GREMLIN Database
Q97UA5 - Acetyl-CoA c-acetyltransferase (Acetoacetyl-CoA thiolase) (AcaB-10)
UniProt: Q97UA5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 385 (345)
Sequences: 15257 (8571)
Seq/√Len: 461.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
177_R181_N3.5731.00
231_S235_L3.5251.00
170_Q293_E3.4761.00
101_G104_I3.1491.00
176_V196_I3.0611.00
89_I341_L2.9491.00
344_A356_Q2.9301.00
229_R233_S2.8951.00
27_S30_E2.8761.00
231_S234_A2.7631.00
177_R180_F2.7521.00
184_Q188_A2.7071.00
162_Y207_Y2.6611.00
25_V105_L2.5501.00
96_I226_V2.5481.00
264_V268_K2.4901.00
5_F342_E2.4871.00
6_A31_M2.4131.00
103_T227_S2.3481.00
28_A225_V2.3461.00
238_I345_L2.2291.00
96_I228_K2.1981.00
92_A104_I2.1691.00
167_T170_Q2.1551.00
242_G268_K2.1131.00
187_K192_D2.1121.00
21_L44_L2.0861.00
264_V371_W2.0821.00
35_D38_Y2.0741.00
3_T227_S2.0621.00
227_S232_K2.0551.00
348_L353_D2.0481.00
277_A322_T2.0091.00
169_E173_L1.9461.00
222_H338_G1.8771.00
38_Y235_L1.8551.00
270_L355_H1.8521.00
160_H166_S1.8491.00
186_S190_F1.8231.00
292_V299_E1.8221.00
323_G347_Q1.8051.00
199_V212_L1.8031.00
242_G264_V1.8001.00
227_S231_S1.7991.00
292_V320_I1.7791.00
183_M190_F1.7591.00
262_P266_S1.7411.00
102_E228_K1.7201.00
347_Q351_M1.7151.00
28_A32_A1.7101.00
198_Q201_K1.6931.00
275_I278_F1.6891.00
276_D353_D1.6871.00
102_E231_S1.6771.00
261_T359_G1.6631.00
111_K114_E1.6621.00
228_K231_S1.6581.00
272_N278_F1.6441.00
76_Q91_R1.6381.00
163_L252_P1.6371.00
239_D373_R1.6341.00
224_F338_G1.6301.00
44_L107_I1.6291.00
95_A101_G1.6231.00
176_V180_F1.6171.00
270_L275_I1.6111.00
183_M187_K1.6111.00
4_G32_A1.6071.00
94_K100_E1.6061.00
154_A206_S1.6051.00
259_V262_P1.5941.00
92_A226_V1.5881.00
103_T231_S1.5601.00
21_L64_V1.5591.00
173_L196_I1.5511.00
277_A347_Q1.5411.00
173_L177_R1.5411.00
19_E67_Y1.5401.00
177_R299_E1.5351.00
25_V64_V1.5281.00
180_F193_P1.5101.00
26_F30_E1.5061.00
347_Q350_D1.4731.00
24_T223_V1.4731.00
244_G263_A1.4631.00
278_F357_V1.4631.00
345_L349_N1.4601.00
24_T221_F1.4591.00
180_F184_Q1.4581.00
27_S31_M1.4471.00
90_H370_G1.4401.00
244_G264_V1.4141.00
270_L371_W1.4081.00
263_A266_S1.3861.00
4_G28_A1.3601.00
275_I371_W1.3601.00
230_S234_A1.3481.00
265_E272_N1.3451.00
158_N207_Y1.3061.00
298_A319_P1.3061.00
22_A67_Y1.3051.00
354_G373_R1.3041.00
255_L258_I1.2981.00
183_M193_P1.2971.00
90_H243_Y1.2911.00
10_Y335_M1.2891.00
60_F109_G1.2881.00
166_S171_R1.2831.00
322_T347_Q1.2741.00
72_P249_P1.2721.00
248_W255_L1.2701.00
170_Q173_L1.2691.00
40_D101_G1.2561.00
262_P294_D1.2531.00
342_E346_L1.2481.00
46_Y49_G1.2471.00
89_I224_F1.2451.00
246_A259_V1.2421.00
83_A368_I1.2381.00
44_L223_V1.2311.00
341_L372_N1.2311.00
38_Y231_S1.2261.00
271_L274_R1.2251.00
168_D210_H1.2231.00
357_V371_W1.2221.00
39_V103_T1.2101.00
261_T357_V1.2001.00
105_L225_V1.1961.00
23_D27_S1.1901.00
260_Y369_G1.1891.00
118_K139_R1.1841.00
159_R163_L1.1771.00
155_L207_Y1.1721.00
5_F346_L1.1701.00
174_I288_V1.1631.00
241_L373_R1.1461.00
43_Y104_I1.1451.00
229_R232_K1.1371.00
183_M192_D1.1361.00
174_I289_M1.1361.00
10_Y329_T1.1301.00
275_I355_H1.1271.00
40_D102_E1.1241.00
86_L341_L1.1131.00
240_I370_G1.1131.00
97_K100_E1.1101.00
242_G267_S1.1021.00
339_V343_E1.0881.00
100_E267_S1.0871.00
176_V199_V1.0861.00
42_I65_A1.0841.00
5_F345_L1.0831.00
92_A106_C1.0821.00
87_S91_R1.0771.00
277_A351_M1.0701.00
246_A263_A1.0681.00
83_A362_V1.0651.00
229_R239_D1.0601.00
196_I200_L1.0591.00
195_T198_Q1.0581.00
45_T84_S1.0521.00
6_A27_S1.0501.00
138_D141_F1.0461.00
89_I226_V1.0421.00
252_P255_L1.0401.00
25_V70_I1.0381.00
276_D319_P1.0371.00
166_S289_M1.0371.00
194_L199_V1.0361.00
272_N275_I1.0351.00
179_R190_F1.0311.00
94_K98_A1.0291.00
202_S212_L1.0251.00
158_N162_Y1.0231.00
276_D348_L1.0151.00
16_S19_E1.0151.00
154_A205_V1.0121.00
164_F255_L1.0081.00
38_Y234_A1.0081.00
183_M191_K1.0031.00
22_A26_F1.0001.00
137_F140_L0.9961.00
323_G350_D0.9961.00
180_F183_M0.9941.00
344_A358_K0.9911.00
124_A129_Y0.9901.00
268_K371_W0.9881.00
322_T351_M0.9841.00
163_L251_M0.9821.00
4_G31_M0.9761.00
29_L70_I0.9751.00
275_I362_V0.9741.00
222_H335_M0.9701.00
169_E200_L0.9621.00
136_P139_R0.9561.00
10_Y218_I0.9541.00
24_T27_S0.9521.00
93_Y240_I0.9511.00
344_A363_V0.9511.00
263_A267_S0.9501.00
202_S210_H0.9501.00
278_F297_L0.9411.00
241_L355_H0.9371.00
297_L320_I0.9351.00
9_L23_D0.9321.00
93_Y97_K0.9311.00
261_T295_I0.9291.00
29_L34_L0.9281.00
188_A350_D0.9221.00
203_P211_L0.9221.00
46_Y56_N0.9161.00
125_I129_Y0.9161.00
270_L362_V0.9131.00
8_S20_L0.9121.00
161_K286_I0.9111.00
145_N149_P0.9081.00
141_F145_N0.9061.00
8_S24_T0.9051.00
70_I73_K0.9021.00
2_I372_N0.8991.00
255_L290_L0.8981.00
146_D149_P0.8941.00
277_A344_A0.8931.00
8_S23_D0.8921.00
176_V193_P0.8851.00
242_G371_W0.8851.00
106_C224_F0.8831.00
43_Y92_A0.8821.00
275_I357_V0.8811.00
164_F294_D0.8761.00
10_Y339_V0.8711.00
43_Y88_M0.8701.00
159_R162_Y0.8681.00
222_H342_E0.8661.00
5_F224_F0.8631.00
280_L359_G0.8631.00
160_H255_L0.8611.00
28_A105_L0.8611.00
326_S336_S0.8591.00
340_I358_K0.8551.00
38_Y103_T0.8541.00
255_L294_D0.8541.00
172_A213_E0.8531.00
24_T28_A0.8491.00
160_H290_L0.8471.00
43_Y76_Q0.8421.00
236_T349_N0.8401.00
41_G95_A0.8381.00
16_S114_E0.8321.00
100_E243_Y0.8311.00
44_L61_T0.8291.00
344_A365_L0.8281.00
66_Q72_P0.8241.00
95_A100_E0.8231.00
285_T327_L0.8231.00
258_I294_D0.8161.00
248_W256_D0.8161.00
230_S233_S0.8141.00
204_L207_Y0.8141.00
88_M338_G0.8141.00
292_V297_L0.8141.00
145_N150_V0.8131.00
144_L148_N0.8131.00
21_L107_I0.8121.00
80_Y87_S0.8111.00
177_R300_K0.8071.00
86_L370_G0.8021.00
181_N184_Q0.8011.00
147_L150_V0.7981.00
55_A114_E0.7981.00
194_L198_Q0.7961.00
17_T109_G0.7961.00
169_E196_I0.7951.00
323_G351_M0.7931.00
182_A190_F0.7921.00
42_I73_K0.7901.00
288_V292_V0.7891.00
186_S192_D0.7871.00
39_V105_L0.7831.00
105_L223_V0.7801.00
170_Q289_M0.7781.00
262_P295_I0.7761.00
213_E285_T0.7751.00
240_I243_Y0.7721.00
29_L39_V0.7691.00
341_L370_G0.7651.00
142_R147_L0.7641.00
28_A223_V0.7621.00
182_A186_S0.7611.00
91_R95_A0.7611.00
143_G146_D0.7591.00
352_A355_H0.7591.00
157_A286_I0.7591.00
40_D263_A0.7541.00
184_Q187_K0.7511.00
227_S235_L0.7471.00
91_R94_K0.7461.00
102_E234_A0.7451.00
26_F36_K0.7451.00
94_K97_K0.7371.00
6_A24_T0.7371.00
355_H373_R0.7351.00
197_E201_K0.7301.00
129_Y134_L0.7301.00
194_L212_L0.7301.00
176_V195_T0.7291.00
249_P252_P0.7281.00
135_T138_D0.7281.00
248_W259_V0.7261.00
190_F193_P0.7251.00
41_G245_E0.7191.00
23_D26_F0.7181.00
135_T139_R0.7161.00
40_D104_I0.7151.00
113_T219_D0.7151.00
265_E270_L0.7141.00
155_L159_R0.7101.00
258_I262_P0.7071.00
273_G296_G0.7071.00
29_L36_K0.7051.00
241_L268_K0.7051.00
348_L356_Q0.7041.00
280_L291_Q0.7031.00
47_L333_A0.6971.00
290_L294_D0.6971.00
176_V194_L0.6971.00
179_R183_M0.6951.00
261_T369_G0.6941.00
355_H371_W0.6921.00
133_S137_F0.6911.00
261_T280_L0.6911.00
362_V368_I0.6911.00
232_K235_L0.6901.00
145_N148_N0.6851.00
46_Y60_F0.6841.00
270_L274_R0.6831.00
70_I105_L0.6831.00
74_F245_E0.6821.00
273_G319_P0.6781.00
272_N297_L0.6781.00
103_T235_L0.6771.00
89_I106_C0.6711.00
228_K232_K0.6711.00
32_A225_V0.6711.00
90_H368_I0.6701.00
157_A161_K0.6691.00
142_R145_N0.6691.00
209_L214_I0.6671.00
95_A104_I0.6671.00
25_V68_L0.6661.00
130_P133_S0.6661.00
224_F342_E0.6621.00
276_D355_H0.6621.00
176_V198_Q0.6611.00
126_D130_P0.6611.00
144_L147_L0.6591.00
43_Y91_R0.6591.00
6_A28_A0.6581.00
21_L109_G0.6571.00
136_P140_L0.6561.00
264_V357_V0.6541.00
166_S170_Q0.6541.00
102_E267_S0.6491.00
179_R327_L0.6481.00
182_A328_N0.6471.00
172_A196_I0.6471.00
131_N140_L0.6441.00
29_L33_G0.6431.00
36_K71_R0.6431.00
18_F67_Y0.6421.00
25_V223_V0.6381.00
80_Y245_E0.6371.00
288_V320_I0.6371.00
160_H164_F0.6371.00
226_V240_I0.6350.99
244_G267_S0.6330.99
172_A200_L0.6310.99
179_R193_P0.6310.99
19_E22_A0.6300.99
329_T339_V0.6290.99
26_F68_L0.6290.99
253_T257_E0.6280.99
22_A68_L0.6260.99
41_G80_Y0.6240.99
3_T232_K0.6240.99
156_V253_T0.6240.99
76_Q87_S0.6200.99
129_Y132_V0.6190.99
259_V263_A0.6180.99
205_V211_L0.6170.99
134_L138_D0.6170.99
266_S271_L0.6170.99
26_F69_G0.6160.99
190_F216_Y0.6160.99
349_N352_A0.6160.99
157_A209_L0.6150.99
78_F91_R0.6140.99
59_F366_N0.6130.99
134_L137_F0.6100.99
261_T272_N0.6090.99
112_A333_A0.6090.99
44_L64_V0.6090.99
92_A101_G0.6060.99
25_V29_L0.6050.99
276_D354_G0.6040.99
248_W252_P0.6040.99
141_F152_D0.6040.99
166_S293_E0.6030.99
97_K243_Y0.6020.99
278_F359_G0.6010.99
65_A75_T0.6000.99
142_R148_N0.5990.99
39_V70_I0.5980.99
262_P296_G0.5980.99
341_L358_K0.5970.99
86_L358_K0.5970.99
55_A118_K0.5930.99
345_L372_N0.5920.99
287_T291_Q0.5920.99
143_G147_L0.5900.99
29_L32_A0.5890.99
107_I223_V0.5890.99
261_T291_Q0.5860.99
41_G101_G0.5820.99
183_M186_S0.5810.99
49_G77_I0.5810.99
173_L299_E0.5810.99
64_V68_L0.5810.99
336_S340_I0.5790.99
182_A329_T0.5790.99
238_I348_L0.5780.99
42_I105_L0.5780.99
65_A70_I0.5770.99
265_E268_K0.5770.99
196_I199_V0.5770.99
88_M106_C0.5710.99
329_T343_E0.5700.99
286_I290_L0.5680.99
164_F252_P0.5680.99
89_I338_G0.5670.99
362_V366_N0.5670.99
181_N299_E0.5660.99
356_Q372_N0.5660.99
144_L149_P0.5660.99
292_V298_A0.5650.99
138_D142_R0.5640.99
188_A323_G0.5640.99
260_Y264_V0.5630.99
43_Y95_A0.5620.99
3_T231_S0.5620.99
241_L270_L0.5620.99
87_S95_A0.5610.99
289_M293_E0.5610.99
18_F56_N0.5600.99
177_R288_V0.5580.99
193_P198_Q0.5560.99
164_F290_L0.5560.99
254_E257_E0.5560.99
248_W254_E0.5530.99
158_N209_L0.5520.99
87_S90_H0.5510.99
129_Y133_S0.5510.99
143_G148_N0.5500.99
335_M338_G0.5500.99
175_A285_T0.5480.99
142_R146_D0.5460.98
245_E368_I0.5450.98
175_A179_R0.5450.98
154_A208_P0.5440.98
357_V360_T0.5440.98
293_E296_G0.5430.98
164_F293_E0.5430.98
64_V109_G0.5430.98
6_A32_A0.5420.98
34_L225_V0.5420.98
283_S331_Q0.5410.98
40_D73_K0.5390.98
89_I240_I0.5380.98
57_S63_Q0.5380.98
119_G136_P0.5360.98
139_R142_R0.5350.98
87_S245_E0.5350.98
283_S287_T0.5330.98
125_I130_P0.5330.98
126_D129_Y0.5310.98
161_K166_S0.5300.98
184_Q354_G0.5280.98
95_A98_A0.5270.98
171_R209_L0.5260.98
261_T265_E0.5240.98
106_C338_G0.5230.98
102_E230_S0.5230.98
93_Y243_Y0.5220.98
277_A363_V0.5210.98
150_V153_Y0.5210.98
278_F319_P0.5200.98
229_R237_N0.5190.98
41_G104_I0.5180.98
280_L288_V0.5180.98
174_I325_G0.5180.98
43_Y78_F0.5180.98
136_P141_F0.5160.98
151_S251_M0.5150.98
142_R149_P0.5150.98
131_N141_F0.5150.98
84_S334_Y0.5140.98
265_E275_I0.5120.98
125_I134_L0.5120.98
240_I372_N0.5100.98
353_D356_Q0.5090.98
180_F196_I0.5090.98
90_H94_K0.5080.98
48_P115_L0.5040.97
47_L81_G0.5040.97
189_M218_I0.5020.97
175_A199_V0.5010.97
140_L144_L0.5010.97
338_G342_E0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zbgA 2 0.9662 100 0.244 Contact Map
4u4eA 1 0.8805 100 0.311 Contact Map
1ulqA 4 0.9169 100 0.343 Contact Map
1wdkC 2 0.8883 100 0.343 Contact Map
2vu1A 4 0.9065 100 0.344 Contact Map
2wu9A 2 0.8935 100 0.348 Contact Map
4e1lA 4 0.8857 100 0.35 Contact Map
4o9aA 4 0.9091 100 0.35 Contact Map
3ss6A 4 0.9091 100 0.351 Contact Map
4nzsA 4 0.9117 100 0.352 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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