GREMLIN Database
Q97U72 - NADH oxidase, putative
UniProt: Q97U72 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 350 (288)
Sequences: 42171 (29690)
Seq/√Len: 1749.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
128_T205_S4.3511.00
30_E64_K4.0231.00
5_R24_N3.3351.00
126_V149_I3.1141.00
151_N183_I3.0561.00
5_R85_D2.6871.00
192_N197_V2.6171.00
73_K245_F2.6131.00
235_D239_R2.5851.00
6_V22_Y2.5611.00
149_I181_N2.4871.00
190_E197_V2.4791.00
4_E26_I2.4361.00
18_A88_I2.4251.00
28_V82_I2.4221.00
96_D215_S2.3921.00
172_Q176_E2.3631.00
126_V151_N2.3071.00
128_T153_V2.2691.00
70_F243_Y2.2631.00
151_N181_N2.2321.00
86_K245_F2.2081.00
155_A187_K2.1961.00
226_S233_L2.1431.00
183_I202_R2.1291.00
7_V28_V2.0311.00
101_K190_E2.0251.00
84_F87_L2.0221.00
126_V206_D2.0221.00
5_R26_I2.0161.00
7_V84_F2.0131.00
186_A200_Q2.0091.00
157_S185_S2.0021.00
67_K76_I1.9221.00
63_A79_N1.8711.00
94_E217_P1.8701.00
14_A249_A1.8511.00
86_K247_Y1.8471.00
227_N231_R1.8211.00
189_E197_V1.8101.00
247_Y277_N1.7631.00
69_D72_E1.7511.00
74_K83_K1.7081.00
7_V82_I1.6831.00
219_I222_E1.6711.00
105_N193_Q1.6701.00
88_I278_A1.6671.00
86_K278_A1.6651.00
94_E215_S1.6541.00
91_L252_C1.6191.00
187_K199_T1.6111.00
236_R285_E1.6101.00
128_T196_V1.6081.00
7_V26_I1.5721.00
7_V75_V1.5641.00
63_A78_T1.5571.00
153_V203_I1.5481.00
183_I186_A1.5281.00
32_D62_K1.5101.00
111_T114_N1.4651.00
126_V204_R1.4341.00
274_A278_A1.4191.00
125_S206_D1.4191.00
6_V88_I1.4161.00
11_G29_D1.4031.00
158_R168_S1.3971.00
34_M37_T1.3951.00
14_A267_S1.3841.00
19_K27_L1.3841.00
21_V272_E1.3831.00
144_R180_V1.3831.00
132_G154_E1.3821.00
186_A202_R1.3661.00
126_V148_H1.3641.00
226_S241_I1.3621.00
232_M248_G1.3581.00
239_R244_D1.3491.00
189_E199_T1.3481.00
174_V177_N1.3471.00
26_I60_D1.3331.00
9_L65_I1.3271.00
154_E184_L1.3261.00
191_V208_V1.3221.00
127_V148_H1.3221.00
127_V143_L1.3221.00
49_P52_Y1.3101.00
67_K222_E1.3091.00
172_Q184_L1.3041.00
198_T203_I1.3021.00
115_I118_I1.2961.00
4_E86_K1.2841.00
186_A199_T1.2791.00
169_R172_Q1.2721.00
275_M279_I1.2701.00
174_V178_Q1.2601.00
24_N60_D1.2501.00
88_I249_A1.2331.00
233_L241_I1.2321.00
66_L76_I1.2241.00
127_V207_Y1.2171.00
271_G275_M1.2071.00
183_I203_I1.2061.00
8_I19_K1.2021.00
249_A274_A1.2001.00
26_I82_I1.1911.00
151_N205_S1.1771.00
273_V277_N1.1731.00
165_S169_R1.1731.00
77_T82_I1.1691.00
70_F246_V1.1681.00
237_Y277_N1.1661.00
137_V152_L1.1621.00
73_K77_T1.1561.00
9_L91_L1.1541.00
151_N203_I1.1491.00
234_V253_A1.1451.00
50_L54_L1.1431.00
124_G148_H1.1391.00
49_P53_A1.1361.00
144_R149_I1.1331.00
57_R60_D1.1191.00
237_Y285_E1.1171.00
39_R42_E1.1151.00
28_V65_I1.1031.00
93_Y214_F1.1021.00
4_E7_V1.0901.00
113_E116_E1.0861.00
219_I223_M1.0841.00
64_K78_T1.0771.00
69_D76_I1.0771.00
234_V248_G1.0741.00
159_L184_L1.0661.00
107_G193_Q1.0621.00
140_A152_L1.0571.00
170_E174_V1.0561.00
90_A249_A1.0531.00
55_I58_K1.0521.00
121_F148_H1.0501.00
4_E24_N1.0501.00
145_K178_Q1.0491.00
8_I15_G1.0471.00
21_V276_N1.0451.00
158_R165_S1.0401.00
69_D74_K1.0391.00
6_V86_K1.0351.00
87_L246_V1.0311.00
130_L208_V1.0281.00
63_A77_T1.0261.00
238_L253_A1.0251.00
114_N117_K1.0251.00
173_R176_E1.0121.00
5_R83_K1.0031.00
234_V238_L0.9991.00
23_P58_K0.9921.00
227_N233_L0.9911.00
186_A198_T0.9811.00
173_R177_N0.9801.00
119_K122_K0.9791.00
69_D73_K0.9771.00
26_I61_V0.9741.00
9_L89_I0.9701.00
130_L212_A0.9591.00
11_G27_L0.9561.00
18_A249_A0.9461.00
205_S208_V0.9361.00
266_V270_A0.9321.00
88_I274_A0.9291.00
70_F73_K0.9281.00
116_E119_K0.9271.00
22_Y275_M0.9211.00
99_K103_A0.9211.00
229_N254_N0.9191.00
4_E60_D0.9171.00
48_L53_A0.9161.00
247_Y278_A0.9161.00
17_A271_G0.9161.00
141_G145_K0.9131.00
227_N254_N0.9121.00
41_V44_I0.9091.00
50_L53_A0.9061.00
65_I75_V0.9041.00
243_Y246_V0.8991.00
130_L210_F0.8991.00
46_K53_A0.8981.00
89_I246_V0.8951.00
158_R172_Q0.8881.00
170_E173_R0.8881.00
45_E48_L0.8851.00
247_Y274_A0.8841.00
122_K146_R0.8811.00
248_G252_C0.8741.00
153_V183_I0.8721.00
144_R178_Q0.8701.00
239_R277_N0.8681.00
129_I140_A0.8681.00
106_Y193_Q0.8681.00
21_V275_M0.8671.00
45_E49_P0.8671.00
192_N195_E0.8671.00
163_L293_I0.8661.00
238_L274_A0.8591.00
77_T80_G0.8571.00
22_Y25_A0.8531.00
28_V77_T0.8451.00
40_L43_V0.8451.00
48_L52_Y0.8441.00
169_R173_R0.8441.00
272_E276_N0.8371.00
63_A66_L0.8341.00
18_A271_G0.8301.00
100_I103_A0.8301.00
68_V87_L0.8291.00
137_V297_I0.8291.00
67_K73_K0.8281.00
240_S248_G0.8261.00
17_A268_L0.8201.00
19_K25_A0.8151.00
48_L51_S0.8141.00
18_A275_M0.8111.00
274_A277_N0.8091.00
89_I252_C0.8071.00
172_Q182_V0.8071.00
239_R247_Y0.8031.00
66_L78_T0.8001.00
248_G253_A0.7991.00
194_N204_R0.7981.00
55_I60_D0.7961.00
153_V198_T0.7961.00
113_E117_K0.7961.00
112_L116_E0.7951.00
46_K49_P0.7921.00
228_K233_L0.7861.00
31_K40_L0.7851.00
17_A21_V0.7841.00
168_S172_Q0.7831.00
154_E161_P0.7791.00
239_R245_F0.7781.00
76_I81_E0.7701.00
103_A210_F0.7671.00
105_N108_I0.7661.00
269_Q272_E0.7651.00
47_N50_L0.7581.00
74_K77_T0.7551.00
98_S210_F0.7541.00
114_N118_I0.7531.00
240_S243_Y0.7511.00
102_G190_E0.7501.00
218_K221_K0.7501.00
158_R169_R0.7491.00
18_A274_A0.7481.00
95_Q98_S0.7481.00
156_E161_P0.7461.00
238_L273_V0.7431.00
144_R179_G0.7421.00
15_G19_K0.7361.00
249_A271_G0.7351.00
5_R82_I0.7331.00
129_I136_G0.7321.00
102_G105_N0.7321.00
40_L44_I0.7291.00
147_G150_V0.7271.00
239_R243_Y0.7261.00
267_S271_G0.7231.00
63_A67_K0.7201.00
128_T203_I0.7191.00
63_A81_E0.7181.00
49_P54_L0.7181.00
77_T81_E0.7171.00
8_I18_A0.7171.00
6_V278_A0.7161.00
232_M252_C0.7151.00
15_G90_A0.7141.00
34_M38_P0.7101.00
112_L115_I0.7061.00
265_Q269_Q0.7051.00
42_E45_E0.7041.00
128_T208_V0.7011.00
67_K70_F0.6971.00
145_K298_G0.6951.00
17_A20_L0.6931.00
231_R262_Q0.6911.00
130_L188_V0.6901.00
136_G154_E0.6901.00
139_L142_A0.6841.00
220_I223_M0.6831.00
113_E118_I0.6821.00
97_L210_F0.6811.00
84_F245_F0.6791.00
96_D99_K0.6781.00
263_S266_V0.6771.00
167_F170_E0.6761.00
153_V186_A0.6751.00
261_P266_V0.6751.00
142_A145_K0.6721.00
132_G159_L0.6721.00
7_V87_L0.6641.00
22_Y278_A0.6631.00
183_I198_T0.6621.00
235_D238_L0.6551.00
276_N281_D0.6531.00
277_N283_K0.6521.00
126_V205_S0.6491.00
198_T202_R0.6461.00
111_T115_I0.6451.00
20_L57_R0.6441.00
28_V63_A0.6421.00
181_N203_I0.6411.00
159_L172_Q0.6401.00
237_Y283_K0.6391.00
30_E217_P0.6371.00
128_T151_N0.6311.00
19_K59_V0.6291.00
139_L209_I0.6281.00
152_L182_V0.6271.00
157_S165_S0.6271.00
295_L298_G0.6251.00
198_T201_G0.6241.00
39_R43_V0.6221.00
135_L211_S0.6201.00
17_A272_E0.6181.00
67_K71_K0.6171.00
255_F261_P0.6161.00
48_L54_L0.6161.00
74_K81_E0.6161.00
175_L182_V0.6131.00
118_I207_Y0.6121.00
237_Y282_E0.6121.00
67_K87_L0.6101.00
115_I119_K0.6091.00
141_G144_R0.6091.00
110_F210_F0.6081.00
140_A180_V0.6071.00
121_F143_L0.6041.00
119_K207_Y0.6021.00
61_V65_I0.6021.00
260_I266_V0.6011.00
191_V196_V0.5991.00
264_A267_S0.5991.00
24_N85_D0.5981.00
42_E47_N0.5961.00
91_L219_I0.5931.00
101_K105_N0.5931.00
268_L272_E0.5901.00
230_N254_N0.5881.00
56_H59_V0.5881.00
71_K74_K0.5871.00
293_I298_G0.5871.00
137_V175_L0.5851.00
116_E120_S0.5851.00
115_I143_L0.5851.00
119_K146_R0.5821.00
8_I90_A0.5821.00
292_A295_L0.5821.00
14_A90_A0.5791.00
38_P41_V0.5791.00
104_E108_I0.5791.00
188_V196_V0.5781.00
181_N184_L0.5771.00
140_A150_V0.5771.00
18_A22_Y0.5751.00
185_S199_T0.5751.00
51_S54_L0.5731.00
120_S207_Y0.5711.00
223_M243_Y0.5711.00
97_L104_E0.5701.00
129_I209_I0.5701.00
40_L113_E0.5691.00
204_R207_Y0.5671.00
269_Q273_V0.5671.00
89_I248_G0.5661.00
41_V45_E0.5661.00
112_L118_I0.5651.00
96_D212_A0.5641.00
13_F264_A0.5631.00
139_L143_L0.5611.00
65_I68_V0.5611.00
166_D169_R0.5571.00
125_S149_I0.5561.00
13_F17_A0.5551.00
227_N230_N0.5541.00
232_M236_R0.5541.00
7_V73_K0.5521.00
158_R161_P0.5491.00
65_I69_D0.5481.00
142_A146_R0.5471.00
286_F289_V0.5471.00
22_Y279_I0.5471.00
94_E218_K0.5471.00
24_N58_K0.5461.00
125_S207_Y0.5451.00
290_Q296_K0.5451.00
287_K290_Q0.5441.00
125_S148_H0.5421.00
8_I27_L0.5411.00
291_R294_V0.5391.00
39_R44_I0.5381.00
253_A270_A0.5381.00
136_G211_S0.5371.00
138_E141_G0.5311.00
46_K54_L0.5301.00
89_I219_I0.5271.00
103_A107_G0.5231.00
106_Y109_G0.5221.00
216_G231_R0.5211.00
291_R295_L0.5211.00
225_L243_Y0.5211.00
71_K243_Y0.5201.00
127_V209_I0.5191.00
181_N202_R0.5191.00
273_V286_F0.5181.00
154_E159_L0.5181.00
124_G206_D0.5171.00
97_L103_A0.5151.00
56_H60_D0.5151.00
171_V297_I0.5151.00
165_S168_S0.5141.00
13_F268_L0.5131.00
103_A191_V0.5111.00
117_K120_S0.5111.00
55_I59_V0.5101.00
288_P292_A0.5101.00
6_V18_A0.5101.00
46_K51_S0.5091.00
23_P59_V0.5091.00
292_A296_K0.5071.00
233_L254_N0.5071.00
234_V237_Y0.5071.00
66_L69_D0.5071.00
4_E85_D0.5061.00
273_V285_E0.5061.00
218_K222_E0.5061.00
6_V275_M0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4g6hA 2 0.9914 100 0.317 Contact Map
4nwzA 2 0.9657 100 0.368 Contact Map
3iwaA 2 0.88 100 0.38 Contact Map
1lvlA 2 0.96 100 0.381 Contact Map
1ojtA 2 0.9686 100 0.381 Contact Map
3l8kA 3 0.9543 100 0.383 Contact Map
2a8xA 2 0.9686 100 0.383 Contact Map
3dk9A 2 0.9657 100 0.384 Contact Map
3cgbA 2 0.9829 100 0.387 Contact Map
2hqmA 2 0.9629 100 0.387 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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