Q97UA5 - SULSO - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

Q97UA5 - Acetyl-CoA c-acetyltransferase (Acetoacetyl-CoA thiolase) (AcaB-10)

UniProt:	Q97UA5	Sequences: MITGFASSLYKKYEGSTFELLADTVFSALEMAGLDKNYVDGIYLTYLPGTFDGYANSHFFTNQVAQYLGIRPKFTQIFDYGGASALSMIHRAYKAIKAGEGETILCIVGGKATELRNKGVTVDAIDKAYPNVSLTPFDRLFRGLNDLNPVSDYALVANRHKYLFKSTDEQRALIAVRQRFNAMQNSKAMFKDPLTIEQVLKSPLVSYPLHLLEIVYPIDGFHVFVVSKRSSKSALTNIDILGYGEAHWPFMPTELDEIVYTPAVESSKGLLNGRIDAFELYDSFTITVMLQVEDIGLAEKGKGGSFFENHDTTFKGDVPINTGGGSLNTGQPAYMSGGVILEEALLQLNDMADGHQVKGTDVVFLNGIGGWNRSHSVSLVLGEKK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	385 (345)
Sequences:	15257 (8571)
Seq/√Len:	461.5

ECOLI - PAAJ ATOB YQEF FADA FADI
BACSU - THL YHFS FADA
HALSA - Q9HRI8 Q9HQZ8 Q9HNK4
SULSO - Q97UA5 Q97VU9 Q97VD4 Q97WQ6 Q97VJ9 Q97UW8 Q97WQ7 Q97VV9 Q97W61 Q7LXW2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
177_R	181_N	3.573	1.00
231_S	235_L	3.525	1.00
170_Q	293_E	3.476	1.00
101_G	104_I	3.149	1.00
176_V	196_I	3.061	1.00
89_I	341_L	2.949	1.00
344_A	356_Q	2.930	1.00
229_R	233_S	2.895	1.00
27_S	30_E	2.876	1.00
231_S	234_A	2.763	1.00
177_R	180_F	2.752	1.00
184_Q	188_A	2.707	1.00
162_Y	207_Y	2.661	1.00
25_V	105_L	2.550	1.00
96_I	226_V	2.548	1.00
264_V	268_K	2.490	1.00
5_F	342_E	2.487	1.00
6_A	31_M	2.413	1.00
103_T	227_S	2.348	1.00
28_A	225_V	2.346	1.00
238_I	345_L	2.229	1.00
96_I	228_K	2.198	1.00
92_A	104_I	2.169	1.00
167_T	170_Q	2.155	1.00
242_G	268_K	2.113	1.00
187_K	192_D	2.112	1.00
21_L	44_L	2.086	1.00
264_V	371_W	2.082	1.00
35_D	38_Y	2.074	1.00
3_T	227_S	2.062	1.00
227_S	232_K	2.055	1.00
348_L	353_D	2.048	1.00
277_A	322_T	2.009	1.00
169_E	173_L	1.946	1.00
222_H	338_G	1.877	1.00
38_Y	235_L	1.855	1.00
270_L	355_H	1.852	1.00
160_H	166_S	1.849	1.00
186_S	190_F	1.823	1.00
292_V	299_E	1.822	1.00
323_G	347_Q	1.805	1.00
199_V	212_L	1.803	1.00
242_G	264_V	1.800	1.00
227_S	231_S	1.799	1.00
292_V	320_I	1.779	1.00
183_M	190_F	1.759	1.00
262_P	266_S	1.741	1.00
102_E	228_K	1.720	1.00
347_Q	351_M	1.715	1.00
28_A	32_A	1.710	1.00
198_Q	201_K	1.693	1.00
275_I	278_F	1.689	1.00
276_D	353_D	1.687	1.00
102_E	231_S	1.677	1.00
261_T	359_G	1.663	1.00
111_K	114_E	1.662	1.00
228_K	231_S	1.658	1.00
272_N	278_F	1.644	1.00
76_Q	91_R	1.638	1.00
163_L	252_P	1.637	1.00
239_D	373_R	1.634	1.00
224_F	338_G	1.630	1.00
44_L	107_I	1.629	1.00
95_A	101_G	1.623	1.00
176_V	180_F	1.617	1.00
270_L	275_I	1.611	1.00
183_M	187_K	1.611	1.00
4_G	32_A	1.607	1.00
94_K	100_E	1.606	1.00
154_A	206_S	1.605	1.00
259_V	262_P	1.594	1.00
92_A	226_V	1.588	1.00
103_T	231_S	1.560	1.00
21_L	64_V	1.559	1.00
173_L	196_I	1.551	1.00
277_A	347_Q	1.541	1.00
173_L	177_R	1.541	1.00
19_E	67_Y	1.540	1.00
177_R	299_E	1.535	1.00
25_V	64_V	1.528	1.00
180_F	193_P	1.510	1.00
26_F	30_E	1.506	1.00
347_Q	350_D	1.473	1.00
24_T	223_V	1.473	1.00
244_G	263_A	1.463	1.00
278_F	357_V	1.463	1.00
345_L	349_N	1.460	1.00
24_T	221_F	1.459	1.00
180_F	184_Q	1.458	1.00
27_S	31_M	1.447	1.00
90_H	370_G	1.440	1.00
244_G	264_V	1.414	1.00
270_L	371_W	1.408	1.00
263_A	266_S	1.386	1.00
4_G	28_A	1.360	1.00
275_I	371_W	1.360	1.00
230_S	234_A	1.348	1.00
265_E	272_N	1.345	1.00
158_N	207_Y	1.306	1.00
298_A	319_P	1.306	1.00
22_A	67_Y	1.305	1.00
354_G	373_R	1.304	1.00
255_L	258_I	1.298	1.00
183_M	193_P	1.297	1.00
90_H	243_Y	1.291	1.00
10_Y	335_M	1.289	1.00
60_F	109_G	1.288	1.00
166_S	171_R	1.283	1.00
322_T	347_Q	1.274	1.00
72_P	249_P	1.272	1.00
248_W	255_L	1.270	1.00
170_Q	173_L	1.269	1.00
40_D	101_G	1.256	1.00
262_P	294_D	1.253	1.00
342_E	346_L	1.248	1.00
46_Y	49_G	1.247	1.00
89_I	224_F	1.245	1.00
246_A	259_V	1.242	1.00
83_A	368_I	1.238	1.00
44_L	223_V	1.231	1.00
341_L	372_N	1.231	1.00
38_Y	231_S	1.226	1.00
271_L	274_R	1.225	1.00
168_D	210_H	1.223	1.00
357_V	371_W	1.222	1.00
39_V	103_T	1.210	1.00
261_T	357_V	1.200	1.00
105_L	225_V	1.196	1.00
23_D	27_S	1.190	1.00
260_Y	369_G	1.189	1.00
118_K	139_R	1.184	1.00
159_R	163_L	1.177	1.00
155_L	207_Y	1.172	1.00
5_F	346_L	1.170	1.00
174_I	288_V	1.163	1.00
241_L	373_R	1.146	1.00
43_Y	104_I	1.145	1.00
229_R	232_K	1.137	1.00
183_M	192_D	1.136	1.00
174_I	289_M	1.136	1.00
10_Y	329_T	1.130	1.00
275_I	355_H	1.127	1.00
40_D	102_E	1.124	1.00
86_L	341_L	1.113	1.00
240_I	370_G	1.113	1.00
97_K	100_E	1.110	1.00
242_G	267_S	1.102	1.00
339_V	343_E	1.088	1.00
100_E	267_S	1.087	1.00
176_V	199_V	1.086	1.00
42_I	65_A	1.084	1.00
5_F	345_L	1.083	1.00
92_A	106_C	1.082	1.00
87_S	91_R	1.077	1.00
277_A	351_M	1.070	1.00
246_A	263_A	1.068	1.00
83_A	362_V	1.065	1.00
229_R	239_D	1.060	1.00
196_I	200_L	1.059	1.00
195_T	198_Q	1.058	1.00
45_T	84_S	1.052	1.00
6_A	27_S	1.050	1.00
138_D	141_F	1.046	1.00
89_I	226_V	1.042	1.00
252_P	255_L	1.040	1.00
25_V	70_I	1.038	1.00
276_D	319_P	1.037	1.00
166_S	289_M	1.037	1.00
194_L	199_V	1.036	1.00
272_N	275_I	1.035	1.00
179_R	190_F	1.031	1.00
94_K	98_A	1.029	1.00
202_S	212_L	1.025	1.00
158_N	162_Y	1.023	1.00
276_D	348_L	1.015	1.00
16_S	19_E	1.015	1.00
154_A	205_V	1.012	1.00
164_F	255_L	1.008	1.00
38_Y	234_A	1.008	1.00
183_M	191_K	1.003	1.00
22_A	26_F	1.000	1.00
137_F	140_L	0.996	1.00
323_G	350_D	0.996	1.00
180_F	183_M	0.994	1.00
344_A	358_K	0.991	1.00
124_A	129_Y	0.990	1.00
268_K	371_W	0.988	1.00
322_T	351_M	0.984	1.00
163_L	251_M	0.982	1.00
4_G	31_M	0.976	1.00
29_L	70_I	0.975	1.00
275_I	362_V	0.974	1.00
222_H	335_M	0.970	1.00
169_E	200_L	0.962	1.00
136_P	139_R	0.956	1.00
10_Y	218_I	0.954	1.00
24_T	27_S	0.952	1.00
93_Y	240_I	0.951	1.00
344_A	363_V	0.951	1.00
263_A	267_S	0.950	1.00
202_S	210_H	0.950	1.00
278_F	297_L	0.941	1.00
241_L	355_H	0.937	1.00
297_L	320_I	0.935	1.00
9_L	23_D	0.932	1.00
93_Y	97_K	0.931	1.00
261_T	295_I	0.929	1.00
29_L	34_L	0.928	1.00
188_A	350_D	0.922	1.00
203_P	211_L	0.922	1.00
46_Y	56_N	0.916	1.00
125_I	129_Y	0.916	1.00
270_L	362_V	0.913	1.00
8_S	20_L	0.912	1.00
161_K	286_I	0.911	1.00
145_N	149_P	0.908	1.00
141_F	145_N	0.906	1.00
8_S	24_T	0.905	1.00
70_I	73_K	0.902	1.00
2_I	372_N	0.899	1.00
255_L	290_L	0.898	1.00
146_D	149_P	0.894	1.00
277_A	344_A	0.893	1.00
8_S	23_D	0.892	1.00
176_V	193_P	0.885	1.00
242_G	371_W	0.885	1.00
106_C	224_F	0.883	1.00
43_Y	92_A	0.882	1.00
275_I	357_V	0.881	1.00
164_F	294_D	0.876	1.00
10_Y	339_V	0.871	1.00
43_Y	88_M	0.870	1.00
159_R	162_Y	0.868	1.00
222_H	342_E	0.866	1.00
5_F	224_F	0.863	1.00
280_L	359_G	0.863	1.00
160_H	255_L	0.861	1.00
28_A	105_L	0.861	1.00
326_S	336_S	0.859	1.00
340_I	358_K	0.855	1.00
38_Y	103_T	0.854	1.00
255_L	294_D	0.854	1.00
172_A	213_E	0.853	1.00
24_T	28_A	0.849	1.00
160_H	290_L	0.847	1.00
43_Y	76_Q	0.842	1.00
236_T	349_N	0.840	1.00
41_G	95_A	0.838	1.00
16_S	114_E	0.832	1.00
100_E	243_Y	0.831	1.00
44_L	61_T	0.829	1.00
344_A	365_L	0.828	1.00
66_Q	72_P	0.824	1.00
95_A	100_E	0.823	1.00
285_T	327_L	0.823	1.00
258_I	294_D	0.816	1.00
248_W	256_D	0.816	1.00
230_S	233_S	0.814	1.00
204_L	207_Y	0.814	1.00
88_M	338_G	0.814	1.00
292_V	297_L	0.814	1.00
145_N	150_V	0.813	1.00
144_L	148_N	0.813	1.00
21_L	107_I	0.812	1.00
80_Y	87_S	0.811	1.00
177_R	300_K	0.807	1.00
86_L	370_G	0.802	1.00
181_N	184_Q	0.801	1.00
147_L	150_V	0.798	1.00
55_A	114_E	0.798	1.00
194_L	198_Q	0.796	1.00
17_T	109_G	0.796	1.00
169_E	196_I	0.795	1.00
323_G	351_M	0.793	1.00
182_A	190_F	0.792	1.00
42_I	73_K	0.790	1.00
288_V	292_V	0.789	1.00
186_S	192_D	0.787	1.00
39_V	105_L	0.783	1.00
105_L	223_V	0.780	1.00
170_Q	289_M	0.778	1.00
262_P	295_I	0.776	1.00
213_E	285_T	0.775	1.00
240_I	243_Y	0.772	1.00
29_L	39_V	0.769	1.00
341_L	370_G	0.765	1.00
142_R	147_L	0.764	1.00
28_A	223_V	0.762	1.00
182_A	186_S	0.761	1.00
91_R	95_A	0.761	1.00
143_G	146_D	0.759	1.00
352_A	355_H	0.759	1.00
157_A	286_I	0.759	1.00
40_D	263_A	0.754	1.00
184_Q	187_K	0.751	1.00
227_S	235_L	0.747	1.00
91_R	94_K	0.746	1.00
102_E	234_A	0.745	1.00
26_F	36_K	0.745	1.00
94_K	97_K	0.737	1.00
6_A	24_T	0.737	1.00
355_H	373_R	0.735	1.00
197_E	201_K	0.730	1.00
129_Y	134_L	0.730	1.00
194_L	212_L	0.730	1.00
176_V	195_T	0.729	1.00
249_P	252_P	0.728	1.00
135_T	138_D	0.728	1.00
248_W	259_V	0.726	1.00
190_F	193_P	0.725	1.00
41_G	245_E	0.719	1.00
23_D	26_F	0.718	1.00
135_T	139_R	0.716	1.00
40_D	104_I	0.715	1.00
113_T	219_D	0.715	1.00
265_E	270_L	0.714	1.00
155_L	159_R	0.710	1.00
258_I	262_P	0.707	1.00
273_G	296_G	0.707	1.00
29_L	36_K	0.705	1.00
241_L	268_K	0.705	1.00
348_L	356_Q	0.704	1.00
280_L	291_Q	0.703	1.00
47_L	333_A	0.697	1.00
290_L	294_D	0.697	1.00
176_V	194_L	0.697	1.00
179_R	183_M	0.695	1.00
261_T	369_G	0.694	1.00
355_H	371_W	0.692	1.00
133_S	137_F	0.691	1.00
261_T	280_L	0.691	1.00
362_V	368_I	0.691	1.00
232_K	235_L	0.690	1.00
145_N	148_N	0.685	1.00
46_Y	60_F	0.684	1.00
270_L	274_R	0.683	1.00
70_I	105_L	0.683	1.00
74_F	245_E	0.682	1.00
273_G	319_P	0.678	1.00
272_N	297_L	0.678	1.00
103_T	235_L	0.677	1.00
89_I	106_C	0.671	1.00
228_K	232_K	0.671	1.00
32_A	225_V	0.671	1.00
90_H	368_I	0.670	1.00
157_A	161_K	0.669	1.00
142_R	145_N	0.669	1.00
209_L	214_I	0.667	1.00
95_A	104_I	0.667	1.00
25_V	68_L	0.666	1.00
130_P	133_S	0.666	1.00
224_F	342_E	0.662	1.00
276_D	355_H	0.662	1.00
176_V	198_Q	0.661	1.00
126_D	130_P	0.661	1.00
144_L	147_L	0.659	1.00
43_Y	91_R	0.659	1.00
6_A	28_A	0.658	1.00
21_L	109_G	0.657	1.00
136_P	140_L	0.656	1.00
264_V	357_V	0.654	1.00
166_S	170_Q	0.654	1.00
102_E	267_S	0.649	1.00
179_R	327_L	0.648	1.00
182_A	328_N	0.647	1.00
172_A	196_I	0.647	1.00
131_N	140_L	0.644	1.00
29_L	33_G	0.643	1.00
36_K	71_R	0.643	1.00
18_F	67_Y	0.642	1.00
25_V	223_V	0.638	1.00
80_Y	245_E	0.637	1.00
288_V	320_I	0.637	1.00
160_H	164_F	0.637	1.00
226_V	240_I	0.635	0.99
244_G	267_S	0.633	0.99
172_A	200_L	0.631	0.99
179_R	193_P	0.631	0.99
19_E	22_A	0.630	0.99
329_T	339_V	0.629	0.99
26_F	68_L	0.629	0.99
253_T	257_E	0.628	0.99
22_A	68_L	0.626	0.99
41_G	80_Y	0.624	0.99
3_T	232_K	0.624	0.99
156_V	253_T	0.624	0.99
76_Q	87_S	0.620	0.99
129_Y	132_V	0.619	0.99
259_V	263_A	0.618	0.99
205_V	211_L	0.617	0.99
134_L	138_D	0.617	0.99
266_S	271_L	0.617	0.99
26_F	69_G	0.616	0.99
190_F	216_Y	0.616	0.99
349_N	352_A	0.616	0.99
157_A	209_L	0.615	0.99
78_F	91_R	0.614	0.99
59_F	366_N	0.613	0.99
134_L	137_F	0.610	0.99
261_T	272_N	0.609	0.99
112_A	333_A	0.609	0.99
44_L	64_V	0.609	0.99
92_A	101_G	0.606	0.99
25_V	29_L	0.605	0.99
276_D	354_G	0.604	0.99
248_W	252_P	0.604	0.99
141_F	152_D	0.604	0.99
166_S	293_E	0.603	0.99
97_K	243_Y	0.602	0.99
278_F	359_G	0.601	0.99
65_A	75_T	0.600	0.99
142_R	148_N	0.599	0.99
39_V	70_I	0.598	0.99
262_P	296_G	0.598	0.99
341_L	358_K	0.597	0.99
86_L	358_K	0.597	0.99
55_A	118_K	0.593	0.99
345_L	372_N	0.592	0.99
287_T	291_Q	0.592	0.99
143_G	147_L	0.590	0.99
29_L	32_A	0.589	0.99
107_I	223_V	0.589	0.99
261_T	291_Q	0.586	0.99
41_G	101_G	0.582	0.99
183_M	186_S	0.581	0.99
49_G	77_I	0.581	0.99
173_L	299_E	0.581	0.99
64_V	68_L	0.581	0.99
336_S	340_I	0.579	0.99
182_A	329_T	0.579	0.99
238_I	348_L	0.578	0.99
42_I	105_L	0.578	0.99
65_A	70_I	0.577	0.99
265_E	268_K	0.577	0.99
196_I	199_V	0.577	0.99
88_M	106_C	0.571	0.99
329_T	343_E	0.570	0.99
286_I	290_L	0.568	0.99
164_F	252_P	0.568	0.99
89_I	338_G	0.567	0.99
362_V	366_N	0.567	0.99
181_N	299_E	0.566	0.99
356_Q	372_N	0.566	0.99
144_L	149_P	0.566	0.99
292_V	298_A	0.565	0.99
138_D	142_R	0.564	0.99
188_A	323_G	0.564	0.99
260_Y	264_V	0.563	0.99
43_Y	95_A	0.562	0.99
3_T	231_S	0.562	0.99
241_L	270_L	0.562	0.99
87_S	95_A	0.561	0.99
289_M	293_E	0.561	0.99
18_F	56_N	0.560	0.99
177_R	288_V	0.558	0.99
193_P	198_Q	0.556	0.99
164_F	290_L	0.556	0.99
254_E	257_E	0.556	0.99
248_W	254_E	0.553	0.99
158_N	209_L	0.552	0.99
87_S	90_H	0.551	0.99
129_Y	133_S	0.551	0.99
143_G	148_N	0.550	0.99
335_M	338_G	0.550	0.99
175_A	285_T	0.548	0.99
142_R	146_D	0.546	0.98
245_E	368_I	0.545	0.98
175_A	179_R	0.545	0.98
154_A	208_P	0.544	0.98
357_V	360_T	0.544	0.98
293_E	296_G	0.543	0.98
164_F	293_E	0.543	0.98
64_V	109_G	0.543	0.98
6_A	32_A	0.542	0.98
34_L	225_V	0.542	0.98
283_S	331_Q	0.541	0.98
40_D	73_K	0.539	0.98
89_I	240_I	0.538	0.98
57_S	63_Q	0.538	0.98
119_G	136_P	0.536	0.98
139_R	142_R	0.535	0.98
87_S	245_E	0.535	0.98
283_S	287_T	0.533	0.98
125_I	130_P	0.533	0.98
126_D	129_Y	0.531	0.98
161_K	166_S	0.530	0.98
184_Q	354_G	0.528	0.98
95_A	98_A	0.527	0.98
171_R	209_L	0.526	0.98
261_T	265_E	0.524	0.98
106_C	338_G	0.523	0.98
102_E	230_S	0.523	0.98
93_Y	243_Y	0.522	0.98
277_A	363_V	0.521	0.98
150_V	153_Y	0.521	0.98
278_F	319_P	0.520	0.98
229_R	237_N	0.519	0.98
41_G	104_I	0.518	0.98
280_L	288_V	0.518	0.98
174_I	325_G	0.518	0.98
43_Y	78_F	0.518	0.98
136_P	141_F	0.516	0.98
151_S	251_M	0.515	0.98
142_R	149_P	0.515	0.98
131_N	141_F	0.515	0.98
84_S	334_Y	0.514	0.98
265_E	275_I	0.512	0.98
125_I	134_L	0.512	0.98
240_I	372_N	0.510	0.98
353_D	356_Q	0.509	0.98
180_F	196_I	0.509	0.98
90_H	94_K	0.508	0.98
48_P	115_L	0.504	0.97
47_L	81_G	0.504	0.97
189_M	218_I	0.502	0.97
175_A	199_V	0.501	0.97
140_L	144_L	0.501	0.97
338_G	342_E	0.500	0.97

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3zbgA	2	0.9662	100	0.244	Contact Map
4u4eA	1	0.8805	100	0.311	Contact Map
1ulqA	4	0.9169	100	0.343	Contact Map
1wdkC	2	0.8883	100	0.343	Contact Map
2vu1A	4	0.9065	100	0.344	Contact Map
2wu9A	2	0.8935	100	0.348	Contact Map
4e1lA	4	0.8857	100	0.35	Contact Map
4o9aA	4	0.9091	100	0.35	Contact Map
3ss6A	4	0.9091	100	0.351	Contact Map
4nzsA	4	0.9117	100	0.352	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0116 seconds.