Q97U79 - SULSO - GREMLIN Contacts

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Q97U79 - Carnitine dehydratase, putative

UniProt:	Q97U79	Sequences: MDKIRVIELGSNISAPLVGTILADLGAEVIKVEPPPYGDDRRRVKPEINGISVYFASTNRGKKSVVINLKSDEGYEIFQRLVKTADVIVTNYRPSALKRLKVDYESVKRINPKIIYCSITGFGNLTEEADRPAYDPIILALSGLMDMTGEENPVKFATSISDITTGLLATVMILWALNKGGPTFIDVPMIYTQFYLTLEDAYMYLNTGKVPKRMGSAHRYLVPYQAFKVVDGYIYVAVFNDEQYLKLCKALNREDLCKFDTLQKRVENRDYLIKELGKIFEKNTRDYWVDLLSKADVPVAPVLSLEQAFKKYGNRLVYEIEGVKYIDFPINITSNKSKAPRLGENTKEVLLELGYSEGEINRLAEKGIIMLI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	372 (354)
Sequences:	10496 (7015)
Seq/√Len:	372.8

ECOLI - FCTA ACOCT CAIB
SULSO - Q97U79 Q97YI0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
103_D	106_S	3.626	1.00
28_E	63_K	3.585	1.00
283_N	287_Y	3.258	1.00
19_G	89_V	3.147	1.00
117_C	173_I	3.042	1.00
83_K	110_I	2.940	1.00
117_C	169_A	2.930	1.00
79_Q	110_I	2.818	1.00
71_S	74_G	2.771	1.00
229_V	285_R	2.631	1.00
283_N	288_W	2.605	1.00
98_K	103_D	2.585	1.00
75_Y	79_Q	2.536	1.00
107_V	114_I	2.527	1.00
104_Y	108_K	2.474	1.00
5_R	28_E	2.470	1.00
284_T	287_Y	2.458	1.00
67_I	78_F	2.422	1.00
230_V	284_T	2.409	1.00
283_N	291_L	2.373	1.00
80_R	83_K	2.298	1.00
343_G	346_T	2.298	1.00
279_I	282_K	2.279	1.00
76_E	80_R	2.234	1.00
228_K	281_E	2.221	1.00
87_V	173_I	2.192	1.00
319_E	324_K	2.153	1.00
77_I	355_Y	2.112	1.00
9_L	78_F	2.059	1.00
345_N	348_E	2.028	1.00
5_R	84_T	2.002	1.00
274_K	278_K	1.994	1.00
268_N	271_Y	1.977	1.00
106_S	109_R	1.976	1.00
63_K	348_E	1.952	1.00
346_T	350_L	1.943	1.00
161_S	193_Q	1.925	1.00
124_N	186_D	1.897	1.00
275_E	278_K	1.887	1.00
253_R	279_I	1.861	1.00
108_K	181_G	1.842	1.00
131_R	293_S	1.836	1.00
304_S	307_Q	1.831	1.00
171_V	174_L	1.819	1.00
7_I	82_V	1.814	1.00
68_N	71_S	1.811	1.00
253_R	256_L	1.807	1.00
25_L	175_W	1.802	1.00
225_Q	273_I	1.791	1.00
128_E	131_R	1.776	1.00
97_L	102_V	1.759	1.00
286_D	290_D	1.727	1.00
82_V	107_V	1.726	1.00
341_R	344_E	1.722	1.00
258_K	271_Y	1.702	1.00
88_I	114_I	1.693	1.00
7_I	85_A	1.692	1.00
128_E	311_K	1.681	1.00
63_K	352_E	1.662	1.00
23_A	61_G	1.661	1.00
183_T	333_T	1.629	1.00
118_S	184_F	1.626	1.00
261_T	264_K	1.612	1.00
250_A	291_L	1.612	1.00
104_Y	116_Y	1.611	1.00
4_I	177_L	1.581	1.00
72_D	75_Y	1.580	1.00
8_E	19_G	1.577	1.00
249_K	254_E	1.577	1.00
290_D	294_K	1.555	1.00
67_I	74_G	1.555	1.00
253_R	275_E	1.542	1.00
142_S	193_Q	1.540	1.00
140_A	235_Y	1.524	1.00
249_K	257_C	1.523	1.00
285_R	307_Q	1.522	1.00
183_T	335_N	1.508	1.00
24_D	60_R	1.499	1.00
82_V	111_N	1.498	1.00
279_I	288_W	1.497	1.00
276_L	280_F	1.495	1.00
65_V	349_V	1.483	1.00
181_G	334_S	1.472	1.00
228_K	277_G	1.459	1.00
164_T	196_L	1.458	1.00
347_K	351_L	1.457	1.00
338_K	344_E	1.452	1.00
264_K	267_E	1.451	1.00
191_Y	314_N	1.427	1.00
287_Y	291_L	1.423	1.00
80_R	355_Y	1.396	1.00
256_L	275_E	1.393	1.00
229_V	234_I	1.385	1.00
149_G	213_R	1.385	1.00
79_Q	106_S	1.384	1.00
67_I	77_I	1.381	1.00
65_V	346_T	1.380	1.00
271_Y	274_K	1.379	1.00
285_R	301_P	1.377	1.00
228_K	233_Y	1.371	1.00
246_K	249_K	1.366	1.00
172_M	330_I	1.364	1.00
128_E	141_L	1.363	1.00
179_K	334_S	1.362	1.00
340_P	345_N	1.358	1.00
90_T	118_S	1.351	1.00
260_D	264_K	1.347	1.00
6_V	87_V	1.341	1.00
104_Y	184_F	1.335	1.00
280_F	288_W	1.330	1.00
81_L	353_L	1.329	1.00
127_E	313_G	1.329	1.00
227_F	273_I	1.326	1.00
96_A	99_R	1.318	1.00
250_A	295_A	1.311	1.00
317_V	324_K	1.305	1.00
247_L	251_L	1.303	1.00
244_Y	248_C	1.284	1.00
119_I	169_A	1.283	1.00
306_E	310_K	1.279	1.00
79_Q	102_V	1.270	1.00
251_L	279_I	1.269	1.00
245_L	249_K	1.251	1.00
241_D	245_L	1.232	1.00
188_P	191_Y	1.222	1.00
289_V	299_V	1.200	1.00
61_G	336_K	1.186	1.00
34_P	37_Y	1.183	1.00
73_E	76_E	1.183	1.00
242_E	246_K	1.182	1.00
168_L	195_Y	1.182	1.00
9_L	88_I	1.176	1.00
135_D	139_L	1.161	1.00
228_K	280_F	1.161	1.00
97_L	116_Y	1.156	1.00
194_F	308_A	1.151	1.00
287_Y	290_D	1.143	1.00
210_V	306_E	1.142	1.00
238_V	247_L	1.139	1.00
35_P	66_V	1.121	1.00
69_L	100_L	1.114	1.00
176_A	183_T	1.114	1.00
18_V	170_T	1.107	1.00
66_V	346_T	1.100	1.00
87_V	115_I	1.100	1.00
183_T	334_S	1.097	1.00
141_L	311_K	1.096	1.00
82_V	110_I	1.094	1.00
289_V	301_P	1.094	1.00
64_S	340_P	1.088	1.00
303_L	311_K	1.087	1.00
70_K	100_L	1.086	1.00
234_I	288_W	1.077	1.00
249_K	295_A	1.071	1.00
77_I	353_L	1.067	1.00
259_F	268_N	1.065	1.00
61_G	337_S	1.060	1.00
77_I	80_R	1.058	1.00
133_A	138_I	1.057	1.00
228_K	232_G	1.055	1.00
5_R	30_I	1.048	1.00
172_M	185_I	1.048	1.00
18_V	169_A	1.044	1.00
139_L	161_S	1.039	1.00
291_L	294_K	1.035	1.00
232_G	285_R	1.034	1.00
107_V	116_Y	1.034	1.00
278_K	282_K	1.033	1.00
234_I	280_F	1.033	1.00
133_A	189_M	1.024	1.00
197_T	305_L	1.023	1.00
286_D	289_V	1.021	1.00
21_I	171_V	1.018	1.00
337_S	345_N	1.016	1.00
7_I	78_F	1.015	1.00
79_Q	83_K	1.013	1.00
104_Y	182_P	1.012	1.00
258_K	268_N	1.010	1.00
247_L	276_L	1.010	1.00
90_T	97_L	1.009	1.00
122_F	141_L	0.995	1.00
78_F	102_V	0.992	1.00
286_D	301_P	0.991	1.00
210_V	304_S	0.989	1.00
10_G	15_A	0.987	1.00
75_Y	102_V	0.976	1.00
153_P	233_Y	0.976	1.00
271_Y	275_E	0.973	1.00
152_N	213_R	0.970	1.00
224_Y	237_A	0.966	1.00
83_K	111_N	0.965	1.00
5_R	85_A	0.960	1.00
292_L	299_V	0.960	1.00
72_D	76_E	0.960	1.00
291_L	295_A	0.949	1.00
20_T	24_D	0.949	1.00
9_L	97_L	0.948	1.00
217_A	269_R	0.946	1.00
320_I	325_Y	0.942	1.00
125_L	313_G	0.939	1.00
116_Y	184_F	0.935	1.00
303_L	307_Q	0.935	1.00
125_L	129_A	0.935	1.00
312_Y	324_K	0.929	1.00
20_T	60_R	0.926	1.00
87_V	177_L	0.926	1.00
76_E	79_Q	0.925	1.00
170_T	174_L	0.923	1.00
277_G	281_E	0.922	1.00
168_L	192_T	0.921	1.00
245_L	257_C	0.919	1.00
244_Y	265_R	0.918	1.00
246_K	250_A	0.915	1.00
290_D	293_S	0.914	1.00
12_N	134_Y	0.911	1.00
124_N	184_F	0.910	1.00
285_R	289_V	0.909	1.00
78_F	88_I	0.909	1.00
45_K	48_I	0.908	1.00
74_G	77_I	0.908	1.00
88_I	107_V	0.906	1.00
32_V	65_V	0.905	1.00
78_F	82_V	0.904	1.00
77_I	350_L	0.904	1.00
348_E	352_E	0.903	1.00
204_Y	306_E	0.898	1.00
318_Y	327_D	0.897	1.00
121_G	133_A	0.893	1.00
259_F	271_Y	0.889	1.00
275_E	279_I	0.887	1.00
92_Y	96_A	0.886	1.00
191_Y	316_L	0.886	1.00
234_I	289_V	0.881	1.00
59_N	62_K	0.880	1.00
148_T	157_A	0.878	1.00
136_P	237_A	0.875	1.00
65_V	77_I	0.872	1.00
98_K	105_E	0.867	1.00
32_V	78_F	0.867	1.00
22_L	173_I	0.865	1.00
23_A	29_V	0.865	1.00
150_E	154_V	0.865	1.00
17_L	21_I	0.864	1.00
120_T	123_G	0.864	1.00
115_I	176_A	0.861	1.00
88_I	97_L	0.859	1.00
262_L	266_V	0.859	1.00
30_I	349_V	0.858	1.00
277_G	280_F	0.856	1.00
246_K	295_A	0.856	1.00
204_Y	210_V	0.855	1.00
14_S	119_I	0.853	1.00
79_Q	111_N	0.853	1.00
234_I	285_R	0.849	1.00
74_G	350_L	0.848	1.00
75_Y	101_K	0.846	1.00
226_A	235_Y	0.840	1.00
25_L	171_V	0.839	1.00
28_E	348_E	0.839	1.00
33_E	42_R	0.835	1.00
136_P	235_Y	0.835	1.00
289_V	293_S	0.835	1.00
10_G	19_G	0.835	1.00
55_F	59_N	0.830	1.00
84_T	352_E	0.827	1.00
140_A	300_A	0.826	1.00
284_T	288_W	0.825	1.00
65_V	350_L	0.821	1.00
332_I	335_N	0.816	1.00
235_Y	300_A	0.810	1.00
230_V	287_Y	0.806	1.00
106_S	110_I	0.806	1.00
141_L	303_L	0.806	1.00
146_D	304_S	0.804	1.00
183_T	332_I	0.803	1.00
79_Q	82_V	0.801	1.00
252_N	291_L	0.799	1.00
88_I	116_Y	0.797	1.00
28_E	352_E	0.794	1.00
18_V	89_V	0.793	1.00
327_D	331_N	0.793	1.00
103_D	116_Y	0.792	1.00
77_I	354_G	0.788	1.00
230_V	282_K	0.787	1.00
259_F	275_E	0.787	1.00
32_V	67_I	0.785	1.00
340_P	344_E	0.784	1.00
5_R	63_K	0.781	1.00
293_S	299_V	0.775	1.00
138_I	161_S	0.771	1.00
171_V	175_W	0.766	1.00
64_S	343_G	0.766	1.00
38_G	342_L	0.765	1.00
96_A	100_L	0.765	1.00
93_R	96_A	0.763	1.00
105_E	108_K	0.761	1.00
316_L	331_N	0.761	1.00
80_R	84_T	0.759	1.00
75_Y	100_L	0.758	1.00
74_G	355_Y	0.757	1.00
167_L	171_V	0.752	1.00
234_I	299_V	0.749	1.00
95_S	98_K	0.748	1.00
66_V	342_L	0.748	1.00
273_I	277_G	0.746	1.00
7_I	88_I	0.740	1.00
25_L	332_I	0.740	1.00
150_E	225_Q	0.740	1.00
98_K	118_S	0.740	1.00
251_L	276_L	0.739	1.00
270_D	274_K	0.739	1.00
253_R	257_C	0.736	1.00
13_I	58_T	0.734	1.00
272_L	276_L	0.733	1.00
274_K	277_G	0.732	1.00
90_T	124_N	0.730	1.00
278_K	281_E	0.730	1.00
147_M	197_T	0.727	1.00
225_Q	277_G	0.727	1.00
30_I	85_A	0.727	1.00
117_C	185_I	0.726	1.00
11_S	40_D	0.726	1.00
315_R	331_N	0.725	1.00
76_E	110_I	0.725	1.00
137_I	300_A	0.725	1.00
226_A	302_V	0.724	1.00
74_G	78_F	0.718	1.00
144_L	156_F	0.717	1.00
144_L	197_T	0.716	1.00
140_A	145_M	0.716	1.00
110_I	113_K	0.715	1.00
194_F	316_L	0.710	1.00
301_P	307_Q	0.709	0.99
104_Y	114_I	0.707	0.99
240_N	243_Q	0.707	0.99
222_V	266_V	0.707	0.99
125_L	331_N	0.706	0.99
67_I	350_L	0.705	0.99
161_S	165_T	0.704	0.99
164_T	167_L	0.704	0.99
95_S	130_D	0.704	0.99
113_K	181_G	0.703	0.99
263_Q	267_E	0.698	0.99
141_L	301_P	0.695	0.99
31_K	39_D	0.695	0.99
7_I	84_T	0.691	0.99
217_A	273_I	0.689	0.99
93_R	132_P	0.689	0.99
17_L	163_I	0.689	0.99
201_A	309_F	0.687	0.99
82_V	102_V	0.687	0.99
84_T	353_L	0.685	0.99
21_I	170_T	0.685	0.99
8_E	15_A	0.684	0.99
248_C	254_E	0.684	0.99
1_M	4_I	0.684	0.99
254_E	257_C	0.683	0.99
201_A	205_L	0.683	0.99
282_K	288_W	0.682	0.99
265_R	268_N	0.681	0.99
164_T	192_T	0.680	0.99
66_V	343_G	0.679	0.99
187_V	192_T	0.677	0.99
120_T	186_D	0.676	0.99
222_V	273_I	0.675	0.99
266_V	269_R	0.674	0.99
147_M	305_L	0.673	0.99
315_R	318_Y	0.673	0.99
204_Y	208_G	0.671	0.99
17_L	195_Y	0.668	0.99
243_Q	298_P	0.668	0.99
7_I	81_L	0.665	0.99
309_F	317_V	0.665	0.99
236_V	280_F	0.664	0.99
229_V	288_W	0.664	0.99
80_R	353_L	0.663	0.99
141_L	300_A	0.663	0.99
123_G	186_D	0.662	0.99
63_K	337_S	0.661	0.99
22_L	170_T	0.661	0.99
56_A	339_A	0.661	0.99
16_P	162_D	0.659	0.99
105_E	109_R	0.656	0.99
8_E	11_S	0.652	0.99
259_F	272_L	0.649	0.99
74_G	354_G	0.648	0.99
165_T	192_T	0.648	0.99
186_D	314_N	0.647	0.99
13_I	159_S	0.646	0.99
136_P	224_Y	0.644	0.99
264_K	268_N	0.641	0.99
111_N	114_I	0.641	0.99
217_A	225_Q	0.641	0.99
176_A	185_I	0.639	0.99
24_D	61_G	0.637	0.99
113_K	179_K	0.637	0.99
205_L	324_K	0.636	0.99
144_L	193_Q	0.634	0.99
31_K	38_G	0.633	0.99
69_L	78_F	0.632	0.99
4_I	87_V	0.632	0.99
37_Y	43_R	0.630	0.99
34_P	66_V	0.627	0.99
165_T	189_M	0.626	0.99
3_K	178_N	0.624	0.99
246_K	296_D	0.624	0.99
51_I	56_A	0.620	0.99
105_E	184_F	0.619	0.99
79_Q	101_K	0.616	0.99
64_S	344_E	0.615	0.99
8_E	62_K	0.614	0.99
90_T	116_Y	0.614	0.99
175_W	332_I	0.613	0.99
132_P	296_D	0.613	0.99
82_V	88_I	0.612	0.99
236_V	299_V	0.611	0.99
348_E	351_L	0.611	0.99
104_Y	118_S	0.611	0.99
169_A	187_V	0.608	0.98
19_G	62_K	0.606	0.98
123_G	126_T	0.606	0.98
98_K	184_F	0.606	0.98
231_D	285_R	0.605	0.98
12_N	40_D	0.605	0.98
1_M	174_L	0.605	0.98
185_I	332_I	0.604	0.98
19_G	29_V	0.603	0.98
312_Y	317_V	0.602	0.98
82_V	85_A	0.602	0.98
87_V	174_L	0.600	0.98
90_T	95_S	0.599	0.98
15_A	89_V	0.598	0.98
51_I	341_R	0.597	0.98
9_L	69_L	0.597	0.98
229_V	280_F	0.596	0.98
64_S	342_L	0.596	0.98
98_K	124_N	0.593	0.98
3_K	28_E	0.591	0.98
236_V	247_L	0.590	0.98
134_Y	240_N	0.589	0.98
203_M	220_Y	0.588	0.98
170_T	175_W	0.588	0.98
337_S	348_E	0.588	0.98
134_Y	298_P	0.587	0.98
169_A	173_I	0.585	0.98
247_L	292_L	0.579	0.98
98_K	106_S	0.574	0.98
94_P	120_T	0.573	0.98
58_T	163_I	0.573	0.98
241_D	265_R	0.573	0.98
250_A	294_K	0.572	0.98
252_N	255_D	0.572	0.98
119_I	165_T	0.571	0.98
17_L	166_G	0.571	0.98
103_D	109_R	0.570	0.98
142_S	190_I	0.568	0.98
14_S	165_T	0.568	0.98
230_V	281_E	0.567	0.98
64_S	345_N	0.567	0.98
66_V	77_I	0.566	0.98
5_R	353_L	0.563	0.97
163_I	198_L	0.562	0.97
222_V	269_R	0.561	0.97
276_L	279_I	0.561	0.97
125_L	314_N	0.561	0.97
161_S	189_M	0.561	0.97
337_S	344_E	0.559	0.97
118_S	124_N	0.557	0.97
108_K	116_Y	0.557	0.97
38_G	42_R	0.557	0.97
251_L	254_E	0.556	0.97
95_S	99_R	0.555	0.97
30_I	84_T	0.554	0.97
113_K	180_G	0.554	0.97
312_Y	315_R	0.553	0.97
231_D	284_T	0.553	0.97
346_T	349_V	0.552	0.97
30_I	81_L	0.551	0.97
2_D	178_N	0.550	0.97
350_L	353_L	0.550	0.97
130_D	293_S	0.549	0.97
15_A	119_I	0.547	0.97
231_D	286_D	0.546	0.97
288_W	291_L	0.543	0.97
79_Q	107_V	0.543	0.97
134_Y	137_I	0.541	0.97
201_A	326_I	0.540	0.97
95_S	103_D	0.539	0.97
156_F	160_I	0.538	0.97
250_A	297_V	0.538	0.97
4_I	174_L	0.537	0.97
137_I	298_P	0.536	0.97
34_P	38_G	0.534	0.97
319_E	322_G	0.533	0.97
34_P	40_D	0.532	0.96
248_C	256_L	0.531	0.96
259_F	265_R	0.530	0.96
349_V	352_E	0.530	0.96
166_G	170_T	0.530	0.96
255_D	275_E	0.528	0.96
307_Q	310_K	0.525	0.96
110_I	114_I	0.523	0.96
165_T	187_V	0.523	0.96
145_M	226_A	0.522	0.96
222_V	272_L	0.521	0.96
33_E	64_S	0.518	0.96
80_R	354_G	0.517	0.96
39_D	42_R	0.516	0.96
229_V	232_G	0.516	0.96
246_K	297_V	0.516	0.96
93_R	296_D	0.511	0.96
138_I	189_M	0.510	0.96
11_S	34_P	0.509	0.95
18_V	119_I	0.509	0.95
63_K	345_N	0.509	0.95
279_I	283_N	0.509	0.95
234_I	292_L	0.508	0.95
18_V	166_G	0.508	0.95
243_Q	246_K	0.506	0.95
151_E	212_K	0.506	0.95
79_Q	97_L	0.505	0.95
148_T	154_V	0.505	0.95
258_K	275_E	0.505	0.95
288_W	292_L	0.504	0.95
12_N	15_A	0.503	0.95
74_G	346_T	0.503	0.95
253_R	278_K	0.503	0.95
350_L	355_Y	0.503	0.95
71_S	75_Y	0.501	0.95
122_F	137_I	0.501	0.95
91_N	162_D	0.500	0.95

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2vjqA	2	0.9892	100	0.067	Contact Map
1q7eA	2	0.9731	100	0.069	Contact Map
3ubmA	2	0.9919	100	0.07	Contact Map
1xk7A	2	0.9812	100	0.078	Contact Map
4ed9A	2	0.9489	100	0.091	Contact Map
4hl6A	2	0.9543	100	0.097	Contact Map
2yimA	2	0.9005	100	0.143	Contact Map
2g04A	2	0.8925	100	0.173	Contact Map
1vl6A	4	0.5296	94.3	0.946	Contact Map
3l07A	2	0.3306	91.4	0.951	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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