GREMLIN Database
Q97U90 - Iron-sulfur protein, conserved putative
UniProt: Q97U90 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 384 (362)
Sequences: 1232 (572)
Seq/√Len: 30.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
59_V64_G4.6091.00
77_E81_K3.9851.00
55_T278_L3.9561.00
56_M60_E3.8101.00
83_V181_I3.6311.00
42_L299_L3.4981.00
181_I216_I3.4611.00
59_V278_L3.3101.00
35_R360_K3.2481.00
80_G109_L3.2251.00
105_Y109_L3.1751.00
64_G276_F3.0491.00
59_V276_F2.9841.00
83_V216_I2.9291.00
58_S61_R2.9271.00
79_V279_I2.9271.00
81_K85_N2.8771.00
362_N365_K2.8131.00
331_A367_L2.7761.00
97_A218_I2.7441.00
67_Y78_I2.7311.00
54_M57_K2.7201.00
354_R364_P2.6881.00
80_G105_Y2.6381.00
195_S252_V2.6301.00
73_E77_E2.6141.00
195_S254_S2.6071.00
126_A140_M2.5911.00
86_G275_E2.5460.99
128_E140_M2.5220.99
297_A329_M2.5060.99
37_V236_L2.4110.99
43_E51_Y2.3990.99
38_R299_L2.3670.99
47_N50_Y2.3270.99
86_G214_V2.3240.99
126_A148_L2.2960.99
64_G278_L2.2710.99
112_E175_K2.2670.99
293_V369_Y2.2630.99
189_V219_T2.1730.98
90_V179_A2.1600.98
90_V116_T2.1440.98
174_Q178_T2.1390.98
332_M363_I2.1220.98
70_E74_Q2.1020.98
213_P274_K2.0770.98
44_V51_Y2.0470.97
221_V280_L2.0190.97
180_D213_P2.0100.97
43_E47_N2.0080.97
186_A219_T1.9650.97
87_K180_D1.9290.96
332_M366_V1.9050.96
347_C363_I1.8820.96
82_I214_V1.8730.96
190_A230_Y1.8720.96
67_Y277_H1.8700.96
96_V281_V1.8280.95
184_T209_S1.8050.95
53_E57_K1.7920.94
288_A336_I1.7890.94
55_T59_V1.7800.94
143_E159_D1.7680.94
89_V183_I1.7590.94
55_T189_V1.7550.94
158_G163_D1.7490.94
71_N74_Q1.7220.93
45_L299_L1.7200.93
69_V78_I1.7090.93
65_K275_E1.7070.93
307_H326_S1.7060.93
92_G205_I1.6890.92
78_I82_I1.6850.92
89_V111_N1.6730.92
100_T218_I1.6450.91
219_T280_L1.6350.91
38_R296_E1.6140.91
31_E360_K1.6040.90
190_A225_L1.5880.90
331_A347_C1.5840.90
127_D152_K1.5750.90
160_K163_D1.5730.89
296_E366_V1.5670.89
54_M58_S1.5390.88
218_I279_I1.5120.88
347_C367_L1.5090.87
290_E295_R1.5050.87
35_R39_E1.4920.87
197_V252_V1.4690.86
85_N275_E1.4550.85
56_M68_F1.4530.85
192_D227_N1.4500.85
147_E151_E1.4440.85
168_A172_L1.4280.84
41_K223_K1.4180.84
76_R100_T1.4040.83
74_Q77_E1.3880.83
118_L168_A1.3720.82
294_L373_K1.3690.82
291_D373_K1.3650.81
149_I168_A1.3400.80
225_L230_Y1.3190.79
79_V100_T1.3100.79
105_Y108_S1.3080.79
189_V280_L1.3040.78
214_V275_E1.3000.78
369_Y372_N1.2940.78
107_Q127_D1.2890.78
181_I214_V1.2890.78
122_L149_I1.2840.77
40_G232_I1.2770.77
84_G109_L1.2740.77
121_L171_F1.2640.76
219_T278_L1.2520.75
349_H367_L1.2420.75
257_S269_P1.2420.75
162_E166_K1.2300.74
296_E299_L1.2270.74
44_V224_I1.2170.73
164_I168_A1.2110.73
96_V219_T1.2090.73
57_K61_R1.2050.73
97_A183_I1.1990.72
16_N135_A1.1960.72
79_V218_I1.1920.72
78_I277_H1.1840.71
47_N51_Y1.1830.71
134_I304_G1.1770.71
196_I276_F1.1610.70
38_R42_L1.1580.69
46_S295_R1.1560.69
44_V47_N1.1430.68
41_K233_Y1.1430.68
100_T281_V1.1310.68
233_Y359_M1.1190.67
8_A141_T1.1130.66
340_D343_P1.1120.66
102_I106_L1.1080.66
238_Q250_I1.1050.66
153_L167_V1.1020.66
76_R281_V1.0900.65
52_I68_F1.0830.64
80_G84_G1.0700.63
75_A100_T1.0690.63
67_Y74_Q1.0680.63
149_I164_I1.0680.63
140_M148_L1.0670.63
161_H165_V1.0580.62
77_E105_Y1.0570.62
38_R360_K1.0530.62
332_M347_C1.0520.62
119_G135_A1.0410.61
101_G129_P1.0370.61
186_A223_K1.0340.61
68_F280_L1.0290.60
197_V230_Y1.0230.60
18_P22_K1.0160.59
150_K156_D1.0150.59
62_I256_P1.0080.59
49_D53_E1.0080.59
218_I281_V1.0060.58
135_A138_V1.0030.58
102_I183_I1.0000.58
94_S97_A0.9890.57
182_G212_P0.9890.57
29_Y32_D0.9870.57
138_V304_G0.9850.57
62_I255_G0.9830.57
32_D35_R0.9790.56
104_K108_S0.9770.56
293_V373_K0.9760.56
88_R175_K0.9740.56
186_A189_V0.9720.56
118_L165_V0.9510.54
82_I86_G0.9460.54
61_R72_A0.9450.54
172_L244_L0.9430.53
196_I219_T0.9400.53
186_A280_L0.9350.53
168_A244_L0.9340.53
85_N377_M0.9310.53
200_E206_R0.9310.53
108_S279_I0.9300.52
115_E325_Y0.9280.52
98_Y103_R0.9270.52
55_T276_F0.9260.52
201_N304_G0.9250.52
196_I217_S0.9220.52
92_G198_L0.9220.52
150_K155_V0.9170.51
199_V234_E0.9170.51
188_A230_Y0.9160.51
35_R38_R0.9160.51
128_E148_L0.9150.51
7_I11_R0.9090.51
72_A76_R0.8990.50
9_I314_R0.8960.50
241_Y304_G0.8850.49
294_L366_V0.8840.49
51_Y226_P0.8720.48
146_R150_K0.8650.47
103_R244_L0.8640.47
234_E250_I0.8610.47
52_I56_M0.8600.47
351_G367_L0.8560.47
209_S253_T0.8530.46
88_R178_T0.8530.46
21_F25_R0.8530.46
354_R362_N0.8510.46
372_N376_S0.8500.46
133_I326_S0.8490.46
49_D289_N0.8480.46
9_I138_V0.8410.45
166_K170_E0.8400.45
369_Y373_K0.8380.45
55_T58_S0.8380.45
91_M350_A0.8350.45
297_A332_M0.8320.45
292_P295_R0.8310.45
244_L248_T0.8260.44
45_L48_L0.8250.44
79_V183_I0.8250.44
58_S192_D0.8220.44
104_K107_Q0.8190.44
140_M144_R0.8180.44
334_S343_P0.8160.43
55_T190_A0.8120.43
94_S218_I0.8110.43
55_T224_I0.8070.43
184_T206_R0.8070.43
184_T215_H0.8040.42
151_E170_E0.8020.42
149_I308_F0.8000.42
200_E251_N0.7960.42
57_K104_K0.7920.42
119_G201_N0.7900.41
255_G351_G0.7890.41
206_R210_V0.7850.41
299_L366_V0.7790.41
123_I128_E0.7760.40
209_S217_S0.7720.40
62_I254_S0.7670.40
188_A359_M0.7660.40
288_A297_A0.7650.39
6_D329_M0.7630.39
103_R350_A0.7630.39
354_R365_K0.7630.39
19_R326_S0.7550.39
146_R159_D0.7550.39
348_S355_E0.7520.39
324_P334_S0.7500.38
246_P250_I0.7470.38
314_R352_N0.7420.38
67_Y82_I0.7420.38
92_G134_I0.7410.38
114_W145_I0.7400.38
88_R112_E0.7380.37
119_G215_H0.7370.37
71_N251_N0.7360.37
183_I216_I0.7360.37
220_G329_M0.7340.37
144_R286_R0.7310.37
31_E34_A0.7300.37
37_V359_M0.7280.37
217_S363_I0.7280.37
53_E68_F0.7260.37
20_V239_A0.7250.36
74_Q181_I0.7240.36
134_I247_P0.7230.36
97_A102_I0.7230.36
115_E186_A0.7210.36
31_E35_R0.7210.36
72_A100_T0.7200.36
316_L320_W0.7150.36
153_L161_H0.7130.36
95_M98_Y0.7120.36
147_E156_D0.7100.35
145_I164_I0.7090.35
114_W175_K0.7090.35
95_M319_K0.7080.35
50_Y54_M0.7070.35
134_I241_Y0.7060.35
234_E238_Q0.7060.35
295_R363_I0.7060.35
137_A145_I0.7050.35
47_N226_P0.7050.35
126_A145_I0.7040.35
43_E227_N0.7010.35
82_I183_I0.6970.34
145_I236_L0.6940.34
328_P363_I0.6940.34
206_R209_S0.6940.34
83_V183_I0.6930.34
146_R158_G0.6910.34
123_I126_A0.6910.34
12_G19_R0.6890.34
20_V356_V0.6890.34
363_I367_L0.6850.34
146_R157_P0.6840.34
334_S338_Y0.6840.34
38_R366_V0.6750.33
198_L253_T0.6720.33
40_G44_V0.6690.32
55_T280_L0.6690.32
134_I138_V0.6680.32
92_G208_S0.6680.32
46_S214_V0.6670.32
305_R361_I0.6640.32
230_Y252_V0.6640.32
155_V167_V0.6640.32
332_M335_G0.6630.32
135_A142_R0.6600.32
97_A103_R0.6600.32
329_M375_F0.6600.32
15_H135_A0.6580.32
8_A198_L0.6580.32
135_A247_P0.6540.31
83_V111_N0.6530.31
175_K249_Y0.6520.31
326_S363_I0.6510.31
183_I218_I0.6500.31
256_P274_K0.6500.31
145_I154_G0.6490.31
289_N335_G0.6490.31
103_R242_A0.6460.31
189_V224_I0.6460.31
103_R176_F0.6460.31
347_C354_R0.6450.31
95_M318_G0.6440.31
186_A217_S0.6440.31
297_A333_W0.6430.31
41_K288_A0.6410.31
165_V347_C0.6390.30
351_G355_E0.6380.30
49_D286_R0.6380.30
62_I258_S0.6370.30
68_F223_K0.6370.30
228_L252_V0.6360.30
172_L242_A0.6350.30
52_I286_R0.6320.30
52_I224_I0.6310.30
70_E147_E0.6290.30
51_Y54_M0.6260.30
55_T217_S0.6250.29
22_K377_M0.6240.29
351_G364_P0.6230.29
90_V208_S0.6220.29
102_I172_L0.6220.29
77_E104_K0.6220.29
354_R360_K0.6190.29
60_E65_K0.6180.29
120_E133_I0.6180.29
49_D68_F0.6160.29
68_F221_V0.6150.29
22_K53_E0.6140.29
80_G111_N0.6130.29
240_A358_P0.6130.29
168_A319_K0.6130.29
287_K290_E0.6120.29
231_A235_A0.6110.29
12_G135_A0.6110.29
101_G104_K0.6100.29
321_G335_G0.6090.28
10_K252_V0.6080.28
52_I335_G0.6070.28
182_G208_S0.6060.28
6_D355_E0.6060.28
288_A337_V0.6060.28
198_L205_I0.6050.28
57_K60_E0.6030.28
75_A218_I0.6010.28
128_E152_K0.6010.28
275_E278_L0.6010.28
103_R319_K0.6000.28
114_W178_T0.6000.28
56_M223_K0.5980.28
92_G119_G0.5970.28
36_K39_E0.5970.28
158_G352_N0.5970.28
273_P328_P0.5960.28
115_E182_G0.5950.28
58_S62_I0.5940.27
41_K370_L0.5940.27
181_I279_I0.5940.27
57_K85_N0.5930.27
91_M103_R0.5920.27
145_I247_P0.5920.27
186_A278_L0.5920.27
280_L289_N0.5910.27
292_P297_A0.5900.27
22_K73_E0.5880.27
20_V241_Y0.5880.27
20_V24_L0.5880.27
44_V216_I0.5870.27
107_Q279_I0.5870.27
206_R253_T0.5870.27
6_D17_V0.5860.27
225_L340_D0.5860.27
44_V368_E0.5850.27
347_C351_G0.5840.27
230_Y233_Y0.5840.27
59_V363_I0.5830.27
129_P229_E0.5810.27
105_Y229_E0.5800.27
115_E208_S0.5800.27
55_T237_V0.5780.26
134_I320_W0.5780.26
309_H326_S0.5760.26
131_S319_K0.5760.26
188_A225_L0.5740.26
147_E170_E0.5720.26
133_I309_H0.5720.26
168_A242_A0.5720.26
196_I209_S0.5710.26
98_Y244_L0.5710.26
77_E147_E0.5690.26
52_I221_V0.5690.26
200_E205_I0.5690.26
65_K85_N0.5670.26
367_L370_L0.5660.26
57_K341_Y0.5660.26
147_E157_P0.5660.26
55_T352_N0.5650.26
205_I254_S0.5640.26
305_R358_P0.5640.26
37_V233_Y0.5620.25
74_Q324_P0.5620.25
288_A334_S0.5610.25
9_I315_V0.5610.25
188_A233_Y0.5600.25
54_M226_P0.5590.25
253_T276_F0.5590.25
144_R280_L0.5590.25
95_M302_R0.5580.25
164_I366_V0.5580.25
96_V220_G0.5580.25
147_E150_K0.5570.25
120_E302_R0.5560.25
92_G200_E0.5560.25
195_S228_L0.5560.25
218_I350_A0.5550.25
227_N363_I0.5550.25
362_N366_V0.5550.25
193_A254_S0.5530.25
27_H64_G0.5530.25
98_Y120_E0.5520.25
321_G348_S0.5520.25
53_E77_E0.5510.25
72_A284_G0.5500.25
37_V89_V0.5500.25
175_K337_V0.5500.25
298_L359_M0.5500.25
8_A11_R0.5500.25
160_K281_V0.5500.25
80_G83_V0.5490.25
335_G361_I0.5490.25
129_P275_E0.5470.25
217_S278_L0.5470.25
22_K151_E0.5460.25
73_E174_Q0.5460.25
22_K46_S0.5450.24
328_P349_H0.5450.24
150_K157_P0.5450.24
42_L45_L0.5440.24
147_E158_G0.5440.24
41_K352_N0.5430.24
184_T348_S0.5430.24
120_E318_G0.5420.24
119_G244_L0.5410.24
32_D36_K0.5400.24
110_G281_V0.5400.24
165_V168_A0.5400.24
71_N159_D0.5400.24
193_A252_V0.5400.24
131_S177_L0.5390.24
182_G257_S0.5380.24
14_E314_R0.5380.24
76_R279_I0.5380.24
111_N254_S0.5360.24
43_E226_P0.5360.24
347_C364_P0.5360.24
107_Q113_V0.5360.24
342_K345_L0.5340.24
359_M366_V0.5330.24
255_G337_V0.5330.24
288_A294_L0.5330.24
192_D376_S0.5320.24
368_E372_N0.5320.24
105_Y279_I0.5310.24
129_P279_I0.5300.24
184_T205_I0.5290.24
44_V226_P0.5290.24
323_P334_S0.5290.24
41_K123_I0.5260.23
144_R208_S0.5260.23
75_A279_I0.5260.23
290_E347_C0.5260.23
34_A153_L0.5240.23
9_I230_Y0.5230.23
121_L244_L0.5230.23
255_G272_G0.5230.23
18_P166_K0.5230.23
21_F184_T0.5210.23
258_S269_P0.5210.23
311_P330_G0.5200.23
122_L164_I0.5200.23
13_V186_A0.5190.23
92_G182_G0.5190.23
170_E296_E0.5180.23
25_R360_K0.5180.23
18_P127_D0.5170.23
92_G220_G0.5170.23
12_G200_E0.5170.23
167_V211_V0.5160.23
76_R102_I0.5150.23
309_H329_M0.5140.23
53_E56_M0.5140.23
287_K291_D0.5120.23
34_A237_V0.5120.23
28_P41_K0.5100.22
209_S214_V0.5080.22
292_P296_E0.5080.22
107_Q112_E0.5080.22
287_K339_N0.5070.22
81_K279_I0.5060.22
179_A212_P0.5060.22
40_G225_L0.5060.22
346_L367_L0.5050.22
16_N186_A0.5050.22
214_V217_S0.5050.22
201_N244_L0.5050.22
336_I370_L0.5030.22
6_D141_T0.5030.22
141_T144_R0.5030.22
318_G329_M0.5020.22
164_I297_A0.5020.22
95_M130_P0.5020.22
351_G359_M0.5010.22
130_P179_A0.5010.22
188_A243_G0.5010.22
52_I346_L0.5000.22
190_A366_V0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3cf4A 2 0.8203 100 0.711 Contact Map
2g40A 2 0.4245 100 0.761 Contact Map
2h88B 1 0.5417 99.5 0.907 Contact Map
1kf6B 1 0.5495 99.4 0.916 Contact Map
4ysxB 1 0.5547 99.4 0.917 Contact Map
2wdqB 1 0.5312 99.2 0.922 Contact Map
2bs2B 1 0.526 99 0.928 Contact Map
4p6vA 1 0.7109 98.8 0.935 Contact Map
3c8yA 1 0.5339 98.7 0.937 Contact Map
2c42A 2 0.8464 98.4 0.942 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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