GREMLIN Database
Q97U95 - Uncharacterized protein
UniProt: Q97U95 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 413 (365)
Sequences: 1496 (1081)
Seq/√Len: 56.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
24_V96_G3.6471.00
27_I97_L3.4031.00
38_H289_N3.3351.00
70_L191_A3.2171.00
267_A305_F3.1811.00
220_L229_V3.1591.00
333_R336_I3.0111.00
34_Q37_R2.9801.00
197_L247_M2.9321.00
68_K96_G2.8001.00
138_I142_R2.7911.00
307_A312_K2.7611.00
101_L104_I2.7001.00
72_R92_L2.6741.00
333_R338_E2.6571.00
303_E307_A2.5911.00
30_T151_Y2.5801.00
37_R57_F2.4921.00
247_M252_Y2.3971.00
26_Q154_K2.3951.00
352_F355_V2.3701.00
45_A257_V2.3191.00
358_S361_E2.2511.00
67_A95_V2.2481.00
13_P51_G2.2131.00
149_G153_D2.2071.00
66_L191_A2.2061.00
107_L113_F2.2001.00
31_E147_Y2.1641.00
266_H269_V2.0641.00
215_R254_H2.0411.00
343_N347_I2.0021.00
145_D166_Q1.9701.00
343_N346_L1.9651.00
330_E333_R1.9591.00
346_L350_H1.9451.00
67_A99_G1.9281.00
148_L152_L1.9111.00
260_Y313_G1.8841.00
345_G348_L1.8691.00
91_Y178_E1.8681.00
336_I339_I1.8571.00
141_N170_S1.8540.99
10_I50_P1.8460.99
229_V237_V1.8180.99
343_N349_Y1.7910.99
347_I350_H1.7880.99
147_Y151_Y1.7870.99
343_N348_L1.7690.99
350_H354_D1.7630.99
338_E341_R1.7470.99
24_V64_M1.7350.99
350_H353_Y1.7340.99
14_I202_Y1.7330.99
351_D355_V1.7220.99
346_L349_Y1.7180.99
64_M96_G1.7110.99
263_V314_F1.7070.99
152_L155_L1.7020.99
333_R337_N1.6990.99
306_D312_K1.6890.99
143_V286_L1.6780.99
336_I341_R1.6740.99
339_I342_E1.6620.99
170_S175_T1.6540.99
335_E339_I1.6480.99
247_M251_I1.6250.99
106_H137_V1.6220.99
357_Y361_E1.6140.99
16_G214_E1.6130.99
178_E181_A1.6070.99
15_H198_L1.6010.98
11_R17_Y1.5940.98
67_A184_I1.5790.98
90_E164_F1.5770.98
345_G350_H1.5700.98
38_H310_Y1.5660.98
333_R339_I1.5570.98
10_I20_V1.5400.98
47_L260_Y1.5320.98
254_H311_R1.5280.98
267_A297_L1.5130.98
70_L220_L1.5120.98
102_H192_D1.5010.98
215_R311_R1.4960.98
301_G310_Y1.4950.98
325_C338_E1.4790.97
13_P202_Y1.4640.97
326_Y333_R1.4520.97
109_F294_M1.4460.97
347_I351_D1.4390.97
281_A284_N1.4270.97
350_H355_V1.4140.97
103_D192_D1.3930.96
190_D193_R1.3920.96
65_H69_E1.3720.96
302_R306_D1.3690.96
24_V97_L1.3670.96
194_G211_F1.3630.96
233_A236_V1.3570.96
95_V185_I1.3560.96
111_H192_D1.3550.96
73_Y217_K1.3540.96
63_V191_A1.3420.95
29_S37_R1.3310.95
102_H136_H1.3290.95
366_D369_E1.3230.95
335_E340_M1.3110.95
95_V181_A1.3060.95
223_V228_A1.2980.95
325_C339_I1.2890.94
271_L300_A1.2820.94
345_G351_D1.2810.94
349_Y352_F1.2790.94
147_Y152_L1.2750.94
109_F393_Y1.2630.94
20_V25_L1.2580.94
186_S190_D1.2570.94
347_I352_F1.2550.94
106_H136_H1.2520.93
335_E342_E1.2510.93
193_R241_L1.2460.93
101_L144_I1.2330.93
255_S316_R1.2300.93
69_E214_E1.2290.93
27_I101_L1.2280.93
284_N287_K1.2270.93
348_L351_D1.2190.92
351_D354_D1.2190.92
263_V313_G1.2050.92
137_V192_D1.2050.92
45_A49_Y1.1970.92
102_H137_V1.1810.91
219_S233_A1.1800.91
182_S185_I1.1720.91
332_K335_E1.1640.91
168_V181_A1.1540.90
198_L213_I1.1510.90
345_G349_Y1.1430.90
136_H192_D1.1410.90
94_L164_F1.1410.90
339_I346_L1.1410.90
32_I146_Y1.1390.90
378_K387_K1.1360.90
28_I33_F1.1310.89
204_A251_I1.1310.89
263_V304_F1.1270.89
11_R49_Y1.1240.89
163_N167_R1.1210.89
226_K363_F1.1180.89
9_I17_Y1.1170.89
20_V28_I1.1140.89
107_L285_Y1.1110.88
208_Y245_M1.1100.88
208_Y247_M1.1080.88
53_R58_E1.1050.88
325_C335_E1.0960.88
102_H106_H1.0960.88
392_G395_E1.0910.88
166_Q169_I1.0900.88
343_N350_H1.0900.88
371_K376_E1.0890.87
164_F176_K1.0890.87
334_K338_E1.0880.87
336_I342_E1.0790.87
206_V247_M1.0780.87
57_F215_R1.0770.87
306_D310_Y1.0670.86
14_I51_G1.0670.86
311_R315_K1.0660.86
197_L201_S1.0630.86
152_L156_S1.0550.86
21_E24_V1.0440.85
67_A191_A1.0410.85
50_P53_R1.0370.85
105_G110_S1.0320.84
348_L355_V1.0310.84
153_D162_V1.0280.84
343_N351_D1.0220.84
69_E72_R1.0200.84
75_K92_L1.0160.84
34_Q109_F1.0150.84
256_V311_R1.0140.83
221_I228_A1.0090.83
334_K339_I1.0070.83
37_R47_L1.0060.83
350_H356_P1.0040.83
349_Y353_Y0.9990.83
276_L279_N0.9990.83
103_D111_H0.9960.82
347_I354_D0.9930.82
104_I375_T0.9830.81
56_R59_H0.9820.81
267_A304_F0.9820.81
104_I140_G0.9800.81
259_L314_F0.9770.81
8_K25_L0.9760.81
333_R341_R0.9730.81
229_V233_A0.9690.81
153_D160_D0.9680.80
148_L151_Y0.9600.80
13_P203_F0.9590.80
111_H137_V0.9580.80
10_I14_I0.9570.80
209_G238_E0.9550.80
325_C333_R0.9520.79
51_G203_F0.9500.79
58_E203_F0.9440.79
243_A247_M0.9430.79
25_L29_S0.9430.79
54_H200_D0.9430.79
348_L352_F0.9400.78
197_L243_A0.9290.78
27_I53_R0.9220.77
29_S311_R0.9150.77
34_Q57_F0.9140.77
150_N153_D0.9130.76
29_S34_Q0.9130.76
326_Y330_E0.9110.76
344_N347_I0.9060.76
52_M204_A0.9030.76
104_I144_I0.9030.76
41_Q54_H0.9010.75
71_T75_K0.8990.75
338_E342_E0.8990.75
181_A185_I0.8960.75
162_V166_Q0.8950.75
169_I190_D0.8940.75
336_I340_M0.8940.75
11_R245_M0.8900.75
332_K339_I0.8900.75
90_E94_L0.8890.74
352_F356_P0.8890.74
65_H68_K0.8880.74
327_E330_E0.8830.74
106_H192_D0.8810.74
248_Y253_F0.8810.74
20_V24_V0.8770.73
306_D326_Y0.8720.73
103_D136_H0.8710.73
292_V296_K0.8700.73
335_E341_R0.8690.73
29_S254_H0.8690.73
335_E338_E0.8660.73
206_V209_G0.8620.72
70_L184_I0.8600.72
331_K338_E0.8560.72
325_C336_I0.8530.71
43_G110_S0.8510.71
42_T204_A0.8510.71
71_T96_G0.8500.71
339_I349_Y0.8470.71
102_H111_H0.8450.71
42_T45_A0.8450.71
38_H291_V0.8410.70
258_G349_Y0.8380.70
138_I170_S0.8360.70
203_F257_V0.8280.69
112_T257_V0.8240.69
345_G353_Y0.8240.69
349_Y354_D0.8220.69
207_G210_N0.8220.69
388_K393_Y0.8220.69
345_G354_D0.8210.68
43_G190_D0.8200.68
111_H136_H0.8200.68
19_E218_R0.8190.68
343_N354_D0.8180.68
114_E242_L0.8180.68
70_L217_K0.8160.68
110_S193_R0.8150.68
17_Y293_I0.8140.68
326_Y340_M0.8080.67
44_L264_L0.8080.67
333_R340_M0.8070.67
74_I77_N0.8060.67
43_G257_V0.8060.67
185_I215_R0.8060.67
137_V140_G0.8040.67
61_L66_L0.8040.67
74_I108_P0.8030.67
60_S96_G0.8020.67
46_Y55_T0.8000.66
30_T147_Y0.7990.66
26_Q29_S0.7990.66
206_V243_A0.7970.66
66_L213_I0.7940.66
73_Y213_I0.7900.65
12_D15_H0.7870.65
345_G352_F0.7870.65
263_V267_A0.7850.65
346_L355_V0.7840.65
267_A308_I0.7840.65
9_I21_E0.7830.65
137_V196_Y0.7830.65
334_K337_N0.7800.64
339_I345_G0.7770.64
20_V64_M0.7670.63
56_R62_G0.7670.63
245_M249_E0.7660.63
180_L222_Y0.7640.63
112_T261_N0.7630.63
55_T83_D0.7630.63
385_I388_K0.7620.63
266_H314_F0.7620.63
347_I353_Y0.7610.63
373_L379_I0.7600.62
301_G309_V0.7590.62
307_A314_F0.7590.62
9_I19_E0.7570.62
160_D164_F0.7530.62
32_I99_G0.7520.62
57_F254_H0.7510.62
71_T92_L0.7490.61
108_P297_L0.7440.61
18_I21_E0.7440.61
156_S160_D0.7430.61
40_T290_D0.7420.61
169_I232_K0.7420.61
114_E238_E0.7410.61
211_F241_L0.7410.61
328_T338_E0.7410.61
187_S194_G0.7400.60
325_C332_K0.7360.60
384_T389_G0.7320.60
382_S386_I0.7300.59
91_Y164_F0.7290.59
194_G198_L0.7290.59
233_A238_E0.7280.59
337_N346_L0.7280.59
108_P294_M0.7260.59
193_R244_R0.7260.59
83_D86_F0.7260.59
103_D137_V0.7250.59
59_H62_G0.7230.59
330_E334_K0.7200.58
339_I353_Y0.7190.58
252_Y311_R0.7180.58
114_E373_L0.7180.58
95_V143_V0.7170.58
332_K341_R0.7170.58
91_Y176_K0.7160.58
14_I18_I0.7140.58
329_L340_M0.7140.58
280_V330_E0.7130.58
110_S261_N0.7110.57
44_L257_V0.7110.57
326_Y332_K0.7100.57
148_L155_L0.7080.57
228_A365_Y0.7070.57
37_R204_A0.7060.57
107_L288_L0.7010.56
21_E96_G0.6970.56
63_V165_V0.6970.56
347_I355_V0.6950.56
34_Q254_H0.6940.56
230_L290_D0.6920.55
10_I264_L0.6920.55
46_Y108_P0.6910.55
393_Y397_A0.6900.55
63_V99_G0.6890.55
343_N355_V0.6880.55
200_D252_Y0.6810.54
44_L261_N0.6800.54
344_N351_D0.6770.54
349_Y356_P0.6770.54
145_D274_K0.6750.53
325_C328_T0.6720.53
46_Y294_M0.6720.53
58_E215_R0.6710.53
375_T381_S0.6710.53
345_G356_P0.6670.53
186_S193_R0.6670.53
150_N154_K0.6650.52
33_F104_I0.6630.52
145_D163_N0.6620.52
140_G147_Y0.6610.52
156_S383_L0.6600.52
161_V168_V0.6590.52
242_L246_Y0.6580.52
148_L166_Q0.6570.52
209_G233_A0.6560.51
42_T112_T0.6560.51
13_P253_F0.6560.51
215_R256_V0.6560.51
338_E350_H0.6550.51
189_L216_I0.6530.51
257_V261_N0.6520.51
137_V193_R0.6480.51
33_F101_L0.6470.50
345_G355_V0.6450.50
193_R248_Y0.6440.50
48_V52_M0.6440.50
13_P18_I0.6440.50
145_D170_S0.6440.50
94_L165_V0.6430.50
189_L229_V0.6410.50
319_K394_H0.6400.50
334_K340_M0.6400.50
209_G247_M0.6390.50
212_D236_V0.6390.50
326_Y371_K0.6390.50
139_F185_I0.6370.49
238_E377_S0.6370.49
348_L353_Y0.6360.49
202_Y248_Y0.6340.49
343_N352_F0.6340.49
138_I274_K0.6310.49
337_N341_R0.6300.49
225_G251_I0.6290.48
235_P250_T0.6280.48
340_M345_G0.6270.48
326_Y329_L0.6260.48
259_L263_V0.6250.48
332_K338_E0.6250.48
61_L237_V0.6220.48
50_P58_E0.6210.48
327_E341_R0.6190.47
373_L377_S0.6180.47
73_Y218_R0.6170.47
239_Q246_Y0.6160.47
40_T53_R0.6160.47
230_L364_V0.6140.47
325_C329_L0.6100.46
383_L386_I0.6060.46
378_K383_L0.6050.46
67_A71_T0.6050.46
15_H94_L0.6040.46
377_S381_S0.6010.45
292_V298_N0.6000.45
64_M255_S0.5990.45
10_I28_I0.5970.45
332_K340_M0.5970.45
363_F367_D0.5960.45
146_Y150_N0.5950.45
71_T268_V0.5950.45
139_F285_Y0.5920.44
117_L285_Y0.5910.44
99_G185_I0.5900.44
326_Y337_N0.5880.44
338_E347_I0.5870.44
270_K273_Q0.5870.44
43_G261_N0.5860.44
364_V388_K0.5850.44
57_F311_R0.5850.44
86_F180_L0.5840.44
19_E303_E0.5830.43
348_L354_D0.5820.43
88_N178_E0.5800.43
32_I150_N0.5790.43
32_I151_Y0.5780.43
330_E343_N0.5780.43
50_P54_H0.5780.43
342_E345_G0.5770.43
143_V282_P0.5770.43
13_P17_Y0.5760.43
46_Y257_V0.5750.43
220_L233_A0.5720.42
113_F188_P0.5690.42
346_L352_F0.5690.42
348_L356_P0.5680.42
103_D106_H0.5670.42
380_V383_L0.5670.42
107_L188_P0.5670.42
106_H196_Y0.5660.42
106_H111_H0.5660.42
100_L105_G0.5650.42
29_S198_L0.5630.41
235_P249_E0.5620.41
28_I61_L0.5620.41
208_Y250_T0.5610.41
10_I343_N0.5610.41
329_L333_R0.5580.41
298_N309_V0.5580.41
17_Y261_N0.5550.40
98_S190_D0.5540.40
240_F255_S0.5540.40
67_A139_F0.5540.40
48_V139_F0.5530.40
347_I356_P0.5530.40
328_T331_K0.5530.40
167_R175_T0.5520.40
385_I389_G0.5520.40
138_I323_G0.5520.40
166_Q232_K0.5510.40
110_S244_R0.5500.40
188_P270_K0.5480.40
285_Y288_L0.5480.40
77_N313_G0.5470.40
190_D196_Y0.5460.40
136_H140_G0.5460.40
145_D330_E0.5450.39
187_S240_F0.5450.39
256_V315_K0.5450.39
44_L194_G0.5440.39
331_K337_N0.5430.39
63_V256_V0.5430.39
193_R240_F0.5410.39
162_V308_I0.5410.39
346_L354_D0.5390.39
15_H37_R0.5390.39
337_N342_E0.5380.39
329_L336_I0.5380.39
64_M68_K0.5370.39
48_V215_R0.5370.39
191_A216_I0.5360.39
344_N348_L0.5360.39
191_A253_F0.5350.38
85_D89_E0.5350.38
372_P375_T0.5340.38
111_H196_Y0.5340.38
24_V191_A0.5340.38
171_S182_S0.5330.38
330_E337_N0.5330.38
143_V285_Y0.5310.38
141_N144_I0.5300.38
30_T33_F0.5280.38
145_D185_I0.5270.38
260_Y266_H0.5260.37
74_I364_V0.5260.37
49_Y254_H0.5260.37
274_K279_N0.5240.37
26_Q46_Y0.5240.37
285_Y300_A0.5230.37
43_G112_T0.5230.37
17_Y230_L0.5190.37
31_E283_E0.5180.37
145_D324_N0.5140.36
36_L41_Q0.5140.36
202_Y217_K0.5130.36
371_K375_T0.5130.36
246_Y250_T0.5130.36
388_K394_H0.5130.36
339_I350_H0.5120.36
107_L252_Y0.5100.36
326_Y339_I0.5100.36
20_V33_F0.5100.36
331_K340_M0.5080.36
389_G393_Y0.5080.36
194_G259_L0.5070.36
197_L208_Y0.5070.36
204_A239_Q0.5070.36
50_P215_R0.5060.35
217_K220_L0.5060.35
140_G227_L0.5050.35
275_N279_N0.5030.35
136_H196_Y0.5010.35
331_K334_K0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4mz7A 4 0.9709 100 0.271 Contact Map
4lrlA 4 0.9443 100 0.298 Contact Map
2hekA 4 0.8789 100 0.33 Contact Map
2q14A 4 0.8838 100 0.344 Contact Map
3bg2A 4 0.7409 100 0.729 Contact Map
2pgsA 4 0.7312 100 0.732 Contact Map
2dqbA 4 0.6901 100 0.744 Contact Map
4x9eA 4 0.7797 100 0.751 Contact Map
2pq7A 2 0.4116 98.5 0.913 Contact Map
3gw7A 2 0.4891 98.4 0.915 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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