Y1.9791.00
106_S148_G1.9791.00
77_S80_K1.9641.00
94_D125_Y1.9451.00
122_V152_L1.9161.00
18_D225_K1.9081.00
105_S108_D1.8901.00
146_S150_D1.8721.00
66_D188_H1.8351.00
106_S151_Y1.8321.00
37_K56_Y1.8271.00
19_M238_A1.8051.00
89_Y216_E1.7711.00
110_K155_K1.7111.00
105_S145_D1.6841.00
24_F27_M1.6061.00
167_I198_I1.5921.00
107_N110_K1.5791.00
224_L233_P1.5711.00
82_N85_Q1.5621.00
150_D154_S1.5311.00
107_N111_K1.5281.00
117_K120_Y1.5111.00
123_M219_F1.5071.00
110_K151_Y1.4831.00
15_L207_K1.4761.00
87_I220_F1.4721.00
130_A206_K1.4711.00
113_D155_K1.4581.00
145_D148_G1.4411.00
220_F239_I1.4201.00
131_T136_D1.4151.00
199_L202_V1.4131.00
129_S206_K1.4111.00
60_H64_H1.4031.00
65_I86_F1.3911.00
107_N147_N1.3811.00
93_L112_F1.3791.00
93_L122_V1.3611.00
45_N73_P1.3491.00
160_V191_L1.3481.00
51_T69_L1.3411.00
203_N206_K1.3361.00
159_A199_L1.3361.00
60_H231_G1.3351.00
65_I159_A1.3321.00
219_F236_L1.3261.00
51_T230_E1.3261.00
78_V81_F1.3231.00
153_V190_K1.2941.00
93_L113_D1.2901.00
199_L221_Y1.2851.00
109_L124_L1.2801.00
21_Y203_N1.2761.00
109_L148_G1.2681.00
98_K108_D1.2671.00
217_A238_A1.2661.00
125_Y206_K1.2621.00
33_D52_L1.2441.00
220_F237_F1.2411.00
23_M36_F1.2391.00
92_V217_A1.2301.00
203_N207_K1.2231.00
128_F142_P1.2231.00
25_N37_K1.2071.00
121_V219_F1.2021.00
87_I218_L1.1961.00
104_I126_T1.1921.00
202_V236_L1.1891.00
191_L196_I1.1751.00
160_V167_I1.1491.00
39_E56_Y1.1461.00
202_V219_F1.1351.00
144_L167_I1.1321.00
16_L83_I1.1291.00
123_M205_M1.1011.00
90_G219_F1.0861.00
53_S230_E1.0831.00
110_K114_D1.0771.00
66_D70_H1.0711.00
126_T162_I1.0701.00
38_H53_S1.0671.00
65_I199_L1.0531.00
221_Y234_T1.0431.00
53_S59_L1.0371.00
95_L108_D1.0361.00
89_Y120_Y1.0351.00
199_L219_F1.0291.00
109_L151_Y1.0080.99
19_M236_L1.0060.99
129_S203_N1.0040.99
87_I237_F1.0030.99
95_L124_L1.0000.99
79_E228_G0.9950.99
57_M233_P0.9940.99
208_V238_A0.9920.99
113_D116_I0.9890.99
76_E85_Q0.9890.99
36_F226_I0.9880.99
67_L231_G0.9850.99
92_V125_Y0.9830.99
149_A190_K0.9780.99
21_Y132_R0.9750.99
70_H188_H0.9730.99
209_L216_E0.9730.99
146_S187_V0.9660.99
116_I122_V0.9560.99
16_L239_I0.9550.99
124_L144_L0.9500.99
90_G123_M0.9450.99
191_L198_I0.9450.99
162_I167_I0.9440.99
168_A187_V0.9430.99
151_Y154_S0.9420.99
159_A219_F0.9360.99
76_E80_K0.9340.99
99_K102_E0.9210.99
65_I221_Y0.9210.99
59_L229_A0.9120.99
218_L239_I0.9080.99
60_H188_H0.8910.99
85_Q195_D0.8860.99
91_N116_I0.8850.99
20_T236_L0.8850.99
161_G199_L0.8750.99
125_Y129_S0.8730.98
48_G73_P0.8690.98
21_Y63_T0.8660.98
88_G158_R0.8620.98
161_G205_M0.8570.98
81_F86_F0.8540.98
76_E82_N0.8540.98
149_A187_V0.8470.98
65_I78_V0.8430.98
90_G208_V0.8360.98
16_L87_I0.8250.98
65_I234_T0.8140.98
111_K114_D0.8140.98
98_K112_F0.8130.98
160_V198_I0.8090.98
153_V196_I0.8070.97
106_S109_L0.8040.97
168_A201_S0.8030.97
34_P54_T0.8030.97
210_E215_G0.8010.97
119_N158_R0.7970.97
187_V190_K0.7950.97
55_V226_I0.7950.97
103_P143_Y0.7940.97
40_Y51_T0.7860.97
57_M61_S0.7790.97
44_G51_T0.7740.97
95_L98_K0.7730.97
141_W170_W0.7630.96
59_L230_E0.7610.96
60_H199_L0.7580.96
71_F185_V0.7550.96
154_S194_N0.7510.96
127_G130_A0.7500.96
23_M224_L0.7490.96
99_K108_D0.7460.96
147_N150_D0.7450.96
125_Y209_L0.7440.96
137_F201_S0.7430.96
165_M201_S0.7430.96
40_Y43_K0.7340.96
89_Y218_L0.7320.96
88_G218_L0.7310.96
117_K155_K0.7230.95
116_I155_K0.7220.95
87_I222_A0.7170.95
40_Y53_S0.7170.95
105_S148_G0.7160.95
168_A185_V0.7140.95
121_V158_R0.7080.95
102_E108_D0.7050.95
91_N216_E0.7000.94
92_V123_M0.6990.94
36_F57_M0.6960.94
143_Y151_Y0.6930.94
144_L148_G0.6900.94
31_I34_P0.6880.94
34_P37_K0.6840.94
116_I120_Y0.6840.94
52_L58_G0.6810.94
141_W166_S0.6790.93
153_V194_N0.6770.93
105_S147_N0.6740.93
141_W165_M0.6690.93
91_N120_Y0.6680.93
85_Q158_R0.6670.93
33_D58_G0.6660.93
23_M57_M0.6640.93
116_I119_N0.6640.93
92_V210_E0.6610.92
89_Y117_K0.6600.92
94_D210_E0.6600.92
223_P232_G0.6570.92
55_V59_L0.6570.92
81_F85_Q0.6560.92
54_T58_G0.6560.92
81_F197_I0.6530.92
66_D200_E0.6500.92
59_L231_G0.6500.92
88_G119_N0.6490.92
69_L74_N0.6480.92
79_E227_V0.6460.92
44_G47_Y0.6420.91
51_T73_P0.6420.91
152_L157_I0.6410.91
21_Y129_S0.6340.91
150_D193_S0.6320.91
34_P58_G0.6310.91
42_R50_V0.6300.91
98_K102_E0.6290.91
64_H230_E0.6270.90
60_H230_E0.6260.90
20_T235_R0.6260.90
95_L104_I0.6260.90
144_L160_V0.6260.90
63_T205_M0.6250.90
17_I207_K0.6230.90
23_M61_S0.6220.90
133_G137_F0.6190.90
103_P145_D0.6170.90
83_I237_F0.6170.90
149_A191_L0.6130.89
23_M27_M0.6090.89
146_S190_K0.6090.89
141_W164_S0.6080.89
66_D231_G0.6060.89
199_L234_T0.6040.89
21_Y201_S0.6030.89
17_I209_L0.6020.89
168_A198_I0.6020.89
128_F164_S0.6020.89
188_H223_P0.6010.88
106_S145_D0.6000.88
131_T134_K0.6000.88
158_R197_I0.5980.88
96_S130_A0.5960.88
83_I222_A0.5960.88
135_E138_L0.5880.87
97_Y102_E0.5830.87
115_R155_K0.5800.87
110_K154_S0.5800.87
168_A186_Y0.5780.86
57_M226_I0.5750.86
27_M165_M0.5740.86
118_E155_K0.5700.86
122_V156_K0.5690.86
30_Y33_D0.5690.86
37_K54_T0.5670.85
225_K235_R0.5640.85
33_D36_F0.5630.85
143_Y229_A0.5580.85
122_V157_I0.5560.84
34_P56_Y0.5550.84
167_I191_L0.5540.84
124_L160_V0.5520.84
43_K47_Y0.5520.84
96_S101_G0.5510.84
16_L222_A0.5510.84
38_H55_V0.5510.84
164_S167_I0.5430.83
166_S170_W0.5430.83
98_K111_K0.5410.83
80_K107_N0.5380.82
126_T164_S0.5370.82
50_V71_F0.5340.82
36_F61_S0.5320.82
159_A192_L0.5270.81
172_G185_V0.5220.80
26_G35_P0.5200.80
67_L232_G0.5180.80
52_L59_L0.5180.80
226_I232_G0.5180.80
78_V84_I0.5160.80
74_N80_K0.5150.80
149_A198_I0.5150.80
143_Y169_G0.5150.80
187_V201_S0.5130.79
99_K140_N0.5130.79
188_H200_E0.5120.79
55_V233_P0.5110.79
121_V161_G0.5110.79
153_V157_I0.5110.79
97_Y101_G0.5100.79
52_L230_E0.5060.78
119_N157_I0.5060.78
102_E140_N0.5050.78
219_F234_T0.5050.78
108_D111_K0.5050.78
125_Y205_M0.5030.78
107_N136_D0.5010.78
148_G151_Y0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4m8dA 4 0.9588 100 0.174 Contact Map
1r61A 3 0.8436 100 0.198 Contact Map
4co9A 2 0.8519 100 0.205 Contact Map
4cogA 3 0.8519 100 0.211 Contact Map
4cobA 2 0.8477 100 0.212 Contact Map
2b0aA 2 0.749 100 0.27 Contact Map
2fi9A 1 0.4856 40 0.95 Contact Map
3cpkA 1 0.4609 35 0.951 Contact Map
1tq1A 1 0.3992 33.3 0.952 Contact Map
2gm2A 1 0.4897 32.8 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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