GREMLIN Database
Q97UE9 - Uncharacterized protein
UniProt: Q97UE9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 253 (229)
Sequences: 5077 (3488)
Seq/√Len: 230.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_Y230_W4.2541.00
39_F237_T3.6081.00
55_A199_V3.3361.00
114_I180_G3.0871.00
12_A15_T3.0111.00
82_L200_V2.7811.00
118_F184_Y2.7541.00
79_S83_I2.5841.00
79_S87_L2.4401.00
17_A171_L2.4071.00
75_L79_S2.3711.00
9_G13_G2.3071.00
9_G181_A2.1871.00
45_S231_L2.1441.00
80_I232_F2.1281.00
16_V23_I2.0461.00
44_L205_L2.0181.00
77_L236_A2.0071.00
16_V20_A1.9981.00
162_G165_V1.9791.00
8_L13_G1.9211.00
8_L12_A1.9211.00
75_L83_I1.9151.00
164_K168_P1.8461.00
236_A240_G1.8401.00
16_V22_I1.8251.00
76_I84_G1.7971.00
68_Y72_T1.7651.00
69_P72_T1.7501.00
84_G88_L1.7401.00
168_P172_L1.7351.00
9_G12_A1.7021.00
84_G87_L1.6781.00
9_G15_T1.6751.00
91_L94_K1.6641.00
46_Y49_L1.6551.00
52_G76_I1.6221.00
31_T226_R1.5971.00
110_G176_P1.5971.00
87_L90_S1.5781.00
46_Y239_Y1.5611.00
6_I10_L1.5571.00
79_S90_S1.5481.00
48_A52_G1.5421.00
68_Y71_F1.5291.00
144_A205_L1.5231.00
73_V76_I1.5181.00
76_I79_S1.4801.00
22_I144_A1.4761.00
158_K161_M1.4731.00
7_L11_I1.4571.00
5_P9_G1.4451.00
35_Y226_R1.4321.00
49_L239_Y1.4271.00
18_I22_I1.3911.00
116_E143_N1.3851.00
11_I15_T1.3791.00
41_G213_N1.3501.00
18_I144_A1.3471.00
76_I87_L1.3381.00
150_I173_A1.3351.00
183_I186_L1.3321.00
112_H142_H1.3241.00
133_W137_I1.3111.00
50_D238_T1.3081.00
106_A169_L1.2971.00
106_A150_I1.2951.00
136_T140_A1.2911.00
143_N205_L1.2721.00
147_G170_S1.2721.00
74_A78_T1.2621.00
232_F236_A1.2581.00
96_P100_G1.2561.00
77_L81_G1.2471.00
106_A154_A1.2431.00
118_F180_G1.2421.00
16_V19_G1.2351.00
73_V84_G1.2241.00
91_L95_N1.2161.00
5_P12_A1.2111.00
113_N173_A1.2031.00
47_L50_D1.2021.00
123_A135_F1.1991.00
48_A206_V1.1991.00
8_L15_T1.1941.00
54_E58_I1.1701.00
182_S186_L1.1681.00
76_I83_I1.1661.00
143_N173_A1.1641.00
75_L78_T1.1601.00
112_H117_G1.1571.00
201_A204_S1.1561.00
143_N147_G1.1471.00
81_G85_T1.1381.00
96_P102_P1.1271.00
154_A161_M1.1251.00
56_E72_T1.1161.00
77_L87_L1.1031.00
92_L95_N1.0971.00
105_V108_A1.0961.00
114_I183_I1.0931.00
83_I87_L1.0851.00
210_I231_L1.0771.00
116_E146_E1.0771.00
54_E57_E1.0761.00
32_T36_L1.0731.00
175_L179_L1.0721.00
15_T140_A1.0621.00
143_N146_E1.0611.00
85_T89_L1.0591.00
12_A16_V1.0561.00
71_F74_A1.0491.00
184_Y187_G1.0441.00
76_I206_V1.0441.00
214_I231_L1.0401.00
43_I210_I1.0371.00
12_A23_I1.0361.00
32_T35_Y1.0341.00
10_L178_T1.0321.00
155_V163_L1.0201.00
73_V79_S1.0191.00
171_L174_G1.0021.00
69_P73_V1.0011.00
138_G238_T1.0011.00
87_L94_K0.9991.00
48_A53_S0.9991.00
120_I139_F0.9981.00
38_A227_F0.9951.00
135_F138_G0.9891.00
41_G214_I0.9711.00
88_L91_L0.9701.00
192_I195_A0.9651.00
70_D79_S0.9621.00
8_L124_L0.9571.00
21_I167_I0.9541.00
113_N178_T0.9441.00
118_F187_G0.9281.00
63_L67_D0.9221.00
73_V240_G0.9211.00
109_L112_H0.9201.00
45_S209_M0.9151.00
64_A67_D0.9040.99
80_I88_L0.9010.99
58_I175_L0.8970.99
147_G205_L0.8960.99
81_G84_G0.8950.99
162_G166_L0.8950.99
5_P15_T0.8910.99
50_D142_H0.8880.99
79_S82_L0.8830.99
27_K30_K0.8830.99
109_L116_E0.8810.99
47_L142_H0.8770.99
41_G108_A0.8760.99
70_D75_L0.8750.99
87_L91_L0.8720.99
46_Y235_I0.8700.99
83_I92_L0.8690.99
109_L147_G0.8670.99
60_T64_A0.8620.99
34_G222_G0.8610.99
34_G217_A0.8570.99
214_I218_S0.8530.99
67_D71_F0.8510.99
120_I136_T0.8510.99
52_G202_S0.8480.99
55_A202_S0.8460.99
226_R230_W0.8430.99
87_L92_L0.8410.99
79_S85_T0.8380.99
73_V77_L0.8380.99
10_L13_G0.8380.99
5_P8_L0.8320.99
86_W90_S0.8290.99
77_L84_G0.8280.99
17_A21_I0.8200.99
72_T76_I0.8170.99
230_W236_A0.8150.99
233_I237_T0.8100.99
89_L92_L0.8090.99
20_A23_I0.8060.99
85_T88_L0.7980.99
55_A72_T0.7910.99
175_L178_T0.7870.99
167_I171_L0.7840.99
13_G23_I0.7780.98
103_V107_S0.7760.98
64_A68_Y0.7750.98
69_P78_T0.7740.98
29_N32_T0.7710.98
82_L86_W0.7700.98
115_G146_E0.7690.98
71_F75_L0.7670.98
73_V78_T0.7620.98
109_L150_I0.7620.98
109_L146_E0.7620.98
120_I177_T0.7530.98
119_A135_F0.7500.98
43_I238_T0.7500.98
88_L92_L0.7490.98
74_A81_G0.7480.98
75_L195_A0.7470.98
76_I85_T0.7460.98
20_A151_S0.7440.98
89_L93_E0.7430.98
149_A153_P0.7370.98
146_E205_L0.7340.98
228_W231_L0.7320.98
50_D241_L0.7320.98
80_I210_I0.7280.98
54_E242_E0.7270.98
17_A20_A0.7260.98
58_I62_F0.7260.98
80_I87_L0.7240.98
77_L83_I0.7240.98
132_A136_T0.7230.98
146_E150_I0.7230.98
19_G22_I0.7230.98
13_G143_N0.7220.98
115_G119_A0.7220.98
34_G227_F0.7220.98
146_E173_A0.7210.97
69_P75_L0.7210.97
143_N150_I0.7190.97
140_A205_L0.7190.97
236_A239_Y0.7190.97
11_I16_V0.7140.97
218_S221_G0.7120.97
75_L199_V0.7060.97
165_V168_P0.7040.97
8_L20_A0.7030.97
68_Y79_S0.7030.97
8_L11_I0.7020.97
110_G114_I0.6980.97
37_G217_A0.6980.97
17_A174_G0.6970.97
143_N204_S0.6970.97
90_S93_E0.6920.97
42_G201_A0.6890.97
143_N177_T0.6880.97
30_K220_L0.6830.97
34_G220_L0.6810.96
39_F233_I0.6790.96
69_P74_A0.6780.96
80_I90_S0.6770.96
72_T87_L0.6750.96
177_T205_L0.6750.96
161_M165_V0.6700.96
74_A195_A0.6530.96
218_S227_F0.6520.95
33_I36_L0.6490.95
140_A143_N0.6490.95
47_L204_S0.6470.95
55_A58_I0.6450.95
69_P79_S0.6450.95
168_P171_L0.6440.95
79_S86_W0.6410.95
161_M166_L0.6400.95
6_I9_G0.6390.95
35_Y39_F0.6390.95
121_A201_A0.6380.95
13_G16_V0.6310.95
78_T82_L0.6290.95
72_T75_L0.6290.95
200_V204_S0.6280.94
89_L94_K0.6260.94
113_N147_G0.6250.94
139_F146_E0.6220.94
84_G94_K0.6210.94
5_P185_Y0.6200.94
38_A230_W0.6170.94
146_E149_A0.6160.94
147_G150_I0.6150.94
119_A203_A0.6100.94
45_S48_A0.6080.93
119_A204_S0.6070.93
75_L84_G0.6070.93
90_S95_N0.6060.93
191_E195_A0.6040.93
86_W91_L0.6000.93
38_A217_A0.5990.93
62_F191_E0.5990.93
117_G142_H0.5990.93
215_N218_S0.5970.93
71_F78_T0.5970.93
59_V62_F0.5960.93
165_V169_L0.5940.93
20_A170_S0.5930.93
84_G207_F0.5930.93
10_L14_G0.5910.93
211_R215_N0.5880.92
209_M213_N0.5880.92
116_E177_T0.5880.92
70_D73_V0.5820.92
79_S89_L0.5810.92
76_I81_G0.5760.92
109_L143_N0.5760.92
170_S173_A0.5760.92
212_I215_N0.5730.91
72_T83_I0.5710.91
37_G40_T0.5680.91
150_I154_A0.5680.91
80_I83_I0.5660.91
47_L201_A0.5600.90
20_A167_I0.5600.90
180_G183_I0.5580.90
15_T18_I0.5580.90
9_G14_G0.5520.90
79_S91_L0.5510.90
75_L87_L0.5490.90
135_F146_E0.5470.89
60_T107_S0.5470.89
40_T153_P0.5450.89
14_G17_A0.5450.89
189_S192_I0.5440.89
112_H116_E0.5440.89
10_L96_P0.5430.89
50_D242_E0.5430.89
172_L176_P0.5420.89
47_L238_T0.5400.89
112_H150_I0.5400.89
5_P13_G0.5380.89
199_V203_A0.5380.89
49_L54_E0.5370.88
201_A214_I0.5360.88
109_L113_N0.5330.88
151_S170_S0.5330.88
217_A227_F0.5320.88
70_D76_I0.5320.88
79_S92_L0.5310.88
44_L177_T0.5300.88
87_L207_F0.5290.88
60_T63_L0.5290.88
113_N143_N0.5230.87
225_A229_T0.5180.87
73_V87_L0.5170.87
31_T35_Y0.5160.86
40_T115_G0.5160.86
168_P188_I0.5140.86
107_S134_A0.5120.86
109_L149_A0.5110.86
207_F229_T0.5110.86
73_V83_I0.5090.86
201_A209_M0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2k1eA 3 0.3557 6.4 0.953 Contact Map
4a01A 2 0.8498 5.8 0.954 Contact Map
3effK 4 0.3557 5.5 0.954 Contact Map
4k0jA 3 0.2451 4.4 0.956 Contact Map
3ne5A 3 0.253 4.4 0.956 Contact Map
4n7wA 2 0.5968 4.1 0.957 Contact Map
4gc0A 1 0.5929 3.9 0.957 Contact Map
3ddlA 2 0.7431 3.6 0.958 Contact Map
1lnqA 6 0.2964 3.1 0.96 Contact Map
4tnwA 3 0.3518 3 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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