GREMLIN Database
Q97U89 - Heterodisulfide reductase related protein
UniProt: Q97U89 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 299 (282)
Sequences: 6127 (4330)
Seq/√Len: 257.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
197_T226_V4.1001.00
104_S297_S3.9131.00
101_N294_E3.7931.00
82_S111_D3.5591.00
197_T228_K3.2381.00
183_Y293_A3.1641.00
121_Y161_T2.9911.00
181_V189_N2.8431.00
188_K218_E2.7111.00
131_M134_E2.5751.00
196_G271_K2.3841.00
89_K121_Y2.3691.00
47_T51_T2.3671.00
122_S161_T2.3561.00
217_R229_E2.3461.00
202_D217_R2.3291.00
102_I157_V2.3271.00
82_S152_K2.2311.00
230_D265_L2.2111.00
28_N31_V2.1821.00
85_K157_V2.1241.00
140_K144_E2.1091.00
89_K161_T2.0551.00
273_L295_V2.0431.00
73_K76_G2.0231.00
97_K294_E1.9841.00
166_F185_E1.9321.00
59_E63_R1.9171.00
60_L63_R1.8981.00
83_I186_L1.8881.00
139_A169_K1.8681.00
156_T162_H1.8471.00
48_I51_T1.8091.00
199_V230_D1.8031.00
251_K255_D1.7941.00
120_P141_K1.7911.00
110_V186_L1.7881.00
51_T55_Y1.7701.00
218_E221_K1.7371.00
217_R221_K1.7281.00
81_S110_V1.6921.00
198_F295_V1.6901.00
70_A73_K1.6881.00
271_K290_Y1.6761.00
197_T270_N1.6591.00
65_D69_P1.6591.00
136_K140_K1.6541.00
89_K122_S1.6411.00
103_A112_F1.6351.00
231_E267_S1.6311.00
102_I183_Y1.6241.00
66_E69_P1.6071.00
98_I294_E1.5791.00
48_I52_G1.5781.00
82_S113_G1.5691.00
153_R181_V1.5671.00
258_A262_A1.5591.00
105_V296_I1.5581.00
91_K99_L1.5571.00
102_I106_L1.5321.00
158_D276_C1.4961.00
153_R179_E1.4741.00
181_V185_E1.4631.00
196_G270_N1.4431.00
20_E28_N1.4421.00
181_V186_L1.4341.00
72_S75_K1.4331.00
185_E212_M1.4241.00
185_E215_S1.4041.00
69_P72_S1.4031.00
124_T160_H1.4011.00
176_W180_I1.3861.00
47_T50_Y1.3721.00
38_G132_V1.3701.00
242_C279_C1.3611.00
255_D286_Y1.3601.00
199_V268_V1.3591.00
263_E267_S1.3351.00
262_A266_K1.3281.00
198_F225_I1.3241.00
220_I273_L1.3041.00
192_V195_E1.2951.00
115_L119_E1.2951.00
101_N297_S1.2801.00
52_G55_Y1.2751.00
258_A286_Y1.2751.00
55_Y58_A1.2591.00
155_I186_L1.2571.00
59_E62_K1.2571.00
69_P75_K1.2521.00
69_P73_K1.2501.00
127_L164_T1.2351.00
71_L75_K1.2231.00
72_S76_G1.2211.00
57_L60_L1.2141.00
191_K194_G1.2021.00
259_R266_K1.1971.00
40_N44_G1.1941.00
272_V283_L1.1901.00
49_I52_G1.1881.00
88_Y158_D1.1701.00
71_L74_F1.1571.00
126_L134_E1.1551.00
258_A282_N1.1521.00
110_V190_V1.1521.00
31_V171_M1.1501.00
65_D68_L1.1471.00
51_T54_S1.1451.00
144_E147_D1.1451.00
153_R186_L1.1371.00
259_R263_E1.1311.00
49_I53_C1.1241.00
70_A74_F1.1111.00
290_Y295_V1.1081.00
198_F271_K1.1011.00
64_F67_I1.0951.00
66_E72_S1.0941.00
58_A62_K1.0941.00
202_D229_E1.0931.00
58_A63_R1.0831.00
83_I155_I1.0831.00
280_Y289_A1.0821.00
66_E73_K1.0731.00
275_A292_F1.0721.00
52_G56_Q1.0721.00
78_E111_D1.0701.00
58_A61_G1.0691.00
203_S274_L1.0671.00
265_L283_L1.0661.00
156_T165_L1.0641.00
245_P249_I1.0641.00
290_Y294_E1.0591.00
83_I112_F1.0571.00
103_A107_K1.0501.00
105_V297_S1.0421.00
107_K112_F1.0401.00
67_I73_K1.0391.00
56_Q59_E1.0361.00
50_Y53_C1.0311.00
62_K66_E1.0251.00
212_M215_S1.0241.00
61_G64_F1.0221.00
41_I45_G1.0221.00
105_V293_A1.0191.00
17_Y20_E1.0171.00
54_S57_L1.0161.00
198_F273_L1.0151.00
46_E51_T1.0121.00
39_L43_R1.0061.00
63_R66_E1.0061.00
162_H210_L1.0031.00
251_K285_P0.9991.00
239_S261_R0.9961.00
127_L135_F0.9931.00
200_F216_I0.9911.00
142_L169_K0.9891.00
170_E177_N0.9831.00
65_D72_S0.9821.00
67_I72_S0.9821.00
62_K65_D0.9751.00
41_I44_G0.9741.00
124_T128_E0.9721.00
95_S98_I0.9721.00
47_T52_G0.9701.00
218_E222_S0.9701.00
175_S178_V0.9671.00
84_L151_V0.9611.00
80_F111_D0.9541.00
7_L11_R0.9331.00
135_F164_T0.9321.00
66_E70_A0.9321.00
79_R111_D0.9311.00
138_Y142_L0.9291.00
183_Y187_I0.9231.00
53_C56_Q0.9221.00
252_E256_K0.9201.00
69_P76_G0.9151.00
102_I293_A0.9121.00
61_G65_D0.9121.00
68_L71_L0.9051.00
203_S276_C0.9041.00
265_L272_V0.9041.00
35_W38_G0.9011.00
128_E160_H0.8981.00
104_S107_K0.8981.00
187_I219_V0.8971.00
254_S282_N0.8951.00
68_L72_S0.8951.00
56_Q61_G0.8941.00
214_D217_R0.8871.00
102_I155_I0.8761.00
63_R72_S0.8741.00
54_S60_L0.8651.00
67_I70_A0.8631.00
85_K99_L0.8520.99
187_I296_I0.8490.99
191_K195_E0.8440.99
144_E148_S0.8410.99
61_G72_S0.8400.99
36_A40_N0.8310.99
14_L257_I0.8300.99
50_Y54_S0.8270.99
17_Y30_S0.8270.99
184_F292_F0.8240.99
214_D218_E0.8220.99
20_E30_S0.8190.99
262_A286_Y0.8160.99
145_V148_S0.8120.99
85_K102_I0.8110.99
100_R104_S0.8090.99
46_E49_I0.8070.99
98_I101_N0.8070.99
100_R103_A0.8070.99
67_I71_L0.8000.99
147_D175_S0.8000.99
46_E50_Y0.7980.99
273_L292_F0.7940.99
127_L132_V0.7940.99
18_L22_Y0.7910.99
138_Y141_K0.7900.99
175_S179_E0.7900.99
87_F99_L0.7880.99
57_L61_G0.7830.99
126_L138_Y0.7800.99
270_N273_L0.7780.99
87_F119_E0.7760.99
147_D176_W0.7750.99
19_M23_L0.7730.99
7_L40_N0.7730.99
67_I75_K0.7730.99
65_D75_K0.7720.99
65_D70_A0.7700.99
274_L280_Y0.7680.99
66_E76_G0.7590.99
65_D73_K0.7540.99
203_S206_Y0.7530.99
160_H276_C0.7520.99
179_E189_N0.7510.99
13_N19_M0.7470.99
231_E264_A0.7450.99
134_E137_E0.7410.99
206_Y212_M0.7400.99
189_N215_S0.7390.99
12_K253_T0.7390.99
55_Y63_R0.7380.99
263_E266_K0.7360.98
59_E75_K0.7360.98
135_F172_L0.7340.98
13_N16_K0.7320.98
204_C241_C0.7310.98
199_V272_V0.7310.98
78_E81_S0.7300.98
61_G75_K0.7290.98
55_Y59_E0.7240.98
220_I225_I0.7240.98
62_K73_K0.7240.98
103_A114_Y0.7230.98
47_T53_C0.7210.98
16_K19_M0.7200.98
162_H180_I0.7190.98
10_I36_A0.7180.98
69_P74_F0.7180.98
13_N23_L0.7170.98
56_Q60_L0.7150.98
61_G69_P0.7150.98
48_I53_C0.7060.98
199_V265_L0.7030.98
221_K227_L0.7030.98
154_I180_I0.7010.98
159_P203_S0.7010.98
62_K69_P0.6990.98
262_A283_L0.6980.98
186_L190_V0.6960.98
160_H205_L0.6940.98
29_R33_Y0.6830.98
188_K222_S0.6820.98
106_L155_I0.6810.97
87_F114_Y0.6790.97
231_E239_S0.6760.97
106_L110_V0.6740.97
162_H166_F0.6720.97
202_D216_I0.6690.97
163_Y209_F0.6680.97
219_V296_I0.6680.97
121_Y125_I0.6660.97
47_T55_Y0.6650.97
105_V187_I0.6650.97
50_Y55_Y0.6650.97
62_K67_I0.6640.97
105_V219_V0.6620.97
42_R133_E0.6620.97
84_L152_K0.6590.97
95_S277_P0.6580.97
66_E74_F0.6560.97
52_G58_A0.6550.97
230_D239_S0.6530.97
63_R73_K0.6520.97
106_L183_Y0.6510.97
200_F275_A0.6460.97
52_G59_E0.6450.97
215_S218_E0.6450.97
256_K259_R0.6440.97
61_G67_I0.6430.96
17_Y209_F0.6410.96
60_L64_F0.6400.96
40_N43_R0.6390.96
255_D259_R0.6390.96
118_D149_H0.6380.96
6_Q9_F0.6370.96
65_D71_L0.6370.96
63_R67_I0.6350.96
15_V33_Y0.6350.96
166_F212_M0.6330.96
202_D213_R0.6320.96
134_E138_Y0.6320.96
48_I55_Y0.6300.96
83_I153_R0.6300.96
64_F68_L0.6290.96
67_I74_F0.6290.96
283_L286_Y0.6280.96
223_S296_I0.6270.96
205_L277_P0.6210.96
99_L103_A0.6180.96
62_K75_K0.6180.96
84_L115_L0.6180.96
6_Q10_I0.6170.96
58_A66_E0.6160.96
201_H206_Y0.6150.95
143_V147_D0.6150.95
60_L67_I0.6110.95
68_L75_K0.6110.95
154_I176_W0.6110.95
57_L62_K0.6100.95
95_S280_Y0.6090.95
294_E297_S0.6070.95
262_A265_L0.6070.95
63_R68_L0.6060.95
64_F72_S0.6050.95
57_L64_F0.6040.95
88_Y161_T0.6040.95
39_L42_R0.6010.95
54_S58_A0.6010.95
158_D161_T0.5990.95
89_K158_D0.5980.95
38_G42_R0.5960.95
224_G227_L0.5950.95
66_E75_K0.5930.94
49_I55_Y0.5930.94
142_L145_V0.5920.94
125_I158_D0.5910.94
227_L230_D0.5890.94
142_L165_L0.5860.94
20_E31_V0.5860.94
97_K100_R0.5820.94
247_A278_F0.5790.94
53_C57_L0.5780.94
260_N264_A0.5750.94
228_K268_V0.5740.93
63_R71_L0.5740.93
62_K70_A0.5730.93
105_V108_S0.5710.93
82_S150_G0.5670.93
129_M245_P0.5660.93
96_Y100_R0.5630.93
184_F275_A0.5630.93
154_I165_L0.5620.93
261_R266_K0.5610.93
67_I76_G0.5610.93
59_E72_S0.5590.93
82_S153_R0.5580.93
141_K144_E0.5570.92
191_K222_S0.5570.92
139_A172_L0.5560.92
49_I56_Q0.5550.92
252_E255_D0.5550.92
60_L65_D0.5540.92
15_V205_L0.5540.92
166_F210_L0.5530.92
214_D221_K0.5520.92
58_A72_S0.5480.92
212_M216_I0.5480.92
53_C58_A0.5480.92
59_E65_D0.5460.92
14_L27_V0.5460.92
101_N105_V0.5460.92
120_P145_V0.5450.92
59_E68_L0.5440.92
35_W39_L0.5440.92
266_K269_H0.5430.92
261_R264_A0.5430.92
56_Q72_S0.5410.91
56_Q69_P0.5390.91
62_K72_S0.5390.91
91_K157_V0.5340.91
133_E136_K0.5320.91
152_K179_E0.5310.91
137_E140_K0.5310.91
56_Q75_K0.5310.91
95_S294_E0.5300.91
137_E141_K0.5290.90
203_S275_A0.5270.90
255_D285_P0.5260.90
56_Q63_R0.5260.90
16_K23_L0.5250.90
196_G225_I0.5240.90
26_P32_C0.5230.90
162_H182_N0.5220.90
180_I183_Y0.5190.90
264_A267_S0.5180.90
246_L249_I0.5180.90
208_R212_M0.5150.89
57_L67_I0.5150.89
63_R76_G0.5140.89
146_F154_I0.5080.89
46_E52_G0.5060.88
200_F227_L0.5050.88
199_V227_L0.5050.88
86_V122_S0.5040.88
54_S61_G0.5040.88
71_L76_G0.5030.88
58_A70_A0.5020.88
253_T256_K0.5000.88
88_Y276_C0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3kwlA 1 0.9064 100 0.374 Contact Map
3cf4A 2 0.8696 100 0.552 Contact Map
3c8yA 1 0.8528 99.4 0.8 Contact Map
1hfeL 2 0.9632 95.6 0.912 Contact Map
2vdcG 1 0.8896 89.6 0.929 Contact Map
7fd1A 1 0.2642 87.3 0.932 Contact Map
4p6vA 1 0.2475 86.3 0.932 Contact Map
4r0vA 1 0.796 86 0.933 Contact Map
4uquA 2 0.2542 82.8 0.935 Contact Map
1jflA 2 0.6823 78.6 0.938 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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