GREMLIN Database
Q97U68 - Second ORF in transposon ISC1904
UniProt: Q97U68 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 423 (342)
Sequences: 4370 (2796)
Seq/√Len: 151.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
263_D267_K5.4071.00
287_S290_S4.4041.00
339_P366_N4.1871.00
319_A326_V3.7181.00
205_L311_I3.0681.00
312_H328_E2.9761.00
283_V315_L2.9191.00
19_F321_L2.8511.00
270_N274_D2.7441.00
310_S314_V2.7311.00
316_K328_E2.4771.00
333_F336_R2.4541.00
337_S344_V2.4301.00
172_P181_L2.4001.00
329_V371_I2.3851.00
310_S313_R2.3831.00
273_L319_A2.3761.00
311_I315_L2.3121.00
225_K301_R2.2471.00
292_F304_S2.2301.00
281_F319_A2.1711.00
353_E360_K2.1181.00
283_V326_V2.1001.00
170_G186_K2.0961.00
224_L260_R2.0641.00
266_R314_V2.0591.00
334_T371_I2.0561.00
54_K119_K2.0551.00
231_K246_G2.0471.00
51_S55_I2.0281.00
266_R317_Y2.0091.00
28_R31_S1.9651.00
269_V314_V1.9481.00
49_L96_I1.9371.00
297_G300_S1.9271.00
36_K179_V1.9211.00
205_L264_F1.9141.00
341_C357_C1.8961.00
262_L310_S1.8781.00
37_E86_H1.8601.00
246_G250_L1.8521.00
265_V314_V1.8201.00
350_K363_R1.8121.00
340_R359_F1.7961.00
241_K244_K1.7741.00
352_F361_L1.7621.00
266_R318_K1.7581.00
338_C341_C1.7571.00
316_K320_P1.7511.00
50_W99_A1.7501.00
341_C354_C1.7411.00
338_C357_C1.7241.00
354_C357_C1.7081.00
265_V310_S1.6731.00
244_K247_R1.6711.00
266_R269_V1.6671.00
283_V328_E1.6581.00
338_C354_C1.6181.00
67_L71_K1.6171.00
283_V312_H1.6021.00
231_K234_K1.5991.00
35_I179_V1.5831.00
44_K83_K1.5691.00
198_I206_D1.5681.00
33_E37_E1.5471.00
195_F372_Y1.5411.00
20_T182_P1.5211.00
207_A365_L1.5171.00
68_P71_K1.5141.00
285_K328_E1.5091.00
351_T360_K1.5081.00
343_F355_E1.5031.00
346_R349_G1.4501.00
347_K350_K1.4491.00
277_P324_S1.4421.00
32_K36_K1.4341.00
49_L99_A1.4291.00
100_F104_K1.4281.00
352_F359_F1.4111.00
369_L373_L1.4021.00
255_H259_N1.4021.00
65_I70_K1.3941.00
269_V318_K1.3731.00
39_G179_V1.3681.00
68_P72_E1.3641.00
105_S117_I1.3571.00
316_K326_V1.3551.00
204_T207_A1.3541.00
235_V247_R1.3421.00
269_V317_Y1.3401.00
231_K253_Y1.3401.00
141_V145_V1.3351.00
284_E331_P1.3251.00
216_I219_K1.3201.00
178_K255_H1.3151.00
294_D300_S1.3101.00
103_L119_K1.2981.00
69_K72_E1.2871.00
104_K108_K1.2811.00
196_L208_Y1.2791.00
208_Y212_K1.2611.00
303_I308_W1.2591.00
75_K78_R1.2511.00
90_H130_K1.2451.00
195_F280_F1.2391.00
176_E255_H1.2321.00
228_M254_S1.2271.00
273_L322_Y1.2231.00
98_D128_R1.2201.00
365_L369_L1.2181.00
55_I59_K1.2151.00
144_T150_Y1.2151.00
109_R117_I1.2141.00
329_V374_K1.1991.00
287_S331_P1.1991.00
29_E32_K1.1941.00
269_V311_I1.1741.00
101_S105_S1.1671.00
109_R118_E1.1661.00
110_A117_I1.1651.00
54_K58_R1.1611.00
339_P369_L1.1601.00
66_T69_K1.1601.00
90_H132_T1.1581.00
271_A275_L1.1571.00
42_L95_A1.1411.00
224_L257_E1.1341.00
196_L276_Y1.1331.00
232_R236_Q1.1301.00
142_R150_Y1.1261.00
197_A372_Y1.1150.99
339_P361_L1.1130.99
198_I208_Y1.1120.99
94_K97_N1.1090.99
228_M250_L1.1070.99
200_S308_W1.1060.99
361_L369_L1.1040.99
337_S374_K1.1020.99
262_L314_V1.1010.99
258_R262_L1.1000.99
314_V317_Y1.0950.99
334_T374_K1.0930.99
78_R92_V1.0930.99
200_S312_H1.0920.99
274_D322_Y1.0890.99
127_V131_T1.0830.99
143_I181_L1.0770.99
347_K363_R1.0710.99
265_V311_I1.0700.99
269_V315_L1.0690.99
202_L306_T1.0670.99
52_L73_V1.0610.99
105_S110_A1.0520.99
345_S349_G1.0520.99
143_I172_P1.0470.99
232_R250_L1.0460.99
138_G141_V1.0350.99
46_I95_A1.0340.99
318_K321_L1.0330.99
227_S231_K1.0330.99
265_V269_V1.0310.99
213_F362_D1.0300.99
66_T70_K1.0270.99
273_L281_F1.0260.99
270_N322_Y1.0240.99
336_R346_R1.0190.99
56_Q60_N1.0140.99
133_L146_R1.0130.99
21_Y185_Y1.0130.99
285_K331_P1.0110.99
60_N63_Y1.0090.99
88_A91_Y1.0090.99
282_A371_I1.0040.99
336_R345_S1.0000.99
27_K31_S0.9990.99
239_A243_T0.9990.99
57_V61_G0.9970.99
235_V250_L0.9900.99
280_F325_F0.9880.99
127_V130_K0.9830.99
273_L324_S0.9830.99
94_K128_R0.9810.99
336_R344_V0.9770.99
374_K379_P0.9760.99
50_W103_L0.9720.99
272_L281_F0.9680.98
294_D297_G0.9680.98
243_T247_R0.9660.98
361_L365_L0.9660.98
313_R316_K0.9640.98
54_K103_L0.9640.98
349_G363_R0.9590.98
231_K250_L0.9590.98
288_K309_G0.9560.98
175_K178_K0.9550.98
65_I69_K0.9500.98
343_F356_R0.9490.98
135_K138_G0.9490.98
294_D298_S0.9460.98
333_F374_K0.9460.98
105_S109_R0.9430.98
40_T43_Q0.9410.98
220_Q260_R0.9370.98
350_K362_D0.9370.98
207_A213_F0.9320.98
231_K249_L0.9310.98
46_I102_I0.9310.98
133_L136_V0.9290.98
70_K74_Y0.9290.98
67_L97_N0.9280.98
32_K179_V0.9240.98
44_K48_Y0.9210.98
206_D268_F0.9200.98
228_M257_E0.9170.98
72_E75_K0.9160.98
195_F282_A0.9150.98
340_R369_L0.9140.98
365_L368_S0.9140.98
339_P359_F0.9080.98
46_I99_A0.9060.98
228_M236_Q0.9050.98
192_P277_P0.9050.98
24_K178_K0.9040.98
106_W120_P0.8990.98
280_F327_K0.8970.98
345_S352_F0.8860.97
232_R254_S0.8820.97
204_T215_T0.8810.97
249_L252_K0.8780.97
339_P373_L0.8780.97
90_H94_K0.8770.97
339_P367_A0.8740.97
331_P334_T0.8690.97
196_L209_D0.8670.97
53_T70_K0.8630.97
135_K144_T0.8620.97
90_H131_T0.8590.97
98_D173_I0.8590.97
71_K75_K0.8580.97
253_Y257_E0.8560.97
65_I74_Y0.8560.97
319_A324_S0.8560.97
70_K73_V0.8540.97
105_S108_K0.8500.97
369_L372_Y0.8490.97
265_V307_V0.8490.97
106_W119_K0.8480.97
351_T361_L0.8450.96
18_Y184_R0.8430.96
220_Q224_L0.8410.96
93_D97_N0.8390.96
174_I181_L0.8360.96
235_V246_G0.8360.96
200_S206_D0.8360.96
229_E233_A0.8290.96
128_R171_E0.8280.96
229_E232_R0.8270.96
202_L302_K0.8270.96
367_A370_N0.8250.96
74_Y77_L0.8240.96
74_Y78_R0.8230.96
290_S331_P0.8210.96
53_T100_F0.8170.96
366_N370_N0.8130.96
74_Y96_I0.8120.96
94_K130_K0.8090.95
214_I264_F0.8090.95
264_F268_F0.8020.95
18_Y186_K0.7990.95
290_S303_I0.7980.95
247_R251_R0.7970.95
337_S370_N0.7970.95
52_L56_Q0.7970.95
285_K312_H0.7970.95
27_K35_I0.7960.95
48_Y52_L0.7960.95
212_K271_A0.7960.95
35_I39_G0.7910.95
268_F271_A0.7900.95
292_F300_S0.7870.95
141_V144_T0.7870.95
173_I182_P0.7850.95
94_K98_D0.7820.95
288_K308_W0.7810.95
69_K74_Y0.7760.94
256_R260_R0.7750.94
23_I157_N0.7710.94
235_V243_T0.7700.94
74_Y93_D0.7680.94
352_F363_R0.7670.94
64_K69_K0.7660.94
57_V103_L0.7660.94
41_L83_K0.7640.94
84_I92_V0.7630.94
196_L281_F0.7570.94
194_N210_G0.7570.94
346_R363_R0.7560.94
53_T103_L0.7540.93
45_A95_A0.7540.93
38_Y42_L0.7530.93
343_F352_F0.7500.93
272_L276_Y0.7470.93
228_M232_R0.7460.93
23_I181_L0.7440.93
270_N318_K0.7430.93
230_V234_K0.7430.93
132_T135_K0.7420.93
153_F156_S0.7380.93
41_L87_L0.7330.92
333_F337_S0.7320.92
204_T213_F0.7310.92
87_L90_H0.7310.92
282_A374_K0.7300.92
191_T194_N0.7300.92
349_G352_F0.7290.92
25_N181_L0.7290.92
234_K237_S0.7250.92
213_F365_L0.7230.92
309_G313_R0.7220.92
257_E305_R0.7210.92
51_S122_V0.7210.92
71_K96_I0.7200.92
282_A372_Y0.7190.92
201_N207_A0.7150.91
44_K81_L0.7130.91
203_Y207_A0.7130.91
40_T44_K0.7100.91
199_D364_Q0.7090.91
34_L38_Y0.7080.91
128_R173_I0.7070.91
24_K180_Y0.7070.91
229_E236_Q0.7050.91
236_Q250_L0.7040.91
96_I100_F0.7020.91
299_L303_I0.7000.91
206_D311_I0.7000.91
23_I163_R0.7000.91
134_R169_L0.6990.91
65_I73_V0.6980.90
29_E33_E0.6970.90
90_H93_D0.6960.90
23_I164_V0.6960.90
171_E184_R0.6950.90
67_L96_I0.6940.90
189_W192_P0.6910.90
242_H245_R0.6880.90
286_L331_P0.6880.90
91_Y127_V0.6880.90
103_L107_R0.6860.90
90_H133_L0.6830.90
233_A236_Q0.6810.89
234_K246_G0.6810.89
333_F344_V0.6790.89
282_A327_K0.6780.89
224_L256_R0.6780.89
221_L224_L0.6770.89
281_F315_L0.6730.89
231_K235_V0.6720.89
243_T250_L0.6710.89
69_K73_V0.6690.89
63_Y69_K0.6680.88
145_V174_I0.6680.88
346_R350_K0.6660.88
205_L306_T0.6650.88
67_L70_K0.6650.88
30_K33_E0.6630.88
371_I374_K0.6610.88
216_I306_T0.6600.88
65_I68_P0.6590.88
41_L44_K0.6580.88
75_K79_E0.6550.88
224_L228_M0.6550.88
262_L266_R0.6540.87
274_D280_F0.6530.87
38_Y87_L0.6530.87
102_I120_P0.6510.87
89_S130_K0.6490.87
294_D303_I0.6480.87
56_Q61_G0.6470.87
103_L106_W0.6470.87
37_E41_L0.6440.87
20_T184_R0.6430.87
76_P80_E0.6430.87
178_K259_N0.6420.86
52_L55_I0.6410.86
261_V305_R0.6410.86
205_L269_V0.6390.86
312_H316_K0.6350.86
92_V95_A0.6340.86
95_A99_A0.6320.86
189_W324_S0.6290.85
106_W109_R0.6270.85
130_K133_L0.6270.85
355_E363_R0.6270.85
234_K249_L0.6210.85
168_E186_K0.6210.85
61_G64_K0.6190.84
332_H336_R0.6190.84
99_A103_L0.6180.84
297_G304_S0.6180.84
148_Y151_I0.6160.84
48_Y77_L0.6160.84
38_Y88_A0.6130.84
137_V140_S0.6130.84
22_S182_P0.6130.84
244_K248_E0.6130.84
73_V77_L0.6120.84
67_L72_E0.6120.84
240_S243_T0.6110.84
233_A237_S0.6100.84
142_R145_V0.6100.84
129_I145_V0.6090.83
224_L253_Y0.6090.83
52_L77_L0.6080.83
73_V76_P0.6070.83
340_R361_L0.6050.83
129_I132_T0.6030.83
317_Y321_L0.6030.83
349_G355_E0.6030.83
39_G127_V0.5990.82
288_K291_M0.5960.82
254_S261_V0.5930.82
254_S258_R0.5930.82
128_R131_T0.5920.82
319_A322_Y0.5920.82
38_Y129_I0.5910.82
27_K32_K0.5870.81
203_Y350_K0.5850.81
229_E237_S0.5850.81
42_L127_V0.5850.81
346_R362_D0.5820.81
27_K151_I0.5800.80
257_E261_V0.5790.80
205_L265_V0.5790.80
337_S342_G0.5790.80
60_N64_K0.5780.80
374_K377_G0.5780.80
21_Y157_N0.5770.80
180_Y255_H0.5770.80
315_L326_V0.5770.80
208_Y214_I0.5750.80
361_L366_N0.5740.80
333_F352_F0.5710.79
347_K362_D0.5690.79
87_L92_V0.5690.79
314_V318_K0.5680.79
276_Y281_F0.5680.79
202_L293_K0.5680.79
243_T246_G0.5650.79
68_P74_Y0.5640.79
222_Y302_K0.5630.78
194_N276_Y0.5630.78
337_S352_F0.5630.78
268_F311_I0.5590.78
288_K303_I0.5590.78
145_V148_Y0.5580.78
330_N333_F0.5580.78
22_S262_L0.5550.77
51_S54_K0.5550.77
221_L225_K0.5530.77
273_L326_V0.5530.77
96_I99_A0.5510.77
199_D335_S0.5500.77
134_R138_G0.5500.77
345_S350_K0.5500.77
214_I271_A0.5490.77
175_K255_H0.5470.76
225_K229_E0.5470.76
63_Y73_V0.5460.76
259_N262_L0.5440.76
309_G312_H0.5440.76
209_D365_L0.5430.76
34_L37_E0.5410.76
307_V310_S0.5410.76
53_T56_Q0.5400.76
334_T337_S0.5360.75
155_W163_R0.5350.75
134_R172_P0.5340.75
270_N273_L0.5330.75
153_F157_N0.5330.75
259_N263_D0.5330.75
48_Y83_K0.5330.75
57_V106_W0.5290.74
222_Y301_R0.5290.74
18_Y170_G0.5280.74
265_V268_F0.5270.74
202_L292_F0.5260.74
289_E309_G0.5260.74
129_I134_R0.5260.74
127_V134_R0.5260.74
26_D154_S0.5260.74
64_K70_K0.5230.73
91_Y129_I0.5180.73
292_F297_G0.5150.72
229_E297_G0.5150.72
290_S293_K0.5140.72
137_V142_R0.5130.72
353_E359_F0.5120.72
70_K77_L0.5110.72
89_S133_L0.5110.72
163_R166_E0.5090.71
203_Y347_K0.5090.71
127_V133_L0.5080.71
67_L74_Y0.5080.71
300_S304_S0.5070.71
347_K351_T0.5070.71
299_L302_K0.5070.71
362_D367_A0.5050.71
64_K71_K0.5050.71
25_N153_F0.5030.70
206_D214_I0.5020.70
170_G184_R0.5020.70
270_N314_V0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nu0A 1 0.3073 94.6 0.935 Contact Map
1vhxA 2 0.3239 93.5 0.938 Contact Map
1iv0A 1 0.2293 91.6 0.942 Contact Map
2k4xA 1 0.1253 85.3 0.948 Contact Map
1qypA 1 0.1017 84.5 0.948 Contact Map
3j20Y 1 0.1135 82.8 0.95 Contact Map
4aybP 1 0.0946 81 0.95 Contact Map
1ffkW 1 0.156 77.6 0.952 Contact Map
3j3w0 1 0.13 71.1 0.954 Contact Map
1vd4A 1 0.1253 67.2 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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