Q97UF0 - SULSO - GREMLIN Contacts

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Q97UF0 - Dihydrodipicolinate synthase (DapA-3)

UniProt:	Q97UF0	Sequences: MRLEGVVVPLITPFLEDYSIDKEGLKWLVSYLSENGVNGIFVNSSVGEFASLTLDEMKLVTKIALDSRKSYSTLIFAGASTNFTEETIKLAKDFKDMGVDAIVVMAPYFFKVREKELLDHFSMIAEKVDLPIIIYNIPLFTGIDIPISVYKMLVSQHSNIIGTKVTLDSLIFFKKLISEIREIRKDFSILTGFDEYLLPLLYMGGNGGVMGLANAIPKLHLKVYESWKNGNLSDANKYWRNVLNLTDIYDYCNSYTASIKLLLKVLNMPIKNVVRPPLSICEEESKIRGMIKDLSSFLTNSK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	302 (282)
Sequences:	10349 (6737)
Seq/√Len:	401.2

ECOLI - YJHH YAGE DAPA NANA
BACSU - DAPA KDGD
HALSA - DAPAL
SULSO - Q97UF0 Q97WF2 KDGA Q97UI2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
231_N	234_D	3.869	1.00
30_S	67_S	3.360	1.00
15_L	19_S	3.214	1.00
118_L	152_M	3.149	1.00
26_K	67_S	2.845	1.00
265_V	288_R	2.788	1.00
22_K	59_L	2.758	1.00
95_K	129_D	2.656	1.00
22_K	63_I	2.653	1.00
26_K	63_I	2.625	1.00
79_A	91_A	2.547	1.00
58_K	93_D	2.515	1.00
226_S	234_D	2.501	1.00
200_L	205_G	2.461	1.00
91_A	102_I	2.289	1.00
234_D	237_K	2.189	1.00
30_S	72_S	2.078	1.00
201_L	227_W	2.051	1.00
7_V	39_G	2.034	1.00
221_L	225_E	2.031	1.00
122_S	157_H	2.013	1.00
114_E	146_P	2.009	1.00
31_Y	35_N	2.004	1.00
226_S	231_N	2.004	1.00
225_E	229_N	2.000	1.00
114_E	149_V	1.999	1.00
126_E	157_H	1.976	1.00
84_T	120_H	1.945	1.00
59_L	62_K	1.914	1.00
38_N	225_E	1.909	1.00
151_K	179_E	1.897	1.00
122_S	126_E	1.881	1.00
30_S	34_E	1.868	1.00
21_D	24_G	1.862	1.00
144_D	172_F	1.862	1.00
115_K	119_D	1.855	1.00
115_K	152_M	1.855	1.00
54_L	86_E	1.851	1.00
26_K	66_D	1.841	1.00
288_R	292_K	1.836	1.00
29_V	64_A	1.754	1.00
219_L	241_N	1.753	1.00
118_L	122_S	1.743	1.00
35_N	218_K	1.719	1.00
62_K	66_D	1.715	1.00
133_I	162_G	1.705	1.00
25_L	64_A	1.692	1.00
59_L	63_I	1.686	1.00
65_L	75_I	1.673	1.00
125_A	157_H	1.646	1.00
8_V	213_A	1.644	1.00
56_E	275_R	1.642	1.00
119_D	122_S	1.620	1.00
104_V	124_I	1.616	1.00
146_P	149_V	1.596	1.00
24_G	27_W	1.589	1.00
42_V	64_A	1.570	1.00
91_A	128_V	1.557	1.00
150_Y	163_T	1.546	1.00
63_I	67_S	1.531	1.00
237_K	241_N	1.508	1.00
61_T	77_A	1.506	1.00
285_S	288_R	1.504	1.00
13_P	25_L	1.488	1.00
33_S	73_T	1.484	1.00
25_L	60_V	1.473	1.00
152_M	156_Q	1.437	1.00
87_T	124_I	1.430	1.00
95_K	128_V	1.413	1.00
222_K	226_S	1.389	1.00
264_K	271_K	1.389	1.00
119_D	123_M	1.374	1.00
95_K	130_L	1.366	1.00
222_K	234_D	1.358	1.00
11_I	263_L	1.350	1.00
7_V	41_F	1.349	1.00
38_N	221_L	1.340	1.00
4_E	228_K	1.328	1.00
175_K	179_E	1.323	1.00
261_L	265_V	1.321	1.00
93_D	96_D	1.318	1.00
122_S	156_Q	1.305	1.00
63_I	66_D	1.298	1.00
81_T	87_T	1.295	1.00
177_I	189_I	1.290	1.00
54_L	89_K	1.290	1.00
218_K	222_K	1.286	1.00
83_F	86_E	1.279	1.00
264_K	269_P	1.278	1.00
285_S	289_G	1.275	1.00
88_I	123_M	1.270	1.00
76_F	101_A	1.253	1.00
133_I	209_V	1.251	1.00
58_K	89_K	1.250	1.00
6_V	37_V	1.248	1.00
31_Y	268_M	1.235	1.00
102_I	128_V	1.222	1.00
48_E	260_K	1.221	1.00
58_K	62_K	1.219	1.00
227_W	232_L	1.215	1.00
54_L	93_D	1.212	1.00
55_D	59_L	1.210	1.00
61_T	94_F	1.206	1.00
198_L	235_A	1.195	1.00
29_V	68_R	1.184	1.00
43_N	60_V	1.168	1.00
123_M	276_P	1.165	1.00
232_L	236_N	1.162	1.00
69_K	72_S	1.158	1.00
65_L	100_D	1.145	1.00
92_K	96_D	1.144	1.00
62_K	93_D	1.141	1.00
233_S	236_N	1.138	1.00
15_L	21_D	1.136	1.00
125_A	159_N	1.135	1.00
33_S	72_S	1.127	1.00
188_S	206_N	1.124	1.00
224_Y	228_K	1.119	1.00
68_R	75_I	1.119	1.00
123_M	126_E	1.109	1.00
123_M	127_K	1.108	1.00
261_L	264_K	1.105	1.00
23_E	26_K	1.100	1.00
24_G	270_I	1.097	1.00
19_S	85_E	1.096	1.00
58_K	96_D	1.090	1.00
252_C	286_K	1.088	1.00
222_K	225_E	1.087	1.00
14_F	52_L	1.086	1.00
22_K	26_K	1.085	1.00
29_V	67_S	1.080	1.00
76_F	133_I	1.068	1.00
92_K	127_K	1.068	1.00
62_K	97_M	1.065	1.00
175_K	247_D	1.062	1.00
289_G	292_K	1.060	1.00
148_S	179_E	1.047	1.00
88_I	92_K	1.035	1.00
8_V	32_L	1.034	1.00
261_L	288_R	1.034	1.00
79_A	94_F	1.030	1.00
102_I	130_L	1.029	1.00
93_D	97_M	1.027	1.00
202_Y	232_L	1.026	1.00
77_A	99_V	1.023	1.00
286_K	289_G	1.020	1.00
4_E	206_N	1.019	1.00
6_V	221_L	1.019	1.00
41_F	103_V	1.019	1.00
115_K	118_L	1.016	1.00
153_L	160_I	1.006	1.00
115_K	282_E	1.001	1.00
8_V	37_V	1.001	1.00
54_L	90_L	0.988	1.00
102_I	132_I	0.980	1.00
234_D	238_Y	0.976	1.00
28_L	263_L	0.973	1.00
88_I	127_K	0.970	1.00
18_Y	85_E	0.968	1.00
236_N	240_R	0.965	1.00
173_F	200_L	0.965	1.00
281_C	287_I	0.965	1.00
26_K	30_S	0.958	1.00
10_L	32_L	0.951	1.00
80_S	105_M	0.949	1.00
134_I	150_Y	0.949	1.00
57_M	90_L	0.942	1.00
55_D	89_K	0.941	1.00
125_A	132_I	0.941	1.00
81_T	86_E	0.934	1.00
65_L	99_V	0.928	1.00
212_L	246_T	0.927	1.00
24_G	269_P	0.924	1.00
114_E	152_M	0.923	1.00
262_L	291_I	0.922	1.00
117_L	143_I	0.921	1.00
201_L	224_Y	0.919	1.00
151_K	180_I	0.919	1.00
33_S	68_R	0.917	1.00
89_K	93_D	0.916	1.00
119_D	279_S	0.914	1.00
136_N	144_D	0.913	1.00
233_S	237_K	0.913	1.00
106_A	143_I	0.911	1.00
118_L	149_V	0.910	1.00
75_I	99_V	0.909	1.00
38_N	224_Y	0.909	1.00
14_F	275_R	0.908	1.00
118_L	156_Q	0.908	1.00
147_I	179_E	0.901	1.00
89_K	92_K	0.900	1.00
79_A	102_I	0.898	1.00
29_V	63_I	0.890	1.00
202_Y	236_N	0.886	1.00
248_I	290_M	0.886	1.00
216_I	245_L	0.885	1.00
65_L	97_M	0.884	1.00
272_N	280_I	0.881	1.00
226_S	238_Y	0.877	1.00
190_L	207_G	0.870	1.00
197_L	208_G	0.862	1.00
92_K	95_K	0.861	1.00
42_V	60_V	0.853	1.00
18_Y	276_P	0.853	1.00
37_V	217_P	0.852	1.00
21_D	269_P	0.850	1.00
210_M	213_A	0.849	1.00
223_V	238_Y	0.844	1.00
125_A	160_I	0.844	1.00
6_V	224_Y	0.843	1.00
104_V	132_I	0.837	1.00
202_Y	227_W	0.831	1.00
84_T	88_I	0.824	1.00
191_T	200_L	0.822	1.00
23_E	27_W	0.819	1.00
157_H	160_I	0.818	1.00
264_K	272_N	0.807	1.00
43_N	77_A	0.807	1.00
10_L	40_I	0.806	1.00
6_V	208_G	0.804	1.00
180_I	184_R	0.801	1.00
27_W	268_M	0.799	1.00
68_R	72_S	0.793	1.00
239_W	243_L	0.790	1.00
35_N	217_P	0.790	1.00
6_V	213_A	0.789	1.00
55_D	58_K	0.787	1.00
61_T	97_M	0.783	1.00
243_L	247_D	0.783	1.00
61_T	99_V	0.780	1.00
45_S	109_F	0.777	1.00
118_L	157_H	0.777	1.00
10_L	25_L	0.776	1.00
175_K	178_S	0.776	1.00
216_I	242_V	0.776	1.00
230_G	233_S	0.773	1.00
147_I	151_K	0.772	1.00
216_I	219_L	0.769	1.00
94_F	99_V	0.768	1.00
199_P	202_Y	0.766	1.00
264_K	270_I	0.760	1.00
39_G	76_F	0.760	1.00
180_I	206_N	0.759	1.00
52_L	60_V	0.756	1.00
147_I	172_F	0.753	1.00
98_G	130_L	0.751	1.00
87_T	104_V	0.748	1.00
85_E	89_K	0.748	1.00
25_L	29_V	0.746	1.00
257_A	281_C	0.736	1.00
106_A	145_I	0.736	1.00
119_D	276_P	0.735	1.00
150_Y	176_L	0.734	1.00
147_I	175_K	0.732	1.00
15_L	18_Y	0.729	1.00
135_Y	164_K	0.727	1.00
15_L	23_E	0.726	1.00
20_I	25_L	0.722	1.00
257_A	274_V	0.721	1.00
198_L	227_W	0.719	1.00
74_L	100_D	0.718	1.00
137_I	141_T	0.716	1.00
229_N	234_D	0.715	1.00
171_I	195_E	0.715	1.00
265_V	292_K	0.711	1.00
122_S	152_M	0.711	1.00
29_V	40_I	0.706	1.00
178_S	240_R	0.705	1.00
271_K	274_V	0.704	1.00
219_L	222_K	0.704	1.00
40_I	68_R	0.704	1.00
114_E	148_S	0.703	1.00
222_K	238_Y	0.698	1.00
274_V	278_L	0.692	1.00
58_K	90_L	0.692	1.00
113_R	257_A	0.690	1.00
223_V	227_W	0.690	1.00
58_K	97_M	0.690	1.00
43_N	52_L	0.686	1.00
49_F	78_G	0.686	1.00
32_L	37_V	0.685	1.00
79_A	104_V	0.683	0.99
136_N	165_V	0.683	0.99
144_D	169_S	0.683	0.99
16_E	272_N	0.681	0.99
33_S	67_S	0.679	0.99
174_K	178_S	0.677	0.99
199_P	203_M	0.676	0.99
134_I	145_I	0.674	0.99
151_K	155_S	0.672	0.99
54_L	58_K	0.672	0.99
84_T	123_M	0.672	0.99
145_I	150_Y	0.671	0.99
173_F	177_I	0.670	0.99
61_T	65_L	0.665	0.99
184_R	187_F	0.662	0.99
62_K	96_D	0.661	0.99
58_K	94_F	0.661	0.99
116_E	279_S	0.660	0.99
218_K	266_L	0.659	0.99
173_F	189_I	0.657	0.99
31_Y	266_L	0.656	0.99
7_V	76_F	0.655	0.99
148_S	151_K	0.651	0.99
129_D	159_N	0.649	0.99
20_I	60_V	0.649	0.99
10_L	64_A	0.644	0.99
174_K	203_M	0.644	0.99
263_L	266_L	0.640	0.99
68_R	73_T	0.636	0.99
32_L	35_N	0.635	0.99
198_L	232_L	0.635	0.99
28_L	32_L	0.634	0.99
53_T	85_E	0.630	0.99
133_I	161_I	0.624	0.99
177_I	206_N	0.620	0.99
197_L	223_V	0.619	0.99
226_S	229_N	0.613	0.99
161_I	188_S	0.613	0.99
148_S	175_K	0.613	0.99
43_N	57_M	0.611	0.99
70_S	100_D	0.611	0.99
113_R	253_N	0.610	0.99
174_K	199_P	0.610	0.99
16_E	271_K	0.609	0.99
285_S	292_K	0.609	0.99
42_V	75_I	0.608	0.99
172_F	176_L	0.605	0.99
86_E	89_K	0.605	0.99
30_S	33_S	0.604	0.99
50_A	110_F	0.603	0.99
126_E	159_N	0.602	0.99
269_P	272_N	0.599	0.99
174_K	239_W	0.597	0.99
286_K	290_M	0.595	0.99
263_L	268_M	0.595	0.99
16_E	270_I	0.595	0.99
22_K	67_S	0.593	0.99
149_V	152_M	0.593	0.99
20_I	63_I	0.590	0.99
14_F	56_E	0.589	0.99
261_L	274_V	0.589	0.99
165_V	173_F	0.589	0.99
169_S	172_F	0.587	0.98
113_R	116_E	0.586	0.98
215_A	262_L	0.586	0.98
199_P	239_W	0.584	0.98
180_I	186_D	0.584	0.98
225_E	228_K	0.583	0.98
274_V	279_S	0.582	0.98
265_V	291_I	0.582	0.98
162_G	188_S	0.581	0.98
36_G	221_L	0.577	0.98
198_L	239_W	0.577	0.98
41_F	76_F	0.576	0.98
145_I	149_V	0.576	0.98
76_F	103_V	0.570	0.98
45_S	135_Y	0.568	0.98
198_L	202_Y	0.567	0.98
99_V	130_L	0.566	0.98
262_L	265_V	0.563	0.98
55_D	93_D	0.561	0.98
177_I	180_I	0.561	0.98
215_A	259_I	0.558	0.98
261_L	281_C	0.558	0.98
11_I	259_I	0.558	0.98
197_L	220_H	0.558	0.98
237_K	240_R	0.555	0.98
106_A	121_F	0.555	0.98
37_V	221_L	0.553	0.98
115_K	279_S	0.551	0.98
170_L	196_Y	0.551	0.98
77_A	94_F	0.550	0.98
120_H	123_M	0.549	0.98
40_I	73_T	0.549	0.98
253_N	282_E	0.548	0.98
111_K	139_L	0.547	0.98
258_S	281_C	0.545	0.98
95_K	127_K	0.539	0.97
176_L	189_I	0.538	0.97
147_I	176_L	0.534	0.97
9_P	210_M	0.534	0.97
238_Y	241_N	0.534	0.97
121_F	160_I	0.533	0.97
4_E	38_N	0.532	0.97
178_S	244_N	0.532	0.97
226_S	235_A	0.532	0.97
9_P	211_G	0.531	0.97
10_L	29_V	0.531	0.97
254_S	258_S	0.527	0.97
65_L	69_K	0.527	0.97
35_N	221_L	0.527	0.97
215_A	263_L	0.524	0.97
66_D	69_K	0.522	0.97
271_K	280_I	0.520	0.97
88_I	124_I	0.520	0.97
31_Y	217_P	0.520	0.97
133_I	188_S	0.519	0.97
51_S	84_T	0.518	0.97
283_E	288_R	0.518	0.97
91_A	124_I	0.517	0.97
201_L	228_K	0.517	0.97
101_A	161_I	0.517	0.97
137_I	140_F	0.517	0.97
211_G	259_I	0.515	0.97
106_A	117_L	0.514	0.97
90_L	94_F	0.514	0.97
227_W	235_A	0.514	0.97
197_L	224_Y	0.514	0.97
87_T	91_A	0.514	0.97
248_I	286_K	0.512	0.96
153_L	157_H	0.512	0.96
43_N	61_T	0.511	0.96
104_V	121_F	0.510	0.96
57_M	81_T	0.510	0.96
57_M	86_E	0.508	0.96
180_I	185_K	0.507	0.96
212_L	216_I	0.504	0.96
28_L	31_Y	0.504	0.96
162_G	187_F	0.503	0.96
19_S	59_L	0.503	0.96
219_L	238_Y	0.502	0.96
64_A	68_R	0.500	0.96

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4pfmA	2	0.9669	100	0.048	Contact Map
3si9A	3	0.9636	100	0.053	Contact Map
3qzeA	2	0.9536	100	0.054	Contact Map
3fluA	3	0.9603	100	0.054	Contact Map
4oe7A	3	0.9801	100	0.055	Contact Map
3na8A	3	0.9636	100	0.057	Contact Map
1xkyA	3	0.957	100	0.058	Contact Map
3eb2A	3	0.9636	100	0.058	Contact Map
2ehhA	3	0.9669	100	0.059	Contact Map
4i7wA	3	0.9536	100	0.06	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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