GREMLIN Database
Q97UC0 - Uncharacterized protein
UniProt: Q97UC0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 220 (188)
Sequences: 1703 (1415)
Seq/√Len: 103.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
185_I190_L4.3691.00
179_F209_I3.7041.00
172_L176_K3.6911.00
200_A204_V3.3441.00
169_I194_L3.2601.00
108_I126_A3.2181.00
197_S200_A3.1331.00
176_K193_E2.9091.00
172_L190_L2.9011.00
180_E184_R2.8671.00
176_K190_L2.7381.00
102_L108_I2.6931.00
185_I189_E2.5081.00
165_K204_V2.4751.00
187_L201_I2.4371.00
174_F214_E2.4311.00
186_G189_E2.4001.00
165_K168_S2.3671.00
181_T202_M2.3381.00
198_K202_M2.0641.00
187_L202_M2.0611.00
183_K206_R2.0401.00
165_K169_I1.9871.00
55_F58_Q1.9721.00
190_L201_I1.9191.00
56_Y82_S1.9151.00
167_L171_K1.8641.00
204_V207_K1.8041.00
30_V35_P1.7511.00
111_M125_I1.7071.00
181_T203_Q1.6491.00
170_L213_T1.6141.00
21_F24_E1.5641.00
169_I204_V1.5441.00
203_Q207_K1.5341.00
204_V211_K1.5161.00
213_T216_S1.4901.00
169_I196_I1.4781.00
196_I201_I1.4721.00
56_Y59_I1.4651.00
26_L30_V1.4331.00
169_I190_L1.4131.00
30_V33_R1.3861.00
170_L179_F1.3801.00
187_L204_V1.3781.00
69_T72_F1.3380.99
73_R185_I1.3260.99
181_T204_V1.3240.99
108_I112_S1.3180.99
177_G184_R1.3020.99
65_R80_N1.2770.99
25_E31_V1.2740.99
212_L216_S1.2710.99
179_F205_L1.2550.99
178_Y183_K1.2420.99
174_F217_I1.2310.99
24_E28_V1.1900.99
200_A208_A1.1650.98
134_I198_K1.1500.98
21_F118_G1.1470.98
197_S206_R1.1400.98
181_T206_R1.1360.98
60_I72_F1.1320.98
51_K59_I1.1250.98
168_S171_K1.1250.98
198_K207_K1.1120.98
191_A201_I1.1000.98
200_A203_Q1.0880.97
190_L194_L1.0860.97
181_T199_P1.0810.97
188_E206_R1.0770.97
181_T210_A1.0600.97
200_A205_L1.0590.97
174_F179_F1.0440.97
133_K136_P1.0430.97
146_K154_P1.0410.97
171_K175_D1.0370.97
55_F117_E1.0260.96
169_I208_A1.0220.96
114_T121_R1.0150.96
28_V31_V1.0040.96
205_L209_I1.0040.96
189_E192_N1.0030.96
192_N195_G1.0020.96
61_R65_R1.0020.96
46_G90_S0.9980.96
187_L198_K0.9970.96
58_Q192_N0.9870.96
133_K184_R0.9860.95
162_L208_A0.9810.95
75_I115_I0.9800.95
125_I179_F0.9720.95
182_P206_R0.9700.95
21_F25_E0.9670.95
196_I199_P0.9670.95
161_E214_E0.9640.95
30_V34_I0.9630.95
57_R61_R0.9610.95
188_E198_K0.9600.95
92_E195_G0.9600.95
89_A163_T0.9520.95
185_I193_E0.9490.94
147_I150_E0.9370.94
178_Y187_L0.9280.94
60_I86_A0.9210.94
99_A201_I0.9190.93
199_P203_Q0.9190.93
121_R148_I0.9180.93
56_Y60_I0.9160.93
138_V143_Y0.9150.93
115_I120_E0.9130.93
111_M199_P0.9080.93
51_K123_N0.8990.93
22_N25_E0.8980.93
150_E178_Y0.8920.92
95_K179_F0.8880.92
171_K217_I0.8850.92
181_T188_E0.8780.92
112_S179_F0.8760.92
58_Q61_R0.8740.92
210_A214_E0.8680.91
135_I145_F0.8670.91
126_A146_K0.8640.91
65_R77_E0.8560.91
213_T217_I0.8520.91
165_K203_Q0.8520.91
69_T152_S0.8520.91
98_I101_R0.8490.90
90_S99_A0.8480.90
113_E122_W0.8460.90
90_S206_R0.8440.90
165_K209_I0.8410.90
181_T200_A0.8350.90
63_L207_K0.8340.90
208_A213_T0.8190.89
146_K180_E0.8080.88
131_F149_E0.8060.88
176_K185_I0.8050.88
123_N131_F0.8050.88
180_E210_A0.8030.88
23_E26_L0.8030.88
52_D74_I0.7940.87
207_K212_L0.7920.87
63_L72_F0.7920.87
132_I135_I0.7910.87
137_E141_L0.7900.87
130_N133_K0.7860.87
121_R191_A0.7580.85
124_V128_S0.7560.85
25_E30_V0.7550.84
135_I200_A0.7550.84
31_V50_A0.7540.84
174_F213_T0.7520.84
194_L201_I0.7510.84
177_G202_M0.7500.84
166_E204_V0.7490.84
161_E215_K0.7490.84
70_I140_E0.7470.84
43_N100_E0.7470.84
107_R196_I0.7440.84
68_T163_T0.7430.84
169_I201_I0.7410.83
66_N69_T0.7330.83
86_A89_A0.7320.83
110_S123_N0.7130.81
177_G180_E0.7090.81
212_L215_K0.7050.80
37_L61_R0.6990.80
71_D74_I0.6880.79
108_I111_M0.6840.78
100_E104_K0.6840.78
164_P180_E0.6800.78
97_R100_E0.6770.77
31_V34_I0.6760.77
176_K201_I0.6760.77
136_P140_E0.6740.77
136_P144_E0.6730.77
23_E31_V0.6720.77
74_I82_S0.6680.77
29_K32_R0.6640.76
60_I88_Y0.6640.76
27_Y114_T0.6640.76
53_K76_D0.6620.76
79_K141_L0.6620.76
33_R44_V0.6610.76
198_K213_T0.6560.75
187_L200_A0.6540.75
148_I152_S0.6540.75
94_L98_I0.6530.75
65_R89_A0.6510.75
168_S172_L0.6500.75
200_A216_S0.6490.74
96_G149_E0.6490.74
75_I127_D0.6460.74
23_E217_I0.6460.74
97_R101_R0.6440.74
45_M48_I0.6400.73
21_F80_N0.6390.73
59_I153_N0.6390.73
155_L180_E0.6380.73
178_Y203_Q0.6370.73
132_I200_A0.6370.73
128_S214_E0.6340.73
62_M65_R0.6310.72
31_V36_S0.6300.72
179_F187_L0.6280.72
24_E32_R0.6270.72
172_L194_L0.6180.71
186_G210_A0.6180.71
87_I118_G0.6170.71
134_I202_M0.6130.70
111_M123_N0.6090.70
102_L145_F0.6080.70
85_R88_Y0.6070.69
69_T74_I0.6070.69
80_N141_L0.6040.69
23_E80_N0.6000.69
26_L32_R0.5980.68
200_A207_K0.5950.68
172_L185_I0.5880.67
76_D194_L0.5860.67
207_K210_A0.5850.67
99_A146_K0.5830.66
107_R115_I0.5820.66
90_S95_K0.5810.66
129_E178_Y0.5810.66
160_E216_S0.5800.66
194_L202_M0.5760.65
75_I85_R0.5700.65
131_F187_L0.5690.65
81_K129_E0.5680.64
57_R70_I0.5610.63
70_I85_R0.5590.63
50_A53_K0.5570.63
69_T123_N0.5570.63
131_F150_E0.5540.62
126_A179_F0.5540.62
48_I88_Y0.5540.62
85_R90_S0.5540.62
107_R179_F0.5520.62
130_N183_K0.5510.62
42_E214_E0.5510.62
110_S169_I0.5490.62
63_L129_E0.5490.62
170_L212_L0.5490.62
113_E184_R0.5450.61
28_V51_K0.5440.61
68_T209_I0.5420.61
86_A122_W0.5420.61
76_D131_F0.5400.61
58_Q62_M0.5400.61
121_R215_K0.5340.60
56_Y155_L0.5340.60
182_P190_L0.5330.60
110_S133_K0.5310.59
109_F125_I0.5290.59
139_K170_L0.5280.59
23_E215_K0.5270.59
94_L99_A0.5250.58
21_F30_V0.5240.58
61_R158_V0.5230.58
119_M180_E0.5210.58
50_A199_P0.5180.57
131_F192_N0.5180.57
28_V32_R0.5180.57
47_I98_I0.5160.57
45_M60_I0.5140.57
58_Q184_R0.5140.57
116_Y119_M0.5130.57
26_L35_P0.5130.57
103_L130_N0.5120.57
26_L130_N0.5110.56
25_E29_K0.5100.56
101_R134_I0.5100.56
107_R126_A0.5090.56
25_E28_V0.5070.56
147_I196_I0.5030.55
21_F28_V0.5030.55
190_L195_G0.5020.55
27_Y92_E0.5010.55
196_I204_V0.5000.55
92_E159_K0.5000.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4wszA 2 0.2545 97.5 0.843 Contact Map
1ku3A 1 0.2682 97.4 0.846 Contact Map
1s7oA 3 0.3136 97.3 0.849 Contact Map
1je8A 2 0.2591 97.3 0.85 Contact Map
1fseA 2 0.2636 97.1 0.854 Contact Map
2rnjA 1 0.2545 97.1 0.855 Contact Map
1x3uA 1 0.3045 97 0.855 Contact Map
1p4wA 1 0.3318 97 0.856 Contact Map
3hugA 3 0.35 97 0.856 Contact Map
2o8xA 7 0.2773 97 0.857 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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