GREMLIN Database
Q97U88 - Uncharacterized protein
UniProt: Q97U88 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 209 (174)
Sequences: 17075 (12191)
Seq/√Len: 924.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
128_T137_C3.9591.00
23_E48_R3.8461.00
52_A63_V3.2511.00
115_E122_K2.6921.00
117_E122_K2.5881.00
49_Y76_L2.5521.00
112_E173_K2.5211.00
123_L140_A2.4781.00
51_I138_I2.3641.00
115_E124_K2.3181.00
125_I136_I2.2561.00
179_D197_K2.2381.00
25_V49_Y2.2081.00
79_E111_K2.1991.00
37_I69_D2.0721.00
76_L108_G2.0621.00
81_D134_G2.0371.00
143_Y184_Y1.9861.00
23_E46_N1.9581.00
125_I138_I1.8641.00
16_Y184_Y1.8421.00
24_G45_I1.7251.00
27_I145_F1.7151.00
67_K107_D1.6981.00
142_G180_E1.6831.00
163_S166_L1.6701.00
111_K114_D1.6411.00
78_N127_E1.6341.00
19_I45_I1.5921.00
139_I181_I1.5801.00
39_T43_E1.5631.00
76_L110_V1.5591.00
179_D194_G1.5551.00
19_I24_G1.4891.00
27_I53_T1.4671.00
25_V51_I1.4391.00
37_I41_R1.4321.00
37_I70_F1.4301.00
65_Q69_D1.4111.00
39_T42_K1.4031.00
40_V47_I1.3911.00
121_E140_A1.3661.00
73_S108_G1.3481.00
195_Y199_K1.3421.00
137_C144_I1.3401.00
169_E172_E1.3391.00
124_K139_I1.3381.00
126_I173_K1.3321.00
78_N136_I1.3111.00
38_Q42_K1.3111.00
139_I144_I1.2951.00
63_V75_F1.2951.00
47_I72_S1.2701.00
64_N68_R1.2651.00
108_G114_D1.2641.00
49_Y73_S1.2541.00
182_I190_F1.2411.00
33_M65_Q1.2321.00
16_Y145_F1.2261.00
130_G170_S1.2181.00
34_S38_Q1.2161.00
126_I139_I1.2031.00
137_C174_L1.1941.00
132_T135_S1.1811.00
47_I70_F1.1761.00
128_T170_S1.1601.00
79_E109_F1.1551.00
166_L169_E1.1421.00
41_R69_D1.1131.00
64_N67_K1.1051.00
82_L109_F1.1041.00
67_K75_F1.1031.00
149_T174_L1.1011.00
183_V191_T1.1001.00
113_G124_K1.0741.00
112_E127_E1.0731.00
173_K176_K1.0681.00
133_M166_L1.0681.00
29_A50_I1.0661.00
24_G47_I1.0631.00
164_E168_R1.0521.00
33_M62_G1.0481.00
193_L196_E1.0461.00
135_S147_G1.0441.00
38_Q41_R1.0411.00
172_E176_K1.0401.00
26_I47_I1.0371.00
143_Y182_I1.0321.00
110_V136_I1.0281.00
80_K127_E1.0261.00
144_I177_L1.0161.00
137_C149_T0.9841.00
139_I142_G0.9821.00
128_T149_T0.9691.00
17_L39_T0.9651.00
121_E141_N0.9651.00
33_M37_I0.9641.00
175_K199_K0.9581.00
53_T147_G0.9521.00
77_I81_D0.9501.00
146_T183_V0.9481.00
164_E167_L0.9411.00
65_Q68_R0.9381.00
117_E120_G0.9351.00
20_A120_G0.9331.00
149_T167_L0.9181.00
51_I123_L0.9041.00
20_A119_G0.9031.00
25_V118_L0.8911.00
191_T196_E0.8901.00
165_K169_E0.8791.00
20_A23_E0.8791.00
139_I177_L0.8781.00
23_E49_Y0.8761.00
157_R160_L0.8761.00
26_I29_A0.8751.00
158_T164_E0.8651.00
32_D35_E0.8641.00
18_V27_I0.8611.00
133_M161_G0.8611.00
144_I183_V0.8601.00
178_P181_I0.8601.00
172_E175_K0.8521.00
149_T170_S0.8521.00
182_I192_V0.8521.00
52_A75_F0.8431.00
55_G81_D0.8351.00
57_F61_M0.8331.00
194_G198_V0.8291.00
118_L121_E0.8291.00
168_R172_E0.8261.00
17_L24_G0.8151.00
184_Y190_F0.8111.00
73_S107_D0.8091.00
175_K197_K0.8071.00
55_G77_I0.8041.00
152_Y189_P0.8001.00
25_V123_L0.7991.00
183_V193_L0.7981.00
171_L175_K0.7961.00
29_A63_V0.7891.00
35_E39_T0.7881.00
152_Y199_K0.7831.00
13_T30_G0.7811.00
15_S36_L0.7801.00
158_T167_L0.7791.00
77_I106_P0.7781.00
135_S149_T0.7711.00
32_D36_L0.7691.00
153_G195_Y0.7671.00
124_K177_L0.7671.00
123_L138_I0.7671.00
153_G199_K0.7651.00
14_N188_G0.7621.00
110_V125_I0.7621.00
110_V138_I0.7621.00
36_L39_T0.7581.00
128_T135_S0.7511.00
35_E38_Q0.7461.00
24_G48_R0.7381.00
13_T186_G0.7351.00
17_L26_I0.7351.00
174_L193_L0.7341.00
63_V67_K0.7321.00
146_T185_P0.7131.00
55_G134_G0.7111.00
19_I43_E0.7091.00
52_A60_I0.7061.00
104_T107_D0.7051.00
145_F184_Y0.7021.00
140_A143_Y0.7011.00
106_P109_F0.7001.00
126_I137_C0.6991.00
139_I179_D0.6941.00
50_I63_V0.6911.00
81_D132_T0.6911.00
127_E136_I0.6911.00
19_I39_T0.6901.00
33_M36_L0.6851.00
127_E173_K0.6851.00
50_I72_S0.6831.00
16_Y186_G0.6821.00
26_I66_I0.6771.00
79_E82_L0.6721.00
49_Y108_G0.6691.00
34_S65_Q0.6691.00
11_L57_F0.6671.00
169_E173_K0.6521.00
62_G65_Q0.6511.00
192_V195_Y0.6511.00
27_I51_I0.6501.00
14_N189_P0.6481.00
24_G40_V0.6461.00
67_K71_P0.6441.00
151_F154_T0.6431.00
15_S30_G0.6431.00
19_I22_K0.6431.00
142_G178_P0.6391.00
167_L171_L0.6381.00
78_N81_D0.6381.00
14_N186_G0.6371.00
113_G173_K0.6321.00
155_V158_T0.6311.00
150_L183_V0.6291.00
77_I82_L0.6261.00
168_R175_K0.6191.00
34_S37_I0.6191.00
20_A121_E0.6111.00
161_G167_L0.6081.00
56_H186_G0.6071.00
153_G156_G0.6061.00
24_G46_N0.6051.00
66_I70_F0.6041.00
151_F156_G0.6021.00
110_V114_D0.6021.00
18_V140_A0.6021.00
36_L40_V0.6021.00
26_I40_V0.6001.00
110_V116_I0.5991.00
21_G120_G0.5991.00
130_G158_T0.5971.00
51_I136_I0.5871.00
27_I138_I0.5861.00
142_G181_I0.5821.00
9_G15_S0.5791.00
148_D187_H0.5771.00
129_P170_S0.5771.00
23_E119_G0.5671.00
76_L107_D0.5671.00
41_R44_K0.5641.00
111_K127_E0.5641.00
50_I66_I0.5641.00
50_I75_F0.5611.00
18_V25_V0.5551.00
60_I63_V0.5551.00
183_V194_G0.5541.00
176_K193_L0.5521.00
152_Y191_T0.5441.00
22_K44_K0.5431.00
195_Y198_V0.5411.00
139_I178_P0.5391.00
144_I193_L0.5391.00
100_I104_T0.5391.00
13_T59_H0.5351.00
40_V45_I0.5341.00
53_T138_I0.5331.00
114_D125_I0.5311.00
22_K119_G0.5281.00
17_L40_V0.5261.00
73_S76_L0.5241.00
76_L114_D0.5231.00
151_F155_V0.5231.00
179_D183_V0.5181.00
68_R71_P0.5151.00
9_G12_A0.5041.00
126_I177_L0.5041.00
40_V70_F0.5031.00
118_L123_L0.5021.00
20_A118_L0.5001.00
22_K46_N0.5001.00
31_G62_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3r2uA 4 0.933 100 0.254 Contact Map
3tp9A 2 0.9378 100 0.254 Contact Map
4yslA 2 0.9904 100 0.27 Contact Map
4efzA 2 0.9904 100 0.273 Contact Map
2xf4A 2 0.9761 100 0.279 Contact Map
1qh5A 1 0.8852 100 0.281 Contact Map
2qedA 1 0.89 100 0.281 Contact Map
2p18A 1 0.8947 100 0.287 Contact Map
1xm8A 1 0.8947 100 0.291 Contact Map
2zwrA 1 0.9713 100 0.308 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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