GREMLIN Database
Q97UA6 - Uncharacterized protein
UniProt: Q97UA6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 116 (104)
Sequences: 1956 (1259)
Seq/√Len: 123.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_Y50_R2.9741.00
23_R49_L2.7171.00
26_K45_D2.5761.00
27_C41_C2.4941.00
27_C38_C2.3791.00
78_E96_K2.3711.00
57_V97_V2.3711.00
25_R47_E2.3311.00
8_S12_K2.2731.00
54_I78_E2.2631.00
38_C41_C2.2311.00
76_E82_K2.1261.00
55_G97_V2.0561.00
13_I20_P2.0051.00
24_C27_C1.9711.00
31_F39_P1.8891.00
57_V91_V1.8821.00
24_C41_C1.8341.00
17_G103_S1.7651.00
24_C38_C1.7581.00
29_N40_K1.7251.00
21_Y51_S1.6821.00
25_R45_D1.6631.00
54_I98_K1.6631.00
53_G79_E1.6321.00
22_I31_F1.6311.00
9_T48_V1.6221.00
57_V73_G1.5831.00
31_F46_L1.5161.00
56_K76_E1.4491.00
75_V85_C1.4161.00
103_S106_D1.4011.00
73_G87_F1.3891.00
17_G101_I1.3481.00
58_F76_E1.3121.00
60_W93_I1.3031.00
20_P50_R1.2981.00
30_T49_L1.2551.00
14_V101_I1.2130.99
23_R30_T1.2080.99
12_K16_S1.2080.99
21_Y81_F1.1860.99
56_K96_K1.1830.99
52_S79_E1.1350.99
60_W91_V1.1170.99
22_I46_L1.0930.99
54_I96_K1.0920.99
52_S78_E1.0600.98
62_K71_I1.0450.98
57_V95_D1.0080.98
43_S46_L1.0020.98
87_F91_V0.9730.97
17_G108_K0.9510.97
15_Q108_K0.9480.97
56_K94_G0.9460.97
55_G75_V0.9170.96
59_S74_I0.9150.96
77_L81_F0.9150.96
30_T51_S0.9130.96
10_Y14_V0.8900.95
74_I84_Y0.8870.95
73_G85_C0.8590.94
90_D95_D0.8560.94
26_K43_S0.8540.94
92_E95_D0.8440.94
31_F35_R0.8360.93
37_L42_G0.8350.93
23_R28_M0.8340.93
88_A100_K0.8170.93
9_T13_I0.7960.92
7_Y11_D0.7930.91
63_I70_S0.7860.91
61_T72_Y0.7810.91
60_W71_I0.7690.90
10_Y13_I0.7660.90
22_I32_F0.7650.90
71_I91_V0.7650.90
9_T12_K0.7600.90
104_L107_G0.7580.90
6_I30_T0.7570.89
37_L44_R0.7540.89
35_R39_P0.7530.89
62_K73_G0.7490.89
14_V99_V0.7460.89
60_W87_F0.7380.88
6_I36_N0.7320.88
103_S108_K0.7270.87
66_K69_T0.7260.87
21_Y49_L0.7250.87
58_F82_K0.7200.87
13_I16_S0.7130.86
64_F69_T0.7120.86
13_I18_Y0.7100.86
29_N39_P0.7090.86
21_Y30_T0.7070.86
19_L51_S0.6960.85
105_E108_K0.6920.85
23_R47_E0.6820.84
91_V97_V0.6720.83
55_G85_C0.6670.83
37_L46_L0.6590.82
70_S86_N0.6450.80
55_G83_I0.6440.80
88_A102_N0.6440.80
76_E81_F0.6430.80
25_R41_C0.6390.80
53_G99_V0.6310.79
51_S81_F0.6280.79
74_I82_K0.6220.78
16_S20_P0.6210.78
21_Y77_L0.6150.77
42_G68_D0.6140.77
103_S107_G0.6070.76
22_I48_V0.6030.76
12_K15_Q0.6010.76
15_Q107_G0.5820.73
80_G85_C0.5780.73
56_K92_E0.5780.73
66_K95_D0.5730.72
102_N107_G0.5700.72
24_C43_S0.5690.72
24_C45_D0.5670.71
14_V108_K0.5660.71
26_K47_E0.5640.71
42_G84_Y0.5620.71
57_V93_I0.5600.70
59_S95_D0.5600.70
33_Y81_F0.5550.70
91_V95_D0.5530.69
66_K70_S0.5520.69
38_C43_S0.5510.69
51_S77_L0.5460.69
64_F104_L0.5440.68
19_L99_V0.5380.67
71_I86_N0.5340.67
65_R68_D0.5320.67
21_Y48_V0.5290.66
67_N105_E0.5290.66
85_C88_A0.5270.66
28_M49_L0.5260.66
35_R84_Y0.5260.66
53_G81_F0.5250.66
75_V97_V0.5250.66
19_L32_F0.5240.65
60_W95_D0.5240.65
40_K44_R0.5200.65
34_V48_V0.5200.65
32_F83_I0.5170.64
10_Y74_I0.5120.64
54_I79_E0.5100.63
32_F66_K0.5060.63
61_T64_F0.5030.62
57_V94_G0.5030.62
63_I66_K0.5020.62
13_I59_S0.5010.62
104_L109_Y0.5000.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3irbA 3 0.9569 100 0.283 Contact Map
2kdxA 1 0.5517 84.4 0.891 Contact Map
5aunA 1 0.5517 83.3 0.893 Contact Map
2lcqA 1 0.431 82.8 0.893 Contact Map
1ltlA 4 0.9224 66.8 0.907 Contact Map
4aybP 1 0.3276 61.2 0.91 Contact Map
3pwfA 4 0.4397 59.5 0.911 Contact Map
1yuzA 2 0.4397 57.9 0.912 Contact Map
2conA 1 0.4655 57.6 0.912 Contact Map
4d02A 2 0.0259 56.4 0.913 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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