GREMLIN Database
Q97U86 - Regulatory protein, putative
UniProt: Q97U86 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 161 (134)
Sequences: 6691 (4276)
Seq/√Len: 369.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_K111_E2.8111.00
64_R103_F2.7811.00
10_F117_V2.7411.00
115_I132_R2.6121.00
116_K130_K2.5711.00
26_T107_T2.3221.00
95_N147_D2.3031.00
18_K113_E2.2951.00
14_K17_Q2.2291.00
113_E132_R2.1641.00
100_H141_E2.1341.00
32_N104_S2.0011.00
25_R31_D1.8691.00
113_E134_Y1.7971.00
49_K53_E1.7611.00
29_D49_K1.7461.00
132_R147_D1.7141.00
76_V135_G1.6961.00
50_D53_E1.6871.00
72_T102_V1.6831.00
136_Y142_K1.6771.00
111_E134_Y1.6641.00
20_K111_E1.6591.00
15_V116_K1.6261.00
37_L42_S1.5981.00
118_R128_I1.5871.00
49_K65_L1.5871.00
134_Y142_K1.5571.00
29_D65_L1.5391.00
28_T31_D1.5321.00
111_E136_Y1.5291.00
102_V143_L1.5091.00
27_I75_I1.4781.00
73_L96_V1.4301.00
49_K64_R1.4031.00
107_T137_N1.3891.00
33_I37_L1.3741.00
115_I147_D1.3691.00
106_D138_Q1.3441.00
130_K147_D1.3221.00
86_Q89_F1.3111.00
94_E130_K1.2851.00
117_V129_V1.2771.00
14_K117_V1.2771.00
15_V117_V1.2551.00
137_N141_E1.2471.00
112_A131_I1.2431.00
132_R145_E1.2361.00
97_K145_E1.2071.00
71_L75_I1.1961.00
24_G107_T1.1931.00
24_G109_Y1.1921.00
79_L110_A1.1901.00
29_D33_I1.1791.00
60_P63_G1.1741.00
130_K149_V1.1641.00
135_G144_I1.1501.00
44_Q51_Y1.1421.00
46_H69_G1.1291.00
36_T68_N1.1281.00
27_I71_L1.1221.00
94_E147_D1.1221.00
110_A133_S1.1211.00
50_D54_K1.1081.00
54_K59_E1.1031.00
36_T47_F1.0641.00
99_L145_E1.0631.00
30_V34_W1.0581.00
23_V82_E1.0571.00
72_T144_I1.0521.00
128_I149_V1.0461.00
131_I150_F1.0381.00
30_V33_I1.0221.00
106_D137_N1.0131.00
103_F106_D1.0111.00
76_V110_A1.0091.00
34_W37_L1.0031.00
115_I130_K0.9931.00
34_W38_L0.9871.00
102_V108_I0.9761.00
32_N67_V0.9721.00
85_S89_F0.9561.00
72_T135_G0.9541.00
110_A135_G0.9421.00
114_V131_I0.9121.00
96_V146_F0.9021.00
30_V37_L0.8981.00
16_G113_E0.8951.00
93_I96_V0.8891.00
78_G82_E0.8771.00
118_R130_K0.8691.00
114_V129_V0.8671.00
106_D139_K0.8651.00
136_Y143_L0.8561.00
70_F77_A0.8521.00
120_S128_I0.8511.00
39_T68_N0.8501.00
48_N51_Y0.8491.00
51_Y59_E0.8481.00
109_Y136_Y0.8461.00
42_S47_F0.8351.00
109_Y140_G0.8181.00
20_K109_Y0.8161.00
83_Q112_A0.8081.00
70_F73_L0.7971.00
13_F129_V0.7821.00
112_A133_S0.7771.00
64_R104_S0.7771.00
66_V103_F0.7741.00
39_T71_L0.7731.00
10_F127_G0.7731.00
120_S151_M0.7721.00
93_I148_R0.7691.00
33_I47_F0.7631.00
126_F151_M0.7611.00
103_F139_K0.7601.00
26_T105_G0.7561.00
41_N68_N0.7551.00
76_V133_S0.7541.00
31_D34_W0.7471.00
10_F119_E0.7461.00
137_N143_L0.7421.00
44_Q59_E0.7351.00
65_L104_S0.7291.00
46_H68_N0.7291.00
70_F93_I0.7181.00
68_N71_L0.7181.00
70_F98_F0.7060.99
80_L148_R0.7030.99
77_A81_V0.7010.99
53_E63_G0.7010.99
120_S126_F0.6990.99
134_Y145_E0.6980.99
99_L144_I0.6960.99
76_V146_F0.6900.99
91_L151_M0.6890.99
25_R75_I0.6750.99
94_E97_K0.6730.99
17_Q117_V0.6680.99
51_Y54_K0.6610.99
76_V144_I0.6580.99
99_L142_K0.6580.99
142_K145_E0.6550.99
44_Q48_N0.6450.99
100_H137_N0.6440.99
136_Y140_G0.6430.99
13_F114_V0.6430.99
13_F17_Q0.6360.99
77_A93_I0.6360.99
80_L131_I0.6300.99
85_S88_G0.6280.99
92_G149_V0.6240.99
25_R71_L0.6240.99
36_T41_N0.6240.99
61_F101_P0.6220.99
128_I151_M0.6210.99
133_S148_R0.6190.99
43_N51_Y0.6180.99
93_I149_V0.6150.99
108_I135_G0.6110.98
59_E63_G0.6070.98
121_K126_F0.6040.98
63_G103_F0.6040.98
70_F74_T0.6030.98
66_V101_P0.5980.98
60_P66_V0.5960.98
84_T87_N0.5950.98
100_H143_L0.5930.98
70_F148_R0.5830.98
73_L98_F0.5820.98
31_D40_N0.5790.98
80_L133_S0.5760.98
80_L150_F0.5720.98
40_N78_G0.5660.97
91_L128_I0.5640.97
73_L144_I0.5630.97
41_N46_H0.5610.97
107_T138_Q0.5590.97
94_E149_V0.5570.97
136_Y139_K0.5560.97
53_E64_R0.5550.97
80_L112_A0.5500.97
26_T31_D0.5500.97
137_N140_G0.5470.97
27_I102_V0.5410.97
84_T88_G0.5390.97
53_E60_P0.5370.97
84_T89_F0.5350.96
28_T33_I0.5340.96
73_L77_A0.5310.96
31_D71_L0.5300.96
23_V79_L0.5300.96
39_T46_H0.5260.96
100_H139_K0.5220.96
36_T42_S0.5220.96
73_L93_I0.5200.96
114_V117_V0.5140.96
117_V127_G0.5110.95
13_F117_V0.5030.95
133_S146_F0.5020.95
118_R121_K0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4e3eA 3 0.9379 100 0.238 Contact Map
1q6wA 6 0.8882 100 0.251 Contact Map
4ffuA 6 0.9503 100 0.252 Contact Map
2bi0A 3 0.9565 100 0.254 Contact Map
3exzA 2 0.9006 100 0.258 Contact Map
3ir3A 2 0.7888 100 0.3 Contact Map
4rv2B 2 0.8447 100 0.31 Contact Map
4v12A 2 0.8758 100 0.316 Contact Map
2c2iA 2 0.882 100 0.324 Contact Map
1iq6A 2 0.8261 100 0.331 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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