Q97U89 - SULSO - GREMLIN Contacts

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Q97U89 - Heterodisulfide reductase related protein

UniProt:	Q97U89	Sequences: MINEDQLNFIRKNLVKYLMEDYLPFPVNRSVCYEWANGLNIRRGGETIIYTGCSYQLAELGKRFDEILPALSKFKGVERFSSILKVFYKPKDTRSYKILRNIASVLKSSVDFGYLYEDEPYSGTILLEMGMVEEFKEYAKKLVEVFDSHGVKRIITVDPHTHYTLFRIKEMLSPSWNVEIVNYFELIKNVKVKGEGTFVFHDSCLYSRFLGMRDSIREVIKSSGIVLKEDEMITGKETSMCCGGPLAPINKETSDKIARNRAEALKSVHNKVLLACPFCYANLSPYVEAYDFAEVISGE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	299 (282)
Sequences:	6127 (4330)
Seq/√Len:	257.9

ECOLI - GLCF GLPC YKGE YDIJ
BACSU - FADF GLCF LUTA
HALSA - Q9HMZ3 Q9HNS2 Q9HHI4 Q9HMR2
SULSO - Q97U89 Q97VI0 Q97U61 Q97Z15 Q7LX43 Q97Z11 Q97W77

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
197_T	226_V	4.100	1.00
104_S	297_S	3.913	1.00
101_N	294_E	3.793	1.00
82_S	111_D	3.559	1.00
197_T	228_K	3.238	1.00
183_Y	293_A	3.164	1.00
121_Y	161_T	2.991	1.00
181_V	189_N	2.843	1.00
188_K	218_E	2.711	1.00
131_M	134_E	2.575	1.00
196_G	271_K	2.384	1.00
89_K	121_Y	2.369	1.00
47_T	51_T	2.367	1.00
122_S	161_T	2.356	1.00
217_R	229_E	2.346	1.00
202_D	217_R	2.329	1.00
102_I	157_V	2.327	1.00
82_S	152_K	2.231	1.00
230_D	265_L	2.211	1.00
28_N	31_V	2.182	1.00
85_K	157_V	2.124	1.00
140_K	144_E	2.109	1.00
89_K	161_T	2.055	1.00
273_L	295_V	2.043	1.00
73_K	76_G	2.023	1.00
97_K	294_E	1.984	1.00
166_F	185_E	1.932	1.00
59_E	63_R	1.917	1.00
60_L	63_R	1.898	1.00
83_I	186_L	1.888	1.00
139_A	169_K	1.868	1.00
156_T	162_H	1.847	1.00
48_I	51_T	1.809	1.00
199_V	230_D	1.803	1.00
251_K	255_D	1.794	1.00
120_P	141_K	1.791	1.00
110_V	186_L	1.788	1.00
51_T	55_Y	1.770	1.00
218_E	221_K	1.737	1.00
217_R	221_K	1.728	1.00
81_S	110_V	1.692	1.00
198_F	295_V	1.690	1.00
70_A	73_K	1.688	1.00
271_K	290_Y	1.676	1.00
197_T	270_N	1.659	1.00
65_D	69_P	1.659	1.00
136_K	140_K	1.654	1.00
89_K	122_S	1.641	1.00
103_A	112_F	1.635	1.00
231_E	267_S	1.631	1.00
102_I	183_Y	1.624	1.00
66_E	69_P	1.607	1.00
98_I	294_E	1.579	1.00
48_I	52_G	1.578	1.00
82_S	113_G	1.569	1.00
153_R	181_V	1.567	1.00
258_A	262_A	1.559	1.00
105_V	296_I	1.558	1.00
91_K	99_L	1.557	1.00
102_I	106_L	1.532	1.00
158_D	276_C	1.496	1.00
153_R	179_E	1.474	1.00
181_V	185_E	1.463	1.00
196_G	270_N	1.443	1.00
20_E	28_N	1.442	1.00
181_V	186_L	1.434	1.00
72_S	75_K	1.433	1.00
185_E	212_M	1.424	1.00
185_E	215_S	1.404	1.00
69_P	72_S	1.403	1.00
124_T	160_H	1.401	1.00
176_W	180_I	1.386	1.00
47_T	50_Y	1.372	1.00
38_G	132_V	1.370	1.00
242_C	279_C	1.361	1.00
255_D	286_Y	1.360	1.00
199_V	268_V	1.359	1.00
263_E	267_S	1.335	1.00
262_A	266_K	1.328	1.00
198_F	225_I	1.324	1.00
220_I	273_L	1.304	1.00
192_V	195_E	1.295	1.00
115_L	119_E	1.295	1.00
101_N	297_S	1.280	1.00
52_G	55_Y	1.275	1.00
258_A	286_Y	1.275	1.00
55_Y	58_A	1.259	1.00
155_I	186_L	1.257	1.00
59_E	62_K	1.257	1.00
69_P	75_K	1.252	1.00
69_P	73_K	1.250	1.00
127_L	164_T	1.235	1.00
71_L	75_K	1.223	1.00
72_S	76_G	1.221	1.00
57_L	60_L	1.214	1.00
191_K	194_G	1.202	1.00
259_R	266_K	1.197	1.00
40_N	44_G	1.194	1.00
272_V	283_L	1.190	1.00
49_I	52_G	1.188	1.00
88_Y	158_D	1.170	1.00
71_L	74_F	1.157	1.00
126_L	134_E	1.155	1.00
258_A	282_N	1.152	1.00
110_V	190_V	1.152	1.00
31_V	171_M	1.150	1.00
65_D	68_L	1.147	1.00
51_T	54_S	1.145	1.00
144_E	147_D	1.145	1.00
153_R	186_L	1.137	1.00
259_R	263_E	1.131	1.00
49_I	53_C	1.124	1.00
70_A	74_F	1.111	1.00
290_Y	295_V	1.108	1.00
198_F	271_K	1.101	1.00
64_F	67_I	1.095	1.00
66_E	72_S	1.094	1.00
58_A	62_K	1.094	1.00
202_D	229_E	1.093	1.00
58_A	63_R	1.083	1.00
83_I	155_I	1.083	1.00
280_Y	289_A	1.082	1.00
66_E	73_K	1.073	1.00
275_A	292_F	1.072	1.00
52_G	56_Q	1.072	1.00
78_E	111_D	1.070	1.00
58_A	61_G	1.069	1.00
203_S	274_L	1.067	1.00
265_L	283_L	1.066	1.00
156_T	165_L	1.064	1.00
245_P	249_I	1.064	1.00
290_Y	294_E	1.059	1.00
83_I	112_F	1.057	1.00
103_A	107_K	1.050	1.00
105_V	297_S	1.042	1.00
107_K	112_F	1.040	1.00
67_I	73_K	1.039	1.00
56_Q	59_E	1.036	1.00
50_Y	53_C	1.031	1.00
62_K	66_E	1.025	1.00
212_M	215_S	1.024	1.00
61_G	64_F	1.022	1.00
41_I	45_G	1.022	1.00
105_V	293_A	1.019	1.00
17_Y	20_E	1.017	1.00
54_S	57_L	1.016	1.00
198_F	273_L	1.015	1.00
46_E	51_T	1.012	1.00
39_L	43_R	1.006	1.00
63_R	66_E	1.006	1.00
162_H	210_L	1.003	1.00
251_K	285_P	0.999	1.00
239_S	261_R	0.996	1.00
127_L	135_F	0.993	1.00
200_F	216_I	0.991	1.00
142_L	169_K	0.989	1.00
170_E	177_N	0.983	1.00
65_D	72_S	0.982	1.00
67_I	72_S	0.982	1.00
62_K	65_D	0.975	1.00
41_I	44_G	0.974	1.00
124_T	128_E	0.972	1.00
95_S	98_I	0.972	1.00
47_T	52_G	0.970	1.00
218_E	222_S	0.970	1.00
175_S	178_V	0.967	1.00
84_L	151_V	0.961	1.00
80_F	111_D	0.954	1.00
7_L	11_R	0.933	1.00
135_F	164_T	0.932	1.00
66_E	70_A	0.932	1.00
79_R	111_D	0.931	1.00
138_Y	142_L	0.929	1.00
183_Y	187_I	0.923	1.00
53_C	56_Q	0.922	1.00
252_E	256_K	0.920	1.00
69_P	76_G	0.915	1.00
102_I	293_A	0.912	1.00
61_G	65_D	0.912	1.00
68_L	71_L	0.905	1.00
203_S	276_C	0.904	1.00
265_L	272_V	0.904	1.00
35_W	38_G	0.901	1.00
128_E	160_H	0.898	1.00
104_S	107_K	0.898	1.00
187_I	219_V	0.897	1.00
254_S	282_N	0.895	1.00
68_L	72_S	0.895	1.00
56_Q	61_G	0.894	1.00
214_D	217_R	0.887	1.00
102_I	155_I	0.876	1.00
63_R	72_S	0.874	1.00
54_S	60_L	0.865	1.00
67_I	70_A	0.863	1.00
85_K	99_L	0.852	0.99
187_I	296_I	0.849	0.99
191_K	195_E	0.844	0.99
144_E	148_S	0.841	0.99
61_G	72_S	0.840	0.99
36_A	40_N	0.831	0.99
14_L	257_I	0.830	0.99
50_Y	54_S	0.827	0.99
17_Y	30_S	0.827	0.99
184_F	292_F	0.824	0.99
214_D	218_E	0.822	0.99
20_E	30_S	0.819	0.99
262_A	286_Y	0.816	0.99
145_V	148_S	0.812	0.99
85_K	102_I	0.811	0.99
100_R	104_S	0.809	0.99
46_E	49_I	0.807	0.99
98_I	101_N	0.807	0.99
100_R	103_A	0.807	0.99
67_I	71_L	0.800	0.99
147_D	175_S	0.800	0.99
46_E	50_Y	0.798	0.99
273_L	292_F	0.794	0.99
127_L	132_V	0.794	0.99
18_L	22_Y	0.791	0.99
138_Y	141_K	0.790	0.99
175_S	179_E	0.790	0.99
87_F	99_L	0.788	0.99
57_L	61_G	0.783	0.99
126_L	138_Y	0.780	0.99
270_N	273_L	0.778	0.99
87_F	119_E	0.776	0.99
147_D	176_W	0.775	0.99
19_M	23_L	0.773	0.99
7_L	40_N	0.773	0.99
67_I	75_K	0.773	0.99
65_D	75_K	0.772	0.99
65_D	70_A	0.770	0.99
274_L	280_Y	0.768	0.99
66_E	76_G	0.759	0.99
65_D	73_K	0.754	0.99
203_S	206_Y	0.753	0.99
160_H	276_C	0.752	0.99
179_E	189_N	0.751	0.99
13_N	19_M	0.747	0.99
231_E	264_A	0.745	0.99
134_E	137_E	0.741	0.99
206_Y	212_M	0.740	0.99
189_N	215_S	0.739	0.99
12_K	253_T	0.739	0.99
55_Y	63_R	0.738	0.99
263_E	266_K	0.736	0.98
59_E	75_K	0.736	0.98
135_F	172_L	0.734	0.98
13_N	16_K	0.732	0.98
204_C	241_C	0.731	0.98
199_V	272_V	0.731	0.98
78_E	81_S	0.730	0.98
61_G	75_K	0.729	0.98
55_Y	59_E	0.724	0.98
220_I	225_I	0.724	0.98
62_K	73_K	0.724	0.98
103_A	114_Y	0.723	0.98
47_T	53_C	0.721	0.98
16_K	19_M	0.720	0.98
162_H	180_I	0.719	0.98
10_I	36_A	0.718	0.98
69_P	74_F	0.718	0.98
13_N	23_L	0.717	0.98
56_Q	60_L	0.715	0.98
61_G	69_P	0.715	0.98
48_I	53_C	0.706	0.98
199_V	265_L	0.703	0.98
221_K	227_L	0.703	0.98
154_I	180_I	0.701	0.98
159_P	203_S	0.701	0.98
62_K	69_P	0.699	0.98
262_A	283_L	0.698	0.98
186_L	190_V	0.696	0.98
160_H	205_L	0.694	0.98
29_R	33_Y	0.683	0.98
188_K	222_S	0.682	0.98
106_L	155_I	0.681	0.97
87_F	114_Y	0.679	0.97
231_E	239_S	0.676	0.97
106_L	110_V	0.674	0.97
162_H	166_F	0.672	0.97
202_D	216_I	0.669	0.97
163_Y	209_F	0.668	0.97
219_V	296_I	0.668	0.97
121_Y	125_I	0.666	0.97
47_T	55_Y	0.665	0.97
105_V	187_I	0.665	0.97
50_Y	55_Y	0.665	0.97
62_K	67_I	0.664	0.97
105_V	219_V	0.662	0.97
42_R	133_E	0.662	0.97
84_L	152_K	0.659	0.97
95_S	277_P	0.658	0.97
66_E	74_F	0.656	0.97
52_G	58_A	0.655	0.97
230_D	239_S	0.653	0.97
63_R	73_K	0.652	0.97
106_L	183_Y	0.651	0.97
200_F	275_A	0.646	0.97
52_G	59_E	0.645	0.97
215_S	218_E	0.645	0.97
256_K	259_R	0.644	0.97
61_G	67_I	0.643	0.96
17_Y	209_F	0.641	0.96
60_L	64_F	0.640	0.96
40_N	43_R	0.639	0.96
255_D	259_R	0.639	0.96
118_D	149_H	0.638	0.96
6_Q	9_F	0.637	0.96
65_D	71_L	0.637	0.96
63_R	67_I	0.635	0.96
15_V	33_Y	0.635	0.96
166_F	212_M	0.633	0.96
202_D	213_R	0.632	0.96
134_E	138_Y	0.632	0.96
48_I	55_Y	0.630	0.96
83_I	153_R	0.630	0.96
64_F	68_L	0.629	0.96
67_I	74_F	0.629	0.96
283_L	286_Y	0.628	0.96
223_S	296_I	0.627	0.96
205_L	277_P	0.621	0.96
99_L	103_A	0.618	0.96
62_K	75_K	0.618	0.96
84_L	115_L	0.618	0.96
6_Q	10_I	0.617	0.96
58_A	66_E	0.616	0.96
201_H	206_Y	0.615	0.95
143_V	147_D	0.615	0.95
60_L	67_I	0.611	0.95
68_L	75_K	0.611	0.95
154_I	176_W	0.611	0.95
57_L	62_K	0.610	0.95
95_S	280_Y	0.609	0.95
294_E	297_S	0.607	0.95
262_A	265_L	0.607	0.95
63_R	68_L	0.606	0.95
64_F	72_S	0.605	0.95
57_L	64_F	0.604	0.95
88_Y	161_T	0.604	0.95
39_L	42_R	0.601	0.95
54_S	58_A	0.601	0.95
158_D	161_T	0.599	0.95
89_K	158_D	0.598	0.95
38_G	42_R	0.596	0.95
224_G	227_L	0.595	0.95
66_E	75_K	0.593	0.94
49_I	55_Y	0.593	0.94
142_L	145_V	0.592	0.94
125_I	158_D	0.591	0.94
227_L	230_D	0.589	0.94
142_L	165_L	0.586	0.94
20_E	31_V	0.586	0.94
97_K	100_R	0.582	0.94
247_A	278_F	0.579	0.94
53_C	57_L	0.578	0.94
260_N	264_A	0.575	0.94
228_K	268_V	0.574	0.93
63_R	71_L	0.574	0.93
62_K	70_A	0.573	0.93
105_V	108_S	0.571	0.93
82_S	150_G	0.567	0.93
129_M	245_P	0.566	0.93
96_Y	100_R	0.563	0.93
184_F	275_A	0.563	0.93
154_I	165_L	0.562	0.93
261_R	266_K	0.561	0.93
67_I	76_G	0.561	0.93
59_E	72_S	0.559	0.93
82_S	153_R	0.558	0.93
141_K	144_E	0.557	0.92
191_K	222_S	0.557	0.92
139_A	172_L	0.556	0.92
49_I	56_Q	0.555	0.92
252_E	255_D	0.555	0.92
60_L	65_D	0.554	0.92
15_V	205_L	0.554	0.92
166_F	210_L	0.553	0.92
214_D	221_K	0.552	0.92
58_A	72_S	0.548	0.92
212_M	216_I	0.548	0.92
53_C	58_A	0.548	0.92
59_E	65_D	0.546	0.92
14_L	27_V	0.546	0.92
101_N	105_V	0.546	0.92
120_P	145_V	0.545	0.92
59_E	68_L	0.544	0.92
35_W	39_L	0.544	0.92
266_K	269_H	0.543	0.92
261_R	264_A	0.543	0.92
56_Q	72_S	0.541	0.91
56_Q	69_P	0.539	0.91
62_K	72_S	0.539	0.91
91_K	157_V	0.534	0.91
133_E	136_K	0.532	0.91
152_K	179_E	0.531	0.91
137_E	140_K	0.531	0.91
56_Q	75_K	0.531	0.91
95_S	294_E	0.530	0.91
137_E	141_K	0.529	0.90
203_S	275_A	0.527	0.90
255_D	285_P	0.526	0.90
56_Q	63_R	0.526	0.90
16_K	23_L	0.525	0.90
196_G	225_I	0.524	0.90
26_P	32_C	0.523	0.90
162_H	182_N	0.522	0.90
180_I	183_Y	0.519	0.90
264_A	267_S	0.518	0.90
246_L	249_I	0.518	0.90
208_R	212_M	0.515	0.89
57_L	67_I	0.515	0.89
63_R	76_G	0.514	0.89
146_F	154_I	0.508	0.89
46_E	52_G	0.506	0.88
200_F	227_L	0.505	0.88
199_V	227_L	0.505	0.88
86_V	122_S	0.504	0.88
54_S	61_G	0.504	0.88
71_L	76_G	0.503	0.88
58_A	70_A	0.502	0.88
253_T	256_K	0.500	0.88
88_Y	276_C	0.500	0.88

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3kwlA	1	0.9064	100	0.374	Contact Map
3cf4A	2	0.8696	100	0.552	Contact Map
3c8yA	1	0.8528	99.4	0.8	Contact Map
1hfeL	2	0.9632	95.6	0.912	Contact Map
2vdcG	1	0.8896	89.6	0.929	Contact Map
7fd1A	1	0.2642	87.3	0.932	Contact Map
4p6vA	1	0.2475	86.3	0.932	Contact Map
4r0vA	1	0.796	86	0.933	Contact Map
4uquA	2	0.2542	82.8	0.935	Contact Map
1jflA	2	0.6823	78.6	0.938	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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