GREMLIN Database
PIP - Proline iminopeptidase
UniProt: Q97UA2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 310 (265)
Sequences: 60464 (50276)
Seq/√Len: 3088.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
31_L67_N5.2521.00
111_V135_G4.3611.00
74_F96_E3.6141.00
57_P293_L3.1111.00
98_E125_Y3.0771.00
275_V295_V2.8131.00
288_E291_K2.7901.00
111_V134_R2.7861.00
248_L299_F2.7181.00
109_K134_R2.6771.00
140_S255_D2.6451.00
253_K278_E2.6401.00
277_F295_V2.4951.00
98_E102_K2.4351.00
98_E132_F2.3611.00
26_N80_D2.3431.00
30_K51_S2.3261.00
139_S292_Y2.3241.00
125_Y129_Y2.2361.00
98_E129_Y2.2021.00
21_R26_N2.1931.00
112_L122_A2.0331.00
253_K276_I2.0271.00
101_R110_I2.0101.00
124_A128_K2.0081.00
102_K132_F1.9931.00
28_Y78_R1.9911.00
29_Y100_L1.9831.00
60_D293_L1.9631.00
39_R111_V1.9551.00
39_R134_R1.9411.00
126_A136_L1.8941.00
111_V300_I1.8921.00
32_Y70_F1.8771.00
40_N69_L1.8671.00
40_N107_N1.8611.00
31_L69_L1.8531.00
280_S288_E1.8491.00
119_G141_G1.8301.00
65_G297_K1.8231.00
95_E128_K1.8081.00
28_Y51_S1.7861.00
266_H272_S1.7841.00
40_N67_N1.7161.00
45_H76_C1.6971.00
248_L275_V1.6861.00
91_D128_K1.6761.00
45_H73_Q1.6531.00
264_L268_N1.6491.00
111_V137_I1.6431.00
44_L97_L1.6411.00
295_V298_E1.6231.00
73_Q121_L1.6191.00
66_I111_V1.6101.00
94_L124_A1.6001.00
28_Y72_D1.5181.00
49_G53_D1.5151.00
247_T269_I1.5041.00
71_Y97_L1.4931.00
44_L73_Q1.4821.00
125_Y133_L1.4751.00
23_F99_E1.4611.00
129_Y132_F1.4571.00
51_S72_D1.4501.00
122_A136_L1.4331.00
123_I138_V1.4041.00
125_Y132_F1.3751.00
33_R67_N1.3711.00
27_I96_E1.3541.00
89_T92_H1.3491.00
124_A127_L1.3431.00
60_D297_K1.3391.00
137_I296_I1.3301.00
291_K295_V1.3301.00
97_L125_Y1.3221.00
138_V141_G1.3131.00
25_I74_F1.3121.00
69_L100_L1.3071.00
294_E298_E1.3061.00
251_V262_A1.2851.00
222_P226_T1.2781.00
116_S282_H1.2681.00
44_L122_A1.2631.00
32_Y58_L1.2581.00
115_H285_M1.2501.00
291_K294_E1.2421.00
227_I230_T1.2401.00
48_P76_C1.2351.00
113_L139_S1.2321.00
41_L66_I1.2091.00
58_L70_F1.1981.00
137_I248_L1.1941.00
102_K129_Y1.1831.00
43_T68_V1.1801.00
239_Q242_K1.1771.00
251_V276_I1.1671.00
251_V274_L1.1621.00
39_R66_I1.1561.00
43_T113_L1.1531.00
60_D63_N1.1481.00
199_M202_P1.1461.00
135_G246_P1.1321.00
224_E228_I1.1271.00
42_V101_R1.1241.00
71_Y100_L1.1221.00
65_G301_D1.1201.00
46_G116_S1.1201.00
51_S78_R1.1171.00
228_I231_I1.1111.00
32_Y62_S1.1071.00
48_P116_S1.1041.00
277_F280_S1.1031.00
266_H274_L1.0981.00
297_K301_D1.0951.00
44_L112_L1.0941.00
250_T277_F1.0941.00
184_A188_F1.0871.00
248_L273_R1.0761.00
202_P206_T1.0711.00
53_D285_M1.0621.00
91_D124_A1.0541.00
51_S70_F1.0471.00
110_I133_L1.0441.00
107_N110_I1.0361.00
72_D77_G1.0281.00
127_L239_Q1.0211.00
101_R125_Y1.0161.00
224_E227_I1.0161.00
62_S65_G1.0141.00
113_L296_I1.0131.00
39_R109_K1.0081.00
277_F291_K1.0071.00
98_E101_R1.0001.00
29_Y105_F0.9991.00
115_H283_M0.9931.00
281_S287_E0.9931.00
114_G122_A0.9911.00
269_I272_S0.9861.00
275_V298_E0.9861.00
292_Y296_I0.9831.00
264_L267_K0.9811.00
263_Q266_H0.9711.00
263_Q267_K0.9681.00
181_Y184_A0.9541.00
185_V188_F0.9521.00
241_Y268_N0.9471.00
164_K168_K0.9391.00
110_I132_F0.9381.00
22_I99_E0.9271.00
60_D290_D0.9261.00
99_E103_Q0.9261.00
66_I300_I0.9241.00
42_V110_I0.9241.00
94_L121_L0.9231.00
25_I80_D0.9201.00
253_K279_N0.9181.00
217_E220_N0.9131.00
38_N67_N0.9031.00
273_R295_V0.9031.00
73_Q117_Y0.8981.00
98_E128_K0.8921.00
139_S284_A0.8911.00
139_S285_M0.8871.00
226_T229_G0.8841.00
56_I59_A0.8791.00
263_Q274_L0.8771.00
55_L70_F0.8761.00
160_P164_K0.8741.00
223_N227_I0.8731.00
290_D294_E0.8721.00
280_S284_A0.8721.00
136_L247_T0.8711.00
280_S287_E0.8701.00
62_S68_V0.8691.00
227_I231_I0.8681.00
99_E102_K0.8591.00
203_V207_F0.8561.00
100_L105_F0.8551.00
42_V97_L0.8481.00
204_K207_F0.8421.00
87_D92_H0.8411.00
92_H95_E0.8371.00
41_L68_V0.8361.00
44_L71_Y0.8351.00
263_Q276_I0.8301.00
27_I79_S0.8281.00
182_L186_N0.8201.00
41_L113_L0.8141.00
37_S67_N0.8101.00
58_L68_V0.8081.00
66_I301_D0.8051.00
52_H55_L0.8021.00
275_V291_K0.8001.00
101_R107_N0.8001.00
163_Y167_I0.7951.00
223_N226_T0.7941.00
115_H140_S0.7931.00
217_E221_G0.7931.00
59_A62_S0.7931.00
163_Y166_I0.7921.00
94_L125_Y0.7911.00
93_G117_Y0.7891.00
222_P225_F0.7871.00
252_G284_A0.7831.00
69_L105_F0.7801.00
39_R135_G0.7751.00
250_T295_V0.7731.00
135_G299_F0.7731.00
160_P163_Y0.7731.00
261_V264_L0.7711.00
112_L125_Y0.7691.00
126_A133_L0.7681.00
183_D187_F0.7671.00
94_L128_K0.7631.00
249_I272_S0.7611.00
293_L297_K0.7611.00
220_N223_N0.7551.00
225_F228_I0.7521.00
244_T270_K0.7501.00
41_L300_I0.7461.00
106_G109_K0.7401.00
168_K172_S0.7401.00
114_G119_G0.7391.00
201_E204_K0.7381.00
155_L158_E0.7361.00
200_P204_K0.7351.00
199_M204_K0.7311.00
40_N66_I0.7291.00
95_E98_E0.7281.00
159_L163_Y0.7281.00
181_Y185_V0.7241.00
51_S71_Y0.7231.00
22_I25_I0.7221.00
187_F190_S0.7201.00
95_E99_E0.7191.00
124_A239_Q0.7141.00
140_S284_A0.7131.00
47_G117_Y0.7131.00
27_I74_F0.7121.00
40_N110_I0.7061.00
279_N288_E0.7041.00
165_T168_K0.7031.00
225_F229_G0.6991.00
30_K55_L0.6981.00
36_G67_N0.6981.00
28_Y79_S0.6971.00
186_N190_S0.6931.00
48_P117_Y0.6931.00
73_Q93_G0.6901.00
43_T54_Y0.6891.00
115_H139_S0.6891.00
164_K167_I0.6841.00
72_D78_R0.6811.00
188_F191_Q0.6811.00
126_A245_V0.6751.00
41_L111_V0.6751.00
127_L242_K0.6751.00
262_A274_L0.6711.00
57_P292_Y0.6711.00
192_H195_R0.6671.00
32_Y59_A0.6661.00
137_I299_F0.6631.00
140_S251_V0.6601.00
69_L107_N0.6581.00
221_G224_E0.6561.00
67_N107_N0.6561.00
207_F211_G0.6551.00
162_K166_I0.6541.00
201_E205_R0.6541.00
140_S252_G0.6521.00
54_Y57_P0.6521.00
42_V71_Y0.6511.00
206_T209_Y0.6491.00
189_Y192_H0.6481.00
294_E297_K0.6471.00
112_L133_L0.6451.00
183_D186_N0.6441.00
204_K208_E0.6441.00
57_P60_D0.6411.00
187_F191_Q0.6391.00
255_D282_H0.6361.00
91_D95_E0.6331.00
55_L59_A0.6321.00
45_H71_Y0.6311.00
74_F93_G0.6301.00
63_N297_K0.6281.00
66_I297_K0.6271.00
209_Y213_R0.6261.00
184_A189_Y0.6251.00
223_N228_I0.6241.00
200_P206_T0.6231.00
208_E211_G0.6211.00
277_F288_E0.6211.00
137_I250_T0.6201.00
184_A187_F0.6191.00
226_T230_T0.6191.00
185_V189_Y0.6181.00
73_Q76_C0.6141.00
262_A266_H0.6131.00
90_I124_A0.6111.00
224_E229_G0.6101.00
113_L137_I0.6091.00
162_K165_T0.6091.00
205_R208_E0.6091.00
250_T292_Y0.6071.00
222_P228_I0.6071.00
133_L245_V0.6061.00
220_N224_E0.6041.00
58_L62_S0.6021.00
159_L166_I0.6021.00
120_A142_L0.6011.00
260_N263_Q0.5931.00
158_E162_K0.5911.00
165_T169_R0.5911.00
181_Y189_Y0.5911.00
135_G300_I0.5881.00
222_P227_I0.5881.00
180_E183_D0.5871.00
218_I221_G0.5871.00
265_I269_I0.5851.00
213_R217_E0.5851.00
202_P205_R0.5851.00
266_H269_I0.5841.00
92_H96_E0.5841.00
123_I143_S0.5831.00
236_V239_Q0.5831.00
116_S283_M0.5781.00
188_F192_H0.5761.00
205_R209_Y0.5751.00
185_V190_S0.5741.00
137_I300_I0.5731.00
59_A63_N0.5731.00
93_G121_L0.5731.00
221_G225_F0.5701.00
155_L159_L0.5681.00
43_T70_F0.5631.00
182_L188_F0.5621.00
30_K52_H0.5611.00
108_D132_F0.5611.00
119_G138_V0.5601.00
110_I125_Y0.5591.00
38_N65_G0.5581.00
249_I274_L0.5571.00
209_Y212_K0.5541.00
246_P271_G0.5531.00
47_G116_S0.5521.00
42_V112_L0.5511.00
94_L98_E0.5501.00
114_G118_G0.5491.00
238_E241_Y0.5491.00
254_Y279_N0.5481.00
161_D164_K0.5471.00
93_G96_E0.5451.00
198_E202_P0.5441.00
200_P207_F0.5421.00
182_L190_S0.5401.00
198_E206_T0.5391.00
31_L36_G0.5381.00
54_Y58_L0.5381.00
65_G68_V0.5381.00
110_I134_R0.5381.00
168_K171_E0.5351.00
126_A243_I0.5331.00
49_G283_M0.5331.00
289_K293_L0.5311.00
144_S264_L0.5271.00
120_A123_I0.5261.00
49_G286_W0.5251.00
206_T210_I0.5231.00
196_L199_M0.5221.00
296_I300_I0.5191.00
156_I160_P0.5191.00
53_D283_M0.5181.00
199_M206_T0.5181.00
30_K70_F0.5181.00
243_I247_T0.5171.00
260_N264_L0.5171.00
180_E184_A0.5171.00
138_V249_I0.5171.00
157_E160_P0.5161.00
33_R36_G0.5151.00
73_Q97_L0.5151.00
208_E212_K0.5121.00
75_G88_Y0.5111.00
23_F92_H0.5101.00
44_L121_L0.5101.00
167_I171_E0.5101.00
88_Y92_H0.5071.00
197_K200_P0.5051.00
213_R216_Y0.5031.00
123_I141_G0.5031.00
43_T61_L0.5021.00
285_M292_Y0.5021.00
50_G76_C0.5011.00
188_F193_L0.5011.00
284_A292_Y0.5001.00
155_L163_Y0.5001.00
166_I170_Y0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4inzA 1 0.9032 100 0.227 Contact Map
1mtzA 1 0.9355 100 0.229 Contact Map
3wmrA 1 0.9387 100 0.23 Contact Map
1ehyA 1 0.8645 100 0.232 Contact Map
3nwoA 1 0.9419 100 0.24 Contact Map
3oosA 1 0.8806 100 0.246 Contact Map
2pujA 4 0.8774 100 0.256 Contact Map
3om8A 4 0.8516 100 0.258 Contact Map
2wueA 4 0.8839 100 0.261 Contact Map
1q0rA 1 0.9194 100 0.264 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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