GREMLIN Database
Q97UB5 - Uncharacterized protein
UniProt: Q97UB5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 262 (241)
Sequences: 103 (94)
Seq/√Len: 6.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
70_L129_V3.4740.88
200_D206_V3.3530.86
245_E256_V3.2690.84
246_E253_I2.9160.76
217_L232_Y2.7750.72
105_P117_P2.7100.71
232_Y253_I2.7030.70
207_L243_Y2.5830.67
56_I61_Y2.5220.65
228_K250_E2.4990.64
207_L244_I2.4530.62
248_R253_I2.4240.61
171_V181_G2.4140.61
232_Y255_Y2.3780.60
162_G169_V2.3430.59
232_Y246_E2.3270.58
139_W207_L2.2780.56
114_S117_P2.2090.54
217_L253_I2.1800.53
13_I20_S2.1200.51
58_G68_L2.0170.47
164_I219_D1.9960.46
169_V173_L1.9760.46
232_Y257_V1.9650.45
232_Y239_V1.9550.45
202_R232_Y1.9550.45
169_V182_N1.9300.44
202_R255_Y1.9190.44
129_V218_A1.8910.43
101_N236_K1.8130.40
224_T237_K1.8090.40
47_I59_A1.8080.40
242_G255_Y1.8070.40
35_A232_Y1.8050.40
206_V234_R1.7780.39
161_G169_V1.7370.37
182_N219_D1.7290.37
61_Y110_I1.6660.35
109_S237_K1.6560.35
83_A237_K1.6520.35
203_D234_R1.6390.34
55_K228_K1.5990.33
86_P111_N1.5070.30
246_E255_Y1.4960.30
209_A237_K1.4930.30
134_V229_S1.4830.29
152_N210_I1.4470.28
177_L181_G1.4400.28
105_P111_N1.4320.28
158_M181_G1.4250.28
59_A62_N1.3830.26
60_K70_L1.3770.26
90_I202_R1.3720.26
117_P202_R1.3720.26
237_K243_Y1.3680.26
141_Y229_S1.3570.26
107_N196_P1.3350.25
35_A54_L1.3340.25
102_I245_E1.3260.25
40_N44_F1.3230.25
108_S245_E1.3230.25
94_E246_E1.3170.25
66_N79_I1.3160.25
160_I174_I1.3100.24
232_Y248_R1.3070.24
77_V159_I1.3040.24
68_L148_T1.2890.24
98_A169_V1.2860.24
117_P233_R1.2840.24
180_R244_I1.2820.24
15_V20_S1.2750.24
164_I168_A1.2730.24
86_P221_V1.2700.23
66_N74_N1.2540.23
191_S194_F1.2470.23
156_I170_L1.2410.23
231_A235_V1.2410.23
164_I191_S1.2400.23
168_A178_L1.2400.23
166_S174_I1.2260.22
239_V246_E1.2140.22
172_S180_R1.2060.22
13_I102_I1.1950.22
14_T19_I1.1870.21
148_T191_S1.1830.21
83_A86_P1.1770.21
32_T131_F1.1740.21
131_F220_I1.1690.21
14_T17_V1.1640.21
239_V253_I1.1610.21
47_I62_N1.1570.21
217_L234_R1.1550.21
86_P120_F1.1460.20
202_R221_V1.1450.20
99_T219_D1.1440.20
90_I216_T1.1430.20
228_K231_A1.1410.20
200_D224_T1.1290.20
70_L237_K1.1230.20
213_G227_P1.1210.20
157_P160_I1.1150.20
152_N165_S1.1150.20
50_N231_A1.1130.20
202_R239_V1.1120.20
237_K253_I1.1110.20
154_L160_I1.1010.19
48_G60_K1.0970.19
7_L146_H1.0960.19
221_V237_K1.0830.19
149_T170_L1.0770.19
12_L16_P1.0730.19
79_I106_L1.0720.19
84_I111_N1.0620.19
221_V232_Y1.0610.19
162_G165_S1.0590.18
102_I129_V1.0390.18
160_I166_S1.0390.18
31_G230_T1.0390.18
239_V255_Y1.0370.18
65_G68_L1.0330.18
80_Y102_I1.0260.18
57_I79_I1.0250.18
28_Y231_A1.0130.17
148_T258_R1.0060.17
156_I165_S1.0030.17
190_E193_D0.9990.17
203_D252_K0.9980.17
66_N226_L0.9980.17
105_P141_Y0.9930.17
217_L248_R0.9860.17
210_I255_Y0.9840.17
234_R252_K0.9810.17
221_V239_V0.9800.17
113_I217_L0.9770.17
155_E184_R0.9760.17
13_I18_I0.9730.17
154_L165_S0.9700.17
31_G46_L0.9540.16
84_I217_L0.9510.16
234_R237_K0.9510.16
229_S243_Y0.9460.16
203_D206_V0.9430.16
164_I181_G0.9390.16
152_N172_S0.9390.16
27_I139_W0.9370.16
213_G233_R0.9370.16
32_T120_F0.9360.16
160_I164_I0.9360.16
63_L173_L0.9360.16
34_E68_L0.9350.16
167_D177_L0.9290.16
239_V248_R0.9250.16
170_L176_F0.9240.16
71_T132_A0.9230.16
63_L206_V0.9200.16
133_N174_I0.9160.16
221_V228_K0.9150.16
221_V231_A0.9130.16
244_I255_Y0.9100.15
61_Y117_P0.9070.15
30_N52_T0.9030.15
59_A117_P0.9020.15
174_I178_L0.8920.15
108_S117_P0.8910.15
12_L22_S0.8880.15
206_V218_A0.8850.15
170_L182_N0.8740.15
173_L180_R0.8690.15
115_P234_R0.8670.15
151_Q161_G0.8650.15
47_I70_L0.8630.15
86_P132_A0.8620.15
7_L12_L0.8530.14
131_F233_R0.8510.14
7_L160_I0.8490.14
61_Y236_K0.8480.14
29_Y35_A0.8390.14
214_T251_G0.8380.14
13_I19_I0.8360.14
118_Y176_F0.8350.14
28_Y190_E0.8300.14
151_Q169_V0.8270.14
110_I203_D0.8270.14
151_Q181_G0.8270.14
80_Y212_M0.8260.14
9_L258_R0.8210.14
166_S198_V0.8200.14
131_F203_D0.8190.14
44_F79_I0.8120.14
206_V251_G0.8120.14
44_F97_N0.8030.14
247_I250_E0.8030.14
121_N173_L0.8020.14
54_L111_N0.8020.14
110_I117_P0.8010.14
113_I232_Y0.8000.14
104_L222_R0.7960.13
50_N74_N0.7920.13
209_A224_T0.7920.13
232_Y237_K0.7910.13
223_Q226_L0.7880.13
151_Q154_L0.7850.13
63_L77_V0.7850.13
111_N254_R0.7800.13
76_T143_L0.7790.13
79_I176_F0.7770.13
220_I244_I0.7740.13
213_G238_L0.7730.13
35_A257_V0.7710.13
81_Y213_G0.7700.13
31_G227_P0.7690.13
166_S201_E0.7680.13
108_S171_V0.7670.13
98_A176_F0.7640.13
215_N229_S0.7550.13
80_Y228_K0.7520.13
234_R253_I0.7500.13
156_I182_N0.7490.13
134_V141_Y0.7480.13
104_L108_S0.7470.13
198_V248_R0.7420.13
35_A84_I0.7410.13
148_T168_A0.7380.13
10_L98_A0.7370.13
105_P110_I0.7340.12
68_L194_F0.7330.12
158_M162_G0.7320.12
54_L108_S0.7270.12
94_E239_V0.7260.12
229_S248_R0.7250.12
59_A134_V0.7250.12
111_N117_P0.7240.12
24_I201_E0.7230.12
223_Q256_V0.7210.12
158_M172_S0.7200.12
41_V110_I0.7200.12
196_P219_D0.7150.12
9_L15_V0.7110.12
142_T212_M0.7100.12
81_Y238_L0.7090.12
9_L179_R0.7050.12
52_T94_E0.7030.12
215_N228_K0.7020.12
59_A222_R0.7000.12
85_L97_N0.7000.12
105_P108_S0.6990.12
201_E204_T0.6950.12
203_D208_E0.6920.12
102_I131_F0.6910.12
53_N66_N0.6900.12
23_S192_V0.6830.12
210_I245_E0.6800.12
37_L251_G0.6800.12
155_E179_R0.6800.12
66_N183_V0.6790.12
110_I121_N0.6780.12
234_R255_Y0.6770.12
81_Y141_Y0.6750.12
40_N131_F0.6730.12
104_L131_F0.6700.11
92_I245_E0.6640.11
32_T220_I0.6590.11
102_I137_V0.6580.11
11_P18_I0.6530.11
206_V228_K0.6500.11
14_T27_I0.6500.11
224_T246_E0.6500.11
163_L174_I0.6490.11
84_I139_W0.6490.11
162_G176_F0.6470.11
190_E194_F0.6470.11
70_L152_N0.6440.11
86_P110_I0.6430.11
27_I116_Q0.6420.11
79_I215_N0.6350.11
203_D243_Y0.6330.11
35_A229_S0.6310.11
175_I201_E0.6310.11
9_L69_Y0.6300.11
82_N232_Y0.6290.11
26_N63_L0.6260.11
228_K234_R0.6260.11
136_S247_I0.6220.11
215_N239_V0.6200.11
147_V219_D0.6180.11
93_N206_V0.6160.11
217_L235_V0.6100.11
216_T248_R0.6100.11
139_W175_I0.6100.11
147_V250_E0.6100.11
56_I137_V0.6080.11
149_T173_L0.6060.11
149_T157_P0.6050.11
203_D224_T0.6050.11
84_I245_E0.6050.11
220_I257_V0.6010.11
54_L169_V0.6010.11
48_G225_G0.6000.11
219_D240_K0.5970.10
198_V249_E0.5960.10
118_Y183_V0.5950.10
234_R254_R0.5940.10
230_T248_R0.5930.10
200_D209_A0.5930.10
109_S212_M0.5890.10
104_L113_I0.5880.10
203_D238_L0.5870.10
44_F70_L0.5850.10
183_V219_D0.5850.10
238_L242_G0.5850.10
224_T240_K0.5820.10
59_A97_N0.5810.10
35_A83_A0.5810.10
92_I100_I0.5800.10
16_P19_I0.5790.10
95_P136_S0.5780.10
151_Q165_S0.5780.10
111_N223_Q0.5760.10
84_I120_F0.5730.10
199_L238_L0.5720.10
205_I222_R0.5660.10
94_E223_Q0.5660.10
157_P174_I0.5570.10
227_P233_R0.5570.10
238_L248_R0.5570.10
162_G183_V0.5570.10
88_G242_G0.5550.10
9_L212_M0.5500.10
51_I251_G0.5500.10
72_P90_I0.5470.10
217_L224_T0.5470.10
139_W200_D0.5430.10
27_I122_V0.5420.10
209_A217_L0.5410.10
67_T255_Y0.5410.10
85_L111_N0.5360.10
68_L173_L0.5350.10
56_I219_D0.5330.10
180_R183_V0.5320.10
209_A236_K0.5290.10
141_Y228_K0.5270.10
31_G248_R0.5250.10
224_T243_Y0.5240.10
44_F201_E0.5240.10
30_N132_A0.5220.10
114_S132_A0.5200.09
213_G242_G0.5190.09
84_I132_A0.5190.09
234_R251_G0.5160.09
206_V231_A0.5160.09
231_A234_R0.5100.09
112_Y232_Y0.5090.09
129_V206_V0.5070.09
68_L193_D0.5070.09
131_F140_L0.5070.09
56_I207_L0.5040.09
12_L15_V0.5040.09
169_V176_F0.5030.09
35_A42_N0.5030.09
19_I184_R0.5000.09
68_L107_N0.5000.09
54_L240_K0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2vxzA 1 0.2595 98.8 0.856 Contact Map
1i1gA 5 0.2443 98.6 0.867 Contact Map
2pn6A 5 0.2443 98.5 0.869 Contact Map
1p6rA 1 0.2672 98.5 0.87 Contact Map
1biaA 1 0.2443 98.5 0.872 Contact Map
1tbxA 3 0.2595 98.5 0.872 Contact Map
2kkoA 2 0.3206 98.5 0.873 Contact Map
3pqkA 2 0.3168 98.4 0.874 Contact Map
2cyyA 2 0.2595 98.4 0.874 Contact Map
3f6oA 2 0.3015 98.4 0.874 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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