ARAD - SULSO - GREMLIN Contacts

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ARAD - Arabinonate dehydratase

UniProt:	Q97U96	Sequences: MIKDIRTYKLCYEGINDERDALAIKGLAEHPMEIVATEIETSDGYVGYGESLAYGCSDAVQVTIEKILKPLLLKEDEELIEYLWDKMYKATLRFGRRGIAIAGISGVDTALWDIMGKKAKKPIYKLLGGSKRKVRAYITGGYYSEKKDLEKLRDEEAYYVKMGFKGIKVKIGAKSMEEDIERLKAIREVVGEDVKIAVDANNVYTFEEALEMGRRLEKLGIWFFEEPIQTDYLDLSARLAEELEVPIAGYETAYTRWEFYEIMRKRAVDIVQTDVMWTGGISEMMKIGNMAKVMGYPLIPHYSAGGISLIGNLHVAAALNSPWIEMHLRKNDLRDKIFKESIEIDNGHLVVPDRPGLGYTIRDGVFEEYKCKS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	373 (319)
Sequences:	12354 (7491)
Seq/√Len:	419.4

ECOLI - RSPA RHMD GUDD GUDX DGOD AEEP MENC
BACSU - YITF AEEP GUDD MENC
HALSA - Q9HS20 Q9HP25 Q9HQN7
SULSO - ARAD GAD Q97VG1 Q97YL9 Q97YR3 Q97UK8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
261_E	265_K	3.541	1.00
75_E	86_K	3.470	1.00
240_A	269_D	3.204	1.00
205_T	208_E	3.151	1.00
133_K	348_H	3.144	1.00
237_A	241_E	3.039	1.00
79_L	82_Y	2.995	1.00
37_T	106_G	2.786	1.00
232_Y	235_L	2.708	1.00
260_Y	264_R	2.706	1.00
40_E	46_V	2.548	1.00
41_T	114_I	2.488	1.00
38_E	46_V	2.467	1.00
45_Y	114_I	2.449	1.00
214_R	217_E	2.401	1.00
62_V	66_K	2.289	1.00
238_R	241_E	2.259	1.00
157_A	189_V	2.248	1.00
214_R	242_E	2.227	1.00
81_E	286_K	2.193	1.00
195_K	222_W	2.174	1.00
256_R	283_E	2.163	1.00
217_E	244_E	2.133	1.00
237_A	265_K	2.092	1.00
213_G	224_F	2.083	1.00
108_D	282_S	2.062	1.00
238_R	242_E	2.061	1.00
270_I	297_P	2.017	1.00
41_T	45_Y	2.008	1.00
181_E	184_K	2.006	1.00
61_Q	65_E	1.981	1.00
43_D	118_K	1.979	1.00
234_D	265_K	1.977	1.00
263_M	296_Y	1.963	1.00
184_K	219_L	1.949	1.00
94_F	257_W	1.936	1.00
215_R	218_K	1.930	1.00
278_T	287_I	1.901	1.00
157_A	161_K	1.865	1.00
213_G	243_L	1.841	1.00
345_D	350_V	1.837	1.00
116_G	123_I	1.836	1.00
83_L	111_L	1.830	1.00
153_R	189_V	1.828	1.00
45_Y	118_K	1.816	1.00
135_R	165_K	1.803	1.00
290_M	294_M	1.799	1.00
75_E	82_Y	1.798	1.00
259_F	287_I	1.788	1.00
180_I	215_R	1.786	1.00
122_P	125_K	1.773	1.00
210_L	242_E	1.755	1.00
212_M	216_L	1.749	1.00
67_I	98_G	1.744	1.00
38_E	48_Y	1.693	1.00
185_A	188_E	1.686	1.00
39_I	111_L	1.664	1.00
149_L	153_R	1.663	1.00
207_E	238_R	1.656	1.00
158_Y	162_M	1.644	1.00
153_R	157_A	1.628	1.00
289_N	292_K	1.619	1.00
121_K	125_K	1.613	1.00
228_I	239_L	1.571	1.00
264_R	294_M	1.571	1.00
45_Y	117_K	1.559	1.00
160_V	194_V	1.558	1.00
186_I	190_V	1.545	1.00
155_E	158_Y	1.526	1.00
148_D	151_K	1.511	1.00
163_G	194_V	1.508	1.00
175_S	178_E	1.501	1.00
85_D	89_K	1.500	1.00
263_M	290_M	1.482	1.00
113_D	117_K	1.479	1.00
41_T	118_K	1.463	1.00
260_Y	290_M	1.443	1.00
180_I	218_K	1.427	1.00
210_L	238_R	1.427	1.00
285_M	289_N	1.423	1.00
69_K	73_L	1.415	1.00
206_F	238_R	1.407	1.00
263_M	294_M	1.406	1.00
178_E	181_E	1.404	1.00
184_K	188_E	1.395	1.00
51_S	106_G	1.382	1.00
262_I	268_V	1.379	1.00
78_E	118_K	1.377	1.00
197_A	223_F	1.374	1.00
65_E	69_K	1.361	1.00
133_K	350_V	1.349	1.00
288_G	319_L	1.328	1.00
82_Y	86_K	1.314	1.00
108_D	112_W	1.310	1.00
253_A	262_I	1.308	1.00
228_I	235_L	1.304	1.00
184_K	218_K	1.300	1.00
75_E	83_L	1.297	1.00
248_A	270_I	1.289	1.00
211_E	214_R	1.289	1.00
231_D	258_E	1.289	1.00
211_E	215_R	1.284	1.00
285_M	319_L	1.283	1.00
237_A	267_A	1.281	1.00
261_E	264_R	1.278	1.00
317_A	351_V	1.274	1.00
87_M	104_I	1.272	1.00
206_F	235_L	1.272	1.00
314_H	340_E	1.263	1.00
206_F	239_L	1.251	1.00
258_E	261_E	1.251	1.00
340_E	343_E	1.244	1.00
109_T	281_I	1.238	1.00
76_D	79_L	1.235	1.00
157_A	160_V	1.235	1.00
59_A	62_V	1.226	1.00
289_N	293_V	1.217	1.00
115_M	119_A	1.215	1.00
121_K	126_L	1.214	1.00
292_K	320_N	1.210	1.00
180_I	184_K	1.200	1.00
208_E	211_E	1.199	1.00
167_I	194_V	1.193	1.00
198_V	221_I	1.193	1.00
197_A	222_W	1.191	1.00
284_M	315_V	1.190	1.00
283_E	286_K	1.180	1.00
332_D	336_K	1.179	1.00
180_I	219_L	1.176	1.00
151_K	154_D	1.174	1.00
256_R	290_M	1.162	1.00
154_D	157_A	1.158	1.00
109_T	311_G	1.158	1.00
135_R	348_H	1.157	1.00
42_S	77_E	1.151	1.00
113_D	311_G	1.143	1.00
116_G	126_L	1.130	1.00
227_P	247_I	1.130	1.00
156_E	167_I	1.121	1.00
255_T	258_E	1.121	1.00
181_E	185_A	1.112	1.00
227_P	239_L	1.111	1.00
214_R	244_E	1.103	1.00
259_F	271_V	1.103	1.00
209_A	213_G	1.095	1.00
177_E	181_E	1.069	1.00
286_K	289_N	1.065	1.00
183_L	187_R	1.062	1.00
183_L	219_L	1.062	1.00
190_V	196_I	1.059	1.00
170_K	201_N	1.057	1.00
249_G	262_I	1.048	1.00
66_K	70_P	1.048	1.00
246_P	323_W	1.047	1.00
271_V	291_A	1.044	1.00
217_E	245_V	1.041	1.00
210_L	239_L	1.029	1.00
200_A	224_F	1.027	1.00
67_I	70_P	1.024	1.00
275_V	284_M	1.017	1.00
240_A	266_R	1.016	1.00
81_E	285_M	1.012	1.00
290_M	293_V	1.012	1.00
180_I	190_V	1.005	1.00
153_R	188_E	1.001	1.00
239_L	247_I	0.996	1.00
156_E	190_V	0.996	1.00
185_A	189_V	0.994	1.00
78_E	115_M	0.992	1.00
112_W	282_S	0.990	1.00
160_V	167_I	0.985	1.00
266_R	296_Y	0.983	1.00
75_E	79_L	0.981	1.00
204_Y	209_A	0.979	1.00
78_E	119_A	0.977	1.00
46_V	49_G	0.965	1.00
36_A	307_I	0.964	1.00
158_Y	161_K	0.958	1.00
68_L	107_V	0.957	1.00
164_F	330_K	0.950	1.00
80_I	115_M	0.949	1.00
169_V	186_I	0.947	1.00
71_L	86_K	0.946	1.00
248_A	272_Q	0.945	1.00
260_Y	294_M	0.942	1.00
200_A	213_G	0.942	1.00
143_Y	151_K	0.939	1.00
274_D	301_H	0.935	1.00
288_G	298_L	0.931	1.00
300_P	321_S	0.927	1.00
187_R	191_G	0.921	1.00
234_D	237_A	0.919	1.00
154_D	158_Y	0.911	1.00
36_A	48_Y	0.910	1.00
153_R	190_V	0.908	1.00
253_A	268_V	0.905	1.00
83_L	86_K	0.904	1.00
141_G	179_D	0.900	1.00
149_L	185_A	0.898	1.00
334_R	337_I	0.896	1.00
226_E	272_Q	0.896	1.00
119_A	126_L	0.895	1.00
127_L	285_M	0.891	1.00
206_F	210_L	0.891	1.00
204_Y	212_M	0.888	1.00
256_R	286_K	0.887	1.00
64_I	107_V	0.884	1.00
228_I	236_S	0.880	1.00
53_A	166_G	0.878	1.00
221_I	245_V	0.878	1.00
175_S	179_D	0.876	1.00
50_E	307_I	0.874	1.00
139_T	160_V	0.871	1.00
278_T	284_M	0.869	1.00
179_D	186_I	0.868	1.00
233_L	267_A	0.867	1.00
187_R	190_V	0.864	1.00
179_D	187_R	0.864	1.00
36_A	343_E	0.861	1.00
81_E	85_D	0.860	1.00
234_D	261_E	0.856	1.00
183_L	198_V	0.855	1.00
72_L	75_E	0.854	1.00
286_K	292_K	0.850	1.00
288_G	292_K	0.843	1.00
84_W	88_Y	0.843	1.00
187_R	196_I	0.842	1.00
263_M	271_V	0.841	1.00
77_E	111_L	0.838	1.00
187_R	193_D	0.833	1.00
84_W	108_D	0.830	1.00
46_V	50_E	0.828	1.00
58_D	62_V	0.826	1.00
190_V	194_V	0.824	1.00
123_I	281_I	0.823	1.00
235_L	238_R	0.818	1.00
288_G	300_P	0.817	1.00
281_I	311_G	0.815	1.00
40_E	44_G	0.812	1.00
172_G	179_D	0.811	1.00
268_V	271_V	0.811	1.00
112_W	281_I	0.809	1.00
35_V	61_Q	0.803	1.00
166_G	197_A	0.803	1.00
183_L	216_L	0.802	1.00
123_I	127_L	0.801	1.00
159_Y	162_M	0.801	1.00
138_I	142_Y	0.801	1.00
241_E	266_R	0.799	1.00
115_M	126_L	0.798	1.00
209_A	228_I	0.795	1.00
180_I	187_R	0.789	1.00
84_W	87_M	0.788	1.00
250_Y	274_D	0.785	1.00
41_T	77_E	0.785	1.00
300_P	316_A	0.784	1.00
169_V	172_G	0.783	1.00
157_A	342_I	0.781	1.00
175_S	188_E	0.778	1.00
211_E	242_E	0.777	1.00
63_T	67_I	0.776	1.00
88_Y	283_E	0.775	1.00
95_G	98_G	0.768	1.00
206_F	228_I	0.768	1.00
253_A	259_F	0.768	1.00
207_E	211_E	0.765	1.00
187_R	220_G	0.764	1.00
150_E	154_D	0.763	1.00
77_E	115_M	0.759	1.00
124_Y	351_V	0.756	1.00
236_S	247_I	0.754	1.00
140_G	143_Y	0.752	1.00
86_K	89_K	0.750	1.00
83_L	87_M	0.739	1.00
239_L	243_L	0.737	1.00
64_I	69_K	0.737	1.00
233_L	262_I	0.736	1.00
281_I	285_M	0.736	1.00
236_S	249_G	0.734	1.00
273_T	288_G	0.731	1.00
124_Y	314_H	0.731	1.00
275_V	315_V	0.731	1.00
176_M	212_M	0.729	1.00
344_I	349_L	0.729	1.00
125_K	130_S	0.728	1.00
62_V	65_E	0.726	1.00
112_W	123_I	0.724	1.00
285_M	318_A	0.722	1.00
249_G	268_V	0.721	1.00
84_W	282_S	0.717	1.00
311_G	315_V	0.716	1.00
175_S	187_R	0.714	1.00
180_I	183_L	0.714	1.00
217_E	243_L	0.713	1.00
40_E	48_Y	0.711	1.00
179_D	188_E	0.710	1.00
273_T	284_M	0.710	1.00
61_Q	64_I	0.709	1.00
275_V	312_N	0.709	1.00
151_K	155_E	0.706	1.00
313_L	351_V	0.706	1.00
104_I	280_G	0.702	1.00
179_D	189_V	0.696	1.00
48_Y	307_I	0.694	1.00
233_L	261_E	0.694	1.00
254_Y	258_E	0.690	1.00
210_L	228_I	0.687	1.00
81_E	282_S	0.686	1.00
332_D	335_D	0.685	1.00
240_A	247_I	0.685	1.00
70_P	73_L	0.681	1.00
113_D	310_I	0.678	1.00
80_I	83_L	0.676	1.00
317_A	352_P	0.674	1.00
256_R	287_I	0.674	1.00
271_V	296_Y	0.673	1.00
136_A	139_T	0.672	1.00
259_F	296_Y	0.671	1.00
156_E	160_V	0.671	1.00
238_R	266_R	0.670	1.00
185_A	190_V	0.667	0.99
85_D	88_Y	0.666	0.99
192_E	220_G	0.666	0.99
71_L	90_A	0.663	0.99
210_L	243_L	0.662	0.99
139_T	143_Y	0.660	0.99
170_K	174_K	0.660	0.99
171_I	200_A	0.659	0.99
257_W	260_Y	0.659	0.99
345_D	348_H	0.658	0.99
137_Y	140_G	0.658	0.99
85_D	286_K	0.657	0.99
253_A	258_E	0.657	0.99
59_A	64_I	0.656	0.99
138_I	164_F	0.652	0.99
40_E	43_D	0.651	0.99
285_M	315_V	0.649	0.99
41_T	44_G	0.648	0.99
292_K	321_S	0.647	0.99
292_K	298_L	0.647	0.99
200_A	204_Y	0.646	0.99
77_E	80_I	0.644	0.99
204_Y	224_F	0.641	0.99
67_I	71_L	0.641	0.99
177_E	215_R	0.641	0.99
71_L	75_E	0.638	0.99
209_A	239_L	0.636	0.99
127_L	281_I	0.635	0.99
154_D	189_V	0.633	0.99
119_A	122_P	0.632	0.99
138_I	159_Y	0.631	0.99
333_L	337_I	0.630	0.99
77_E	118_K	0.627	0.99
112_W	127_L	0.623	0.99
116_G	121_K	0.622	0.99
49_G	106_G	0.618	0.99
256_R	260_Y	0.617	0.99
179_D	204_Y	0.615	0.99
210_L	214_R	0.615	0.99
273_T	298_L	0.611	0.99
236_S	239_L	0.610	0.99
39_I	72_L	0.607	0.99
259_F	291_A	0.607	0.99
123_I	126_L	0.607	0.99
155_E	159_Y	0.603	0.99
291_A	296_Y	0.602	0.99
46_V	117_K	0.601	0.99
58_D	66_K	0.599	0.99
149_L	181_E	0.598	0.99
308_S	336_K	0.593	0.99
325_E	329_R	0.592	0.99
233_L	265_K	0.591	0.99
169_V	173_A	0.587	0.99
167_I	190_V	0.583	0.99
213_G	245_V	0.580	0.99
179_D	190_V	0.579	0.99
116_G	119_A	0.578	0.99
127_L	318_A	0.577	0.99
130_S	133_K	0.577	0.99
178_E	182_R	0.576	0.99
272_Q	301_H	0.576	0.99
313_L	349_L	0.575	0.99
323_W	327_H	0.574	0.98
111_L	115_M	0.574	0.98
257_W	261_E	0.573	0.98
153_R	185_A	0.573	0.98
325_E	328_L	0.573	0.98
64_I	68_L	0.571	0.98
149_L	168_K	0.570	0.98
259_F	273_T	0.570	0.98
76_D	125_K	0.568	0.98
77_E	114_I	0.567	0.98
114_I	118_K	0.567	0.98
178_E	187_R	0.566	0.98
139_T	142_Y	0.565	0.98
128_G	131_K	0.564	0.98
189_V	192_E	0.563	0.98
35_V	60_V	0.563	0.98
115_M	118_K	0.562	0.98
141_G	186_I	0.561	0.98
323_W	326_M	0.560	0.98
226_E	251_E	0.560	0.98
166_G	195_K	0.559	0.98
179_D	182_R	0.558	0.98
79_L	125_K	0.558	0.98
52_L	55_G	0.558	0.98
343_E	350_V	0.556	0.98
123_I	314_H	0.556	0.98
267_A	296_Y	0.554	0.98
271_V	287_I	0.551	0.98
183_L	186_I	0.550	0.98
169_V	183_L	0.549	0.98
128_G	133_K	0.549	0.98
331_N	334_R	0.548	0.98
223_F	299_I	0.545	0.98
310_I	314_H	0.544	0.98
137_Y	141_G	0.542	0.98
88_Y	104_I	0.540	0.98
268_V	296_Y	0.540	0.98
129_G	132_R	0.540	0.98
177_E	180_I	0.539	0.98
122_P	128_G	0.537	0.98
298_L	321_S	0.537	0.98
258_E	267_A	0.537	0.98
183_L	190_V	0.536	0.98
291_A	298_L	0.535	0.98
72_L	111_L	0.535	0.98
83_L	107_V	0.533	0.98
63_T	99_I	0.532	0.98
57_S	60_V	0.532	0.98
151_K	159_Y	0.532	0.98
87_M	280_G	0.529	0.97
184_K	187_R	0.529	0.97
165_K	346_N	0.529	0.97
83_L	88_Y	0.529	0.97
275_V	281_I	0.529	0.97
207_E	210_L	0.528	0.97
37_T	64_I	0.528	0.97
170_K	173_A	0.527	0.97
47_G	113_D	0.526	0.97
156_E	186_I	0.526	0.97
333_L	336_K	0.526	0.97
36_A	340_E	0.526	0.97
179_D	185_A	0.525	0.97
135_R	195_K	0.525	0.97
187_R	219_L	0.525	0.97
64_I	106_G	0.523	0.97
186_I	189_V	0.521	0.97
243_L	247_I	0.521	0.97
226_E	252_T	0.521	0.97
72_L	107_V	0.519	0.97
82_Y	85_D	0.519	0.97
164_F	329_R	0.519	0.97
56_C	59_A	0.518	0.97
157_A	190_V	0.517	0.97
304_A	308_S	0.516	0.97
80_I	282_S	0.515	0.97
80_I	126_L	0.514	0.97
140_G	159_Y	0.514	0.97
226_E	250_Y	0.514	0.97
143_Y	148_D	0.514	0.97
184_K	215_R	0.514	0.97
117_K	120_K	0.513	0.97
281_I	315_V	0.513	0.97
213_G	216_L	0.512	0.97
316_A	322_P	0.510	0.97
237_A	266_R	0.509	0.97
68_L	91_T	0.509	0.97
324_I	327_H	0.508	0.97
156_E	185_A	0.506	0.97
176_M	180_I	0.506	0.97
156_E	189_V	0.506	0.97
222_W	246_P	0.504	0.97
160_V	190_V	0.503	0.97
338_F	341_S	0.502	0.97
63_T	103_G	0.501	0.96
133_K	346_N	0.500	0.96
180_I	189_V	0.500	0.96

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3s5sA	2	0.9491	100	0.167	Contact Map
3i4kA	4	0.9598	100	0.184	Contact Map
3fcpA	5	0.9249	100	0.184	Contact Map
3u9iA	2	0.9088	100	0.185	Contact Map
3dgbA	5	0.9598	100	0.188	Contact Map
3ddmA	2	0.9357	100	0.191	Contact Map
3qldA	2	0.9437	100	0.191	Contact Map
1wueA	2	0.9517	100	0.191	Contact Map
1sjdA	5	0.9437	100	0.192	Contact Map
3i6eA	4	0.9249	100	0.192	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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