GREMLIN Database
Q97UD1 - Uncharacterized protein
UniProt: Q97UD1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 409 (376)
Sequences: 118 (101)
Seq/√Len: 5.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
97_G329_G3.8580.89
35_G257_T3.4410.82
60_I64_L3.1340.76
109_G121_S3.1190.75
28_L66_A2.9570.71
127_W131_F2.8300.68
51_S378_T2.7530.65
64_L95_L2.7480.65
327_C338_G2.6530.62
216_N220_A2.6280.62
108_A129_E2.6030.61
95_L393_G2.5630.60
116_L122_G2.5320.59
25_G325_M2.5220.58
132_G355_F2.5060.58
66_A99_I2.4310.55
225_N232_G2.2670.50
51_S379_N2.2390.49
291_F378_T2.2080.48
234_E389_I2.2000.48
324_I383_L2.1920.47
200_Q203_T2.1740.47
99_I401_A2.1710.47
108_A119_A2.1540.46
96_V400_L2.1510.46
358_G362_G2.1190.45
101_F104_G2.0910.44
104_G364_G2.0860.44
35_G360_L2.0820.44
120_A378_T2.0810.44
324_I345_P2.0730.43
199_L228_I2.0460.43
20_L292_E2.0320.42
133_M323_V2.0260.42
107_L400_L2.0210.42
192_L225_N2.0060.41
59_L401_A1.9820.40
111_C358_G1.9780.40
111_C362_G1.9720.40
120_A330_A1.9350.39
132_G384_G1.9070.38
20_L268_V1.8550.37
349_S400_L1.8510.36
131_F294_L1.8480.36
130_L358_G1.8470.36
204_K207_W1.8370.36
186_L233_E1.8370.36
35_G337_S1.8290.36
121_S330_A1.8190.35
114_S133_M1.8040.35
146_P330_A1.7970.35
11_Q95_L1.7940.35
35_G368_A1.7840.34
358_G397_G1.7810.34
396_L400_L1.7680.34
186_L391_L1.7650.34
396_L404_V1.7460.33
69_S116_L1.7440.33
199_L203_T1.7190.32
62_F167_Y1.7160.32
34_R390_F1.7040.32
191_P202_Y1.6970.32
95_L324_I1.6940.32
320_T324_I1.6890.32
261_L368_A1.6840.31
129_E251_P1.6810.31
386_D390_F1.6810.31
288_G373_V1.6760.31
185_T192_L1.6570.31
258_T303_F1.6550.31
45_S126_N1.6470.30
16_L119_A1.6430.30
281_V374_G1.6400.30
263_L297_L1.6300.30
25_G29_G1.6270.30
163_G190_L1.6210.30
43_M107_L1.6160.30
362_G397_G1.6130.29
111_C397_G1.6130.29
102_G370_G1.5790.29
37_Y336_L1.5780.28
245_L392_F1.5720.28
28_L99_I1.5500.28
112_N287_G1.5340.27
49_A150_Y1.5230.27
98_S363_I1.5040.27
136_G359_M1.4930.26
65_S377_W1.4900.26
390_F394_M1.4860.26
128_I404_V1.4750.26
259_I304_L1.4670.26
48_T127_W1.4600.25
358_G387_G1.4590.25
203_T207_W1.4450.25
44_T378_T1.4450.25
222_A389_I1.4370.25
207_W292_E1.4330.25
61_L258_T1.4070.24
212_S327_C1.4070.24
200_Q204_K1.4010.24
333_A336_L1.3860.24
53_E72_L1.3730.23
372_N375_L1.3350.22
129_E363_I1.3170.22
266_L344_I1.3130.22
11_Q233_E1.3120.22
222_A226_Q1.3070.22
105_A384_G1.3070.22
112_N361_V1.3050.22
108_A357_G1.3040.22
187_V396_L1.2890.21
34_R248_L1.2850.21
115_M384_G1.2840.21
341_K359_M1.2820.21
51_S288_G1.2800.21
98_S293_Y1.2710.21
130_L290_F1.2660.21
224_Y339_D1.2540.21
110_G283_T1.2490.20
38_C375_L1.2490.20
70_G307_P1.2400.20
212_S348_K1.2270.20
191_P404_V1.2250.20
350_R355_F1.2190.20
187_V231_S1.2180.20
113_L116_L1.2160.20
51_S120_A1.2150.20
102_G371_C1.2130.20
71_L74_A1.2090.20
194_F215_I1.2040.20
357_G371_C1.2000.19
107_L395_L1.2000.19
78_I332_S1.1990.19
283_T373_V1.1950.19
166_E380_F1.1930.19
239_T328_I1.1910.19
348_K398_V1.1900.19
220_A223_Y1.1860.19
37_Y122_G1.1810.19
30_W34_R1.1770.19
47_F363_I1.1750.19
65_S261_L1.1700.19
23_L306_T1.1680.19
190_L232_G1.1650.19
103_F180_S1.1650.19
129_E255_N1.1620.19
18_Y357_G1.1540.18
112_N132_G1.1470.18
132_G377_W1.1440.18
31_A260_I1.1430.18
310_N396_L1.1300.18
357_G364_G1.1280.18
186_L193_I1.1200.18
213_L351_L1.1190.18
10_L96_V1.1190.18
104_G357_G1.1180.18
106_A343_R1.1180.18
191_P405_Q1.1180.18
36_N109_G1.1180.18
238_L243_K1.1080.18
28_L182_Y1.1030.18
31_A67_L1.1020.17
35_G350_R1.1020.17
138_Y309_F1.1020.17
146_P310_N1.1020.17
95_L226_Q1.1010.17
154_N393_G1.1000.17
98_S290_F1.0990.17
66_A334_S1.0880.17
262_A303_F1.0860.17
283_T364_G1.0830.17
101_F370_G1.0820.17
116_L372_N1.0810.17
99_I223_Y1.0760.17
280_L290_F1.0690.17
31_A261_L1.0620.17
39_F140_F1.0550.17
389_I395_L1.0540.17
361_V376_M1.0520.17
27_I180_S1.0360.16
111_C371_C1.0270.16
248_L325_M1.0250.16
39_F362_G1.0200.16
69_S122_G1.0190.16
112_N326_L1.0150.16
135_I339_D1.0090.16
20_L342_I1.0040.16
232_G235_K1.0000.16
212_S219_A0.9970.16
237_S396_L0.9950.16
299_N361_V0.9940.16
60_I356_G0.9930.15
321_L356_G0.9930.15
24_S324_I0.9900.15
328_I351_L0.9890.15
194_F259_I0.9860.15
51_S373_V0.9820.15
327_C345_P0.9800.15
298_G343_R0.9790.15
54_R98_S0.9790.15
164_Y256_L0.9780.15
28_L32_A0.9740.15
12_E302_L0.9690.15
349_S404_V0.9660.15
313_L316_V0.9650.15
266_L320_T0.9620.15
208_A220_A0.9610.15
23_L107_L0.9570.15
9_V13_S0.9540.15
108_A349_S0.9540.15
206_K311_D0.9530.15
39_F114_S0.9520.15
114_S132_G0.9520.15
99_I400_L0.9490.15
217_L220_A0.9490.15
38_C384_G0.9490.15
169_P172_I0.9450.15
95_L232_G0.9400.15
186_L192_L0.9380.15
44_T402_I0.9370.15
340_F364_G0.9360.15
262_A267_L0.9350.15
75_F221_R0.9330.14
186_L396_L0.9320.14
72_L194_F0.9310.14
280_L323_V0.9290.14
362_G387_G0.9290.14
79_P253_G0.9250.14
12_E333_A0.9230.14
40_V398_V0.9170.14
57_A173_F0.9170.14
327_C363_I0.9130.14
122_G334_S0.9100.14
268_V337_S0.9100.14
24_S63_G0.9040.14
79_P396_L0.9040.14
38_C45_S0.9010.14
126_N134_M0.8990.14
104_G340_F0.8980.14
75_F327_C0.8980.14
129_E301_K0.8930.14
120_A379_N0.8900.14
68_G222_A0.8900.14
315_I331_F0.8890.14
285_S369_L0.8890.14
126_N357_G0.8870.14
173_F275_Y0.8860.14
76_G324_I0.8860.14
96_V356_G0.8840.14
190_L348_K0.8830.14
29_G361_V0.8820.14
187_V195_I0.8800.14
115_M287_G0.8750.14
274_G317_D0.8740.14
305_N331_F0.8710.13
198_Y356_G0.8680.13
163_G261_L0.8660.13
283_T369_L0.8650.13
258_T402_I0.8620.13
18_Y259_I0.8590.13
31_A164_Y0.8580.13
43_M112_N0.8570.13
355_F384_G0.8560.13
127_W301_K0.8560.13
206_K210_S0.8540.13
13_S283_T0.8540.13
105_A372_N0.8530.13
33_Q45_S0.8480.13
33_Q61_L0.8470.13
15_A259_I0.8470.13
170_Y386_D0.8460.13
37_Y327_C0.8460.13
188_V248_L0.8450.13
96_V127_W0.8440.13
154_N368_A0.8410.13
30_W325_M0.8410.13
169_P391_L0.8400.13
126_N281_V0.8400.13
260_I327_C0.8390.13
122_G333_A0.8380.13
168_L385_Y0.8370.13
96_V227_N0.8370.13
63_G193_I0.8360.13
375_L384_G0.8340.13
202_Y259_I0.8340.13
224_Y230_T0.8330.13
110_G115_M0.8240.13
68_G347_N0.8240.13
372_N384_G0.8230.13
199_L206_K0.8200.13
362_G372_N0.8200.13
152_M400_L0.8190.13
39_F136_G0.8150.13
106_A390_F0.8120.13
97_G370_G0.8100.13
97_G102_G0.8100.13
37_Y254_T0.8070.13
28_L305_N0.8030.12
30_W117_Y0.8030.12
127_W367_M0.8020.12
328_I396_L0.7990.12
330_A405_Q0.7960.12
302_L305_N0.7930.12
40_V133_M0.7920.12
182_Y288_G0.7910.12
133_M280_L0.7880.12
40_V375_L0.7870.12
217_L349_S0.7870.12
285_S381_A0.7820.12
99_I152_M0.7810.12
234_E332_S0.7740.12
264_D395_L0.7710.12
96_V399_Y0.7700.12
129_E274_G0.7690.12
190_L194_F0.7680.12
338_G400_L0.7640.12
39_F105_A0.7640.12
227_N356_G0.7610.12
43_M127_W0.7600.12
299_N366_R0.7590.12
320_T390_F0.7590.12
93_Y386_D0.7590.12
362_G373_V0.7580.12
33_Q255_N0.7570.12
110_G299_N0.7540.12
35_G57_A0.7530.12
34_R247_L0.7520.12
102_G364_G0.7460.12
364_G370_G0.7460.12
90_A94_I0.7460.12
169_P265_L0.7450.12
174_H253_G0.7440.12
40_V50_K0.7420.12
67_L394_M0.7410.12
133_M281_V0.7360.12
226_Q229_S0.7340.12
365_V379_N0.7340.12
205_R208_A0.7300.11
54_R390_F0.7300.11
70_G247_L0.7290.11
31_A303_F0.7290.11
21_F285_S0.7280.11
14_W316_V0.7280.11
382_Q385_Y0.7280.11
107_L249_R0.7270.11
236_V332_S0.7250.11
20_L262_A0.7230.11
283_T322_M0.7230.11
60_I389_I0.7230.11
347_N359_M0.7210.11
36_N63_G0.7190.11
127_W233_E0.7190.11
182_Y321_L0.7190.11
60_I243_K0.7170.11
134_M228_I0.7150.11
343_R352_L0.7120.11
35_G140_F0.7110.11
68_G261_L0.7070.11
130_L217_L0.7050.11
39_F169_P0.7040.11
114_S384_G0.7040.11
230_T233_E0.7040.11
287_G336_L0.7030.11
9_V330_A0.7010.11
85_Y165_V0.7010.11
62_F387_G0.7000.11
75_F180_S0.7000.11
107_L262_A0.6960.11
109_G120_A0.6960.11
47_F133_M0.6950.11
33_Q36_N0.6950.11
252_Y361_V0.6920.11
23_L194_F0.6890.11
249_R394_M0.6890.11
24_S212_S0.6880.11
74_A167_Y0.6880.11
250_K350_R0.6870.11
109_G368_A0.6860.11
87_N316_V0.6850.11
334_S346_R0.6850.11
54_R394_M0.6850.11
180_S219_A0.6830.11
216_N223_Y0.6800.11
108_A124_V0.6800.11
302_L351_L0.6780.11
111_C114_S0.6760.11
110_G322_M0.6720.11
37_Y331_F0.6710.11
96_V295_L0.6710.11
279_Y376_M0.6700.11
101_F371_C0.6700.11
29_G358_G0.6690.11
205_R328_I0.6670.11
40_V280_L0.6660.11
45_S284_S0.6650.11
95_L332_S0.6630.11
340_F357_G0.6620.11
139_V188_V0.6600.11
134_M275_Y0.6580.11
387_G397_G0.6580.11
39_F358_G0.6570.11
180_S404_V0.6570.11
187_V393_G0.6560.10
255_N258_T0.6550.10
95_L231_S0.6530.10
378_T402_I0.6520.10
79_P403_K0.6510.10
309_F344_I0.6500.10
102_G329_G0.6500.10
329_G370_G0.6500.10
96_V191_P0.6500.10
253_G256_L0.6490.10
67_L230_T0.6480.10
95_L263_L0.6480.10
153_A259_I0.6470.10
194_F242_I0.6470.10
109_G129_E0.6450.10
100_I150_Y0.6440.10
313_L380_F0.6420.10
72_L338_G0.6410.10
260_I352_L0.6410.10
40_V372_N0.6410.10
115_M372_N0.6380.10
62_F382_Q0.6380.10
201_Q204_K0.6370.10
131_F330_A0.6370.10
163_G212_S0.6350.10
110_G282_I0.6340.10
122_G350_R0.6330.10
78_I87_N0.6320.10
364_G378_T0.6310.10
33_Q38_C0.6290.10
129_E402_I0.6290.10
120_A129_E0.6280.10
38_C114_S0.6270.10
233_E392_F0.6260.10
391_L394_M0.6250.10
114_S281_V0.6250.10
231_S348_K0.6250.10
269_F295_L0.6220.10
173_F181_V0.6220.10
66_A199_L0.6160.10
34_R253_G0.6160.10
269_F383_L0.6150.10
169_P376_M0.6140.10
134_M166_E0.6100.10
240_K243_K0.6100.10
297_L403_K0.6090.10
60_I238_L0.6090.10
103_F184_T0.6080.10
50_K207_W0.6070.10
96_V294_L0.6060.10
242_I389_I0.6060.10
195_I349_S0.6060.10
226_Q327_C0.6060.10
282_I319_S0.6050.10
55_F206_K0.6030.10
39_F133_M0.6030.10
235_K347_N0.6020.10
55_F282_I0.6010.10
272_G295_L0.6010.10
21_F137_T0.5990.10
55_F274_G0.5950.10
194_F320_T0.5930.10
22_A261_L0.5930.10
63_G217_L0.5920.10
66_A262_A0.5910.10
180_S350_R0.5900.10
67_L243_K0.5890.10
65_S127_W0.5870.10
399_Y403_K0.5870.10
37_Y58_L0.5870.10
120_A291_F0.5840.10
28_L394_M0.5830.10
111_C387_G0.5810.10
134_M287_G0.5800.10
292_E334_S0.5780.10
113_L362_G0.5770.10
61_L259_I0.5770.10
127_W294_L0.5760.10
209_I230_T0.5760.10
88_Y369_L0.5760.10
116_L268_V0.5750.10
67_L79_P0.5750.10
99_I294_L0.5740.10
96_V228_I0.5720.09
118_R121_S0.5720.09
204_K376_M0.5710.09
20_L332_S0.5710.09
28_L262_A0.5710.09
132_G340_F0.5700.09
119_A339_D0.5670.09
50_K387_G0.5660.09
23_L146_P0.5650.09
27_I119_A0.5630.09
39_F111_C0.5620.09
9_V357_G0.5620.09
291_F352_L0.5610.09
294_L297_L0.5580.09
144_I288_G0.5580.09
268_V345_P0.5570.09
360_L404_V0.5560.09
34_R169_P0.5550.09
22_A168_L0.5550.09
119_A141_A0.5550.09
250_K328_I0.5540.09
38_C323_V0.5540.09
111_C372_N0.5540.09
219_A227_N0.5520.09
29_G364_G0.5520.09
329_G368_A0.5500.09
67_L212_S0.5480.09
104_G370_G0.5460.09
192_L235_K0.5450.09
50_K272_G0.5450.09
112_N372_N0.5450.09
256_L360_L0.5440.09
28_L46_I0.5440.09
92_W304_L0.5440.09
110_G137_T0.5420.09
389_I392_F0.5410.09
36_N336_L0.5400.09
97_G368_A0.5370.09
190_L247_L0.5370.09
34_R118_R0.5360.09
175_S183_I0.5360.09
167_Y235_K0.5360.09
195_I396_L0.5350.09
85_Y369_L0.5330.09
121_S251_P0.5310.09
198_Y263_L0.5290.09
113_L361_V0.5280.09
317_D368_A0.5280.09
38_C118_R0.5280.09
151_T164_Y0.5250.09
60_I405_Q0.5250.09
21_F284_S0.5250.09
63_G309_F0.5250.09
38_C380_F0.5240.09
135_I139_V0.5230.09
21_F365_V0.5220.09
106_A337_S0.5200.09
262_A356_G0.5190.09
38_C133_M0.5190.09
105_A111_C0.5180.09
96_V255_N0.5160.09
189_S267_L0.5150.09
212_S215_I0.5140.09
139_V381_A0.5140.09
172_I265_L0.5130.09
341_K392_F0.5130.09
192_L224_Y0.5130.09
67_L332_S0.5130.09
165_V292_E0.5120.09
86_Y165_V0.5110.09
19_G137_T0.5100.09
129_E258_T0.5100.09
201_Q333_A0.5080.09
38_C42_A0.5060.09
274_G307_P0.5040.09
358_G372_N0.5040.09
251_P330_A0.5030.09
190_L230_T0.5000.09
210_S239_T0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4j05A 3 0.78 90.3 0.957 Contact Map
4tphA 2 0.401 53.8 0.969 Contact Map
4oh3A 2 0.4719 51.4 0.97 Contact Map
4pypA 1 0.3961 49.8 0.97 Contact Map
3wdoA 1 0.5061 46.5 0.971 Contact Map
2jp3A 1 0.1516 36.7 0.972 Contact Map
2l2tA 2 0.1076 36.4 0.972 Contact Map
2m20A 2 0.1467 33.4 0.973 Contact Map
2zxeG 1 0.0831 25.9 0.974 Contact Map
4xnjA 1 0.401 23.5 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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