GREMLIN Database
Q97UB3 - Thermostable carboxypeptidase 1
UniProt: Q97UB3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 467 (460)
Sequences: 1203 (879)
Seq/√Len: 41.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
364_D370_R4.7411.00
153_E339_Y4.0701.00
337_I363_M4.0511.00
350_L358_L3.9241.00
450_E453_N3.9011.00
341_I358_L3.4501.00
295_K416_D3.3811.00
372_K376_E3.2851.00
162_G462_R3.2291.00
116_E353_S3.0671.00
438_Y446_R3.0471.00
26_S208_R3.0021.00
87_K117_Q2.9031.00
361_D370_R2.8601.00
65_G68_R2.8551.00
162_G458_L2.8451.00
450_E456_R2.8241.00
112_K353_S2.7091.00
112_K352_A2.6611.00
202_L249_S2.6381.00
453_N456_R2.4051.00
197_I300_L2.4031.00
291_Y308_D2.3991.00
60_N63_E2.3971.00
409_M423_I2.3691.00
357_S361_D2.3641.00
405_V431_I2.2711.00
134_H347_E2.2671.00
103_K232_R2.2431.00
373_N376_E2.2401.00
445_M451_A2.2341.00
50_R74_Y2.2151.00
407_Y456_R2.2061.00
400_V452_Y2.2011.00
361_D365_K2.1620.99
204_M209_F2.1590.99
57_E71_E2.1150.99
362_L366_Y2.1140.99
355_F378_V2.1020.99
306_S309_D2.0730.99
158_E455_S2.0630.99
160_L340_E2.0550.99
281_R399_N2.0510.99
273_M394_T2.0320.99
192_K196_A2.0200.99
111_F385_S2.0180.99
106_G373_N2.0080.99
101_N105_K1.9890.99
282_F423_I1.9730.99
285_N289_R1.9700.99
405_V444_Q1.9700.99
7_A37_R1.9660.99
29_K94_E1.9620.99
153_E343_K1.9530.99
340_E362_L1.9460.99
460_Y464_K1.9280.99
332_N399_N1.8940.99
344_R349_S1.8780.98
408_H411_S1.8630.98
26_S207_D1.8540.98
137_S150_T1.8520.98
412_E430_R1.8340.98
84_L124_E1.8200.98
119_L345_A1.7840.98
407_Y450_E1.7760.98
44_K82_E1.7640.98
229_I252_A1.7610.98
405_V447_S1.7570.98
133_D137_S1.7570.98
84_L128_K1.7550.98
169_K462_R1.7530.98
66_L265_S1.7510.98
109_N112_K1.7440.97
71_E75_K1.7420.97
199_Y249_S1.7180.97
11_A15_L1.7040.97
195_E245_L1.6920.97
117_Q120_E1.6650.97
5_I45_L1.6610.97
282_F409_M1.6500.96
98_V114_Y1.6490.96
151_D441_K1.6480.96
80_V85_D1.6430.96
4_D45_L1.6290.96
407_Y459_D1.6260.96
105_K110_A1.6200.96
298_Y307_I1.6190.96
431_I443_L1.6160.96
184_K235_G1.6050.96
198_A242_L1.6020.96
244_S324_V1.5770.95
259_D433_K1.5710.95
424_K428_R1.5600.95
123_R351_E1.5500.95
76_Y142_R1.5200.94
219_T227_V1.5130.94
120_E124_E1.4860.94
231_V245_L1.4800.93
106_G374_D1.4630.93
112_K116_E1.4570.93
400_V457_L1.4530.93
340_E366_Y1.4500.93
33_E90_R1.4480.93
192_K213_V1.4460.93
291_Y311_Y1.4430.93
26_S205_P1.4420.93
287_V423_I1.4380.92
198_A246_V1.4360.92
298_Y310_V1.4360.92
53_I71_E1.4240.92
5_I42_R1.4200.92
12_I35_L1.4190.92
83_E87_K1.4120.92
281_R285_N1.3950.91
298_Y302_N1.3930.91
119_L389_F1.3900.91
188_F192_K1.3830.91
123_R346_I1.3750.91
80_V125_I1.3700.90
167_L171_D1.3580.90
137_S149_V1.3580.90
339_Y343_K1.3560.90
92_T118_I1.3520.90
144_E272_S1.3460.90
106_G375_G1.3410.90
116_E120_E1.3410.90
187_V213_V1.3340.89
87_K124_E1.3320.89
438_Y443_L1.3290.89
258_I270_A1.3280.89
115_L352_A1.3270.89
178_Y316_G1.3260.89
341_I355_F1.3190.89
194_I301_L1.3180.89
431_I447_S1.2950.88
98_V110_A1.2940.88
419_N422_G1.2920.88
160_L336_A1.2850.87
189_Q304_K1.2790.87
173_K176_R1.2780.87
91_I114_Y1.2780.87
406_Y410_K1.2780.87
345_A350_L1.2750.87
88_L122_K1.2710.87
206_K209_F1.2690.87
434_Y438_Y1.2690.87
94_E117_Q1.2680.87
107_D110_A1.2640.87
249_S252_A1.2640.87
139_L346_I1.2620.86
189_Q193_T1.2550.86
25_Q207_D1.2540.86
170_I329_V1.2530.86
201_V297_I1.2530.86
130_G138_A1.2500.86
362_L365_K1.2460.86
201_V296_T1.2450.86
40_N86_M1.2440.86
410_K414_G1.2300.85
73_E436_S1.2290.85
108_F374_D1.2270.85
363_M367_L1.2240.85
364_D371_P1.2160.84
86_M90_R1.2150.84
75_K79_A1.2050.84
455_S459_D1.2050.84
281_R332_N1.2010.84
408_H447_S1.1990.83
458_L462_R1.1960.83
360_N374_D1.1950.83
200_E206_K1.1940.83
185_Y305_D1.1910.83
401_I444_Q1.1860.83
271_P440_P1.1840.83
351_E354_E1.1790.82
43_R85_D1.1740.82
197_I304_K1.1700.82
243_Y314_V1.1700.82
282_F406_Y1.1690.82
127_H135_P1.1610.81
20_Q96_T1.1590.81
158_E454_P1.1550.81
160_L366_Y1.1550.81
127_H131_Y1.1460.81
214_S219_T1.1440.80
72_R141_D1.1400.80
163_L167_L1.1310.80
408_H412_E1.1280.79
151_D154_R1.1230.79
202_L420_I1.1190.79
400_V461_M1.1150.79
442_E446_R1.1100.78
428_R432_H1.1100.78
4_D41_L1.1080.78
457_L461_M1.1070.78
192_K233_Y1.1030.78
227_V256_L1.0920.77
186_D235_G1.0900.77
168_N172_D1.0790.76
232_R324_V1.0740.76
234_E240_R1.0700.76
294_I297_I1.0700.76
439_S442_E1.0690.76
283_W287_V1.0650.75
208_R225_N1.0640.75
249_S253_I1.0610.75
321_P376_E1.0600.75
244_S281_R1.0540.75
144_E274_G1.0530.75
315_N464_K1.0510.74
332_N396_T1.0460.74
36_A90_R1.0410.74
106_G376_E1.0400.74
62_I437_I1.0310.73
92_T385_S1.0310.73
25_Q101_N1.0300.73
361_D364_D1.0260.73
346_I389_F1.0230.72
321_P369_I1.0220.72
13_S221_S1.0210.72
100_R382_V1.0180.72
85_D89_H1.0160.72
356_P374_D1.0150.72
133_D150_T1.0130.72
257_Q428_R1.0070.71
202_L246_V1.0010.71
406_Y409_M0.9980.71
32_G93_S0.9960.70
84_L121_I0.9960.70
307_I310_V0.9930.70
53_I70_L0.9870.70
108_F112_K0.9860.70
415_F420_I0.9840.69
103_K376_E0.9830.69
434_Y446_R0.9820.69
258_I268_A0.9800.69
65_G69_V0.9790.69
88_L125_I0.9790.69
118_I389_F0.9760.69
215_P382_V0.9760.69
68_R439_S0.9730.69
131_Y134_H0.9720.68
28_I32_G0.9670.68
209_F256_L0.9660.68
434_Y437_I0.9660.68
56_L67_K0.9650.68
15_L34_A0.9640.68
19_I28_I0.9630.68
430_R433_K0.9620.68
143_Y388_S0.9600.68
358_L362_L0.9590.67
225_N260_P0.9520.67
371_P376_E0.9470.66
336_A340_E0.9470.66
162_G166_I0.9460.66
459_D463_E0.9450.66
53_I74_Y0.9450.66
254_Y443_L0.9440.66
101_N110_A0.9420.66
14_L222_M0.9380.66
425_N429_E0.9310.65
298_Y306_S0.9280.65
125_I129_L0.9260.65
108_F379_L0.9250.65
246_V288_G0.9250.65
202_L283_W0.9230.64
187_V235_G0.9180.64
165_K169_K0.9150.64
143_Y394_T0.9140.64
253_I424_K0.9120.63
443_L446_R0.9110.63
194_I242_L0.9100.63
213_V233_Y0.9050.63
160_L362_L0.9040.63
166_I319_R0.9010.63
143_Y393_P0.9010.63
148_T151_D0.9000.62
344_R350_L0.8980.62
299_P302_N0.8970.62
233_Y241_V0.8950.62
8_I41_L0.8940.62
126_A138_A0.8870.61
296_T418_S0.8850.61
43_R77_Y0.8850.61
271_P436_S0.8850.61
69_V436_S0.8840.61
14_L27_G0.8830.61
344_R362_L0.8820.61
74_Y78_D0.8820.61
96_T100_R0.8740.60
360_N370_R0.8740.60
130_G133_D0.8700.60
17_W212_D0.8690.60
95_A118_I0.8690.60
49_I52_E0.8670.60
152_A272_S0.8660.59
31_R210_R0.8640.59
345_A378_V0.8640.59
441_K452_Y0.8630.59
131_Y138_A0.8630.59
31_R212_D0.8620.59
452_Y457_L0.8610.59
283_W424_K0.8610.59
54_E71_E0.8570.59
94_E114_Y0.8570.59
17_W210_R0.8520.58
10_H34_A0.8500.58
407_Y453_N0.8500.58
186_D189_Q0.8480.58
126_A135_P0.8460.58
136_Y393_P0.8460.58
87_K91_I0.8460.58
41_L44_K0.8450.58
144_E394_T0.8430.57
287_V415_F0.8420.57
168_N171_D0.8420.57
155_V400_V0.8420.57
225_N263_E0.8410.57
221_S224_R0.8400.57
116_E352_A0.8400.57
50_R54_E0.8380.57
194_I294_I0.8370.57
197_I303_V0.8330.56
103_K215_P0.8320.56
91_I117_Q0.8280.56
287_V409_M0.8280.56
116_E351_E0.8240.56
238_F301_L0.8240.56
219_T244_S0.8210.55
170_I173_K0.8210.55
204_M229_I0.8200.55
193_T304_K0.8190.55
291_Y295_K0.8170.55
20_Q100_R0.8160.55
50_R78_D0.8140.55
181_E313_Y0.8110.54
136_Y140_L0.8100.54
300_L303_V0.8070.54
259_D262_L0.8060.54
119_L350_L0.8040.54
43_R47_L0.8040.54
109_N113_P0.8040.54
134_H137_S0.8030.54
196_A206_K0.8020.54
286_V402_A0.7990.53
441_K451_A0.7960.53
72_R145_E0.7940.53
51_G55_K0.7930.53
344_R358_L0.7930.53
410_K463_E0.7930.53
179_H309_D0.7930.53
294_I310_V0.7920.53
88_L121_I0.7910.53
275_L401_I0.7890.52
171_D319_R0.7870.52
349_S357_S0.7850.52
429_E433_K0.7810.52
205_P256_L0.7810.52
238_F305_D0.7790.51
106_G110_A0.7790.51
281_R305_D0.7780.51
49_I74_Y0.7770.51
208_R256_L0.7770.51
154_R158_E0.7760.51
160_L164_S0.7750.51
211_I245_L0.7730.51
19_I35_L0.7710.51
255_E270_A0.7700.51
62_I267_L0.7680.50
95_A385_S0.7680.50
13_S220_V0.7640.50
147_F152_A0.7620.50
363_M369_I0.7620.50
66_L266_P0.7600.50
442_E445_M0.7600.50
128_K379_L0.7580.50
102_A379_L0.7580.50
88_L128_K0.7570.49
198_A202_L0.7560.49
456_R459_D0.7560.49
147_F151_D0.7560.49
28_I97_V0.7550.49
406_Y423_I0.7510.49
40_N82_E0.7510.49
84_L88_L0.7510.49
158_E458_L0.7500.49
285_N399_N0.7500.49
149_V343_K0.7460.48
177_K180_F0.7430.48
413_R422_G0.7410.48
214_S230_T0.7380.48
300_L304_K0.7370.48
111_F325_D0.7360.47
320_Q330_T0.7350.47
132_K137_S0.7340.47
262_L265_S0.7330.47
240_R324_V0.7320.47
160_L246_V0.7300.47
224_R263_E0.7280.47
119_L352_A0.7270.47
407_Y411_S0.7230.46
164_S333_F0.7210.46
321_P363_M0.7170.46
204_M252_A0.7170.46
166_I461_M0.7150.46
100_R215_P0.7150.46
91_I121_I0.7140.45
119_L351_E0.7130.45
263_E268_A0.7120.45
8_I23_M0.7100.45
187_V192_K0.7090.45
243_Y294_I0.7080.45
273_M386_Q0.7080.45
8_I42_R0.7070.45
155_V454_P0.7060.45
180_F313_Y0.7040.45
422_G425_N0.7030.44
315_N460_Y0.7000.44
62_I262_L0.6970.44
332_N402_A0.6940.44
16_D20_Q0.6930.44
112_K152_A0.6930.44
154_R157_N0.6930.44
232_R244_S0.6910.43
102_A108_F0.6910.43
188_F193_T0.6890.43
415_F423_I0.6870.43
129_L138_A0.6870.43
5_I46_L0.6860.43
230_T278_S0.6840.43
194_I198_A0.6840.43
109_N374_D0.6840.43
309_D312_Y0.6830.43
259_D268_A0.6820.43
219_T457_L0.6810.42
424_K432_H0.6800.42
400_V456_R0.6800.42
194_I237_D0.6790.42
259_D270_A0.6770.42
92_T386_Q0.6760.42
123_R138_A0.6760.42
22_Y212_D0.6740.42
167_L317_V0.6720.42
177_K309_D0.6710.42
255_E276_H0.6710.42
159_L400_V0.6710.42
21_T336_A0.6700.41
122_K346_I0.6680.41
166_I462_R0.6680.41
162_G165_K0.6680.41
82_E86_M0.6660.41
13_S222_M0.6660.41
108_F351_E0.6650.41
138_A346_I0.6650.41
328_E464_K0.6650.41
90_R94_E0.6650.41
254_Y272_S0.6650.41
143_Y335_I0.6630.41
294_I301_L0.6610.41
84_L91_I0.6610.41
143_Y391_Y0.6610.41
16_D96_T0.6590.40
391_Y394_T0.6590.40
172_D175_T0.6580.40
105_K109_N0.6580.40
341_I344_R0.6570.40
244_S399_N0.6560.40
11_A38_L0.6550.40
251_H276_H0.6540.40
350_L378_V0.6520.40
32_G85_D0.6510.40
9_E42_R0.6500.40
96_T382_V0.6490.40
329_V457_L0.6480.39
305_D399_N0.6460.39
206_K256_L0.6450.39
282_F394_T0.6430.39
95_A386_Q0.6410.39
204_M335_I0.6400.39
285_N464_K0.6390.39
122_K125_I0.6390.39
72_R90_R0.6380.39
14_L221_S0.6370.39
89_H129_L0.6370.39
354_E357_S0.6360.38
391_Y397_L0.6360.38
155_V452_Y0.6320.38
240_R325_D0.6320.38
292_G416_D0.6320.38
211_I244_S0.6310.38
155_V396_T0.6300.38
85_D121_I0.6300.38
156_F396_T0.6300.38
337_I367_L0.6290.38
409_M413_R0.6290.38
273_M391_Y0.6270.38
96_T386_Q0.6270.38
177_K316_G0.6260.38
42_R245_L0.6240.37
425_N428_R0.6240.37
92_T95_A0.6240.37
190_M235_G0.6240.37
275_L440_P0.6240.37
16_D220_V0.6240.37
423_I431_I0.6230.37
37_R363_M0.6230.37
400_V454_P0.6210.37
414_G423_I0.6200.37
113_P116_E0.6190.37
79_A129_L0.6190.37
196_A200_E0.6190.37
345_A355_F0.6190.37
129_L142_R0.6180.37
297_I301_L0.6160.37
42_R46_L0.6160.37
84_L125_I0.6160.37
160_L245_L0.6150.37
294_I307_I0.6150.37
13_S27_G0.6120.36
126_A346_I0.6100.36
27_G224_R0.6100.36
32_G94_E0.6090.36
302_N411_S0.6090.36
410_K413_R0.6070.36
419_N425_N0.6070.36
230_T280_S0.6070.36
294_I314_V0.6060.36
193_T433_K0.6030.36
43_R126_A0.5990.35
108_F378_V0.5990.35
127_H130_G0.5990.35
62_I66_L0.5990.35
370_R373_N0.5990.35
63_E66_L0.5990.35
111_F143_Y0.5970.35
23_M31_R0.5970.35
435_G443_L0.5960.35
166_I458_L0.5950.35
295_K307_I0.5950.35
323_R331_Y0.5940.35
10_H222_M0.5910.35
46_L70_L0.5890.34
169_K172_D0.5890.34
227_V252_A0.5890.34
140_L391_Y0.5890.34
130_G135_P0.5870.34
32_G112_K0.5850.34
53_I67_K0.5850.34
286_V399_N0.5840.34
224_R268_A0.5840.34
417_I421_E0.5840.34
218_F276_H0.5820.34
219_T252_A0.5820.34
152_A155_V0.5820.34
267_L437_I0.5800.34
297_I420_I0.5780.33
364_D417_I0.5770.33
8_I154_R0.5770.33
349_S361_D0.5770.33
313_Y379_L0.5770.33
88_L91_I0.5760.33
199_Y229_I0.5760.33
134_H343_K0.5760.33
161_P165_K0.5750.33
72_R120_E0.5750.33
279_Q427_L0.5740.33
170_I317_V0.5710.33
221_S402_A0.5710.33
119_L378_V0.5700.33
285_N332_N0.5690.33
202_L253_I0.5690.33
248_E276_H0.5690.33
122_K142_R0.5690.33
140_L153_E0.5680.33
27_G258_I0.5670.33
100_R103_K0.5670.33
382_V385_S0.5670.33
248_E251_H0.5660.32
17_W209_F0.5660.32
294_I431_I0.5660.32
341_I345_A0.5650.32
294_I298_Y0.5650.32
64_K109_N0.5640.32
61_D64_K0.5610.32
215_P232_R0.5600.32
76_Y141_D0.5590.32
66_L267_L0.5570.32
332_N457_L0.5560.32
328_E460_Y0.5560.32
410_K430_R0.5560.32
251_H398_G0.5550.32
204_M256_L0.5540.32
164_S167_L0.5530.31
124_E429_E0.5530.31
51_G124_E0.5500.31
119_L341_I0.5500.31
344_R348_G0.5490.31
202_L447_S0.5480.31
167_L333_F0.5480.31
281_R289_R0.5470.31
103_K213_V0.5460.31
144_E401_I0.5460.31
109_N348_G0.5440.31
119_L123_R0.5440.31
91_I118_I0.5440.31
108_F360_N0.5440.31
348_G396_T0.5430.31
64_K369_I0.5430.31
348_G354_E0.5420.31
102_A114_Y0.5420.31
205_P209_F0.5410.30
5_I49_I0.5410.30
157_N161_P0.5410.30
224_R260_P0.5400.30
11_A42_R0.5400.30
290_S415_F0.5400.30
251_H280_S0.5390.30
253_I447_S0.5380.30
8_I45_L0.5370.30
35_L78_D0.5360.30
140_L393_P0.5360.30
265_S281_R0.5350.30
198_A297_I0.5350.30
405_V427_L0.5350.30
157_N160_L0.5350.30
391_Y396_T0.5340.30
430_R438_Y0.5340.30
350_L362_L0.5340.30
383_H398_G0.5340.30
356_P363_M0.5330.30
76_Y129_L0.5330.30
20_Q219_T0.5330.30
15_L220_V0.5320.30
152_A157_N0.5310.30
135_P138_A0.5300.30
168_N453_N0.5300.30
103_K249_S0.5300.30
140_L335_I0.5290.30
285_N328_E0.5290.30
7_A33_E0.5290.30
305_D363_M0.5280.29
52_E70_L0.5280.29
275_L444_Q0.5280.29
183_E298_Y0.5280.29
35_L39_S0.5270.29
103_K195_E0.5260.29
266_P402_A0.5260.29
165_K168_N0.5260.29
16_D185_Y0.5240.29
317_V328_E0.5240.29
199_Y371_P0.5240.29
245_L249_S0.5240.29
144_E393_P0.5220.29
218_F230_T0.5210.29
50_R53_I0.5200.29
404_M456_R0.5200.29
248_E280_S0.5200.29
49_I70_L0.5180.29
27_G208_R0.5170.29
124_E127_H0.5170.29
258_I262_L0.5170.29
140_L339_Y0.5170.29
12_I42_R0.5160.29
154_R414_G0.5160.29
103_K252_A0.5150.28
276_H280_S0.5140.28
32_G229_I0.5140.28
283_W415_F0.5140.28
283_W420_I0.5090.28
405_V415_F0.5090.28
202_L245_L0.5090.28
285_N315_N0.5080.28
167_L330_T0.5070.28
23_M56_L0.5070.28
168_N365_K0.5070.28
296_T420_I0.5070.28
169_K357_S0.5060.28
20_Q214_S0.5050.28
185_Y281_R0.5040.28
123_R344_R0.5040.28
144_E440_P0.5030.28
182_D335_I0.5030.28
36_A202_L0.5030.28
135_P447_S0.5020.28
123_R318_K0.5020.28
282_F287_V0.5020.28
136_Y391_Y0.5020.28
160_L365_K0.5010.27
100_R199_Y0.5010.27
309_D313_Y0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hoaA 2 0.9979 100 0.263 Contact Map
3dwcA 3 0.9957 100 0.267 Contact Map
3hq2A 2 0.9979 100 0.386 Contact Map
1ka2A 2 0.9957 100 0.386 Contact Map
4ca7A 1 0.9486 100 0.659 Contact Map
4ca6A 1 0.955 100 0.664 Contact Map
4c2oA 1 0.9507 100 0.675 Contact Map
1r42A 1 0.955 100 0.688 Contact Map
3ahnA 1 0.9143 100 0.763 Contact Map
3ce2A 1 0.9122 100 0.767 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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