GREMLIN Database
ARAD - Arabinonate dehydratase
UniProt: Q97U96 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 373 (319)
Sequences: 12354 (7491)
Seq/√Len: 419.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
261_E265_K3.5411.00
75_E86_K3.4701.00
240_A269_D3.2041.00
205_T208_E3.1511.00
133_K348_H3.1441.00
237_A241_E3.0391.00
79_L82_Y2.9951.00
37_T106_G2.7861.00
232_Y235_L2.7081.00
260_Y264_R2.7061.00
40_E46_V2.5481.00
41_T114_I2.4881.00
38_E46_V2.4671.00
45_Y114_I2.4491.00
214_R217_E2.4011.00
62_V66_K2.2891.00
238_R241_E2.2591.00
157_A189_V2.2481.00
214_R242_E2.2271.00
81_E286_K2.1931.00
195_K222_W2.1741.00
256_R283_E2.1631.00
217_E244_E2.1331.00
237_A265_K2.0921.00
213_G224_F2.0831.00
108_D282_S2.0621.00
238_R242_E2.0611.00
270_I297_P2.0171.00
41_T45_Y2.0081.00
181_E184_K2.0061.00
61_Q65_E1.9811.00
43_D118_K1.9791.00
234_D265_K1.9771.00
263_M296_Y1.9631.00
184_K219_L1.9491.00
94_F257_W1.9361.00
215_R218_K1.9301.00
278_T287_I1.9011.00
157_A161_K1.8651.00
213_G243_L1.8411.00
345_D350_V1.8371.00
116_G123_I1.8361.00
83_L111_L1.8301.00
153_R189_V1.8281.00
45_Y118_K1.8161.00
135_R165_K1.8031.00
290_M294_M1.7991.00
75_E82_Y1.7981.00
259_F287_I1.7881.00
180_I215_R1.7861.00
122_P125_K1.7731.00
210_L242_E1.7551.00
212_M216_L1.7491.00
67_I98_G1.7441.00
38_E48_Y1.6931.00
185_A188_E1.6861.00
39_I111_L1.6641.00
149_L153_R1.6631.00
207_E238_R1.6561.00
158_Y162_M1.6441.00
153_R157_A1.6281.00
289_N292_K1.6191.00
121_K125_K1.6131.00
228_I239_L1.5711.00
264_R294_M1.5711.00
45_Y117_K1.5591.00
160_V194_V1.5581.00
186_I190_V1.5451.00
155_E158_Y1.5261.00
148_D151_K1.5111.00
163_G194_V1.5081.00
175_S178_E1.5011.00
85_D89_K1.5001.00
263_M290_M1.4821.00
113_D117_K1.4791.00
41_T118_K1.4631.00
260_Y290_M1.4431.00
180_I218_K1.4271.00
210_L238_R1.4271.00
285_M289_N1.4231.00
69_K73_L1.4151.00
206_F238_R1.4071.00
263_M294_M1.4061.00
178_E181_E1.4041.00
184_K188_E1.3951.00
51_S106_G1.3821.00
262_I268_V1.3791.00
78_E118_K1.3771.00
197_A223_F1.3741.00
65_E69_K1.3611.00
133_K350_V1.3491.00
288_G319_L1.3281.00
82_Y86_K1.3141.00
108_D112_W1.3101.00
253_A262_I1.3081.00
228_I235_L1.3041.00
184_K218_K1.3001.00
75_E83_L1.2971.00
248_A270_I1.2891.00
211_E214_R1.2891.00
231_D258_E1.2891.00
211_E215_R1.2841.00
285_M319_L1.2831.00
237_A267_A1.2811.00
261_E264_R1.2781.00
317_A351_V1.2741.00
87_M104_I1.2721.00
206_F235_L1.2721.00
314_H340_E1.2631.00
206_F239_L1.2511.00
258_E261_E1.2511.00
340_E343_E1.2441.00
109_T281_I1.2381.00
76_D79_L1.2351.00
157_A160_V1.2351.00
59_A62_V1.2261.00
289_N293_V1.2171.00
115_M119_A1.2151.00
121_K126_L1.2141.00
292_K320_N1.2101.00
180_I184_K1.2001.00
208_E211_E1.1991.00
167_I194_V1.1931.00
198_V221_I1.1931.00
197_A222_W1.1911.00
284_M315_V1.1901.00
283_E286_K1.1801.00
332_D336_K1.1791.00
180_I219_L1.1761.00
151_K154_D1.1741.00
256_R290_M1.1621.00
154_D157_A1.1581.00
109_T311_G1.1581.00
135_R348_H1.1571.00
42_S77_E1.1511.00
113_D311_G1.1431.00
116_G126_L1.1301.00
227_P247_I1.1301.00
156_E167_I1.1211.00
255_T258_E1.1211.00
181_E185_A1.1121.00
227_P239_L1.1111.00
214_R244_E1.1031.00
259_F271_V1.1031.00
209_A213_G1.0951.00
177_E181_E1.0691.00
286_K289_N1.0651.00
183_L187_R1.0621.00
183_L219_L1.0621.00
190_V196_I1.0591.00
170_K201_N1.0571.00
249_G262_I1.0481.00
66_K70_P1.0481.00
246_P323_W1.0471.00
271_V291_A1.0441.00
217_E245_V1.0411.00
210_L239_L1.0291.00
200_A224_F1.0271.00
67_I70_P1.0241.00
275_V284_M1.0171.00
240_A266_R1.0161.00
81_E285_M1.0121.00
290_M293_V1.0121.00
180_I190_V1.0051.00
153_R188_E1.0011.00
239_L247_I0.9961.00
156_E190_V0.9961.00
185_A189_V0.9941.00
78_E115_M0.9921.00
112_W282_S0.9901.00
160_V167_I0.9851.00
266_R296_Y0.9831.00
75_E79_L0.9811.00
204_Y209_A0.9791.00
78_E119_A0.9771.00
46_V49_G0.9651.00
36_A307_I0.9641.00
158_Y161_K0.9581.00
68_L107_V0.9571.00
164_F330_K0.9501.00
80_I115_M0.9491.00
169_V186_I0.9471.00
71_L86_K0.9461.00
248_A272_Q0.9451.00
260_Y294_M0.9421.00
200_A213_G0.9421.00
143_Y151_K0.9391.00
274_D301_H0.9351.00
288_G298_L0.9311.00
300_P321_S0.9271.00
187_R191_G0.9211.00
234_D237_A0.9191.00
154_D158_Y0.9111.00
36_A48_Y0.9101.00
153_R190_V0.9081.00
253_A268_V0.9051.00
83_L86_K0.9041.00
141_G179_D0.9001.00
149_L185_A0.8981.00
334_R337_I0.8961.00
226_E272_Q0.8961.00
119_A126_L0.8951.00
127_L285_M0.8911.00
206_F210_L0.8911.00
204_Y212_M0.8881.00
256_R286_K0.8871.00
64_I107_V0.8841.00
228_I236_S0.8801.00
53_A166_G0.8781.00
221_I245_V0.8781.00
175_S179_D0.8761.00
50_E307_I0.8741.00
139_T160_V0.8711.00
278_T284_M0.8691.00
179_D186_I0.8681.00
233_L267_A0.8671.00
187_R190_V0.8641.00
179_D187_R0.8641.00
36_A343_E0.8611.00
81_E85_D0.8601.00
234_D261_E0.8561.00
183_L198_V0.8551.00
72_L75_E0.8541.00
286_K292_K0.8501.00
288_G292_K0.8431.00
84_W88_Y0.8431.00
187_R196_I0.8421.00
263_M271_V0.8411.00
77_E111_L0.8381.00
187_R193_D0.8331.00
84_W108_D0.8301.00
46_V50_E0.8281.00
58_D62_V0.8261.00
190_V194_V0.8241.00
123_I281_I0.8231.00
235_L238_R0.8181.00
288_G300_P0.8171.00
281_I311_G0.8151.00
40_E44_G0.8121.00
172_G179_D0.8111.00
268_V271_V0.8111.00
112_W281_I0.8091.00
35_V61_Q0.8031.00
166_G197_A0.8031.00
183_L216_L0.8021.00
123_I127_L0.8011.00
159_Y162_M0.8011.00
138_I142_Y0.8011.00
241_E266_R0.7991.00
115_M126_L0.7981.00
209_A228_I0.7951.00
180_I187_R0.7891.00
84_W87_M0.7881.00
250_Y274_D0.7851.00
41_T77_E0.7851.00
300_P316_A0.7841.00
169_V172_G0.7831.00
157_A342_I0.7811.00
175_S188_E0.7781.00
211_E242_E0.7771.00
63_T67_I0.7761.00
88_Y283_E0.7751.00
95_G98_G0.7681.00
206_F228_I0.7681.00
253_A259_F0.7681.00
207_E211_E0.7651.00
187_R220_G0.7641.00
150_E154_D0.7631.00
77_E115_M0.7591.00
124_Y351_V0.7561.00
236_S247_I0.7541.00
140_G143_Y0.7521.00
86_K89_K0.7501.00
83_L87_M0.7391.00
239_L243_L0.7371.00
64_I69_K0.7371.00
233_L262_I0.7361.00
281_I285_M0.7361.00
236_S249_G0.7341.00
273_T288_G0.7311.00
124_Y314_H0.7311.00
275_V315_V0.7311.00
176_M212_M0.7291.00
344_I349_L0.7291.00
125_K130_S0.7281.00
62_V65_E0.7261.00
112_W123_I0.7241.00
285_M318_A0.7221.00
249_G268_V0.7211.00
84_W282_S0.7171.00
311_G315_V0.7161.00
175_S187_R0.7141.00
180_I183_L0.7141.00
217_E243_L0.7131.00
40_E48_Y0.7111.00
179_D188_E0.7101.00
273_T284_M0.7101.00
61_Q64_I0.7091.00
275_V312_N0.7091.00
151_K155_E0.7061.00
313_L351_V0.7061.00
104_I280_G0.7021.00
179_D189_V0.6961.00
48_Y307_I0.6941.00
233_L261_E0.6941.00
254_Y258_E0.6901.00
210_L228_I0.6871.00
81_E282_S0.6861.00
332_D335_D0.6851.00
240_A247_I0.6851.00
70_P73_L0.6811.00
113_D310_I0.6781.00
80_I83_L0.6761.00
317_A352_P0.6741.00
256_R287_I0.6741.00
271_V296_Y0.6731.00
136_A139_T0.6721.00
259_F296_Y0.6711.00
156_E160_V0.6711.00
238_R266_R0.6701.00
185_A190_V0.6670.99
85_D88_Y0.6660.99
192_E220_G0.6660.99
71_L90_A0.6630.99
210_L243_L0.6620.99
139_T143_Y0.6600.99
170_K174_K0.6600.99
171_I200_A0.6590.99
257_W260_Y0.6590.99
345_D348_H0.6580.99
137_Y140_G0.6580.99
85_D286_K0.6570.99
253_A258_E0.6570.99
59_A64_I0.6560.99
138_I164_F0.6520.99
40_E43_D0.6510.99
285_M315_V0.6490.99
41_T44_G0.6480.99
292_K321_S0.6470.99
292_K298_L0.6470.99
200_A204_Y0.6460.99
77_E80_I0.6440.99
204_Y224_F0.6410.99
67_I71_L0.6410.99
177_E215_R0.6410.99
71_L75_E0.6380.99
209_A239_L0.6360.99
127_L281_I0.6350.99
154_D189_V0.6330.99
119_A122_P0.6320.99
138_I159_Y0.6310.99
333_L337_I0.6300.99
77_E118_K0.6270.99
112_W127_L0.6230.99
116_G121_K0.6220.99
49_G106_G0.6180.99
256_R260_Y0.6170.99
179_D204_Y0.6150.99
210_L214_R0.6150.99
273_T298_L0.6110.99
236_S239_L0.6100.99
39_I72_L0.6070.99
259_F291_A0.6070.99
123_I126_L0.6070.99
155_E159_Y0.6030.99
291_A296_Y0.6020.99
46_V117_K0.6010.99
58_D66_K0.5990.99
149_L181_E0.5980.99
308_S336_K0.5930.99
325_E329_R0.5920.99
233_L265_K0.5910.99
169_V173_A0.5870.99
167_I190_V0.5830.99
213_G245_V0.5800.99
179_D190_V0.5790.99
116_G119_A0.5780.99
127_L318_A0.5770.99
130_S133_K0.5770.99
178_E182_R0.5760.99
272_Q301_H0.5760.99
313_L349_L0.5750.99
323_W327_H0.5740.98
111_L115_M0.5740.98
257_W261_E0.5730.98
153_R185_A0.5730.98
325_E328_L0.5730.98
64_I68_L0.5710.98
149_L168_K0.5700.98
259_F273_T0.5700.98
76_D125_K0.5680.98
77_E114_I0.5670.98
114_I118_K0.5670.98
178_E187_R0.5660.98
139_T142_Y0.5650.98
128_G131_K0.5640.98
189_V192_E0.5630.98
35_V60_V0.5630.98
115_M118_K0.5620.98
141_G186_I0.5610.98
323_W326_M0.5600.98
226_E251_E0.5600.98
166_G195_K0.5590.98
179_D182_R0.5580.98
79_L125_K0.5580.98
52_L55_G0.5580.98
343_E350_V0.5560.98
123_I314_H0.5560.98
267_A296_Y0.5540.98
271_V287_I0.5510.98
183_L186_I0.5500.98
169_V183_L0.5490.98
128_G133_K0.5490.98
331_N334_R0.5480.98
223_F299_I0.5450.98
310_I314_H0.5440.98
137_Y141_G0.5420.98
88_Y104_I0.5400.98
268_V296_Y0.5400.98
129_G132_R0.5400.98
177_E180_I0.5390.98
122_P128_G0.5370.98
298_L321_S0.5370.98
258_E267_A0.5370.98
183_L190_V0.5360.98
291_A298_L0.5350.98
72_L111_L0.5350.98
83_L107_V0.5330.98
63_T99_I0.5320.98
57_S60_V0.5320.98
151_K159_Y0.5320.98
87_M280_G0.5290.97
184_K187_R0.5290.97
165_K346_N0.5290.97
83_L88_Y0.5290.97
275_V281_I0.5290.97
207_E210_L0.5280.97
37_T64_I0.5280.97
170_K173_A0.5270.97
47_G113_D0.5260.97
156_E186_I0.5260.97
333_L336_K0.5260.97
36_A340_E0.5260.97
179_D185_A0.5250.97
135_R195_K0.5250.97
187_R219_L0.5250.97
64_I106_G0.5230.97
186_I189_V0.5210.97
243_L247_I0.5210.97
226_E252_T0.5210.97
72_L107_V0.5190.97
82_Y85_D0.5190.97
164_F329_R0.5190.97
56_C59_A0.5180.97
157_A190_V0.5170.97
304_A308_S0.5160.97
80_I282_S0.5150.97
80_I126_L0.5140.97
140_G159_Y0.5140.97
226_E250_Y0.5140.97
143_Y148_D0.5140.97
184_K215_R0.5140.97
117_K120_K0.5130.97
281_I315_V0.5130.97
213_G216_L0.5120.97
316_A322_P0.5100.97
237_A266_R0.5090.97
68_L91_T0.5090.97
324_I327_H0.5080.97
156_E185_A0.5060.97
176_M180_I0.5060.97
156_E189_V0.5060.97
222_W246_P0.5040.97
160_V190_V0.5030.97
338_F341_S0.5020.97
63_T103_G0.5010.96
133_K346_N0.5000.96
180_I189_V0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3s5sA 2 0.9491 100 0.167 Contact Map
3i4kA 4 0.9598 100 0.184 Contact Map
3fcpA 5 0.9249 100 0.184 Contact Map
3u9iA 2 0.9088 100 0.185 Contact Map
3dgbA 5 0.9598 100 0.188 Contact Map
3ddmA 2 0.9357 100 0.191 Contact Map
3qldA 2 0.9437 100 0.191 Contact Map
1wueA 2 0.9517 100 0.191 Contact Map
1sjdA 5 0.9437 100 0.192 Contact Map
3i6eA 4 0.9249 100 0.192 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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