Q97UC0 - SULSO - GREMLIN Contacts

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Q97UC0 - Uncharacterized protein

UniProt:	Q97UC0	Sequences: MIKSYTIVLSHDDWSRYTERFNEEELYVKVVRRIPSLDGLTENVMGIIYAKDKEFYRQIIRMLSRNETTIDFRIIDEYKNKSNIRAIYASIESLKGRIAERLLKDCRIFSMSETIYEGMERWNVIADSENFIKIIPEVKELTYEFKIIEESSNPLLSVKEELTPKELSILKLAFDKGYFETPKRIGLEELANELGISKPAIMQVLRKAIAKLTEKSIKDF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	220 (188)
Sequences:	1703 (1415)
Seq/√Len:	103.2

HALSA - Q9HSM9 Q9HR58 Q9HSR5 O54637 Q9HQD9 Q9HPS7 DMSR Q9HQU9
SULSO - Q97UC0 Q97UD7 Q97YL7 Q97WR0 Q97YT8 Q7LXI8 Q97Y14 Q97ZB6 Q97X87 Q97ZX5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
185_I	190_L	4.369	1.00
179_F	209_I	3.704	1.00
172_L	176_K	3.691	1.00
200_A	204_V	3.344	1.00
169_I	194_L	3.260	1.00
108_I	126_A	3.218	1.00
197_S	200_A	3.133	1.00
176_K	193_E	2.909	1.00
172_L	190_L	2.901	1.00
180_E	184_R	2.867	1.00
176_K	190_L	2.738	1.00
102_L	108_I	2.693	1.00
185_I	189_E	2.508	1.00
165_K	204_V	2.475	1.00
187_L	201_I	2.437	1.00
174_F	214_E	2.431	1.00
186_G	189_E	2.400	1.00
165_K	168_S	2.367	1.00
181_T	202_M	2.338	1.00
198_K	202_M	2.064	1.00
187_L	202_M	2.061	1.00
183_K	206_R	2.040	1.00
165_K	169_I	1.987	1.00
55_F	58_Q	1.972	1.00
190_L	201_I	1.919	1.00
56_Y	82_S	1.915	1.00
167_L	171_K	1.864	1.00
204_V	207_K	1.804	1.00
30_V	35_P	1.751	1.00
111_M	125_I	1.707	1.00
181_T	203_Q	1.649	1.00
170_L	213_T	1.614	1.00
21_F	24_E	1.564	1.00
169_I	204_V	1.544	1.00
203_Q	207_K	1.534	1.00
204_V	211_K	1.516	1.00
213_T	216_S	1.490	1.00
169_I	196_I	1.478	1.00
196_I	201_I	1.472	1.00
56_Y	59_I	1.465	1.00
26_L	30_V	1.433	1.00
169_I	190_L	1.413	1.00
30_V	33_R	1.386	1.00
170_L	179_F	1.380	1.00
187_L	204_V	1.378	1.00
69_T	72_F	1.338	0.99
73_R	185_I	1.326	0.99
181_T	204_V	1.324	0.99
108_I	112_S	1.318	0.99
177_G	184_R	1.302	0.99
65_R	80_N	1.277	0.99
25_E	31_V	1.274	0.99
212_L	216_S	1.271	0.99
179_F	205_L	1.255	0.99
178_Y	183_K	1.242	0.99
174_F	217_I	1.231	0.99
24_E	28_V	1.190	0.99
200_A	208_A	1.165	0.98
134_I	198_K	1.150	0.98
21_F	118_G	1.147	0.98
197_S	206_R	1.140	0.98
181_T	206_R	1.136	0.98
60_I	72_F	1.132	0.98
51_K	59_I	1.125	0.98
168_S	171_K	1.125	0.98
198_K	207_K	1.112	0.98
191_A	201_I	1.100	0.98
200_A	203_Q	1.088	0.97
190_L	194_L	1.086	0.97
181_T	199_P	1.081	0.97
188_E	206_R	1.077	0.97
181_T	210_A	1.060	0.97
200_A	205_L	1.059	0.97
174_F	179_F	1.044	0.97
133_K	136_P	1.043	0.97
146_K	154_P	1.041	0.97
171_K	175_D	1.037	0.97
55_F	117_E	1.026	0.96
169_I	208_A	1.022	0.96
114_T	121_R	1.015	0.96
28_V	31_V	1.004	0.96
205_L	209_I	1.004	0.96
189_E	192_N	1.003	0.96
192_N	195_G	1.002	0.96
61_R	65_R	1.002	0.96
46_G	90_S	0.998	0.96
187_L	198_K	0.997	0.96
58_Q	192_N	0.987	0.96
133_K	184_R	0.986	0.95
162_L	208_A	0.981	0.95
75_I	115_I	0.980	0.95
125_I	179_F	0.972	0.95
182_P	206_R	0.970	0.95
21_F	25_E	0.967	0.95
196_I	199_P	0.967	0.95
161_E	214_E	0.964	0.95
30_V	34_I	0.963	0.95
57_R	61_R	0.961	0.95
188_E	198_K	0.960	0.95
92_E	195_G	0.960	0.95
89_A	163_T	0.952	0.95
185_I	193_E	0.949	0.94
147_I	150_E	0.937	0.94
178_Y	187_L	0.928	0.94
60_I	86_A	0.921	0.94
99_A	201_I	0.919	0.93
199_P	203_Q	0.919	0.93
121_R	148_I	0.918	0.93
56_Y	60_I	0.916	0.93
138_V	143_Y	0.915	0.93
115_I	120_E	0.913	0.93
111_M	199_P	0.908	0.93
51_K	123_N	0.899	0.93
22_N	25_E	0.898	0.93
150_E	178_Y	0.892	0.92
95_K	179_F	0.888	0.92
171_K	217_I	0.885	0.92
181_T	188_E	0.878	0.92
112_S	179_F	0.876	0.92
58_Q	61_R	0.874	0.92
210_A	214_E	0.868	0.91
135_I	145_F	0.867	0.91
126_A	146_K	0.864	0.91
65_R	77_E	0.856	0.91
213_T	217_I	0.852	0.91
165_K	203_Q	0.852	0.91
69_T	152_S	0.852	0.91
98_I	101_R	0.849	0.90
90_S	99_A	0.848	0.90
113_E	122_W	0.846	0.90
90_S	206_R	0.844	0.90
165_K	209_I	0.841	0.90
181_T	200_A	0.835	0.90
63_L	207_K	0.834	0.90
208_A	213_T	0.819	0.89
146_K	180_E	0.808	0.88
131_F	149_E	0.806	0.88
176_K	185_I	0.805	0.88
123_N	131_F	0.805	0.88
180_E	210_A	0.803	0.88
23_E	26_L	0.803	0.88
52_D	74_I	0.794	0.87
207_K	212_L	0.792	0.87
63_L	72_F	0.792	0.87
132_I	135_I	0.791	0.87
137_E	141_L	0.790	0.87
130_N	133_K	0.786	0.87
121_R	191_A	0.758	0.85
124_V	128_S	0.756	0.85
25_E	30_V	0.755	0.84
135_I	200_A	0.755	0.84
31_V	50_A	0.754	0.84
174_F	213_T	0.752	0.84
194_L	201_I	0.751	0.84
177_G	202_M	0.750	0.84
166_E	204_V	0.749	0.84
161_E	215_K	0.749	0.84
70_I	140_E	0.747	0.84
43_N	100_E	0.747	0.84
107_R	196_I	0.744	0.84
68_T	163_T	0.743	0.84
169_I	201_I	0.741	0.83
66_N	69_T	0.733	0.83
86_A	89_A	0.732	0.83
110_S	123_N	0.713	0.81
177_G	180_E	0.709	0.81
212_L	215_K	0.705	0.80
37_L	61_R	0.699	0.80
71_D	74_I	0.688	0.79
108_I	111_M	0.684	0.78
100_E	104_K	0.684	0.78
164_P	180_E	0.680	0.78
97_R	100_E	0.677	0.77
31_V	34_I	0.676	0.77
176_K	201_I	0.676	0.77
136_P	140_E	0.674	0.77
136_P	144_E	0.673	0.77
23_E	31_V	0.672	0.77
74_I	82_S	0.668	0.77
29_K	32_R	0.664	0.76
60_I	88_Y	0.664	0.76
27_Y	114_T	0.664	0.76
53_K	76_D	0.662	0.76
79_K	141_L	0.662	0.76
33_R	44_V	0.661	0.76
198_K	213_T	0.656	0.75
187_L	200_A	0.654	0.75
148_I	152_S	0.654	0.75
94_L	98_I	0.653	0.75
65_R	89_A	0.651	0.75
168_S	172_L	0.650	0.75
200_A	216_S	0.649	0.74
96_G	149_E	0.649	0.74
75_I	127_D	0.646	0.74
23_E	217_I	0.646	0.74
97_R	101_R	0.644	0.74
45_M	48_I	0.640	0.73
21_F	80_N	0.639	0.73
59_I	153_N	0.639	0.73
155_L	180_E	0.638	0.73
178_Y	203_Q	0.637	0.73
132_I	200_A	0.637	0.73
128_S	214_E	0.634	0.73
62_M	65_R	0.631	0.72
31_V	36_S	0.630	0.72
179_F	187_L	0.628	0.72
24_E	32_R	0.627	0.72
172_L	194_L	0.618	0.71
186_G	210_A	0.618	0.71
87_I	118_G	0.617	0.71
134_I	202_M	0.613	0.70
111_M	123_N	0.609	0.70
102_L	145_F	0.608	0.70
85_R	88_Y	0.607	0.69
69_T	74_I	0.607	0.69
80_N	141_L	0.604	0.69
23_E	80_N	0.600	0.69
26_L	32_R	0.598	0.68
200_A	207_K	0.595	0.68
172_L	185_I	0.588	0.67
76_D	194_L	0.586	0.67
207_K	210_A	0.585	0.67
99_A	146_K	0.583	0.66
107_R	115_I	0.582	0.66
90_S	95_K	0.581	0.66
129_E	178_Y	0.581	0.66
160_E	216_S	0.580	0.66
194_L	202_M	0.576	0.65
75_I	85_R	0.570	0.65
131_F	187_L	0.569	0.65
81_K	129_E	0.568	0.64
57_R	70_I	0.561	0.63
70_I	85_R	0.559	0.63
50_A	53_K	0.557	0.63
69_T	123_N	0.557	0.63
131_F	150_E	0.554	0.62
126_A	179_F	0.554	0.62
48_I	88_Y	0.554	0.62
85_R	90_S	0.554	0.62
107_R	179_F	0.552	0.62
130_N	183_K	0.551	0.62
42_E	214_E	0.551	0.62
110_S	169_I	0.549	0.62
63_L	129_E	0.549	0.62
170_L	212_L	0.549	0.62
113_E	184_R	0.545	0.61
28_V	51_K	0.544	0.61
68_T	209_I	0.542	0.61
86_A	122_W	0.542	0.61
76_D	131_F	0.540	0.61
58_Q	62_M	0.540	0.61
121_R	215_K	0.534	0.60
56_Y	155_L	0.534	0.60
182_P	190_L	0.533	0.60
110_S	133_K	0.531	0.59
109_F	125_I	0.529	0.59
139_K	170_L	0.528	0.59
23_E	215_K	0.527	0.59
94_L	99_A	0.525	0.58
21_F	30_V	0.524	0.58
61_R	158_V	0.523	0.58
119_M	180_E	0.521	0.58
50_A	199_P	0.518	0.57
131_F	192_N	0.518	0.57
28_V	32_R	0.518	0.57
47_I	98_I	0.516	0.57
45_M	60_I	0.514	0.57
58_Q	184_R	0.514	0.57
116_Y	119_M	0.513	0.57
26_L	35_P	0.513	0.57
103_L	130_N	0.512	0.57
26_L	130_N	0.511	0.56
25_E	29_K	0.510	0.56
101_R	134_I	0.510	0.56
107_R	126_A	0.509	0.56
25_E	28_V	0.507	0.56
147_I	196_I	0.503	0.55
21_F	28_V	0.503	0.55
190_L	195_G	0.502	0.55
27_Y	92_E	0.501	0.55
196_I	204_V	0.500	0.55
92_E	159_K	0.500	0.55

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4wszA	2	0.2545	97.5	0.843	Contact Map
1ku3A	1	0.2682	97.4	0.846	Contact Map
1s7oA	3	0.3136	97.3	0.849	Contact Map
1je8A	2	0.2591	97.3	0.85	Contact Map
1fseA	2	0.2636	97.1	0.854	Contact Map
2rnjA	1	0.2545	97.1	0.855	Contact Map
1x3uA	1	0.3045	97	0.855	Contact Map
1p4wA	1	0.3318	97	0.856	Contact Map
3hugA	3	0.35	97	0.856	Contact Map
2o8xA	7	0.2773	97	0.857	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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