GREMLIN Database
Q97UB0 - Sec-independent protein translocase protein TatC
UniProt: Q97UB0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 289 (237)
Sequences: 3347 (2132)
Seq/√Len: 138.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
224_T280_S4.2461.00
238_W274_F4.0531.00
38_A128_L4.0051.00
30_I34_R3.7291.00
235_R281_F3.7091.00
34_R128_L3.3621.00
131_R135_A3.1121.00
246_F266_G2.9701.00
231_A284_E2.7761.00
43_F121_A2.6381.00
27_E31_R2.6191.00
241_G273_Y2.2661.00
35_I129_I2.2261.00
100_K191_E2.1591.00
46_Y120_L2.0921.00
230_K233_T2.0881.00
44_F48_M2.0341.00
220_M234_W2.0231.00
231_A280_S1.9961.00
223_L228_I1.9861.00
255_G261_M1.9601.00
165_L169_L1.9541.00
33_R37_A1.9541.00
183_T192_P1.9131.00
141_L145_E1.9111.00
34_R132_E1.8891.00
104_I195_S1.8821.00
49_T52_E1.8581.00
273_Y277_M1.8561.00
102_I193_T1.8521.00
242_V270_S1.8341.00
53_W120_L1.8311.00
240_W244_V1.8011.00
42_S121_A1.7961.00
108_D195_S1.7951.00
32_L36_I1.7871.00
153_M157_F1.7841.00
121_A125_S1.7771.00
39_L118_L1.7631.00
245_S269_L1.7571.00
20_P23_D1.7521.00
160_F211_G1.7171.00
31_R135_A1.7001.00
246_F262_E1.6951.00
229_V234_W1.6921.00
257_T262_E1.6721.00
235_R238_W1.6511.00
105_N108_D1.6431.00
156_A215_E1.6211.00
31_R132_E1.6121.00
237_Y240_W1.6111.00
125_S129_I1.5621.00
248_I252_I1.5611.00
42_S124_T1.5441.00
231_A281_F1.5321.00
106_L176_F1.5251.00
232_S236_N1.5241.00
233_T237_Y1.5221.00
224_T231_A1.5061.00
161_F165_L1.5031.00
138_A146_K1.5011.00
35_I125_S1.4981.00
231_A235_R1.4951.00
103_I109_P1.4461.00
235_R274_F1.4451.00
45_F48_M1.4121.00
19_K23_D1.4061.00
34_R37_A1.3991.00
38_A125_S1.3891.00
106_L109_P1.3731.00
42_S125_S1.3581.00
158_L162_S1.3331.00
195_S198_S1.3191.00
225_H283_V1.3141.00
113_S182_Y1.2971.00
221_I283_V1.2891.00
250_W262_E1.2811.00
39_L125_S1.2811.00
126_L130_I1.2741.00
243_L247_I1.2741.00
39_L129_I1.2461.00
278_G282_L1.2401.00
232_S235_R1.2121.00
255_G262_E1.2091.00
105_N198_S1.2081.00
106_L202_T1.2051.00
252_I265_I1.1991.00
180_S192_P1.1991.00
234_W273_Y1.1931.00
220_M280_S1.1821.00
220_M276_G1.1761.00
164_S207_M1.1480.99
26_R30_I1.1430.99
41_I45_F1.1420.99
136_F139_P1.1420.99
274_F278_G1.1380.99
104_I193_T1.1340.99
263_T267_L1.1270.99
172_I203_T1.1250.99
50_G113_S1.1040.99
24_H145_E1.1040.99
122_L129_I1.0960.99
45_F49_T1.0910.99
107_F179_I1.0840.99
245_S270_S1.0810.99
56_I169_L1.0800.99
35_I38_A1.0800.99
140_G145_E1.0720.99
164_S211_G1.0700.99
143_K147_K1.0650.99
34_R131_R1.0550.99
231_A277_M1.0400.99
36_I40_A1.0340.99
237_Y241_G1.0300.99
37_A41_I1.0240.99
216_M245_S1.0150.99
103_I196_L0.9990.98
103_I190_V0.9980.98
47_F113_S0.9980.98
24_H136_F0.9920.98
37_A40_A0.9850.98
27_E132_E0.9840.98
249_A253_S0.9810.98
132_E135_A0.9770.98
235_R277_M0.9660.98
47_F114_L0.9650.98
239_R262_E0.9630.98
31_R140_G0.9530.98
250_W253_S0.9400.98
174_L177_D0.9290.97
24_H27_E0.9280.97
46_Y124_T0.9200.97
122_L126_L0.9170.97
232_S281_F0.9170.97
253_S265_I0.9170.97
172_I176_F0.9130.97
136_F140_G0.9120.97
40_A44_F0.9050.97
216_M276_G0.8960.97
190_V196_L0.8930.97
175_M261_M0.8900.97
103_I108_D0.8890.97
249_A252_I0.8850.96
229_V233_T0.8810.96
39_L122_L0.8810.96
24_H28_L0.8800.96
176_F202_T0.8740.96
106_L194_I0.8740.96
163_G211_G0.8730.96
24_H139_P0.8720.96
238_W278_G0.8650.96
136_F145_E0.8610.96
209_S252_I0.8600.96
242_V274_F0.8590.96
175_M179_I0.8580.96
238_W242_V0.8580.96
242_V266_G0.8570.96
245_S249_A0.8570.96
234_W277_M0.8560.96
253_S262_E0.8540.96
262_E266_G0.8540.96
280_S284_E0.8520.96
123_L164_S0.8460.95
83_A87_T0.8450.95
134_W149_F0.8410.95
105_N197_S0.8390.95
244_V247_I0.8380.95
278_G281_F0.8340.95
126_L129_I0.8310.95
42_S46_Y0.8270.95
226_L229_V0.8190.95
213_A269_L0.8190.95
103_I192_P0.8100.94
179_I216_M0.8080.94
216_M269_L0.8040.94
27_E136_F0.7990.94
103_I183_T0.7940.94
156_A218_L0.7930.94
84_V93_H0.7830.93
48_M52_E0.7820.93
183_T190_V0.7770.93
256_T261_M0.7750.93
47_F51_Y0.7740.93
48_M117_S0.7740.93
150_K154_I0.7730.93
256_T262_E0.7700.93
110_I182_Y0.7690.93
174_L264_I0.7670.92
24_H140_G0.7610.92
83_A86_V0.7610.92
115_Y201_S0.7610.92
249_A266_G0.7520.92
43_F118_L0.7500.92
109_P182_Y0.7480.91
84_V87_T0.7460.91
148_I151_L0.7400.91
32_L35_I0.7370.91
29_A33_R0.7370.91
51_Y55_N0.7350.91
157_F161_F0.7310.91
220_M229_V0.7290.90
180_S194_I0.7250.90
21_L30_I0.7230.90
149_F153_M0.7210.90
239_R242_V0.7060.89
142_Y145_E0.7050.89
149_F157_F0.6960.88
51_Y113_S0.6940.88
46_Y49_T0.6910.88
126_L157_F0.6890.88
246_F270_S0.6860.88
38_A129_I0.6820.87
111_Y115_Y0.6790.87
148_I222_G0.6790.87
177_D181_F0.6770.87
46_Y121_A0.6760.87
117_S120_L0.6760.87
201_S205_L0.6710.86
47_F117_S0.6710.86
159_L272_L0.6710.86
166_F276_G0.6690.86
109_P192_P0.6680.86
52_E56_I0.6660.86
138_A142_Y0.6640.86
51_Y103_I0.6610.86
108_D112_A0.6590.85
15_F18_E0.6580.85
122_L208_G0.6560.85
104_I108_D0.6560.85
176_F182_Y0.6550.85
122_L156_A0.6540.85
42_S45_F0.6530.85
34_R38_A0.6520.85
205_L208_G0.6490.85
136_F141_L0.6460.84
196_L218_L0.6410.84
206_L210_L0.6400.84
112_A116_V0.6350.83
130_I156_A0.6330.83
257_T261_M0.6330.83
221_I279_I0.6320.83
213_A265_I0.6310.83
128_L132_E0.6280.83
139_P199_F0.6260.82
54_I116_V0.6260.82
31_R139_P0.6230.82
101_I167_A0.6220.82
139_P145_E0.6200.82
214_F272_L0.6200.82
270_S274_F0.6190.82
224_T234_W0.6150.81
22_L25_L0.6130.81
242_V246_F0.6120.81
35_I121_A0.6090.81
121_A148_I0.6080.81
45_F124_T0.6080.81
267_L271_S0.6070.80
225_H279_I0.6050.80
109_P190_V0.6040.80
100_K193_T0.5980.79
167_A210_L0.5940.79
174_L262_E0.5930.79
137_L149_F0.5920.79
155_P218_L0.5900.79
205_L261_M0.5900.79
160_F163_G0.5890.78
224_T284_E0.5870.78
118_L122_L0.5870.78
225_H286_K0.5820.78
119_Y204_F0.5820.78
175_M239_R0.5800.77
160_F215_E0.5790.77
24_H31_R0.5770.77
167_A206_L0.5760.77
113_S184_E0.5760.77
180_S183_T0.5760.77
167_A172_I0.5720.76
174_L276_G0.5690.76
24_H141_L0.5680.76
27_E139_P0.5680.76
21_L26_R0.5640.75
116_V161_F0.5640.75
162_S165_L0.5620.75
52_E55_N0.5620.75
93_H96_P0.5620.75
255_G263_T0.5600.75
101_I117_S0.5580.75
16_F19_K0.5550.74
108_D197_S0.5530.74
119_Y123_L0.5520.74
200_I278_G0.5520.74
109_P134_W0.5510.74
49_T55_N0.5510.74
192_P195_S0.5500.74
274_F277_M0.5490.73
54_I113_S0.5480.73
39_L42_S0.5480.73
264_I269_L0.5470.73
199_F203_T0.5450.73
246_F263_T0.5450.73
153_M200_I0.5450.73
112_A196_L0.5440.73
210_L265_I0.5420.72
164_S212_L0.5410.72
130_I134_W0.5390.72
132_E145_E0.5390.72
108_D194_I0.5390.72
238_W277_M0.5390.72
231_A238_W0.5380.72
223_L229_V0.5380.72
49_T53_W0.5370.72
253_S261_M0.5370.72
57_D220_M0.5350.72
261_M265_I0.5350.72
151_L154_I0.5340.71
21_L136_F0.5330.71
171_L235_R0.5330.71
56_I161_F0.5320.71
107_F111_Y0.5310.71
43_F117_S0.5300.71
123_L208_G0.5280.71
19_K22_L0.5280.71
27_E135_A0.5270.70
27_E140_G0.5270.70
220_M272_L0.5250.70
119_Y122_L0.5250.70
163_G214_F0.5240.70
134_W138_A0.5240.70
127_P163_G0.5230.70
277_M280_S0.5220.70
229_V276_G0.5220.70
251_I257_T0.5220.70
106_L179_I0.5210.70
54_I200_I0.5200.69
277_M284_E0.5180.69
242_V245_S0.5180.69
19_K27_E0.5180.69
146_K150_K0.5170.69
271_S282_L0.5170.69
57_D203_T0.5160.69
176_F193_T0.5160.69
167_A211_G0.5150.69
236_N243_L0.5140.68
95_L219_I0.5120.68
249_A260_V0.5120.68
237_Y244_V0.5110.68
132_E139_P0.5100.68
30_I236_N0.5100.68
263_T266_G0.5080.68
115_Y119_Y0.5070.67
23_D26_R0.5050.67
243_L250_W0.5050.67
134_W171_L0.5040.67
22_L26_R0.5040.67
96_P99_T0.5020.67
148_I226_L0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4httA 1 0.7716 100 0.175 Contact Map
4b4aA 1 0.7716 100 0.192 Contact Map
4ui9I 1 0.0415 13.3 0.963 Contact Map
2mfrA 1 0.1522 11.1 0.964 Contact Map
4p02A 1 0.173 11 0.964 Contact Map
2m7xA 1 0.1038 10.2 0.965 Contact Map
3o7qA 1 0.6782 9.3 0.966 Contact Map
2ww9B 1 0.1557 7.8 0.967 Contact Map
2cfqA 1 0.7197 7.2 0.967 Contact Map
4cbcA 3 0.0035 6.5 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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