GREMLIN Database
Q97UE8 - Uncharacterized protein
UniProt: Q97UE8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 284 (255)
Sequences: 31870 (23986)
Seq/√Len: 1502.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
101_S157_A3.4091.00
109_S154_N2.8681.00
230_Y234_K2.8191.00
31_I230_Y2.8161.00
255_A261_Q2.7161.00
65_G187_L2.6271.00
100_S156_L2.4771.00
230_Y233_N2.3881.00
58_F194_I2.3811.00
45_F215_G2.3791.00
40_G250_M2.3101.00
111_T251_A2.2821.00
97_F159_L2.2591.00
47_K261_Q2.1911.00
207_P211_L2.1811.00
77_R80_I2.1641.00
46_V99_V2.1631.00
63_I217_V2.1501.00
32_L231_T2.1501.00
97_F156_L2.0511.00
120_F161_A1.9851.00
126_K172_S1.9341.00
217_V222_L1.9201.00
40_G254_L1.9081.00
93_L163_S1.8891.00
79_I82_K1.8371.00
69_L183_P1.8311.00
121_A241_T1.8161.00
62_L190_S1.7981.00
37_V250_M1.7841.00
41_T215_G1.7461.00
116_T120_F1.7221.00
65_G190_S1.7191.00
105_T154_N1.7101.00
155_V159_L1.7091.00
206_N209_S1.6761.00
104_L152_F1.6631.00
78_K82_K1.6631.00
97_F163_S1.6221.00
191_I195_P1.6211.00
51_I209_S1.6051.00
70_P73_S1.5791.00
122_M132_I1.5771.00
49_C56_I1.5621.00
69_L73_S1.5561.00
110_S157_A1.5541.00
105_T153_G1.5431.00
120_F165_A1.5341.00
236_P239_L1.5341.00
177_D180_S1.5321.00
264_D267_E1.5181.00
195_P198_P1.5181.00
64_A186_Y1.5071.00
120_F162_I1.4571.00
56_I216_L1.4541.00
58_F190_S1.4501.00
71_F75_R1.4411.00
151_I154_N1.4371.00
35_G231_T1.4361.00
50_T209_S1.4171.00
38_A219_V1.4151.00
171_L229_I1.4141.00
100_S104_L1.4141.00
31_I227_S1.4121.00
135_A245_L1.4041.00
250_M254_L1.3981.00
66_I70_P1.3941.00
265_T269_I1.3861.00
105_T109_S1.3851.00
254_L258_I1.3711.00
70_P74_K1.3621.00
29_K243_A1.3561.00
48_F212_A1.3511.00
52_T55_F1.3401.00
112_I271_G1.3371.00
83_R170_F1.3321.00
207_P210_I1.3251.00
268_L272_T1.3061.00
100_S103_F1.2931.00
208_I211_L1.2901.00
83_R174_L1.2791.00
44_I254_L1.2751.00
141_I273_I1.2671.00
165_A169_Y1.2371.00
80_I176_Y1.2361.00
124_F169_Y1.2361.00
86_L170_F1.2301.00
67_L222_L1.2281.00
41_T254_L1.2241.00
172_S236_P1.2231.00
107_I255_A1.2161.00
108_A252_T1.2051.00
27_R234_K1.1991.00
208_I212_A1.1951.00
272_T276_I1.1911.00
77_R81_L1.1811.00
246_I250_M1.1741.00
60_R221_T1.1711.00
133_I137_L1.1701.00
90_F166_I1.1681.00
45_F212_A1.1681.00
92_S192_F1.1651.00
76_R80_I1.1621.00
192_F195_P1.1491.00
125_K130_P1.1491.00
85_I188_I1.1481.00
39_F224_G1.1431.00
54_P196_V1.1321.00
65_G183_P1.1281.00
127_K131_F1.1231.00
105_T157_A1.1191.00
104_L156_L1.1191.00
30_I34_L1.1171.00
151_I155_V1.1121.00
39_F228_V1.1101.00
113_L161_A1.1091.00
205_I210_I1.1081.00
89_L192_F1.1071.00
58_F197_L1.0901.00
140_F144_F1.0851.00
92_S193_M1.0821.00
88_S188_I1.0781.00
141_I266_Q1.0771.00
54_P96_L1.0751.00
152_F156_L1.0721.00
102_V110_S1.0671.00
58_F62_L1.0661.00
144_F264_D1.0651.00
211_L215_G1.0611.00
98_F102_V1.0611.00
90_F163_S1.0591.00
46_V102_V1.0571.00
104_L150_Y1.0511.00
104_L153_G1.0491.00
77_R82_K1.0461.00
57_T99_V1.0391.00
28_D234_K1.0391.00
263_P268_L1.0381.00
173_R176_Y1.0351.00
49_C209_S1.0261.00
49_C212_A1.0231.00
35_G227_S1.0181.00
131_F280_F1.0161.00
44_I258_I1.0151.00
106_T109_S1.0131.00
28_D231_T1.0051.00
161_A165_A1.0051.00
62_L194_I1.0051.00
211_L214_L1.0051.00
67_L218_L1.0011.00
83_R87_P0.9861.00
35_G39_F0.9861.00
265_T268_L0.9841.00
214_L217_V0.9811.00
61_F189_S0.9741.00
121_A168_T0.9741.00
152_F155_V0.9711.00
112_I140_F0.9661.00
252_T263_P0.9641.00
50_T206_N0.9611.00
113_L154_N0.9601.00
232_A236_P0.9561.00
121_A165_A0.9541.00
172_S237_I0.9541.00
113_L157_A0.9531.00
249_V271_G0.9521.00
121_A237_I0.9521.00
33_F250_M0.9511.00
134_M277_S0.9451.00
57_T193_M0.9451.00
121_A169_Y0.9441.00
232_A240_V0.9351.00
34_L227_S0.9311.00
236_P240_V0.9301.00
126_K129_D0.9301.00
125_K128_I0.9051.00
196_V200_Y0.9031.00
107_I261_Q0.9001.00
210_I214_L0.9001.00
142_M270_G0.8991.00
215_G219_V0.8971.00
36_G246_I0.8931.00
90_F170_F0.8881.00
107_I259_F0.8871.00
138_G270_G0.8871.00
38_A227_S0.8841.00
92_S96_L0.8811.00
235_L240_V0.8811.00
153_G157_A0.8791.00
195_P199_F0.8781.00
83_R173_R0.8751.00
53_P57_T0.8711.00
252_T271_G0.8711.00
125_K129_D0.8681.00
219_V223_I0.8671.00
29_K239_L0.8671.00
55_F197_L0.8651.00
36_G40_G0.8601.00
148_F151_I0.8551.00
139_I143_N0.8521.00
82_K86_L0.8471.00
43_A98_F0.8461.00
69_L187_L0.8441.00
36_G250_M0.8381.00
68_L222_L0.8381.00
91_L167_Y0.8341.00
116_T139_I0.8331.00
213_V217_V0.8291.00
87_P90_F0.8221.00
96_L100_S0.8191.00
206_N210_I0.8161.00
44_I255_A0.8151.00
135_A277_S0.8071.00
256_I263_P0.8031.00
150_Y154_N0.8021.00
199_F202_L0.7951.00
214_L218_L0.7951.00
172_S175_D0.7861.00
101_S110_S0.7861.00
223_I227_S0.7841.00
256_I262_I0.7811.00
91_L225_H0.7781.00
196_V199_F0.7751.00
198_P201_G0.7721.00
231_T240_V0.7711.00
138_G274_T0.7711.00
119_I135_A0.7691.00
124_F166_I0.7581.00
164_F168_T0.7501.00
141_I269_I0.7501.00
42_A220_P0.7461.00
235_L239_L0.7461.00
72_V183_P0.7421.00
94_H163_S0.7421.00
78_K81_L0.7391.00
59_L63_I0.7351.00
127_K130_P0.7341.00
266_Q269_I0.7321.00
137_L141_I0.7311.00
62_L66_I0.7261.00
180_S184_I0.7221.00
67_L70_P0.7221.00
44_I107_I0.7191.00
271_G275_L0.7151.00
43_A111_T0.7101.00
63_I213_V0.7061.00
67_L217_V0.6991.00
38_A220_P0.6961.00
55_F59_L0.6941.00
269_I273_I0.6911.00
183_P187_L0.6901.00
101_S153_G0.6891.00
157_A161_A0.6891.00
166_I170_F0.6881.00
187_L191_I0.6871.00
51_I55_F0.6871.00
167_Y229_I0.6871.00
205_I209_S0.6861.00
184_I188_I0.6841.00
126_K238_S0.6761.00
64_A217_V0.6761.00
59_L213_V0.6751.00
27_R31_I0.6731.00
188_I192_F0.6711.00
113_L158_I0.6681.00
115_S118_P0.6651.00
91_L185_I0.6621.00
206_N211_L0.6611.00
182_I229_I0.6591.00
124_F162_I0.6581.00
212_A215_G0.6571.00
52_T201_G0.6551.00
71_F74_K0.6541.00
188_I191_I0.6521.00
83_R86_L0.6501.00
246_I249_V0.6451.00
262_I266_Q0.6451.00
137_L273_I0.6441.00
51_I56_I0.6431.00
255_A259_F0.6421.00
263_P267_E0.6401.00
146_T149_G0.6361.00
93_L97_F0.6351.00
75_R177_D0.6351.00
120_F158_I0.6311.00
164_F228_V0.6291.00
253_I256_I0.6291.00
168_T228_V0.6261.00
226_G230_Y0.6261.00
42_A216_L0.6251.00
262_I267_E0.6221.00
32_L235_L0.6191.00
253_I257_P0.6151.00
65_G69_L0.6141.00
48_F259_F0.6141.00
231_T235_L0.6141.00
252_T256_I0.6131.00
88_S92_S0.6121.00
71_F179_L0.6111.00
72_V75_R0.6091.00
200_Y203_G0.6091.00
84_F181_I0.6061.00
148_F152_F0.6061.00
76_R82_K0.6051.00
42_A99_V0.6051.00
123_L132_I0.6041.00
190_S194_I0.6021.00
278_I281_A0.6011.00
264_D268_L0.6011.00
64_A222_L0.6001.00
105_T110_S0.5991.00
32_L243_A0.5981.00
168_T241_T0.5961.00
184_I187_L0.5891.00
209_S212_A0.5881.00
254_L257_P0.5881.00
112_I143_N0.5881.00
63_I67_L0.5861.00
178_S182_I0.5811.00
92_S196_V0.5811.00
98_F160_S0.5801.00
156_L159_L0.5791.00
75_R179_L0.5791.00
167_Y185_I0.5741.00
44_I251_A0.5691.00
27_R230_Y0.5691.00
94_H98_F0.5681.00
28_D235_L0.5641.00
187_L190_S0.5631.00
64_A221_T0.5631.00
98_F110_S0.5571.00
122_M128_I0.5541.00
118_P245_L0.5531.00
116_T119_I0.5531.00
267_E271_G0.5521.00
29_K235_L0.5521.00
76_R79_I0.5511.00
198_P202_L0.5481.00
79_I83_R0.5461.00
197_L201_G0.5441.00
84_F184_I0.5441.00
40_G247_E0.5431.00
32_L228_V0.5431.00
38_A224_G0.5421.00
162_I166_I0.5421.00
54_P193_M0.5411.00
91_L95_M0.5401.00
33_F36_G0.5351.00
27_R30_I0.5331.00
167_Y171_L0.5321.00
136_I245_L0.5311.00
28_D31_I0.5311.00
276_I280_F0.5311.00
277_S281_A0.5301.00
84_F188_I0.5301.00
116_T161_A0.5291.00
201_G204_D0.5291.00
147_S150_Y0.5281.00
147_S151_I0.5281.00
85_I89_L0.5281.00
34_L38_A0.5271.00
36_G247_E0.5271.00
54_P200_Y0.5271.00
115_S161_A0.5271.00
40_G251_A0.5261.00
199_F203_G0.5241.00
141_I267_E0.5231.00
52_T200_Y0.5181.00
143_N154_N0.5181.00
189_S193_M0.5171.00
115_S139_I0.5161.00
72_V180_S0.5141.00
249_V275_L0.5121.00
245_L278_I0.5121.00
91_L189_S0.5121.00
88_S192_F0.5111.00
94_H114_V0.5091.00
89_L92_S0.5081.00
85_I192_F0.5061.00
70_P75_R0.5041.00
97_F160_S0.5011.00
268_L271_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2i68A 2 0.2711 98.8 0.777 Contact Map
3b5dA 2 0.3521 98.3 0.812 Contact Map
4xnjA 1 0.7887 13.7 0.945 Contact Map
2cfqA 1 0.6232 6.5 0.953 Contact Map
2gfpA 2 0.6585 6 0.954 Contact Map
3o7qA 1 0.9085 5.2 0.955 Contact Map
1pw4A 1 0.9824 4.9 0.955 Contact Map
3dh4A 3 0.1655 4.4 0.956 Contact Map
2ksfA 1 0.338 4.2 0.957 Contact Map
2xq2A 2 0.2535 4 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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