GREMLIN Database
Q97UD7 - Uncharacterized protein
UniProt: Q97UD7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 221 (200)
Sequences: 1861 (1527)
Seq/√Len: 108.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
179_F209_M4.2871.00
185_V190_L4.0761.00
172_K176_M3.7091.00
102_L107_A3.2991.00
169_I194_L3.2501.00
200_A204_A3.1051.00
180_D184_K3.0461.00
176_M190_L2.9721.00
185_V189_E2.9431.00
197_S200_A2.9231.00
107_A125_I2.8741.00
172_K190_L2.8271.00
176_M193_E2.7271.00
84_L87_L2.5621.00
174_Y214_R2.5571.00
86_A89_L2.5221.00
165_K204_A2.5061.00
186_D189_E2.4701.00
187_L201_T2.3081.00
85_R88_I2.2411.00
165_K168_E2.1931.00
22_D117_G2.1891.00
181_W202_L2.1751.00
165_K169_I1.9811.00
26_L32_I1.9261.00
10_S118_L1.8321.00
48_A59_L1.8131.00
187_L202_L1.7891.00
84_L88_I1.7721.00
198_K202_L1.7301.00
196_I201_T1.6841.00
204_A207_R1.6571.00
213_I216_Y1.6531.00
85_R89_L1.6511.00
169_I204_A1.6451.00
170_I213_I1.6161.00
167_F171_Y1.6071.00
190_L201_T1.6031.00
56_L59_L1.5671.00
32_I35_P1.5671.00
88_I91_S1.5521.00
183_K206_R1.5471.00
55_I58_E1.5431.00
174_Y217_V1.4251.00
169_I190_L1.4061.00
181_W203_Q1.3851.00
34_T37_F1.3841.00
110_I124_V1.3711.00
203_Q207_R1.3701.00
91_S96_G1.3591.00
170_I179_F1.3501.00
169_I196_I1.2870.99
69_V72_V1.2850.99
177_G184_K1.2840.99
73_K185_V1.2400.99
21_Y66_N1.2380.99
204_A211_K1.2360.99
185_V193_E1.2160.99
212_L216_Y1.2060.99
56_L60_I1.2050.99
74_I86_A1.1960.99
89_L92_A1.1880.99
179_F205_L1.1360.98
200_A203_Q1.1360.98
25_D28_V1.1260.98
60_I72_V1.1150.98
58_E61_N1.1060.98
181_W204_A1.1050.98
100_E104_N1.0980.98
187_L204_A1.0880.98
128_K197_S1.0870.98
176_M185_V1.0820.98
200_A205_L1.0790.98
9_L123_L1.0760.98
30_M33_R1.0640.97
120_K148_I1.0610.97
181_W199_A1.0600.97
86_A92_A1.0510.97
200_A208_A1.0500.97
192_E195_G1.0490.97
174_Y179_F1.0430.97
28_V32_I1.0290.97
169_I201_T1.0180.97
180_D210_G1.0170.97
210_G214_R1.0030.96
58_E192_E1.0030.96
26_L29_L1.0020.96
190_L194_L0.9980.96
10_S148_I0.9830.96
97_G100_E0.9790.96
17_L21_Y0.9770.96
31_K47_E0.9750.96
26_L30_M0.9700.96
187_L198_K0.9700.96
162_L208_A0.9650.96
181_W206_R0.9550.95
129_I132_E0.9530.95
178_Y187_L0.9530.95
92_A96_G0.9510.95
189_E192_E0.9500.95
16_L19_D0.9490.95
17_L20_K0.9440.95
169_I208_A0.9430.95
107_A111_S0.9410.95
75_I114_I0.9190.94
26_L31_K0.9130.94
165_K203_Q0.9080.94
111_S179_F0.9060.94
9_L135_L0.9020.94
199_A203_Q0.9010.94
194_L201_T0.8950.93
213_I217_V0.8860.93
46_A91_S0.8830.93
109_Y132_E0.8820.93
188_K198_K0.8780.93
13_D16_L0.8720.92
178_Y183_K0.8690.92
25_D35_P0.8670.92
188_K206_R0.8640.92
132_E136_P0.8620.92
147_I150_K0.8620.92
132_E184_K0.8620.92
26_L35_P0.8550.92
198_K207_R0.8520.92
28_V34_T0.8510.92
113_R120_K0.8510.92
166_E211_K0.8500.91
171_Y175_K0.8480.91
125_I179_F0.8470.91
181_W210_G0.8440.91
32_I36_S0.8410.91
26_L34_T0.8400.91
110_I122_S0.8340.91
197_S206_R0.8290.90
150_K178_Y0.8270.90
191_S201_T0.8240.90
205_L209_M0.8160.90
109_Y123_L0.8100.89
99_S109_Y0.8100.89
11_H16_L0.8070.89
64_K72_V0.8050.89
125_I146_K0.7970.89
208_A213_I0.7880.88
107_A112_E0.7840.88
179_F208_A0.7840.88
10_S146_K0.7830.88
55_I116_N0.7820.88
13_D17_L0.7810.88
172_K193_E0.7730.87
42_E93_K0.7710.87
124_V179_F0.7680.87
135_L145_L0.7670.87
161_L215_N0.7620.86
25_D32_I0.7620.86
25_D31_K0.7610.86
108_Y124_V0.7590.86
133_I203_Q0.7580.86
136_P140_E0.7580.86
165_K209_M0.7540.86
58_E62_I0.7530.86
114_I119_E0.7530.86
44_I47_E0.7520.86
181_W188_K0.7520.86
200_A216_Y0.7510.86
91_S94_L0.7480.85
33_R36_S0.7450.85
79_R84_L0.7400.85
170_I217_V0.7390.85
48_A52_D0.7370.84
58_E72_V0.7330.84
179_F187_L0.7320.84
133_I136_P0.7260.84
47_E135_L0.7220.83
138_L143_Y0.7210.83
9_L121_W0.7150.83
168_E171_Y0.7140.83
19_D22_D0.7130.82
22_D118_L0.7090.82
182_P206_R0.7080.82
85_R92_A0.7080.82
207_R210_G0.7060.82
107_A110_I0.7050.82
133_I198_K0.7030.82
99_S201_T0.7020.81
30_M34_T0.6980.81
37_F195_G0.6970.81
105_K137_T0.6970.81
93_K96_G0.6900.80
14_W19_D0.6880.80
70_T73_K0.6860.80
168_E172_K0.6850.80
14_W56_L0.6840.80
166_E204_A0.6840.80
176_M201_T0.6830.80
32_I37_F0.6780.79
181_W200_A0.6780.79
172_K185_V0.6770.79
143_Y204_A0.6750.79
146_K180_D0.6740.79
172_K194_L0.6740.79
71_R74_I0.6740.79
8_V17_L0.6720.79
212_L215_N0.6690.78
61_N65_S0.6660.78
15_T196_I0.6650.78
43_N148_I0.6640.78
106_G137_T0.6570.77
123_L127_D0.6550.77
109_Y147_I0.6530.77
60_I77_N0.6460.76
45_I112_E0.6460.76
20_K98_I0.6460.76
178_Y212_L0.6460.76
31_K140_E0.6420.75
95_R132_E0.6390.75
131_R135_L0.6380.75
167_F215_N0.6350.75
25_D30_M0.6330.74
108_Y201_T0.6300.74
16_L98_I0.6290.74
48_A62_I0.6260.74
130_F149_E0.6240.73
185_V206_R0.6220.73
101_L186_D0.6210.73
207_R212_L0.6190.73
108_Y206_R0.6180.73
23_E117_G0.6170.72
68_R209_M0.6140.72
99_S147_I0.6140.72
196_I199_A0.6130.72
146_K154_N0.6100.72
211_K215_N0.6060.71
43_N108_Y0.6040.71
44_I119_E0.5990.70
145_L202_L0.5980.70
86_A91_S0.5980.70
157_S200_A0.5980.70
13_D19_D0.5950.70
91_S95_R0.5940.70
178_Y205_L0.5920.69
123_L133_I0.5920.69
63_I208_A0.5890.69
148_I152_D0.5880.69
103_M190_L0.5870.69
99_S209_M0.5870.69
177_G202_L0.5870.69
42_E72_V0.5850.68
137_T141_Y0.5840.68
194_L202_L0.5820.68
52_D61_N0.5760.67
101_L104_N0.5750.67
84_L92_A0.5730.67
200_A207_R0.5710.67
59_L63_I0.5710.67
149_E190_L0.5710.67
65_S157_S0.5710.67
115_S118_L0.5710.67
18_T119_E0.5700.66
44_I109_Y0.5690.66
75_I126_D0.5680.66
171_Y217_V0.5660.66
46_A88_I0.5650.66
148_I210_G0.5650.66
94_L101_L0.5620.65
133_I143_Y0.5560.65
9_L12_E0.5550.64
24_E140_E0.5540.64
155_L180_D0.5540.64
201_T212_L0.5530.64
135_L200_A0.5530.64
102_L123_L0.5520.64
91_S104_N0.5510.64
139_K196_I0.5430.63
13_D18_T0.5410.62
99_S208_A0.5410.62
143_Y207_R0.5400.62
44_I91_S0.5380.62
64_K132_E0.5360.62
186_D216_Y0.5330.61
177_G180_D0.5310.61
88_I129_I0.5290.61
20_K68_R0.5280.61
130_F150_K0.5230.60
119_E200_A0.5220.60
111_S124_V0.5200.59
100_E106_G0.5200.59
11_H145_L0.5200.59
110_I199_A0.5190.59
21_Y68_R0.5170.59
112_E121_W0.5140.59
73_K89_L0.5130.58
139_K184_K0.5120.58
131_R146_K0.5120.58
120_K191_S0.5120.58
88_I137_T0.5090.58
27_R32_I0.5060.57
102_L121_W0.5060.57
179_F213_I0.5050.57
98_I102_L0.5050.57
36_S130_F0.5000.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4wszA 2 0.2579 97.6 0.837 Contact Map
1ku3A 1 0.2715 97.5 0.84 Contact Map
1je8A 2 0.2624 97.3 0.845 Contact Map
1s7oA 3 0.3167 97.3 0.846 Contact Map
3c57A 2 0.2308 97.3 0.846 Contact Map
1fseA 2 0.267 97.2 0.847 Contact Map
1x3uA 1 0.3077 97.2 0.848 Contact Map
4g6dA 1 0.2805 97 0.852 Contact Map
1xsvA 2 0.3167 97 0.852 Contact Map
1p4wA 1 0.3348 97 0.852 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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