PIP - SULSO - GREMLIN Contacts

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PIP - Proline iminopeptidase

UniProt:	Q97UA2	Sequences: MSYYFITMKGYSINVEEGYKRIFGINIYYKLYRVKGSNRNLVTLHGGPGGSHDYLIPLADLSNYGINVLFYDQFGCGRSDDPKDTSDYTIDHGLEELEELRKQVFGNDKIVLLGHSYGGALAIAYALKYQQFLRGLIVSSGLSSVPYTVKEMRRLIEELPDKYKTIIKRYESLGDFKNPEYLDAVNFFYSQHLLRLKEMPEPVKRTFEYIGKRRTYEIMNGPNEFTIIGTIKDWDVTEQLYKITVPTLITVGKYDEVTVNVAQLIHKNIKGSRLVIFENSSHMAMWEEKDKYLEVIKEFIDQVYSLNMVK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	310 (265)
Sequences:	60464 (50276)
Seq/√Len:	3088.4

ECOLI - MHPC PLDB RUTD YBFF BIOH MENH YCJY YFHR
BACSU - YFHM YBFK YUGF NAP YBAC YRAK YDJP YCGS MENH YISY RSBQ YBDG YVAM YCLE YQJL PLBAC EST YQKD
HALSA - Q9HPT9 Q9HHP4 Q9HRJ0
SULSO - PIP Q7LXY9 Q97WG0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
31_L	67_N	5.252	1.00
111_V	135_G	4.361	1.00
74_F	96_E	3.614	1.00
57_P	293_L	3.111	1.00
98_E	125_Y	3.077	1.00
275_V	295_V	2.813	1.00
288_E	291_K	2.790	1.00
111_V	134_R	2.786	1.00
248_L	299_F	2.718	1.00
109_K	134_R	2.677	1.00
140_S	255_D	2.645	1.00
253_K	278_E	2.640	1.00
277_F	295_V	2.495	1.00
98_E	102_K	2.435	1.00
98_E	132_F	2.361	1.00
26_N	80_D	2.343	1.00
30_K	51_S	2.326	1.00
139_S	292_Y	2.324	1.00
125_Y	129_Y	2.236	1.00
98_E	129_Y	2.202	1.00
21_R	26_N	2.193	1.00
112_L	122_A	2.033	1.00
253_K	276_I	2.027	1.00
101_R	110_I	2.010	1.00
124_A	128_K	2.008	1.00
102_K	132_F	1.993	1.00
28_Y	78_R	1.991	1.00
29_Y	100_L	1.983	1.00
60_D	293_L	1.963	1.00
39_R	111_V	1.955	1.00
39_R	134_R	1.941	1.00
126_A	136_L	1.894	1.00
111_V	300_I	1.892	1.00
32_Y	70_F	1.877	1.00
40_N	69_L	1.867	1.00
40_N	107_N	1.861	1.00
31_L	69_L	1.853	1.00
280_S	288_E	1.849	1.00
119_G	141_G	1.830	1.00
65_G	297_K	1.823	1.00
95_E	128_K	1.808	1.00
28_Y	51_S	1.786	1.00
266_H	272_S	1.784	1.00
40_N	67_N	1.716	1.00
45_H	76_C	1.697	1.00
248_L	275_V	1.686	1.00
91_D	128_K	1.676	1.00
45_H	73_Q	1.653	1.00
264_L	268_N	1.649	1.00
111_V	137_I	1.643	1.00
44_L	97_L	1.641	1.00
295_V	298_E	1.623	1.00
73_Q	121_L	1.619	1.00
66_I	111_V	1.610	1.00
94_L	124_A	1.600	1.00
28_Y	72_D	1.518	1.00
49_G	53_D	1.515	1.00
247_T	269_I	1.504	1.00
71_Y	97_L	1.493	1.00
44_L	73_Q	1.482	1.00
125_Y	133_L	1.475	1.00
23_F	99_E	1.461	1.00
129_Y	132_F	1.457	1.00
51_S	72_D	1.450	1.00
122_A	136_L	1.433	1.00
123_I	138_V	1.404	1.00
125_Y	132_F	1.375	1.00
33_R	67_N	1.371	1.00
27_I	96_E	1.354	1.00
89_T	92_H	1.349	1.00
124_A	127_L	1.343	1.00
60_D	297_K	1.339	1.00
137_I	296_I	1.330	1.00
291_K	295_V	1.330	1.00
97_L	125_Y	1.322	1.00
138_V	141_G	1.313	1.00
25_I	74_F	1.312	1.00
69_L	100_L	1.307	1.00
294_E	298_E	1.306	1.00
251_V	262_A	1.285	1.00
222_P	226_T	1.278	1.00
116_S	282_H	1.268	1.00
44_L	122_A	1.263	1.00
32_Y	58_L	1.258	1.00
115_H	285_M	1.250	1.00
291_K	294_E	1.242	1.00
227_I	230_T	1.240	1.00
48_P	76_C	1.235	1.00
113_L	139_S	1.232	1.00
41_L	66_I	1.209	1.00
58_L	70_F	1.198	1.00
137_I	248_L	1.194	1.00
102_K	129_Y	1.183	1.00
43_T	68_V	1.180	1.00
239_Q	242_K	1.177	1.00
251_V	276_I	1.167	1.00
251_V	274_L	1.162	1.00
39_R	66_I	1.156	1.00
43_T	113_L	1.153	1.00
60_D	63_N	1.148	1.00
199_M	202_P	1.146	1.00
135_G	246_P	1.132	1.00
224_E	228_I	1.127	1.00
42_V	101_R	1.124	1.00
71_Y	100_L	1.122	1.00
65_G	301_D	1.120	1.00
46_G	116_S	1.120	1.00
51_S	78_R	1.117	1.00
228_I	231_I	1.111	1.00
32_Y	62_S	1.107	1.00
48_P	116_S	1.104	1.00
277_F	280_S	1.103	1.00
266_H	274_L	1.098	1.00
297_K	301_D	1.095	1.00
44_L	112_L	1.094	1.00
250_T	277_F	1.094	1.00
184_A	188_F	1.087	1.00
248_L	273_R	1.076	1.00
202_P	206_T	1.071	1.00
53_D	285_M	1.062	1.00
91_D	124_A	1.054	1.00
51_S	70_F	1.047	1.00
110_I	133_L	1.044	1.00
107_N	110_I	1.036	1.00
72_D	77_G	1.028	1.00
127_L	239_Q	1.021	1.00
101_R	125_Y	1.016	1.00
224_E	227_I	1.016	1.00
62_S	65_G	1.014	1.00
113_L	296_I	1.013	1.00
39_R	109_K	1.008	1.00
277_F	291_K	1.007	1.00
98_E	101_R	1.000	1.00
29_Y	105_F	0.999	1.00
115_H	283_M	0.993	1.00
281_S	287_E	0.993	1.00
114_G	122_A	0.991	1.00
269_I	272_S	0.986	1.00
275_V	298_E	0.986	1.00
292_Y	296_I	0.983	1.00
264_L	267_K	0.981	1.00
263_Q	266_H	0.971	1.00
263_Q	267_K	0.968	1.00
181_Y	184_A	0.954	1.00
185_V	188_F	0.952	1.00
241_Y	268_N	0.947	1.00
164_K	168_K	0.939	1.00
110_I	132_F	0.938	1.00
22_I	99_E	0.927	1.00
60_D	290_D	0.926	1.00
99_E	103_Q	0.926	1.00
66_I	300_I	0.924	1.00
42_V	110_I	0.924	1.00
94_L	121_L	0.923	1.00
25_I	80_D	0.920	1.00
253_K	279_N	0.918	1.00
217_E	220_N	0.913	1.00
38_N	67_N	0.903	1.00
273_R	295_V	0.903	1.00
73_Q	117_Y	0.898	1.00
98_E	128_K	0.892	1.00
139_S	284_A	0.891	1.00
139_S	285_M	0.887	1.00
226_T	229_G	0.884	1.00
56_I	59_A	0.879	1.00
263_Q	274_L	0.877	1.00
55_L	70_F	0.876	1.00
160_P	164_K	0.874	1.00
223_N	227_I	0.873	1.00
290_D	294_E	0.872	1.00
280_S	284_A	0.872	1.00
136_L	247_T	0.871	1.00
280_S	287_E	0.870	1.00
62_S	68_V	0.869	1.00
227_I	231_I	0.868	1.00
99_E	102_K	0.859	1.00
203_V	207_F	0.856	1.00
100_L	105_F	0.855	1.00
42_V	97_L	0.848	1.00
204_K	207_F	0.842	1.00
87_D	92_H	0.841	1.00
92_H	95_E	0.837	1.00
41_L	68_V	0.836	1.00
44_L	71_Y	0.835	1.00
263_Q	276_I	0.830	1.00
27_I	79_S	0.828	1.00
182_L	186_N	0.820	1.00
41_L	113_L	0.814	1.00
37_S	67_N	0.810	1.00
58_L	68_V	0.808	1.00
66_I	301_D	0.805	1.00
52_H	55_L	0.802	1.00
275_V	291_K	0.800	1.00
101_R	107_N	0.800	1.00
163_Y	167_I	0.795	1.00
223_N	226_T	0.794	1.00
115_H	140_S	0.793	1.00
217_E	221_G	0.793	1.00
59_A	62_S	0.793	1.00
163_Y	166_I	0.792	1.00
94_L	125_Y	0.791	1.00
93_G	117_Y	0.789	1.00
222_P	225_F	0.787	1.00
252_G	284_A	0.783	1.00
69_L	105_F	0.780	1.00
39_R	135_G	0.775	1.00
250_T	295_V	0.773	1.00
135_G	299_F	0.773	1.00
160_P	163_Y	0.773	1.00
261_V	264_L	0.771	1.00
112_L	125_Y	0.769	1.00
126_A	133_L	0.768	1.00
183_D	187_F	0.767	1.00
94_L	128_K	0.763	1.00
249_I	272_S	0.761	1.00
293_L	297_K	0.761	1.00
220_N	223_N	0.755	1.00
225_F	228_I	0.752	1.00
244_T	270_K	0.750	1.00
41_L	300_I	0.746	1.00
106_G	109_K	0.740	1.00
168_K	172_S	0.740	1.00
114_G	119_G	0.739	1.00
201_E	204_K	0.738	1.00
155_L	158_E	0.736	1.00
200_P	204_K	0.735	1.00
199_M	204_K	0.731	1.00
40_N	66_I	0.729	1.00
95_E	98_E	0.728	1.00
159_L	163_Y	0.728	1.00
181_Y	185_V	0.724	1.00
51_S	71_Y	0.723	1.00
22_I	25_I	0.722	1.00
187_F	190_S	0.720	1.00
95_E	99_E	0.719	1.00
124_A	239_Q	0.714	1.00
140_S	284_A	0.713	1.00
47_G	117_Y	0.713	1.00
27_I	74_F	0.712	1.00
40_N	110_I	0.706	1.00
279_N	288_E	0.704	1.00
165_T	168_K	0.703	1.00
225_F	229_G	0.699	1.00
30_K	55_L	0.698	1.00
36_G	67_N	0.698	1.00
28_Y	79_S	0.697	1.00
186_N	190_S	0.693	1.00
48_P	117_Y	0.693	1.00
73_Q	93_G	0.690	1.00
43_T	54_Y	0.689	1.00
115_H	139_S	0.689	1.00
164_K	167_I	0.684	1.00
72_D	78_R	0.681	1.00
188_F	191_Q	0.681	1.00
126_A	245_V	0.675	1.00
41_L	111_V	0.675	1.00
127_L	242_K	0.675	1.00
262_A	274_L	0.671	1.00
57_P	292_Y	0.671	1.00
192_H	195_R	0.667	1.00
32_Y	59_A	0.666	1.00
137_I	299_F	0.663	1.00
140_S	251_V	0.660	1.00
69_L	107_N	0.658	1.00
221_G	224_E	0.656	1.00
67_N	107_N	0.656	1.00
207_F	211_G	0.655	1.00
162_K	166_I	0.654	1.00
201_E	205_R	0.654	1.00
140_S	252_G	0.652	1.00
54_Y	57_P	0.652	1.00
42_V	71_Y	0.651	1.00
206_T	209_Y	0.649	1.00
189_Y	192_H	0.648	1.00
294_E	297_K	0.647	1.00
112_L	133_L	0.645	1.00
183_D	186_N	0.644	1.00
204_K	208_E	0.644	1.00
57_P	60_D	0.641	1.00
187_F	191_Q	0.639	1.00
255_D	282_H	0.636	1.00
91_D	95_E	0.633	1.00
55_L	59_A	0.632	1.00
45_H	71_Y	0.631	1.00
74_F	93_G	0.630	1.00
63_N	297_K	0.628	1.00
66_I	297_K	0.627	1.00
209_Y	213_R	0.626	1.00
184_A	189_Y	0.625	1.00
223_N	228_I	0.624	1.00
200_P	206_T	0.623	1.00
208_E	211_G	0.621	1.00
277_F	288_E	0.621	1.00
137_I	250_T	0.620	1.00
184_A	187_F	0.619	1.00
226_T	230_T	0.619	1.00
185_V	189_Y	0.618	1.00
73_Q	76_C	0.614	1.00
262_A	266_H	0.613	1.00
90_I	124_A	0.611	1.00
224_E	229_G	0.610	1.00
113_L	137_I	0.609	1.00
162_K	165_T	0.609	1.00
205_R	208_E	0.609	1.00
250_T	292_Y	0.607	1.00
222_P	228_I	0.607	1.00
133_L	245_V	0.606	1.00
220_N	224_E	0.604	1.00
58_L	62_S	0.602	1.00
159_L	166_I	0.602	1.00
120_A	142_L	0.601	1.00
260_N	263_Q	0.593	1.00
158_E	162_K	0.591	1.00
165_T	169_R	0.591	1.00
181_Y	189_Y	0.591	1.00
135_G	300_I	0.588	1.00
222_P	227_I	0.588	1.00
180_E	183_D	0.587	1.00
218_I	221_G	0.587	1.00
265_I	269_I	0.585	1.00
213_R	217_E	0.585	1.00
202_P	205_R	0.585	1.00
266_H	269_I	0.584	1.00
92_H	96_E	0.584	1.00
123_I	143_S	0.583	1.00
236_V	239_Q	0.583	1.00
116_S	283_M	0.578	1.00
188_F	192_H	0.576	1.00
205_R	209_Y	0.575	1.00
185_V	190_S	0.574	1.00
137_I	300_I	0.573	1.00
59_A	63_N	0.573	1.00
93_G	121_L	0.573	1.00
221_G	225_F	0.570	1.00
155_L	159_L	0.568	1.00
43_T	70_F	0.563	1.00
182_L	188_F	0.562	1.00
30_K	52_H	0.561	1.00
108_D	132_F	0.561	1.00
119_G	138_V	0.560	1.00
110_I	125_Y	0.559	1.00
38_N	65_G	0.558	1.00
249_I	274_L	0.557	1.00
209_Y	212_K	0.554	1.00
246_P	271_G	0.553	1.00
47_G	116_S	0.552	1.00
42_V	112_L	0.551	1.00
94_L	98_E	0.550	1.00
114_G	118_G	0.549	1.00
238_E	241_Y	0.549	1.00
254_Y	279_N	0.548	1.00
161_D	164_K	0.547	1.00
93_G	96_E	0.545	1.00
198_E	202_P	0.544	1.00
200_P	207_F	0.542	1.00
182_L	190_S	0.540	1.00
198_E	206_T	0.539	1.00
31_L	36_G	0.538	1.00
54_Y	58_L	0.538	1.00
65_G	68_V	0.538	1.00
110_I	134_R	0.538	1.00
168_K	171_E	0.535	1.00
126_A	243_I	0.533	1.00
49_G	283_M	0.533	1.00
289_K	293_L	0.531	1.00
144_S	264_L	0.527	1.00
120_A	123_I	0.526	1.00
49_G	286_W	0.525	1.00
206_T	210_I	0.523	1.00
196_L	199_M	0.522	1.00
296_I	300_I	0.519	1.00
156_I	160_P	0.519	1.00
53_D	283_M	0.518	1.00
199_M	206_T	0.518	1.00
30_K	70_F	0.518	1.00
243_I	247_T	0.517	1.00
260_N	264_L	0.517	1.00
180_E	184_A	0.517	1.00
138_V	249_I	0.517	1.00
157_E	160_P	0.516	1.00
33_R	36_G	0.515	1.00
73_Q	97_L	0.515	1.00
208_E	212_K	0.512	1.00
75_G	88_Y	0.511	1.00
23_F	92_H	0.510	1.00
44_L	121_L	0.510	1.00
167_I	171_E	0.510	1.00
88_Y	92_H	0.507	1.00
197_K	200_P	0.505	1.00
213_R	216_Y	0.503	1.00
123_I	141_G	0.503	1.00
43_T	61_L	0.502	1.00
285_M	292_Y	0.502	1.00
50_G	76_C	0.501	1.00
188_F	193_L	0.501	1.00
284_A	292_Y	0.500	1.00
155_L	163_Y	0.500	1.00
166_I	170_Y	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4inzA	1	0.9032	100	0.227	Contact Map
1mtzA	1	0.9355	100	0.229	Contact Map
3wmrA	1	0.9387	100	0.23	Contact Map
1ehyA	1	0.8645	100	0.232	Contact Map
3nwoA	1	0.9419	100	0.24	Contact Map
3oosA	1	0.8806	100	0.246	Contact Map
2pujA	4	0.8774	100	0.256	Contact Map
3om8A	4	0.8516	100	0.258	Contact Map
2wueA	4	0.8839	100	0.261	Contact Map
1q0rA	1	0.9194	100	0.264	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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