GREMLIN Database
Q97UA8 - Uncharacterized protein
UniProt: Q97UA8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 174 (165)
Sequences: 228 (195)
Seq/√Len: 15.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
65_I83_G4.5411.00
19_Q56_S4.1101.00
41_I158_V3.7321.00
53_F57_I3.6521.00
41_I154_E3.3620.99
112_G133_T3.3410.99
47_G95_N2.9530.98
149_G152_G2.8890.97
115_A126_W2.6590.96
88_L103_A2.6100.95
108_F158_V2.2250.89
20_F23_F2.1140.87
20_F24_F2.0940.86
19_Q23_F2.0510.85
39_N43_D1.9290.81
126_W164_W1.8830.79
70_L128_I1.8770.79
24_F159_Y1.8540.78
80_F84_L1.8430.78
58_V62_I1.8130.77
66_I134_L1.7550.74
42_S100_H1.7390.73
25_I30_L1.7360.73
59_I163_I1.5890.66
125_F129_L1.5880.66
58_V90_G1.5490.64
67_A78_L1.5240.63
69_I106_I1.4800.61
136_S157_I1.4670.60
89_V154_E1.4610.60
68_S80_F1.4300.58
59_I169_A1.4210.57
140_F149_G1.4180.57
108_F160_P1.4130.57
95_N140_F1.4060.57
53_F103_A1.4030.56
57_I115_A1.3730.55
53_F86_A1.3640.54
24_F36_V1.3630.54
52_I56_S1.3490.53
29_I33_N1.3360.53
12_L132_A1.3350.53
16_G73_A1.3330.52
115_A162_I1.3110.51
108_F157_I1.3100.51
61_G90_G1.3100.51
13_I67_A1.3060.51
30_L33_N1.2610.48
92_F116_L1.2560.48
11_Y80_F1.2490.48
27_S102_I1.2480.48
156_M167_S1.2460.48
33_N67_A1.2440.47
132_A135_V1.2250.46
73_A116_L1.2210.46
70_L92_F1.2120.46
41_I108_F1.2070.45
39_N56_S1.1900.44
84_L138_I1.1870.44
104_S112_G1.1760.44
111_G161_E1.1690.43
13_I64_V1.1580.43
9_S170_T1.1490.42
103_A106_I1.1480.42
66_I131_I1.1480.42
67_A93_P1.1370.41
21_L79_V1.1310.41
152_G172_L1.1240.41
60_M165_G1.0930.39
9_S13_I1.0920.39
65_I84_L1.0850.39
85_G106_I1.0810.38
102_I141_I1.0480.37
59_I65_I1.0450.36
46_V131_I1.0430.36
81_L84_L1.0190.35
42_S104_S1.0120.35
35_S166_I1.0090.35
66_I72_R1.0070.35
59_I166_I1.0040.34
9_S115_A1.0020.34
74_N128_I0.9970.34
94_E125_F0.9810.33
53_F88_L0.9780.33
24_F34_Y0.9710.33
85_G103_A0.9630.32
65_I106_I0.9590.32
116_L131_I0.9550.32
77_P122_R0.9490.32
93_P160_P0.9480.32
90_G105_L0.9450.31
84_L91_I0.9450.31
81_L135_V0.9360.31
83_G91_I0.9280.31
69_I157_I0.9210.30
157_I160_P0.9190.30
41_I125_F0.9150.30
40_Y43_D0.9060.30
17_V148_L0.8990.29
58_V166_I0.8970.29
85_G104_S0.8950.29
16_G139_L0.8930.29
85_G111_G0.8890.29
10_G17_V0.8880.29
71_L92_F0.8870.29
109_L121_K0.8820.28
36_V53_F0.8730.28
26_I160_P0.8700.28
76_S127_G0.8600.27
115_A170_T0.8590.27
25_I136_S0.8580.27
32_P172_L0.8550.27
18_S169_A0.8470.27
24_F103_A0.8460.27
88_L170_T0.8450.27
11_Y125_F0.8360.26
74_N87_A0.8300.26
8_V21_L0.8270.26
112_G158_V0.8250.26
62_I131_I0.8190.26
20_F140_F0.8050.25
108_F154_E0.8040.25
12_L21_L0.7950.25
148_L152_G0.7940.25
62_I145_Y0.7920.24
15_V92_F0.7920.24
77_P138_I0.7850.24
26_I90_G0.7800.24
28_E36_V0.7800.24
117_V167_S0.7800.24
56_S94_E0.7760.24
79_V114_G0.7740.24
12_L33_N0.7710.24
58_V110_F0.7640.23
85_G89_V0.7640.23
28_E31_Y0.7630.23
128_I132_A0.7600.23
102_I125_F0.7590.23
9_S24_F0.7560.23
39_N63_L0.7550.23
130_G134_L0.7470.23
113_I132_A0.7370.22
135_V163_I0.7310.22
112_G130_G0.7260.22
128_I161_E0.7250.22
99_P135_V0.7190.22
56_S164_W0.7160.21
36_V159_Y0.7140.21
44_L155_R0.7120.21
89_V104_S0.7120.21
12_L125_F0.7070.21
59_I142_L0.7070.21
26_I30_L0.7050.21
85_G158_V0.7040.21
64_V165_G0.7010.21
61_G83_G0.6960.21
90_G97_G0.6950.21
60_M160_P0.6940.21
56_S110_F0.6910.21
94_E157_I0.6880.20
40_Y158_V0.6860.20
120_I170_T0.6840.20
42_S154_E0.6840.20
84_L116_L0.6820.20
66_I82_V0.6820.20
118_T129_L0.6820.20
59_I78_L0.6780.20
86_A108_F0.6770.20
40_Y94_E0.6740.20
48_K67_A0.6710.20
13_I71_L0.6680.20
113_I117_V0.6660.20
94_E115_A0.6610.19
87_A119_S0.6600.19
62_I99_P0.6530.19
137_L153_L0.6420.19
89_V129_L0.6420.19
91_I146_G0.6390.19
119_S127_G0.6350.19
43_D83_G0.6340.18
129_L163_I0.6310.18
76_S116_L0.6300.18
13_I19_Q0.6260.18
10_G92_F0.6250.18
133_T169_A0.6250.18
86_A158_V0.6250.18
18_S79_V0.6220.18
108_F112_G0.6210.18
33_N172_L0.6200.18
62_I117_V0.6160.18
111_G169_A0.6150.18
15_V131_I0.6150.18
130_G154_E0.6140.18
24_F53_F0.6130.18
134_L163_I0.6130.18
106_I172_L0.6120.18
47_G67_A0.6080.18
8_V122_R0.6070.18
163_I167_S0.6040.17
73_A80_F0.6020.17
97_G169_A0.5990.17
9_S12_L0.5990.17
85_G159_Y0.5980.17
22_L70_L0.5980.17
78_L109_L0.5910.17
47_G108_F0.5910.17
10_G112_G0.5850.17
83_G167_S0.5850.17
24_F57_I0.5800.17
113_I135_V0.5780.17
66_I73_A0.5770.17
29_I112_G0.5720.16
113_I152_G0.5650.16
101_L169_A0.5600.16
139_L143_K0.5590.16
111_G158_V0.5560.16
20_F86_A0.5550.16
17_V20_F0.5540.16
36_V133_T0.5530.16
46_V122_R0.5520.16
28_E133_T0.5520.16
13_I164_W0.5510.16
89_V94_E0.5480.16
104_S107_T0.5460.16
145_Y153_L0.5460.16
88_L99_P0.5450.16
29_I138_I0.5430.16
40_Y103_A0.5430.16
46_V95_N0.5400.15
54_N95_N0.5360.15
117_V127_G0.5360.15
25_I105_L0.5350.15
80_F139_L0.5330.15
100_H155_R0.5320.15
35_S162_I0.5240.15
61_G155_R0.5240.15
40_Y108_F0.5230.15
38_Y138_I0.5230.15
20_F88_L0.5180.15
64_V149_G0.5150.15
61_G91_I0.5090.15
39_N118_T0.5070.15
113_I170_T0.5050.14
102_I161_E0.5050.14
58_V127_G0.5040.14
22_L83_G0.5030.14
131_I137_L0.5030.14
77_P81_L0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pe9A 1 0.3333 1.3 0.967 Contact Map
4kppA 1 0.3736 1.3 0.967 Contact Map
2v2fA 1 0.0862 1 0.969 Contact Map
1pclA 1 0.3276 1 0.969 Contact Map
1gff3 1 0.069 0.9 0.97 Contact Map
3x29A 1 0.3736 0.8 0.97 Contact Map
3oufA 4 0.5172 0.8 0.971 Contact Map
4pypA 1 0.9368 0.7 0.972 Contact Map
1jb0M 1 0.1782 0.7 0.972 Contact Map
2ww8A 1 0.2241 0.7 0.973 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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