GREMLIN Database
Q97U79 - Carnitine dehydratase, putative
UniProt: Q97U79 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 372 (354)
Sequences: 10496 (7015)
Seq/√Len: 372.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
103_D106_S3.6261.00
28_E63_K3.5851.00
283_N287_Y3.2581.00
19_G89_V3.1471.00
117_C173_I3.0421.00
83_K110_I2.9401.00
117_C169_A2.9301.00
79_Q110_I2.8181.00
71_S74_G2.7711.00
229_V285_R2.6311.00
283_N288_W2.6051.00
98_K103_D2.5851.00
75_Y79_Q2.5361.00
107_V114_I2.5271.00
104_Y108_K2.4741.00
5_R28_E2.4701.00
284_T287_Y2.4581.00
67_I78_F2.4221.00
230_V284_T2.4091.00
283_N291_L2.3731.00
80_R83_K2.2981.00
343_G346_T2.2981.00
279_I282_K2.2791.00
76_E80_R2.2341.00
228_K281_E2.2211.00
87_V173_I2.1921.00
319_E324_K2.1531.00
77_I355_Y2.1121.00
9_L78_F2.0591.00
345_N348_E2.0281.00
5_R84_T2.0021.00
274_K278_K1.9941.00
268_N271_Y1.9771.00
106_S109_R1.9761.00
63_K348_E1.9521.00
346_T350_L1.9431.00
161_S193_Q1.9251.00
124_N186_D1.8971.00
275_E278_K1.8871.00
253_R279_I1.8611.00
108_K181_G1.8421.00
131_R293_S1.8361.00
304_S307_Q1.8311.00
171_V174_L1.8191.00
7_I82_V1.8141.00
68_N71_S1.8111.00
253_R256_L1.8071.00
25_L175_W1.8021.00
225_Q273_I1.7911.00
128_E131_R1.7761.00
97_L102_V1.7591.00
286_D290_D1.7271.00
82_V107_V1.7261.00
341_R344_E1.7221.00
258_K271_Y1.7021.00
88_I114_I1.6931.00
7_I85_A1.6921.00
128_E311_K1.6811.00
63_K352_E1.6621.00
23_A61_G1.6611.00
183_T333_T1.6291.00
118_S184_F1.6261.00
261_T264_K1.6121.00
250_A291_L1.6121.00
104_Y116_Y1.6111.00
4_I177_L1.5811.00
72_D75_Y1.5801.00
8_E19_G1.5771.00
249_K254_E1.5771.00
290_D294_K1.5551.00
67_I74_G1.5551.00
253_R275_E1.5421.00
142_S193_Q1.5401.00
140_A235_Y1.5241.00
249_K257_C1.5231.00
285_R307_Q1.5221.00
183_T335_N1.5081.00
24_D60_R1.4991.00
82_V111_N1.4981.00
279_I288_W1.4971.00
276_L280_F1.4951.00
65_V349_V1.4831.00
181_G334_S1.4721.00
228_K277_G1.4591.00
164_T196_L1.4581.00
347_K351_L1.4571.00
338_K344_E1.4521.00
264_K267_E1.4511.00
191_Y314_N1.4271.00
287_Y291_L1.4231.00
80_R355_Y1.3961.00
256_L275_E1.3931.00
229_V234_I1.3851.00
149_G213_R1.3851.00
79_Q106_S1.3841.00
67_I77_I1.3811.00
65_V346_T1.3801.00
271_Y274_K1.3791.00
285_R301_P1.3771.00
228_K233_Y1.3711.00
246_K249_K1.3661.00
172_M330_I1.3641.00
128_E141_L1.3631.00
179_K334_S1.3621.00
340_P345_N1.3581.00
90_T118_S1.3511.00
260_D264_K1.3471.00
6_V87_V1.3411.00
104_Y184_F1.3351.00
280_F288_W1.3301.00
81_L353_L1.3291.00
127_E313_G1.3291.00
227_F273_I1.3261.00
96_A99_R1.3181.00
250_A295_A1.3111.00
317_V324_K1.3051.00
247_L251_L1.3031.00
244_Y248_C1.2841.00
119_I169_A1.2831.00
306_E310_K1.2791.00
79_Q102_V1.2701.00
251_L279_I1.2691.00
245_L249_K1.2511.00
241_D245_L1.2321.00
188_P191_Y1.2221.00
289_V299_V1.2001.00
61_G336_K1.1861.00
34_P37_Y1.1831.00
73_E76_E1.1831.00
242_E246_K1.1821.00
168_L195_Y1.1821.00
9_L88_I1.1761.00
135_D139_L1.1611.00
228_K280_F1.1611.00
97_L116_Y1.1561.00
194_F308_A1.1511.00
287_Y290_D1.1431.00
210_V306_E1.1421.00
238_V247_L1.1391.00
35_P66_V1.1211.00
69_L100_L1.1141.00
176_A183_T1.1141.00
18_V170_T1.1071.00
66_V346_T1.1001.00
87_V115_I1.1001.00
183_T334_S1.0971.00
141_L311_K1.0961.00
82_V110_I1.0941.00
289_V301_P1.0941.00
64_S340_P1.0881.00
303_L311_K1.0871.00
70_K100_L1.0861.00
234_I288_W1.0771.00
249_K295_A1.0711.00
77_I353_L1.0671.00
259_F268_N1.0651.00
61_G337_S1.0601.00
77_I80_R1.0581.00
133_A138_I1.0571.00
228_K232_G1.0551.00
5_R30_I1.0481.00
172_M185_I1.0481.00
18_V169_A1.0441.00
139_L161_S1.0391.00
291_L294_K1.0351.00
232_G285_R1.0341.00
107_V116_Y1.0341.00
278_K282_K1.0331.00
234_I280_F1.0331.00
133_A189_M1.0241.00
197_T305_L1.0231.00
286_D289_V1.0211.00
21_I171_V1.0181.00
337_S345_N1.0161.00
7_I78_F1.0151.00
79_Q83_K1.0131.00
104_Y182_P1.0121.00
258_K268_N1.0101.00
247_L276_L1.0101.00
90_T97_L1.0091.00
122_F141_L0.9951.00
78_F102_V0.9921.00
286_D301_P0.9911.00
210_V304_S0.9891.00
10_G15_A0.9871.00
75_Y102_V0.9761.00
153_P233_Y0.9761.00
271_Y275_E0.9731.00
152_N213_R0.9701.00
224_Y237_A0.9661.00
83_K111_N0.9651.00
5_R85_A0.9601.00
292_L299_V0.9601.00
72_D76_E0.9601.00
291_L295_A0.9491.00
20_T24_D0.9491.00
9_L97_L0.9481.00
217_A269_R0.9461.00
320_I325_Y0.9421.00
125_L313_G0.9391.00
116_Y184_F0.9351.00
303_L307_Q0.9351.00
125_L129_A0.9351.00
312_Y324_K0.9291.00
20_T60_R0.9261.00
87_V177_L0.9261.00
76_E79_Q0.9251.00
170_T174_L0.9231.00
277_G281_E0.9221.00
168_L192_T0.9211.00
245_L257_C0.9191.00
244_Y265_R0.9181.00
246_K250_A0.9151.00
290_D293_S0.9141.00
12_N134_Y0.9111.00
124_N184_F0.9101.00
285_R289_V0.9091.00
78_F88_I0.9091.00
45_K48_I0.9081.00
74_G77_I0.9081.00
88_I107_V0.9061.00
32_V65_V0.9051.00
78_F82_V0.9041.00
77_I350_L0.9041.00
348_E352_E0.9031.00
204_Y306_E0.8981.00
318_Y327_D0.8971.00
121_G133_A0.8931.00
259_F271_Y0.8891.00
275_E279_I0.8871.00
92_Y96_A0.8861.00
191_Y316_L0.8861.00
234_I289_V0.8811.00
59_N62_K0.8801.00
148_T157_A0.8781.00
136_P237_A0.8751.00
65_V77_I0.8721.00
98_K105_E0.8671.00
32_V78_F0.8671.00
22_L173_I0.8651.00
23_A29_V0.8651.00
150_E154_V0.8651.00
17_L21_I0.8641.00
120_T123_G0.8641.00
115_I176_A0.8611.00
88_I97_L0.8591.00
262_L266_V0.8591.00
30_I349_V0.8581.00
277_G280_F0.8561.00
246_K295_A0.8561.00
204_Y210_V0.8551.00
14_S119_I0.8531.00
79_Q111_N0.8531.00
234_I285_R0.8491.00
74_G350_L0.8481.00
75_Y101_K0.8461.00
226_A235_Y0.8401.00
25_L171_V0.8391.00
28_E348_E0.8391.00
33_E42_R0.8351.00
136_P235_Y0.8351.00
289_V293_S0.8351.00
10_G19_G0.8351.00
55_F59_N0.8301.00
84_T352_E0.8271.00
140_A300_A0.8261.00
284_T288_W0.8251.00
65_V350_L0.8211.00
332_I335_N0.8161.00
235_Y300_A0.8101.00
230_V287_Y0.8061.00
106_S110_I0.8061.00
141_L303_L0.8061.00
146_D304_S0.8041.00
183_T332_I0.8031.00
79_Q82_V0.8011.00
252_N291_L0.7991.00
88_I116_Y0.7971.00
28_E352_E0.7941.00
18_V89_V0.7931.00
327_D331_N0.7931.00
103_D116_Y0.7921.00
77_I354_G0.7881.00
230_V282_K0.7871.00
259_F275_E0.7871.00
32_V67_I0.7851.00
340_P344_E0.7841.00
5_R63_K0.7811.00
293_S299_V0.7751.00
138_I161_S0.7711.00
171_V175_W0.7661.00
64_S343_G0.7661.00
38_G342_L0.7651.00
96_A100_L0.7651.00
93_R96_A0.7631.00
105_E108_K0.7611.00
316_L331_N0.7611.00
80_R84_T0.7591.00
75_Y100_L0.7581.00
74_G355_Y0.7571.00
167_L171_V0.7521.00
234_I299_V0.7491.00
95_S98_K0.7481.00
66_V342_L0.7481.00
273_I277_G0.7461.00
7_I88_I0.7401.00
25_L332_I0.7401.00
150_E225_Q0.7401.00
98_K118_S0.7401.00
251_L276_L0.7391.00
270_D274_K0.7391.00
253_R257_C0.7361.00
13_I58_T0.7341.00
272_L276_L0.7331.00
274_K277_G0.7321.00
90_T124_N0.7301.00
278_K281_E0.7301.00
147_M197_T0.7271.00
225_Q277_G0.7271.00
30_I85_A0.7271.00
117_C185_I0.7261.00
11_S40_D0.7261.00
315_R331_N0.7251.00
76_E110_I0.7251.00
137_I300_A0.7251.00
226_A302_V0.7241.00
74_G78_F0.7181.00
144_L156_F0.7171.00
144_L197_T0.7161.00
140_A145_M0.7161.00
110_I113_K0.7151.00
194_F316_L0.7101.00
301_P307_Q0.7090.99
104_Y114_I0.7070.99
240_N243_Q0.7070.99
222_V266_V0.7070.99
125_L331_N0.7060.99
67_I350_L0.7050.99
161_S165_T0.7040.99
164_T167_L0.7040.99
95_S130_D0.7040.99
113_K181_G0.7030.99
263_Q267_E0.6980.99
141_L301_P0.6950.99
31_K39_D0.6950.99
7_I84_T0.6910.99
217_A273_I0.6890.99
93_R132_P0.6890.99
17_L163_I0.6890.99
201_A309_F0.6870.99
82_V102_V0.6870.99
84_T353_L0.6850.99
21_I170_T0.6850.99
8_E15_A0.6840.99
248_C254_E0.6840.99
1_M4_I0.6840.99
254_E257_C0.6830.99
201_A205_L0.6830.99
282_K288_W0.6820.99
265_R268_N0.6810.99
164_T192_T0.6800.99
66_V343_G0.6790.99
187_V192_T0.6770.99
120_T186_D0.6760.99
222_V273_I0.6750.99
266_V269_R0.6740.99
147_M305_L0.6730.99
315_R318_Y0.6730.99
204_Y208_G0.6710.99
17_L195_Y0.6680.99
243_Q298_P0.6680.99
7_I81_L0.6650.99
309_F317_V0.6650.99
236_V280_F0.6640.99
229_V288_W0.6640.99
80_R353_L0.6630.99
141_L300_A0.6630.99
123_G186_D0.6620.99
63_K337_S0.6610.99
22_L170_T0.6610.99
56_A339_A0.6610.99
16_P162_D0.6590.99
105_E109_R0.6560.99
8_E11_S0.6520.99
259_F272_L0.6490.99
74_G354_G0.6480.99
165_T192_T0.6480.99
186_D314_N0.6470.99
13_I159_S0.6460.99
136_P224_Y0.6440.99
264_K268_N0.6410.99
111_N114_I0.6410.99
217_A225_Q0.6410.99
176_A185_I0.6390.99
24_D61_G0.6370.99
113_K179_K0.6370.99
205_L324_K0.6360.99
144_L193_Q0.6340.99
31_K38_G0.6330.99
69_L78_F0.6320.99
4_I87_V0.6320.99
37_Y43_R0.6300.99
34_P66_V0.6270.99
165_T189_M0.6260.99
3_K178_N0.6240.99
246_K296_D0.6240.99
51_I56_A0.6200.99
105_E184_F0.6190.99
79_Q101_K0.6160.99
64_S344_E0.6150.99
8_E62_K0.6140.99
90_T116_Y0.6140.99
175_W332_I0.6130.99
132_P296_D0.6130.99
82_V88_I0.6120.99
236_V299_V0.6110.99
348_E351_L0.6110.99
104_Y118_S0.6110.99
169_A187_V0.6080.98
19_G62_K0.6060.98
123_G126_T0.6060.98
98_K184_F0.6060.98
231_D285_R0.6050.98
12_N40_D0.6050.98
1_M174_L0.6050.98
185_I332_I0.6040.98
19_G29_V0.6030.98
312_Y317_V0.6020.98
82_V85_A0.6020.98
87_V174_L0.6000.98
90_T95_S0.5990.98
15_A89_V0.5980.98
51_I341_R0.5970.98
9_L69_L0.5970.98
229_V280_F0.5960.98
64_S342_L0.5960.98
98_K124_N0.5930.98
3_K28_E0.5910.98
236_V247_L0.5900.98
134_Y240_N0.5890.98
203_M220_Y0.5880.98
170_T175_W0.5880.98
337_S348_E0.5880.98
134_Y298_P0.5870.98
169_A173_I0.5850.98
247_L292_L0.5790.98
98_K106_S0.5740.98
94_P120_T0.5730.98
58_T163_I0.5730.98
241_D265_R0.5730.98
250_A294_K0.5720.98
252_N255_D0.5720.98
119_I165_T0.5710.98
17_L166_G0.5710.98
103_D109_R0.5700.98
142_S190_I0.5680.98
14_S165_T0.5680.98
230_V281_E0.5670.98
64_S345_N0.5670.98
66_V77_I0.5660.98
5_R353_L0.5630.97
163_I198_L0.5620.97
222_V269_R0.5610.97
276_L279_I0.5610.97
125_L314_N0.5610.97
161_S189_M0.5610.97
337_S344_E0.5590.97
118_S124_N0.5570.97
108_K116_Y0.5570.97
38_G42_R0.5570.97
251_L254_E0.5560.97
95_S99_R0.5550.97
30_I84_T0.5540.97
113_K180_G0.5540.97
312_Y315_R0.5530.97
231_D284_T0.5530.97
346_T349_V0.5520.97
30_I81_L0.5510.97
2_D178_N0.5500.97
350_L353_L0.5500.97
130_D293_S0.5490.97
15_A119_I0.5470.97
231_D286_D0.5460.97
288_W291_L0.5430.97
79_Q107_V0.5430.97
134_Y137_I0.5410.97
201_A326_I0.5400.97
95_S103_D0.5390.97
156_F160_I0.5380.97
250_A297_V0.5380.97
4_I174_L0.5370.97
137_I298_P0.5360.97
34_P38_G0.5340.97
319_E322_G0.5330.97
34_P40_D0.5320.96
248_C256_L0.5310.96
259_F265_R0.5300.96
349_V352_E0.5300.96
166_G170_T0.5300.96
255_D275_E0.5280.96
307_Q310_K0.5250.96
110_I114_I0.5230.96
165_T187_V0.5230.96
145_M226_A0.5220.96
222_V272_L0.5210.96
33_E64_S0.5180.96
80_R354_G0.5170.96
39_D42_R0.5160.96
229_V232_G0.5160.96
246_K297_V0.5160.96
93_R296_D0.5110.96
138_I189_M0.5100.96
11_S34_P0.5090.95
18_V119_I0.5090.95
63_K345_N0.5090.95
279_I283_N0.5090.95
234_I292_L0.5080.95
18_V166_G0.5080.95
243_Q246_K0.5060.95
151_E212_K0.5060.95
79_Q97_L0.5050.95
148_T154_V0.5050.95
258_K275_E0.5050.95
288_W292_L0.5040.95
12_N15_A0.5030.95
74_G346_T0.5030.95
253_R278_K0.5030.95
350_L355_Y0.5030.95
71_S75_Y0.5010.95
122_F137_I0.5010.95
91_N162_D0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2vjqA 2 0.9892 100 0.067 Contact Map
1q7eA 2 0.9731 100 0.069 Contact Map
3ubmA 2 0.9919 100 0.07 Contact Map
1xk7A 2 0.9812 100 0.078 Contact Map
4ed9A 2 0.9489 100 0.091 Contact Map
4hl6A 2 0.9543 100 0.097 Contact Map
2yimA 2 0.9005 100 0.143 Contact Map
2g04A 2 0.8925 100 0.173 Contact Map
1vl6A 4 0.5296 94.3 0.946 Contact Map
3l07A 2 0.3306 91.4 0.951 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0111 seconds.