GREMLIN Database
Q97UA9 - Uncharacterized protein
UniProt: Q97UA9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 205 (176)
Sequences: 3796 (2607)
Seq/√Len: 196.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
91_I125_I3.8371.00
106_L112_K3.4321.00
87_T116_K3.4221.00
161_L165_G2.9831.00
65_V79_I2.8661.00
28_E108_P2.6591.00
89_H136_V2.5841.00
127_L156_I2.5391.00
70_V90_S2.4411.00
57_I79_I2.4141.00
123_R152_F2.3361.00
98_E119_I2.3081.00
149_N152_F2.2361.00
50_R78_I2.2181.00
89_H118_Y2.1941.00
95_E99_N2.1781.00
138_I168_L2.1201.00
156_I159_D2.0541.00
83_L86_G1.9771.00
64_I87_T1.9391.00
143_S153_E1.8971.00
83_L88_L1.8431.00
66_I136_V1.8091.00
23_W81_S1.8071.00
144_E149_N1.7651.00
139_F161_L1.7351.00
139_F157_A1.7101.00
120_G125_I1.6881.00
77_T111_L1.6711.00
57_I138_I1.6491.00
98_E117_L1.6431.00
118_Y125_I1.6371.00
105_F115_W1.6351.00
13_E17_V1.6181.00
154_L169_I1.5521.00
76_S88_L1.5421.00
54_Y82_A1.5401.00
121_R124_D1.5331.00
32_G108_P1.5261.00
64_I134_G1.4041.00
94_R97_L1.3811.00
123_R149_N1.3631.00
59_Y166_I1.3381.00
32_G103_V1.3291.00
188_K192_L1.3011.00
150_V169_I1.2981.00
141_H167_L1.2951.00
22_Y30_N1.2841.00
103_V108_P1.2841.00
92_D98_E1.2811.00
145_H150_V1.2721.00
191_E194_N1.2551.00
43_Y71_G1.2461.00
169_I194_N1.2281.00
135_K162_R1.2191.00
77_T109_E1.2041.00
151_T155_N1.2031.00
33_I44_A1.1931.00
22_Y26_A1.1851.00
190_Y194_N1.1481.00
54_Y78_I1.1421.00
79_I88_L1.1321.00
102_Q119_I1.1291.00
65_V88_L1.1281.00
33_I72_P1.1261.00
45_L50_R1.1181.00
57_I82_A1.1161.00
89_H116_K1.1111.00
54_Y58_K1.0991.00
29_I33_I1.0971.00
103_V106_L1.0971.00
95_E119_I1.0971.00
23_W26_A1.0951.00
105_F111_L1.0861.00
27_E31_N1.0501.00
76_S105_F1.0451.00
111_L114_K1.0431.00
56_I168_L1.0411.00
28_E32_G1.0401.00
27_E81_S1.0391.00
145_H170_D1.0391.00
29_I109_E1.0381.00
76_S79_I1.0321.00
98_E102_Q1.0301.00
45_L75_S1.0301.00
93_V121_R1.0211.00
162_R165_G1.0161.00
62_P86_G1.0111.00
16_N48_T1.0081.00
186_G189_L1.0071.00
68_T91_I0.9901.00
102_Q106_L0.9871.00
152_F155_N0.9861.00
144_E148_E0.9830.99
105_F117_L0.9720.99
189_L192_L0.9700.99
185_K188_K0.9610.99
141_H169_I0.9520.99
53_L168_L0.9470.99
99_N103_V0.9420.99
50_R74_V0.9420.99
22_Y27_E0.9390.99
64_I136_V0.9260.99
51_Y54_Y0.9220.99
155_N158_W0.9130.99
80_L115_W0.9110.99
84_E114_K0.9010.99
64_I135_K0.8990.99
137_D162_R0.8950.99
25_E28_E0.8900.99
24_N27_E0.8840.99
57_I60_Y0.8830.99
185_K192_L0.8830.99
188_K191_E0.8830.99
57_I65_V0.8790.99
67_E88_L0.8720.99
80_L111_L0.8690.99
32_G104_G0.8630.99
121_R125_I0.8620.99
125_I128_D0.8530.99
80_L88_L0.8520.99
177_A180_Y0.8500.99
173_D178_P0.8480.99
90_S115_W0.8470.98
65_V83_L0.8470.98
186_G190_Y0.8470.98
53_L57_I0.8460.98
45_L49_K0.8440.98
36_V40_S0.8400.98
118_Y128_D0.8400.98
29_I77_T0.8340.98
154_L158_W0.8330.98
34_K47_E0.8320.98
64_I89_H0.8290.98
190_Y193_T0.8250.98
55_S59_Y0.8240.98
189_L193_T0.8210.98
55_S166_I0.8190.98
77_T105_F0.8150.98
12_K16_N0.8120.98
139_F165_G0.8110.98
124_D128_D0.8020.98
135_K163_N0.8000.98
91_I121_R0.7970.98
161_L167_L0.7900.98
185_K190_Y0.7860.98
100_G103_V0.7860.98
174_F188_K0.7830.97
54_Y81_S0.7820.97
145_H171_N0.7780.97
57_I62_P0.7700.97
91_I118_Y0.7630.97
120_G124_D0.7610.97
109_E112_K0.7560.97
188_K194_N0.7520.97
133_L160_Y0.7500.97
53_L79_I0.7450.97
186_G191_E0.7360.96
60_Y162_R0.7340.96
15_F19_L0.7290.96
183_K186_G0.7280.96
85_R114_K0.7280.96
14_I18_D0.7280.96
102_Q112_K0.7210.96
26_A29_I0.7180.96
75_S140_L0.7150.96
75_S142_D0.7100.96
66_I139_F0.7090.96
51_Y78_I0.7060.95
70_V105_F0.7040.95
62_P65_V0.7040.95
70_V76_S0.7020.95
79_I90_S0.6990.95
13_E16_N0.6970.95
66_I157_A0.6910.95
70_V117_L0.6900.95
36_V100_G0.6820.94
90_S105_F0.6730.94
92_D117_L0.6680.94
83_L114_K0.6670.94
76_S80_L0.6650.94
49_K172_L0.6620.94
16_N20_S0.6620.94
45_L53_L0.6610.94
50_R53_L0.6570.93
157_A160_Y0.6530.93
188_K193_T0.6500.93
56_I59_Y0.6480.93
129_L134_G0.6440.93
62_P137_D0.6400.92
126_L157_A0.6370.92
36_V72_P0.6360.92
140_L171_N0.6350.92
25_E104_G0.6350.92
102_Q117_L0.6320.92
80_L114_K0.6300.92
141_H153_E0.6290.92
187_V191_E0.6230.91
48_T52_V0.6210.91
186_G192_L0.6190.91
65_V138_I0.6180.91
141_H157_A0.6170.91
52_V56_I0.6160.91
140_L170_D0.6160.91
149_N153_E0.6130.91
123_R156_I0.6090.90
104_G108_P0.6090.90
28_E31_N0.6060.90
92_D101_K0.6060.90
67_E76_S0.6050.90
123_R153_E0.6050.90
41_F71_G0.6040.90
12_K15_F0.6040.90
18_D22_Y0.6030.90
32_G37_L0.6020.90
49_K53_L0.6000.90
150_V170_D0.5990.90
93_V119_I0.5970.90
150_V171_N0.5960.89
89_H134_G0.5920.89
144_E153_E0.5860.89
158_W161_L0.5860.89
74_V78_I0.5850.89
15_F18_D0.5840.89
124_D127_L0.5830.88
78_I82_A0.5820.88
77_T81_S0.5810.88
184_Q187_V0.5790.88
54_Y57_I0.5740.88
76_S90_S0.5730.88
189_L194_N0.5710.87
118_Y129_L0.5700.87
55_S58_K0.5670.87
56_I166_I0.5650.87
187_V193_T0.5630.87
43_Y145_H0.5620.87
141_H154_L0.5610.87
87_T134_G0.5550.86
187_V190_Y0.5550.86
42_R71_G0.5540.86
159_D163_N0.5520.86
175_T178_P0.5480.85
185_K191_E0.5460.85
79_I138_I0.5400.84
174_F178_P0.5390.84
180_Y192_L0.5390.84
122_S153_E0.5370.84
78_I81_S0.5350.84
126_L160_Y0.5320.84
157_A161_L0.5310.83
60_Y138_I0.5290.83
42_R175_T0.5260.83
182_T193_T0.5240.83
45_L140_L0.5230.82
125_I129_L0.5190.82
26_A30_N0.5170.82
67_E170_D0.5130.81
68_T122_S0.5110.81
13_E27_E0.5080.81
152_F156_I0.5070.81
187_V194_N0.5030.80
125_I134_G0.5030.80
50_R82_A0.5010.80
121_R149_N0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tosA 5 0.9024 100 0.472 Contact Map
3tr6A 2 0.961 100 0.484 Contact Map
1suiA 2 0.9659 100 0.523 Contact Map
2hnkA 2 0.9561 100 0.526 Contact Map
3c3yA 2 0.961 99.9 0.53 Contact Map
4ymhA 2 0.9659 99.9 0.53 Contact Map
3r3hA 2 0.9463 99.9 0.533 Contact Map
3cbgA 2 0.9512 99.9 0.54 Contact Map
3dr5A 2 0.9073 99.9 0.544 Contact Map
2gpyA 2 0.8049 99.9 0.544 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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