GREMLIN Database
Q97U78 - Acyl-CoA dehydrogenase (Acd-7)
UniProt: Q97U78 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 389 (363)
Sequences: 33911 (19224)
Seq/√Len: 1009.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
146_S220_K4.0841.00
150_K218_G3.8411.00
293_K334_E3.4211.00
24_Y45_D3.0611.00
103_K107_E2.8801.00
112_D117_A2.8801.00
142_K223_E2.8611.00
31_D35_K2.7881.00
66_G69_L2.7481.00
18_D76_N2.7351.00
143_V220_K2.6881.00
185_T226_V2.6341.00
199_E217_D2.6191.00
286_P338_V2.4141.00
265_E269_N2.3871.00
112_D118_K2.3621.00
152_H215_F2.2431.00
257_E298_S2.2321.00
306_R310_K2.1071.00
229_E232_K2.0581.00
169_A187_F2.0501.00
276_Q279_S2.0491.00
19_Q23_K1.9741.00
103_K106_I1.9711.00
350_V355_E1.9621.00
102_G105_I1.9281.00
267_A342_V1.9171.00
143_V146_S1.9021.00
355_E359_R1.8941.00
57_P98_S1.8681.00
75_Y298_S1.8561.00
232_K235_Y1.8471.00
165_M191_L1.8301.00
147_F187_F1.8021.00
152_H213_E1.8021.00
260_I294_L1.7761.00
330_E371_Q1.7731.00
44_N48_K1.7551.00
10_E69_L1.7501.00
45_D48_K1.7501.00
79_L261_N1.7181.00
257_E261_N1.6821.00
282_G285_F1.6561.00
121_S165_M1.6511.00
271_V276_Q1.6391.00
76_N79_L1.6301.00
195_R219_L1.6291.00
141_E150_K1.6281.00
108_K224_D1.6151.00
222_P225_N1.6051.00
307_V320_Y1.6021.00
275_K279_S1.5851.00
267_A283_V1.5771.00
148_F220_K1.5701.00
125_T155_F1.5681.00
290_V335_A1.5611.00
148_F218_G1.5531.00
58_V64_G1.5471.00
190_D225_N1.5371.00
296_S327_L1.5161.00
21_M80_R1.5101.00
147_F223_E1.5091.00
108_K112_D1.5091.00
11_K14_L1.5071.00
159_L212_Y1.5061.00
107_E111_K1.5001.00
346_Y352_T1.4991.00
303_E307_V1.4891.00
226_V230_V1.4811.00
150_K217_D1.4771.00
126_E153_K1.4761.00
10_E66_G1.4631.00
145_N223_E1.4571.00
272_V280_F1.4571.00
112_D115_N1.4561.00
142_K146_S1.4521.00
12_L15_S1.4511.00
259_F336_G1.4501.00
15_S19_Q1.4401.00
283_V342_V1.4371.00
201_R213_E1.4311.00
297_L328_A1.4291.00
223_E226_V1.4141.00
262_K265_E1.4131.00
84_S90_H1.4071.00
142_K230_V1.4021.00
262_K353_G1.4011.00
104_R108_K1.3981.00
12_L16_T1.3971.00
295_V303_E1.3951.00
258_W262_K1.3831.00
60_Y106_I1.3831.00
199_E215_F1.3691.00
264_V268_K1.3671.00
334_E338_V1.3621.00
34_Q202_E1.3601.00
333_W365_K1.3571.00
160_K212_Y1.3561.00
140_A187_F1.3551.00
143_V148_F1.3421.00
326_Y371_Q1.3421.00
100_H239_D1.3401.00
149_I187_F1.3311.00
146_S223_E1.3241.00
68_R306_R1.3241.00
75_Y302_N1.3231.00
290_V338_V1.3171.00
202_E350_V1.3171.00
337_N362_R1.3171.00
10_E72_L1.3111.00
17_V51_L1.3081.00
14_L76_N1.3071.00
192_R195_R1.3071.00
221_V225_N1.3071.00
79_L257_E1.3051.00
67_V309_E1.2891.00
190_D195_R1.2791.00
105_I109_Y1.2751.00
75_Y257_E1.2641.00
145_N220_K1.2641.00
289_E375_L1.2571.00
54_I73_I1.2521.00
104_R224_D1.2491.00
113_L120_L1.2481.00
256_A294_L1.2431.00
123_A156_I1.2421.00
263_A339_A1.2391.00
111_K115_N1.2351.00
32_K208_N1.2301.00
256_A335_A1.2251.00
44_N47_M1.2181.00
191_L198_I1.2171.00
337_N365_K1.2131.00
11_K15_S1.2111.00
201_R215_F1.2071.00
106_I110_F1.2061.00
198_I219_L1.2011.00
244_E368_P1.1931.00
171_T185_T1.1871.00
303_E306_R1.1841.00
332_A361_T1.1831.00
260_I264_V1.1811.00
294_L335_A1.1771.00
66_G309_E1.1771.00
108_K225_N1.1691.00
307_V312_K1.1661.00
250_A301_F1.1661.00
141_E148_F1.1631.00
275_K280_F1.1581.00
128_Q137_K1.1581.00
101_S105_I1.1541.00
195_R225_N1.1531.00
242_N318_G1.1531.00
71_S305_L1.1511.00
65_K69_L1.1481.00
262_K343_Y1.1481.00
339_A354_I1.1461.00
258_W357_K1.1451.00
56_I114_A1.1431.00
14_L72_L1.1361.00
16_T49_L1.1361.00
286_P372_N1.1341.00
28_Y32_K1.1311.00
234_F238_L1.1261.00
291_Y295_V1.1241.00
109_Y164_F1.1231.00
45_D49_L1.1191.00
118_K163_D1.1151.00
322_N374_I1.1151.00
198_I214_V1.1121.00
362_R365_K1.1121.00
168_V186_L1.1031.00
30_L34_Q1.0991.00
205_T360_E1.0981.00
139_V150_K1.0941.00
87_V90_H1.0931.00
297_L331_I1.0911.00
333_W337_N1.0851.00
105_I188_L1.0841.00
71_S250_A1.0791.00
167_L189_V1.0771.00
47_M52_G1.0741.00
17_V21_M1.0691.00
293_K338_V1.0681.00
138_T149_I1.0621.00
142_K147_F1.0521.00
59_E107_E1.0451.00
168_V184_I1.0431.00
120_L164_F1.0411.00
292_A323_I1.0401.00
40_I44_N1.0331.00
123_A165_M1.0331.00
140_A169_A1.0321.00
365_K371_Q1.0291.00
191_L200_M1.0241.00
44_N117_A1.0231.00
147_F230_V1.0211.00
253_I294_L1.0191.00
144_G220_K1.0191.00
85_Y90_H1.0191.00
132_D135_K1.0161.00
149_I167_L1.0111.00
147_F171_T1.0101.00
104_R107_E1.0081.00
86_F90_H1.0061.00
41_D44_N1.0061.00
220_K223_E0.9981.00
16_T51_L0.9911.00
293_K331_I0.9901.00
167_L216_I0.9861.00
336_G361_T0.9841.00
86_F89_G0.9821.00
141_E218_G0.9821.00
268_K278_G0.9811.00
99_K239_D0.9801.00
197_G219_L0.9791.00
93_N120_L0.9761.00
28_Y31_D0.9741.00
326_Y375_L0.9721.00
195_R198_I0.9711.00
123_A216_I0.9701.00
87_V91_Y0.9681.00
333_W358_L0.9621.00
141_E172_T0.9611.00
330_E334_E0.9611.00
252_M364_Y0.9551.00
253_I301_F0.9511.00
20_L45_D0.9501.00
264_V287_I0.9391.00
267_A277_I0.9381.00
59_E103_K0.9381.00
299_S303_E0.9301.00
108_K190_D0.9271.00
149_I169_A0.9211.00
330_E365_K0.9181.00
165_M214_V0.9151.00
187_F226_V0.9141.00
100_H236_Y0.9101.00
172_T183_G0.9091.00
56_I94_T0.9071.00
259_F357_K0.9071.00
331_I334_E0.9041.00
371_Q375_L0.9011.00
363_L367_A0.8991.00
17_V73_I0.8941.00
155_F346_Y0.8941.00
329_T371_Q0.8921.00
164_F190_D0.8911.00
68_R309_E0.8871.00
105_I225_N0.8871.00
154_I213_E0.8861.00
304_G324_S0.8851.00
33_D359_R0.8811.00
124_L241_L0.8801.00
267_A278_G0.8771.00
185_T230_V0.8761.00
289_E293_K0.8751.00
291_Y323_I0.8731.00
18_D22_D0.8731.00
330_E375_L0.8701.00
93_N166_I0.8671.00
121_S191_L0.8651.00
149_I221_V0.8641.00
88_H91_Y0.8561.00
206_M363_L0.8551.00
21_M77_I0.8541.00
155_F349_A0.8521.00
340_M358_L0.8511.00
170_R184_I0.8511.00
121_S162_T0.8511.00
20_L49_L0.8501.00
196_D220_K0.8501.00
165_M198_I0.8461.00
192_R196_D0.8461.00
261_N265_E0.8441.00
197_G201_R0.8401.00
131_S373_L0.8351.00
34_Q350_V0.8291.00
57_P60_Y0.8281.00
293_K327_L0.8271.00
84_S91_Y0.8261.00
163_D192_R0.8241.00
285_F376_A0.8241.00
102_G106_I0.8211.00
59_E62_G0.8191.00
364_Y367_A0.8161.00
333_W362_R0.8131.00
265_E268_K0.8091.00
263_A342_V0.8081.00
85_Y91_Y0.8031.00
28_Y41_D0.8031.00
68_R302_N0.8011.00
255_N357_K0.8001.00
285_F289_E0.7961.00
267_A287_I0.7941.00
31_D34_Q0.7901.00
68_R72_L0.7901.00
20_L46_F0.7891.00
118_K164_F0.7871.00
216_I219_L0.7871.00
204_K358_L0.7871.00
314_T320_Y0.7861.00
255_N332_A0.7841.00
331_I335_A0.7841.00
284_Q376_A0.7821.00
30_L356_R0.7821.00
123_A167_L0.7811.00
146_S222_P0.7801.00
14_L18_D0.7801.00
336_G357_K0.7791.00
55_L70_A0.7791.00
147_F226_V0.7791.00
295_V298_S0.7781.00
337_N358_L0.7771.00
187_F221_V0.7761.00
170_R173_P0.7751.00
202_E207_S0.7731.00
16_T19_Q0.7731.00
136_I168_V0.7721.00
185_T231_G0.7711.00
22_D79_L0.7711.00
256_A331_I0.7701.00
263_A343_Y0.7691.00
140_A147_F0.7681.00
46_F51_L0.7641.00
109_Y188_L0.7631.00
20_L24_Y0.7621.00
142_K148_F0.7611.00
166_I186_L0.7611.00
248_I368_P0.7591.00
295_V299_S0.7581.00
255_N361_T0.7571.00
164_F188_L0.7561.00
138_T153_K0.7521.00
207_S360_E0.7501.00
340_M354_I0.7491.00
41_D45_D0.7471.00
142_K145_N0.7461.00
172_T231_G0.7441.00
85_Y89_G0.7441.00
290_V339_A0.7431.00
286_P342_V0.7421.00
40_I163_D0.7411.00
292_A327_L0.7401.00
60_Y103_K0.7391.00
262_K357_K0.7371.00
260_I291_Y0.7361.00
253_I297_L0.7351.00
10_E68_R0.7351.00
22_D80_R0.7331.00
289_E338_V0.7311.00
358_L362_R0.7311.00
259_F339_A0.7291.00
336_G358_L0.7271.00
140_A171_T0.7271.00
196_D201_R0.7261.00
146_S224_D0.7261.00
249_A324_S0.7261.00
266_Y346_Y0.7251.00
72_L76_N0.7231.00
263_A267_A0.7191.00
84_S89_G0.7181.00
122_L237_L0.7161.00
289_E334_E0.7141.00
136_I184_I0.7141.00
126_E138_T0.7131.00
159_L200_M0.7131.00
21_M25_N0.7111.00
300_Y323_I0.7111.00
292_A326_Y0.7111.00
327_L331_I0.7091.00
22_D26_E0.7081.00
123_A214_V0.7061.00
109_Y225_N0.7061.00
226_V229_E0.7061.00
124_L133_T0.7051.00
257_E291_Y0.7051.00
84_S87_V0.7051.00
59_E106_I0.7011.00
163_D191_L0.6991.00
72_L302_N0.6981.00
79_L258_W0.6981.00
206_M367_A0.6971.00
19_Q22_D0.6961.00
200_M214_V0.6961.00
171_T183_G0.6951.00
300_Y324_S0.6931.00
341_D362_R0.6921.00
281_Q285_F0.6891.00
249_A301_F0.6891.00
296_S300_Y0.6881.00
94_T113_L0.6861.00
86_F91_Y0.6841.00
334_E337_N0.6821.00
280_F284_Q0.6801.00
149_I189_V0.6791.00
376_A380_H0.6781.00
252_M329_T0.6781.00
166_I227_I0.6731.00
356_R360_E0.6731.00
54_I65_K0.6731.00
192_R198_I0.6731.00
105_I108_K0.6701.00
374_I377_Y0.6671.00
204_K355_E0.6671.00
277_I280_F0.6621.00
25_N42_F0.6581.00
340_M347_G0.6571.00
249_A328_A0.6541.00
185_T228_G0.6521.00
136_I170_R0.6521.00
170_R183_G0.6511.00
29_W356_R0.6501.00
232_K236_Y0.6491.00
113_L164_F0.6491.00
42_F45_D0.6481.00
160_K210_N0.6481.00
260_I382_I0.6461.00
301_F328_A0.6431.00
203_I211_A0.6421.00
293_K296_S0.6401.00
156_I214_V0.6401.00
14_L75_Y0.6371.00
332_A336_G0.6361.00
145_N224_D0.6351.00
168_V237_L0.6331.00
36_R202_E0.6331.00
205_T348_Y0.6331.00
336_G354_I0.6331.00
83_N208_N0.6321.00
59_E64_G0.6311.00
284_Q379_A0.6311.00
319_S381_H0.6261.00
305_L309_E0.6241.00
56_I60_Y0.6231.00
298_S302_N0.6211.00
270_R273_F0.6201.00
171_T230_V0.6181.00
33_D207_S0.6181.00
191_L195_R0.6161.00
57_P62_G0.6161.00
370_S373_L0.6121.00
207_S350_V0.6091.00
101_S106_I0.6091.00
300_Y327_L0.6091.00
343_Y354_I0.6071.00
143_V223_E0.6051.00
109_Y118_K0.6041.00
144_G148_F0.6031.00
138_T216_I0.6021.00
263_A290_V0.6011.00
13_I73_I0.5951.00
9_E12_L0.5951.00
13_I69_L0.5941.00
18_D79_L0.5941.00
323_I378_I0.5911.00
326_Y378_I0.5901.00
286_P289_E0.5851.00
256_A297_L0.5841.00
246_F305_L0.5831.00
180_K183_G0.5781.00
81_G84_S0.5741.00
283_V287_I0.5741.00
142_K220_K0.5731.00
286_P341_D0.5731.00
82_G255_N0.5731.00
127_P152_H0.5721.00
9_E69_L0.5721.00
139_V173_P0.5721.00
345_G348_Y0.5691.00
40_I161_Y0.5671.00
250_A254_G0.5651.00
293_K330_E0.5651.00
297_L327_L0.5631.00
258_W353_G0.5631.00
78_N85_Y0.5631.00
242_N321_A0.5621.00
273_F280_F0.5611.00
96_L240_L0.5591.00
272_V277_I0.5581.00
42_F84_S0.5571.00
97_L101_S0.5571.00
85_Y88_H0.5561.00
189_V219_L0.5561.00
303_E320_Y0.5531.00
94_T110_F0.5531.00
13_I17_V0.5521.00
96_L100_H0.5521.00
189_V216_I0.5461.00
124_L168_V0.5441.00
36_R207_S0.5441.00
283_V286_P0.5441.00
256_A259_F0.5441.00
253_I257_E0.5441.00
326_Y330_E0.5421.00
139_V172_T0.5421.00
295_V300_Y0.5421.00
195_R201_R0.5411.00
157_S211_A0.5401.00
223_E230_V0.5371.00
258_W261_N0.5351.00
67_V308_I0.5351.00
292_A296_S0.5351.00
333_W361_T0.5351.00
289_E330_E0.5331.00
70_A247_M0.5331.00
18_D80_R0.5301.00
300_Y304_G0.5301.00
167_L219_L0.5291.00
32_K37_E0.5281.00
289_E292_A0.5271.00
297_L324_S0.5261.00
164_F225_N0.5241.00
16_T63_V0.5231.00
257_E294_L0.5231.00
60_Y111_K0.5221.00
98_S106_I0.5221.00
53_S63_V0.5201.00
93_N113_L0.5181.00
198_I201_R0.5181.00
362_R366_V0.5181.00
235_Y239_D0.5171.00
129_V137_K0.5161.00
171_T187_F0.5161.00
36_R350_V0.5161.00
341_D372_N0.5141.00
187_F225_N0.5141.00
40_I119_V0.5131.00
138_T151_G0.5131.00
108_K111_K0.5121.00
138_T167_L0.5121.00
290_V342_V0.5111.00
373_L376_A0.5091.00
71_S302_N0.5081.00
329_T364_Y0.5081.00
291_Y382_I0.5081.00
270_R345_G0.5061.00
60_Y107_E0.5051.00
266_Y269_N0.5051.00
80_R258_W0.5011.00
280_F283_V0.5011.00
53_S114_A0.5011.00
297_L335_A0.5001.00
241_L244_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4l1fA 4 0.964 100 0.121 Contact Map
2jifA 4 0.9666 100 0.123 Contact Map
2d29A 4 0.9769 100 0.125 Contact Map
2vigA 6 0.964 100 0.126 Contact Map
1ivhA 4 0.9717 100 0.13 Contact Map
4p13A 4 0.9794 100 0.134 Contact Map
1bucA 4 0.9614 100 0.136 Contact Map
3pfdA 4 0.9409 100 0.137 Contact Map
1rx0A 4 0.9666 100 0.138 Contact Map
4irnA 4 0.9537 100 0.14 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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