GREMLIN Database
Q97UF0 - Dihydrodipicolinate synthase (DapA-3)
UniProt: Q97UF0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 302 (282)
Sequences: 10349 (6737)
Seq/√Len: 401.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
231_N234_D3.8691.00
30_S67_S3.3601.00
15_L19_S3.2141.00
118_L152_M3.1491.00
26_K67_S2.8451.00
265_V288_R2.7881.00
22_K59_L2.7581.00
95_K129_D2.6561.00
22_K63_I2.6531.00
26_K63_I2.6251.00
79_A91_A2.5471.00
58_K93_D2.5151.00
226_S234_D2.5011.00
200_L205_G2.4611.00
91_A102_I2.2891.00
234_D237_K2.1891.00
30_S72_S2.0781.00
201_L227_W2.0511.00
7_V39_G2.0341.00
221_L225_E2.0311.00
122_S157_H2.0131.00
114_E146_P2.0091.00
31_Y35_N2.0041.00
226_S231_N2.0041.00
225_E229_N2.0001.00
114_E149_V1.9991.00
126_E157_H1.9761.00
84_T120_H1.9451.00
59_L62_K1.9141.00
38_N225_E1.9091.00
151_K179_E1.8971.00
122_S126_E1.8811.00
30_S34_E1.8681.00
21_D24_G1.8621.00
144_D172_F1.8621.00
115_K119_D1.8551.00
115_K152_M1.8551.00
54_L86_E1.8511.00
26_K66_D1.8411.00
288_R292_K1.8361.00
29_V64_A1.7541.00
219_L241_N1.7531.00
118_L122_S1.7431.00
35_N218_K1.7191.00
62_K66_D1.7151.00
133_I162_G1.7051.00
25_L64_A1.6921.00
59_L63_I1.6861.00
65_L75_I1.6731.00
125_A157_H1.6461.00
8_V213_A1.6441.00
56_E275_R1.6421.00
119_D122_S1.6201.00
104_V124_I1.6161.00
146_P149_V1.5961.00
24_G27_W1.5891.00
42_V64_A1.5701.00
91_A128_V1.5571.00
150_Y163_T1.5461.00
63_I67_S1.5311.00
237_K241_N1.5081.00
61_T77_A1.5061.00
285_S288_R1.5041.00
13_P25_L1.4881.00
33_S73_T1.4841.00
25_L60_V1.4731.00
152_M156_Q1.4371.00
87_T124_I1.4301.00
95_K128_V1.4131.00
222_K226_S1.3891.00
264_K271_K1.3891.00
119_D123_M1.3741.00
95_K130_L1.3661.00
222_K234_D1.3581.00
11_I263_L1.3501.00
7_V41_F1.3491.00
38_N221_L1.3401.00
4_E228_K1.3281.00
175_K179_E1.3231.00
261_L265_V1.3211.00
93_D96_D1.3181.00
122_S156_Q1.3051.00
63_I66_D1.2981.00
81_T87_T1.2951.00
177_I189_I1.2901.00
54_L89_K1.2901.00
218_K222_K1.2861.00
83_F86_E1.2791.00
264_K269_P1.2781.00
285_S289_G1.2751.00
88_I123_M1.2701.00
76_F101_A1.2531.00
133_I209_V1.2511.00
58_K89_K1.2501.00
6_V37_V1.2481.00
31_Y268_M1.2351.00
102_I128_V1.2221.00
48_E260_K1.2211.00
58_K62_K1.2191.00
227_W232_L1.2151.00
54_L93_D1.2121.00
55_D59_L1.2101.00
61_T94_F1.2061.00
198_L235_A1.1951.00
29_V68_R1.1841.00
43_N60_V1.1681.00
123_M276_P1.1651.00
232_L236_N1.1621.00
69_K72_S1.1581.00
65_L100_D1.1451.00
92_K96_D1.1441.00
62_K93_D1.1411.00
233_S236_N1.1381.00
15_L21_D1.1361.00
125_A159_N1.1351.00
33_S72_S1.1271.00
188_S206_N1.1241.00
224_Y228_K1.1191.00
68_R75_I1.1191.00
123_M126_E1.1091.00
123_M127_K1.1081.00
261_L264_K1.1051.00
23_E26_K1.1001.00
24_G270_I1.0971.00
19_S85_E1.0961.00
58_K96_D1.0901.00
252_C286_K1.0881.00
222_K225_E1.0871.00
14_F52_L1.0861.00
22_K26_K1.0851.00
29_V67_S1.0801.00
76_F133_I1.0681.00
92_K127_K1.0681.00
62_K97_M1.0651.00
175_K247_D1.0621.00
289_G292_K1.0601.00
148_S179_E1.0471.00
88_I92_K1.0351.00
8_V32_L1.0341.00
261_L288_R1.0341.00
79_A94_F1.0301.00
102_I130_L1.0291.00
93_D97_M1.0271.00
202_Y232_L1.0261.00
77_A99_V1.0231.00
286_K289_G1.0201.00
4_E206_N1.0191.00
6_V221_L1.0191.00
41_F103_V1.0191.00
115_K118_L1.0161.00
153_L160_I1.0061.00
115_K282_E1.0011.00
8_V37_V1.0011.00
54_L90_L0.9881.00
102_I132_I0.9801.00
234_D238_Y0.9761.00
28_L263_L0.9731.00
88_I127_K0.9701.00
18_Y85_E0.9681.00
236_N240_R0.9651.00
173_F200_L0.9651.00
281_C287_I0.9651.00
26_K30_S0.9581.00
10_L32_L0.9511.00
80_S105_M0.9491.00
134_I150_Y0.9491.00
57_M90_L0.9421.00
55_D89_K0.9411.00
125_A132_I0.9411.00
81_T86_E0.9341.00
65_L99_V0.9281.00
212_L246_T0.9271.00
24_G269_P0.9241.00
114_E152_M0.9231.00
262_L291_I0.9221.00
117_L143_I0.9211.00
201_L224_Y0.9191.00
151_K180_I0.9191.00
33_S68_R0.9171.00
89_K93_D0.9161.00
119_D279_S0.9141.00
136_N144_D0.9131.00
233_S237_K0.9131.00
106_A143_I0.9111.00
118_L149_V0.9101.00
75_I99_V0.9091.00
38_N224_Y0.9091.00
14_F275_R0.9081.00
118_L156_Q0.9081.00
147_I179_E0.9011.00
89_K92_K0.9001.00
79_A102_I0.8981.00
29_V63_I0.8901.00
202_Y236_N0.8861.00
248_I290_M0.8861.00
216_I245_L0.8851.00
65_L97_M0.8841.00
272_N280_I0.8811.00
226_S238_Y0.8771.00
190_L207_G0.8701.00
197_L208_G0.8621.00
92_K95_K0.8611.00
42_V60_V0.8531.00
18_Y276_P0.8531.00
37_V217_P0.8521.00
21_D269_P0.8501.00
210_M213_A0.8491.00
223_V238_Y0.8441.00
125_A160_I0.8441.00
6_V224_Y0.8431.00
104_V132_I0.8371.00
202_Y227_W0.8311.00
84_T88_I0.8241.00
191_T200_L0.8221.00
23_E27_W0.8191.00
157_H160_I0.8181.00
264_K272_N0.8071.00
43_N77_A0.8071.00
10_L40_I0.8061.00
6_V208_G0.8041.00
180_I184_R0.8011.00
27_W268_M0.7991.00
68_R72_S0.7931.00
239_W243_L0.7901.00
35_N217_P0.7901.00
6_V213_A0.7891.00
55_D58_K0.7871.00
61_T97_M0.7831.00
243_L247_D0.7831.00
61_T99_V0.7801.00
45_S109_F0.7771.00
118_L157_H0.7771.00
10_L25_L0.7761.00
175_K178_S0.7761.00
216_I242_V0.7761.00
230_G233_S0.7731.00
147_I151_K0.7721.00
216_I219_L0.7691.00
94_F99_V0.7681.00
199_P202_Y0.7661.00
264_K270_I0.7601.00
39_G76_F0.7601.00
180_I206_N0.7591.00
52_L60_V0.7561.00
147_I172_F0.7531.00
98_G130_L0.7511.00
87_T104_V0.7481.00
85_E89_K0.7481.00
25_L29_V0.7461.00
257_A281_C0.7361.00
106_A145_I0.7361.00
119_D276_P0.7351.00
150_Y176_L0.7341.00
147_I175_K0.7321.00
15_L18_Y0.7291.00
135_Y164_K0.7271.00
15_L23_E0.7261.00
20_I25_L0.7221.00
257_A274_V0.7211.00
198_L227_W0.7191.00
74_L100_D0.7181.00
137_I141_T0.7161.00
229_N234_D0.7151.00
171_I195_E0.7151.00
265_V292_K0.7111.00
122_S152_M0.7111.00
29_V40_I0.7061.00
178_S240_R0.7051.00
271_K274_V0.7041.00
219_L222_K0.7041.00
40_I68_R0.7041.00
114_E148_S0.7031.00
222_K238_Y0.6981.00
274_V278_L0.6921.00
58_K90_L0.6921.00
113_R257_A0.6901.00
223_V227_W0.6901.00
58_K97_M0.6901.00
43_N52_L0.6861.00
49_F78_G0.6861.00
32_L37_V0.6851.00
79_A104_V0.6830.99
136_N165_V0.6830.99
144_D169_S0.6830.99
16_E272_N0.6810.99
33_S67_S0.6790.99
174_K178_S0.6770.99
199_P203_M0.6760.99
134_I145_I0.6740.99
151_K155_S0.6720.99
54_L58_K0.6720.99
84_T123_M0.6720.99
145_I150_Y0.6710.99
173_F177_I0.6700.99
61_T65_L0.6650.99
184_R187_F0.6620.99
62_K96_D0.6610.99
58_K94_F0.6610.99
116_E279_S0.6600.99
218_K266_L0.6590.99
173_F189_I0.6570.99
31_Y266_L0.6560.99
7_V76_F0.6550.99
148_S151_K0.6510.99
129_D159_N0.6490.99
20_I60_V0.6490.99
10_L64_A0.6440.99
174_K203_M0.6440.99
263_L266_L0.6400.99
68_R73_T0.6360.99
32_L35_N0.6350.99
198_L232_L0.6350.99
28_L32_L0.6340.99
53_T85_E0.6300.99
133_I161_I0.6240.99
177_I206_N0.6200.99
197_L223_V0.6190.99
226_S229_N0.6130.99
161_I188_S0.6130.99
148_S175_K0.6130.99
43_N57_M0.6110.99
70_S100_D0.6110.99
113_R253_N0.6100.99
174_K199_P0.6100.99
16_E271_K0.6090.99
285_S292_K0.6090.99
42_V75_I0.6080.99
172_F176_L0.6050.99
86_E89_K0.6050.99
30_S33_S0.6040.99
50_A110_F0.6030.99
126_E159_N0.6020.99
269_P272_N0.5990.99
174_K239_W0.5970.99
286_K290_M0.5950.99
263_L268_M0.5950.99
16_E270_I0.5950.99
22_K67_S0.5930.99
149_V152_M0.5930.99
20_I63_I0.5900.99
14_F56_E0.5890.99
261_L274_V0.5890.99
165_V173_F0.5890.99
169_S172_F0.5870.98
113_R116_E0.5860.98
215_A262_L0.5860.98
199_P239_W0.5840.98
180_I186_D0.5840.98
225_E228_K0.5830.98
274_V279_S0.5820.98
265_V291_I0.5820.98
162_G188_S0.5810.98
36_G221_L0.5770.98
198_L239_W0.5770.98
41_F76_F0.5760.98
145_I149_V0.5760.98
76_F103_V0.5700.98
45_S135_Y0.5680.98
198_L202_Y0.5670.98
99_V130_L0.5660.98
262_L265_V0.5630.98
55_D93_D0.5610.98
177_I180_I0.5610.98
215_A259_I0.5580.98
261_L281_C0.5580.98
11_I259_I0.5580.98
197_L220_H0.5580.98
237_K240_R0.5550.98
106_A121_F0.5550.98
37_V221_L0.5530.98
115_K279_S0.5510.98
170_L196_Y0.5510.98
77_A94_F0.5500.98
120_H123_M0.5490.98
40_I73_T0.5490.98
253_N282_E0.5480.98
111_K139_L0.5470.98
258_S281_C0.5450.98
95_K127_K0.5390.97
176_L189_I0.5380.97
147_I176_L0.5340.97
9_P210_M0.5340.97
238_Y241_N0.5340.97
121_F160_I0.5330.97
4_E38_N0.5320.97
178_S244_N0.5320.97
226_S235_A0.5320.97
9_P211_G0.5310.97
10_L29_V0.5310.97
254_S258_S0.5270.97
65_L69_K0.5270.97
35_N221_L0.5270.97
215_A263_L0.5240.97
66_D69_K0.5220.97
271_K280_I0.5200.97
88_I124_I0.5200.97
31_Y217_P0.5200.97
133_I188_S0.5190.97
51_S84_T0.5180.97
283_E288_R0.5180.97
91_A124_I0.5170.97
201_L228_K0.5170.97
101_A161_I0.5170.97
137_I140_F0.5170.97
211_G259_I0.5150.97
106_A117_L0.5140.97
90_L94_F0.5140.97
227_W235_A0.5140.97
197_L224_Y0.5140.97
87_T91_A0.5140.97
248_I286_K0.5120.96
153_L157_H0.5120.96
43_N61_T0.5110.96
104_V121_F0.5100.96
57_M81_T0.5100.96
57_M86_E0.5080.96
180_I185_K0.5070.96
212_L216_I0.5040.96
28_L31_Y0.5040.96
162_G187_F0.5030.96
19_S59_L0.5030.96
219_L238_Y0.5020.96
64_A68_R0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pfmA 2 0.9669 100 0.048 Contact Map
3si9A 3 0.9636 100 0.053 Contact Map
3qzeA 2 0.9536 100 0.054 Contact Map
3fluA 3 0.9603 100 0.054 Contact Map
4oe7A 3 0.9801 100 0.055 Contact Map
3na8A 3 0.9636 100 0.057 Contact Map
1xkyA 3 0.957 100 0.058 Contact Map
3eb2A 3 0.9636 100 0.058 Contact Map
2ehhA 3 0.9669 100 0.059 Contact Map
4i7wA 3 0.9536 100 0.06 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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