GREMLIN Database
KDAD - 2-dehydro-3-deoxy-D-arabinonate dehydratase
UniProt: Q97UA0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 298 (265)
Sequences: 6307 (4590)
Seq/√Len: 281.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
167_M258_T3.6501.00
218_V275_D3.6431.00
212_D228_S3.5811.00
278_E288_I3.5721.00
280_T286_T3.3071.00
152_A167_M3.1101.00
278_E286_T3.0171.00
135_A290_P2.7211.00
214_T280_T2.6641.00
237_K240_E2.6491.00
212_D282_S2.4981.00
190_A250_P2.3721.00
149_P215_L2.3171.00
276_I288_I2.2701.00
195_F256_I2.2161.00
216_K278_E2.2061.00
214_T228_S2.1991.00
164_Y202_S2.1321.00
152_A165_T2.0711.00
158_N252_P2.0561.00
12_V71_R2.0371.00
229_V233_K2.0041.00
12_V73_T1.9841.00
149_P279_I1.9611.00
84_S120_I1.9141.00
216_K280_T1.9011.00
149_P213_I1.9001.00
158_N253_D1.8801.00
166_I281_I1.8801.00
212_D230_N1.8331.00
135_A292_K1.8071.00
217_I271_L1.7781.00
36_I43_S1.7711.00
120_I245_L1.7701.00
35_P38_A1.7651.00
90_M233_K1.7431.00
167_M193_C1.7421.00
127_N252_P1.7121.00
138_V145_T1.7071.00
153_V238_I1.6881.00
27_T64_S1.6811.00
175_L189_Y1.6811.00
155_L242_I1.6791.00
152_A258_T1.6771.00
66_Q69_D1.6531.00
205_I211_L1.6361.00
162_L199_I1.6351.00
220_E269_K1.6131.00
136_I277_V1.5891.00
151_L281_I1.5601.00
210_S232_N1.5501.00
28_I70_I1.5471.00
130_V134_E1.5401.00
36_I39_L1.5291.00
265_P269_K1.5181.00
160_K190_A1.5161.00
209_Y239_E1.4891.00
71_R134_E1.4881.00
89_E93_E1.4861.00
165_T195_F1.4851.00
273_D292_K1.4851.00
152_A256_I1.4791.00
276_I290_P1.4751.00
122_F125_T1.4631.00
39_L43_S1.4511.00
142_S174_D1.4431.00
265_P268_D1.4301.00
131_G134_E1.4221.00
13_K16_Y1.4141.00
137_A191_G1.3911.00
154_V199_I1.3781.00
209_Y237_K1.3761.00
136_I170_V1.3711.00
79_P252_P1.3711.00
207_N210_S1.3651.00
11_V20_Y1.3631.00
143_E174_D1.3601.00
125_T188_I1.3591.00
128_R193_C1.3461.00
193_C258_T1.3451.00
122_F184_P1.3381.00
84_S245_L1.3241.00
262_A267_R1.3141.00
40_M43_S1.3101.00
81_V193_C1.3011.00
39_L42_Y1.2891.00
89_E115_A1.2731.00
144_W174_D1.2591.00
142_S145_T1.2541.00
35_P43_S1.2481.00
11_V21_A1.2471.00
9_F28_I1.2421.00
10_R77_D1.2391.00
206_K283_N1.2171.00
128_R250_P1.2111.00
145_T291_V1.2001.00
153_V257_L1.1921.00
21_A28_I1.1891.00
216_K286_T1.1831.00
19_S30_R1.1811.00
161_I238_I1.1801.00
211_L281_I1.1781.00
36_I42_Y1.1701.00
165_T284_I1.1651.00
263_I270_G1.1641.00
137_A292_K1.1631.00
51_D54_T1.1591.00
201_T204_E1.1541.00
200_V284_I1.1421.00
37_K41_R1.1341.00
158_N250_P1.1191.00
170_V194_A1.1191.00
9_F72_I1.1161.00
43_S46_K1.1131.00
9_F22_I1.1111.00
38_A41_R1.1101.00
168_D289_T1.0891.00
74_K129_C1.0861.00
262_A265_P1.0821.00
243_Q247_R1.0761.00
209_Y234_M1.0631.00
184_P188_I1.0601.00
167_M195_F1.0551.00
215_L279_I1.0511.00
151_L231_T1.0491.00
133_G287_L1.0451.00
24_D27_T1.0391.00
9_F198_V1.0391.00
84_S241_Q1.0311.00
56_I59_Q1.0281.00
43_S47_E1.0281.00
42_Y45_N1.0271.00
154_V165_T1.0131.00
156_D162_L1.0061.00
86_I95_Y0.9991.00
152_A195_F0.9951.00
72_I132_H0.9931.00
138_V291_V0.9901.00
118_P241_Q0.9881.00
27_T66_Q0.9871.00
160_K250_P0.9861.00
153_V242_I0.9701.00
114_D235_R0.9691.00
80_E125_T0.9671.00
46_K50_G0.9671.00
87_S241_Q0.9581.00
36_I40_M0.9581.00
75_P165_T0.9421.00
65_F70_I0.9361.00
11_V70_I0.9351.00
51_D55_G0.9301.00
133_G288_I0.9201.00
166_I279_I0.9171.00
28_I67_I0.9091.00
29_I64_S0.9071.00
198_V284_I0.9061.00
39_L46_K0.9061.00
144_W270_G0.9011.00
130_V191_G0.9001.00
214_T282_S0.8981.00
138_V273_D0.8901.00
9_F23_L0.8881.00
23_L198_V0.8861.00
174_D178_E0.8851.00
154_V256_I0.8851.00
67_I72_I0.8831.00
129_C195_F0.8811.00
37_K40_M0.8811.00
136_I291_V0.8801.00
82_W249_N0.8771.00
19_S23_L0.8731.00
240_E243_Q0.8721.00
119_E183_L0.8641.00
46_K49_L0.8631.00
45_N49_L0.8621.00
18_I73_T0.8601.00
83_G128_R0.8591.00
18_I30_R0.8591.00
216_K219_R0.8571.00
34_D38_A0.8561.00
212_D232_N0.8551.00
38_A43_S0.8551.00
145_T192_C0.8531.00
41_R44_E0.8461.00
11_V28_I0.8441.00
171_S176_E0.8431.00
262_A268_D0.8381.00
12_V17_Y0.8371.00
88_Y231_T0.8361.00
234_M241_Q0.8351.00
74_K132_H0.8341.00
82_W122_F0.8271.00
144_W178_E0.8251.00
251_I257_L0.8241.00
217_I277_V0.8231.00
49_L52_R0.8221.00
47_E50_G0.8201.00
146_L173_R0.8180.99
98_E114_D0.8160.99
153_V164_Y0.8140.99
168_D277_V0.8100.99
83_G258_T0.8090.99
76_I154_V0.8070.99
45_N48_V0.8060.99
166_I284_I0.8040.99
136_I192_C0.8020.99
80_E190_A0.8020.99
136_I191_G0.8000.99
179_N248_D0.7990.99
80_E122_F0.7970.99
184_P189_Y0.7930.99
35_P40_M0.7920.99
59_Q63_K0.7900.99
8_L201_T0.7900.99
161_I242_I0.7880.99
139_R192_C0.7880.99
57_D61_L0.7850.99
35_P42_Y0.7770.99
35_P39_L0.7760.99
179_N185_Q0.7750.99
44_E47_E0.7730.99
118_P244_Y0.7720.99
92_R114_D0.7720.99
164_Y208_P0.7630.99
263_I268_D0.7620.99
95_Y171_S0.7590.99
163_G199_I0.7540.99
88_Y259_T0.7540.99
116_V236_R0.7530.99
172_A192_C0.7530.99
132_H287_L0.7530.99
47_E51_D0.7520.99
206_K209_Y0.7500.99
117_R178_E0.7470.99
83_G186_S0.7440.99
127_N190_A0.7400.99
66_Q70_I0.7320.99
40_M162_L0.7310.99
57_D60_S0.7280.99
6_M201_T0.7280.99
161_I239_E0.7250.99
236_R240_E0.7250.99
60_S64_S0.7250.99
89_E114_D0.7240.99
23_L67_I0.7210.99
82_W245_L0.7180.99
210_S230_N0.7180.99
147_P271_L0.7130.99
7_K198_V0.7120.99
262_A266_G0.7110.99
216_K228_S0.7100.99
80_E126_P0.7100.99
23_L26_S0.7090.99
204_E210_S0.7070.99
211_L217_I0.7050.99
58_Y62_L0.7030.98
37_K43_S0.7030.98
21_A31_L0.7020.98
43_S50_G0.7010.98
97_E177_A0.6970.98
243_Q246_I0.6960.98
239_E243_Q0.6830.98
219_R276_I0.6820.98
86_I119_E0.6810.98
11_V30_R0.6800.98
238_I259_T0.6800.98
157_S253_D0.6770.98
48_V52_R0.6760.98
141_D247_R0.6740.98
202_S206_K0.6740.98
159_G246_I0.6700.98
67_I70_I0.6680.98
172_A175_L0.6670.98
139_R189_Y0.6640.98
9_F13_K0.6640.98
21_A24_D0.6630.98
40_M47_E0.6620.98
185_Q248_D0.6610.98
209_Y238_I0.6560.98
241_Q259_T0.6550.98
195_F258_T0.6550.98
81_V167_M0.6550.98
242_I257_L0.6530.98
205_I209_Y0.6530.98
115_A236_R0.6520.98
264_V268_D0.6520.98
11_V72_I0.6510.98
74_K195_F0.6470.97
39_L50_G0.6470.97
241_Q245_L0.6410.97
142_S172_A0.6410.97
136_I289_T0.6400.97
149_P166_I0.6400.97
151_L164_Y0.6380.97
18_I21_A0.6370.97
79_P127_N0.6340.97
95_Y119_E0.6340.97
159_G242_I0.6310.97
91_A146_L0.6310.97
182_Y188_I0.6300.97
213_I281_I0.6270.97
42_Y46_K0.6240.97
155_L251_I0.6230.97
202_S242_I0.6230.97
91_A176_E0.6200.97
78_P252_P0.6170.97
208_P231_T0.6160.97
277_V291_V0.6120.96
33_E63_K0.6110.96
205_I284_I0.6100.96
48_V51_D0.6050.96
175_L247_R0.6030.96
187_K247_R0.6020.96
7_K204_E0.6020.96
75_P199_I0.6020.96
284_I287_L0.6010.96
30_R33_E0.6000.96
219_R278_E0.5990.96
48_V203_D0.5980.96
189_Y248_D0.5980.96
165_T196_G0.5970.96
86_I92_R0.5960.96
54_T57_D0.5960.96
131_G197_P0.5950.96
231_T282_S0.5950.96
170_V277_V0.5930.96
117_R179_N0.5900.96
9_F20_Y0.5870.95
145_T170_V0.5870.95
211_L231_T0.5850.95
43_S162_L0.5840.95
74_K78_P0.5820.95
125_T184_P0.5810.95
80_E184_P0.5780.95
63_K66_Q0.5760.95
95_Y177_A0.5730.95
44_E48_V0.5720.95
92_R235_R0.5710.95
147_P279_I0.5690.95
83_G183_L0.5690.95
81_V129_C0.5670.95
18_I32_D0.5660.94
95_Y264_V0.5660.94
90_M93_E0.5650.94
89_E233_K0.5630.94
245_L249_N0.5630.94
38_A42_Y0.5610.94
27_T65_F0.5610.94
208_P211_L0.5600.94
120_I241_Q0.5600.94
30_R65_F0.5590.94
13_K65_F0.5580.94
90_M229_V0.5580.94
36_I41_R0.5560.94
234_M239_E0.5550.94
271_L277_V0.5550.94
170_V191_G0.5530.94
80_E127_N0.5520.94
8_L31_L0.5500.94
120_I185_Q0.5470.93
46_K51_D0.5470.93
173_R176_E0.5470.93
91_A173_R0.5450.93
263_I266_G0.5450.93
79_P126_P0.5430.93
129_C132_H0.5420.93
86_I171_S0.5410.93
178_E244_Y0.5400.93
92_R96_S0.5400.93
35_P41_R0.5400.93
156_D253_D0.5390.93
93_E233_K0.5380.93
59_Q66_Q0.5350.93
139_R142_S0.5340.93
213_I233_K0.5290.92
231_T238_I0.5280.92
179_N184_P0.5280.92
40_M44_E0.5260.92
137_A160_K0.5260.92
86_I97_E0.5260.92
92_R95_Y0.5240.92
146_L176_E0.5230.92
82_W125_T0.5190.92
41_R45_N0.5190.92
127_N250_P0.5160.91
6_M203_D0.5140.91
18_I23_L0.5110.91
170_V291_V0.5110.91
205_I208_P0.5090.91
126_P129_C0.5070.91
60_S63_K0.5040.90
20_Y23_L0.5040.90
77_D252_P0.5020.90
148_E169_D0.5020.90
39_L47_E0.5010.90
10_R19_S0.5000.90
130_V291_V0.5000.90
24_D29_I0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2q18X 3 0.9195 100 0.264 Contact Map
3r6oA 2 0.8289 100 0.273 Contact Map
3lzkA 2 0.9463 100 0.292 Contact Map
4dbfA 2 0.8121 100 0.306 Contact Map
3rr6A 1 0.8121 100 0.324 Contact Map
4qkuA 2 0.9698 100 0.324 Contact Map
1wzoA 4 0.7718 100 0.33 Contact Map
2dfuA 2 0.7752 100 0.342 Contact Map
1hyoA 2 0.9664 100 0.361 Contact Map
1gttA 1 0.8758 100 0.374 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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