GREMLIN Database
Q97U67 - First ORF in transposon ISC1904
UniProt: Q97U67 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 192 (182)
Sequences: 481 (333)
Seq/√Len: 24.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
56_V117_R4.3151.00
60_A78_L4.0361.00
82_V119_V3.5501.00
117_R144_E3.5131.00
7_A11_L2.7960.99
58_L148_L2.6550.99
103_F126_L2.6220.99
110_I138_C2.5980.99
13_I21_Y2.4570.99
17_T21_Y2.4570.99
91_D102_G2.4250.98
5_K9_Q2.2740.98
135_E139_K2.2550.97
16_A19_R2.1930.97
2_L7_A2.1800.97
106_L115_V2.1480.96
75_V88_V2.0370.95
22_V37_W1.9340.94
111_L141_H1.8970.93
18_L39_F1.8850.93
98_M132_E1.8740.93
77_Y121_A1.8630.92
96_L129_F1.8460.92
58_L78_L1.8250.92
131_F145_I1.8210.91
55_K109_M1.7630.90
119_V132_E1.7380.89
75_V90_T1.7040.88
110_I118_V1.6900.88
131_F147_V1.6830.88
110_I115_V1.6780.88
138_C143_C1.6650.87
3_R34_S1.6600.87
89_I102_G1.5690.84
22_V29_P1.5620.84
127_V131_F1.5600.83
4_P19_R1.5580.83
58_L88_V1.5360.82
85_Y146_V1.5330.82
109_M114_E1.5000.81
72_V76_K1.4770.80
98_M167_S1.4650.79
166_V177_S1.4490.79
70_D73_N1.4030.76
16_A24_K1.4020.76
155_E159_E1.3990.76
26_Y33_Q1.3920.76
56_V144_E1.3810.75
7_A44_I1.3730.75
12_G142_G1.3730.75
40_R43_D1.3600.74
17_T20_E1.3500.73
31_I37_W1.3060.71
27_I30_V1.3040.71
167_S170_G1.3030.71
96_L130_G1.3010.70
119_V146_V1.2700.69
4_P18_L1.2400.67
138_C172_L1.2360.66
7_A27_I1.2130.65
8_C13_I1.2090.65
89_I118_V1.2080.65
20_E23_K1.2060.65
166_V170_G1.2010.64
14_S20_E1.1950.64
121_A178_H1.1910.64
170_G175_M1.1860.63
15_Y19_R1.1830.63
22_V27_I1.1740.62
62_V67_Q1.1700.62
110_I120_V1.1660.62
8_C15_Y1.1660.62
131_F134_L1.1540.61
91_D167_S1.1520.61
57_I75_V1.1460.60
43_D46_R1.1260.59
122_Y159_E1.1200.59
64_S67_Q1.1000.57
62_V71_L1.0830.56
22_V39_F1.0780.56
67_Q70_D1.0740.55
78_L148_L1.0720.55
58_L82_V1.0620.55
28_K43_D1.0420.53
68_K179_K1.0360.53
173_Y176_R1.0320.52
159_E170_G1.0220.52
57_I89_I1.0210.52
76_K79_E1.0200.52
170_G177_S1.0170.51
164_I174_G1.0040.50
3_R38_R1.0030.50
82_V85_Y0.9950.50
89_I106_L0.9930.50
26_Y34_S0.9760.48
56_V119_V0.9760.48
91_D121_A0.9760.48
27_I134_L0.9740.48
72_V75_V0.9720.48
2_L38_R0.9680.48
95_G126_L0.9640.48
117_R146_V0.9630.47
11_L18_L0.9580.47
4_P29_P0.9550.47
98_M127_V0.9510.47
8_C18_L0.9360.45
56_V93_G0.9310.45
127_V134_L0.9290.45
81_Q146_V0.9150.44
75_V107_L0.9110.44
54_R142_G0.9090.44
161_L165_L0.9080.44
158_V161_L0.8910.42
39_F43_D0.8820.42
171_K175_M0.8790.41
77_Y149_N0.8790.41
3_R33_Q0.8750.41
18_L22_V0.8670.41
13_I20_E0.8630.40
4_P15_Y0.8610.40
22_V31_I0.8590.40
148_L154_E0.8590.40
134_L138_C0.8570.40
156_E168_F0.8540.40
157_L166_V0.8510.40
14_S172_L0.8500.39
129_F160_D0.8440.39
51_I134_L0.8400.39
5_K34_S0.8390.39
19_R39_F0.8380.39
78_L143_C0.8310.38
19_R22_V0.8290.38
7_A18_L0.8270.38
155_E158_V0.8260.38
8_C171_K0.8230.38
166_V178_H0.8200.37
48_M108_R0.8150.37
108_R140_A0.8140.37
138_C169_S0.8120.37
161_L174_G0.8090.37
7_A38_R0.8060.36
79_E88_V0.7960.36
110_I143_C0.7900.35
157_L160_D0.7890.35
63_S67_Q0.7860.35
95_G103_F0.7770.35
42_E73_N0.7640.34
50_I114_E0.7540.33
4_P7_A0.7460.33
161_L164_I0.7450.33
2_L11_L0.7340.32
30_V38_R0.7310.32
73_N162_V0.7270.31
50_I116_S0.7260.31
6_E43_D0.7250.31
93_G163_S0.7230.31
97_N128_R0.7170.31
118_V145_I0.7120.30
97_N141_H0.7090.30
84_E119_V0.7070.30
100_R127_V0.6980.30
19_R36_K0.6980.30
63_S128_R0.6920.29
160_D174_G0.6830.29
81_Q85_Y0.6800.29
33_Q113_N0.6790.28
55_K116_S0.6740.28
121_A166_V0.6710.28
19_R31_I0.6710.28
130_G146_V0.6700.28
160_D164_I0.6700.28
64_S73_N0.6690.28
137_T140_A0.6690.28
13_I16_A0.6680.28
91_D145_I0.6680.28
56_V116_S0.6670.28
57_I106_L0.6650.28
135_E152_D0.6640.28
57_I115_V0.6640.28
153_K175_M0.6620.27
81_Q149_N0.6590.27
87_L100_R0.6560.27
86_D119_V0.6560.27
9_Q68_K0.6550.27
19_R37_W0.6490.27
119_V134_L0.6470.27
107_L146_V0.6470.27
70_D121_A0.6460.27
103_F127_V0.6450.27
73_N76_K0.6420.26
67_Q73_N0.6410.26
31_I36_K0.6400.26
64_S174_G0.6400.26
178_H182_K0.6340.26
6_E146_V0.6320.26
54_R112_N0.6300.26
119_V136_E0.6300.26
147_V165_L0.6240.25
54_R143_C0.6220.25
45_E48_M0.6200.25
14_S22_V0.6200.25
103_F167_S0.6200.25
76_K80_E0.6190.25
139_K171_K0.6180.25
157_L168_F0.6170.25
93_G97_N0.6160.25
134_L157_L0.6160.25
9_Q57_I0.6050.24
12_G129_F0.6030.24
129_F164_I0.6030.24
4_P8_C0.5970.24
35_G90_T0.5890.24
107_L118_V0.5860.23
135_E145_I0.5860.23
15_Y37_W0.5850.23
129_F174_G0.5840.23
23_K101_K0.5820.23
52_R65_S0.5800.23
77_Y91_D0.5800.23
92_I100_R0.5790.23
6_E157_L0.5790.23
20_E29_P0.5770.23
53_K57_I0.5770.23
103_F116_S0.5700.23
77_Y178_H0.5660.22
32_L41_E0.5660.22
175_M182_K0.5650.22
120_V147_V0.5650.22
107_L111_L0.5640.22
127_V163_S0.5590.22
8_C12_G0.5580.22
110_I145_I0.5570.22
69_D164_I0.5560.22
90_T137_T0.5550.22
66_T121_A0.5550.22
44_I118_V0.5510.22
92_I101_K0.5510.22
32_L36_K0.5500.22
161_L168_F0.5480.21
177_S180_Y0.5480.21
77_Y163_S0.5470.21
130_G169_S0.5470.21
91_D98_M0.5460.21
10_R90_T0.5440.21
93_G144_E0.5440.21
170_G178_H0.5420.21
81_Q148_L0.5350.21
52_R179_K0.5340.21
22_V32_L0.5330.21
48_M114_E0.5320.21
34_S113_N0.5320.21
96_L156_E0.5320.21
92_I145_I0.5310.21
2_L22_V0.5310.21
96_L133_I0.5300.21
165_L169_S0.5260.20
97_N106_L0.5250.20
149_N153_K0.5230.20
169_S175_M0.5220.20
63_S129_F0.5210.20
8_C103_F0.5210.20
30_V43_D0.5190.20
44_I48_M0.5180.20
27_I43_D0.5150.20
115_V143_C0.5120.20
111_L137_T0.5120.20
99_K171_K0.5120.20
16_A26_Y0.5060.19
99_K141_H0.5050.19
98_M118_V0.5040.19
65_S113_N0.5010.19
120_V160_D0.5010.19
67_Q101_K0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ilxA 2 0.7188 100 0.65 Contact Map
3lhkA 2 0.7292 99.9 0.658 Contact Map
3g13A 2 0.7292 99.8 0.737 Contact Map
3bvpA 4 0.625 99.8 0.745 Contact Map
4bqqA 2 0.6979 99.8 0.747 Contact Map
3guvA 2 0.6875 99.8 0.748 Contact Map
2mhcA 1 0.5625 99.8 0.749 Contact Map
2gm5A 4 0.6146 99.7 0.757 Contact Map
1gdtA 2 0.6875 99.7 0.763 Contact Map
3pkzA 4 0.5833 99.7 0.764 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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