GREMLIN Database
Q97U66 - Tryptophan repressor binding protein (WrbA)
UniProt: Q97U66 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 197 (187)
Sequences: 2802 (1605)
Seq/√Len: 117.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
186_K190_E3.1831.00
76_V188_V2.9101.00
29_E186_K2.8921.00
112_G184_L2.6941.00
19_L181_A2.6301.00
126_S129_L2.4681.00
11_Y87_T2.4331.00
24_A28_K2.3891.00
175_E179_N2.1411.00
25_E182_K2.1091.00
27_A34_V2.0891.00
5_K33_E2.0801.00
17_V21_K2.0781.00
79_S87_T2.0111.00
97_T138_H2.0101.00
185_G189_A1.9741.00
110_P195_L1.9701.00
76_V112_G1.9301.00
115_T165_S1.9171.00
112_G188_V1.9111.00
29_E182_K1.8841.00
111_V135_A1.8371.00
107_Y148_G1.7971.00
6_I74_G1.7791.00
22_N182_K1.7771.00
113_F131_M1.7531.00
100_L105_S1.7461.00
91_K134_Y1.7291.00
22_N25_E1.7271.00
35_K68_D1.7171.00
67_S70_E1.7131.00
70_E100_L1.6771.00
160_S165_S1.6611.00
91_K95_D1.6461.00
143_V191_V1.6401.00
145_V180_I1.6251.00
26_G185_G1.6181.00
42_Y92_L1.6071.00
22_N178_I1.5911.00
70_E105_S1.5901.00
164_A184_L1.5621.00
136_Y144_P1.5341.00
39_V90_L1.5161.00
78_G114_F1.5151.00
23_V114_F1.4691.00
77_M131_M1.4511.00
18_D21_K1.4231.00
85_N130_A1.4211.00
7_L72_A1.4061.00
25_E28_K1.3911.00
19_L164_A1.3451.00
79_S131_M1.3331.00
117_A124_H1.3271.00
17_V61_I1.3201.00
108_G190_E1.3071.00
35_K72_A1.3001.00
32_K193_K1.2931.00
108_G187_R1.2891.00
115_T128_I1.2550.99
190_E194_K1.2400.99
10_F61_I1.2270.99
48_V53_I1.2250.99
18_D178_I1.2240.99
104_G107_Y1.2220.99
110_P188_V1.2120.99
8_V24_A1.2100.99
6_I27_A1.2030.99
67_S71_W1.2010.99
132_A136_Y1.1970.99
8_V27_A1.1920.99
111_V140_M1.1900.99
181_A185_G1.1770.99
136_Y142_I1.1650.99
7_L37_A1.1500.99
151_E179_N1.1470.99
74_G188_V1.1400.99
157_T174_D1.1130.99
30_I193_K1.1090.99
157_T176_N1.1050.99
89_Q95_D1.1030.99
75_I140_M1.0910.98
64_A68_D1.0910.98
48_V55_I1.0890.98
86_M91_K1.0870.98
28_K34_V1.0800.98
116_E168_G1.0690.98
86_M131_M1.0440.98
173_L178_I1.0420.98
32_K189_A1.0390.98
48_V51_F1.0340.98
43_F51_F1.0300.98
47_I50_K1.0280.98
25_E29_E1.0280.98
37_A68_D1.0210.98
5_K71_W1.0200.98
110_P192_A1.0200.98
21_K28_K1.0070.97
69_L97_T1.0000.97
100_L106_L0.9990.97
113_F132_A0.9930.97
141_I191_V0.9920.97
26_G189_A0.9910.97
85_N134_Y0.9900.97
113_F128_I0.9790.97
43_F48_V0.9740.97
191_V195_L0.9730.97
174_D177_E0.9710.97
31_T193_K0.9700.97
66_L96_Q0.9620.96
88_G92_L0.9600.96
178_I182_K0.9480.96
68_D71_W0.9450.96
70_E103_K0.9400.96
21_K36_L0.9340.96
85_N91_K0.9300.96
79_S86_M0.9290.96
30_I189_A0.9270.96
52_R56_D0.9150.95
149_I180_I0.9140.95
94_L134_Y0.9100.95
65_T68_D0.9050.95
90_L94_L0.9050.95
47_I51_F0.9040.95
74_G110_P0.9040.95
86_M130_A0.9020.95
117_A167_L0.9010.95
4_P32_K0.8980.95
184_L188_V0.8970.95
112_G164_A0.8970.95
5_K73_D0.8940.95
19_L166_H0.8930.95
10_F17_V0.8870.94
16_I78_G0.8830.94
5_K35_K0.8780.94
27_A32_K0.8760.94
26_G181_A0.8740.94
30_I190_E0.8720.94
51_F54_P0.8630.94
175_E178_I0.8600.93
35_K71_W0.8600.93
36_L61_I0.8580.93
27_A189_A0.8540.93
6_I189_A0.8530.93
18_D172_E0.8510.93
4_P192_A0.8510.93
6_I32_K0.8440.93
150_K153_S0.8420.93
110_P191_V0.8390.93
86_M134_Y0.8260.92
183_F187_R0.8260.92
77_M94_L0.8240.92
23_V185_G0.8220.92
154_S176_N0.8200.92
28_K33_E0.8140.91
21_K61_I0.8040.91
129_L162_Y0.8000.91
129_L133_N0.7980.91
81_T117_A0.7880.90
135_A140_M0.7810.90
113_F135_A0.7810.90
113_F142_I0.7790.90
148_G183_F0.7780.90
17_V38_R0.7750.89
16_I114_F0.7740.89
66_L97_T0.7690.89
20_A114_F0.7690.89
40_K63_E0.7680.89
23_V26_G0.7680.89
81_T127_T0.7670.89
149_I183_F0.7610.88
23_V184_L0.7580.88
130_A133_N0.7570.88
48_V56_D0.7560.88
23_V181_A0.7450.87
166_H173_L0.7400.87
21_K60_D0.7400.87
24_A36_L0.7360.87
88_G95_D0.7230.86
21_K24_A0.7200.86
179_N182_K0.7190.85
143_V188_V0.7180.85
49_N52_R0.7140.85
126_S130_A0.7120.85
182_K186_K0.7030.84
66_L100_L0.6990.84
49_N55_I0.6960.84
125_E133_N0.6950.84
128_I131_M0.6880.83
74_G192_A0.6840.83
118_S169_N0.6830.82
43_F92_L0.6790.82
66_L70_E0.6780.82
77_M90_L0.6750.82
110_P141_I0.6740.82
32_K73_D0.6680.81
22_N26_G0.6680.81
149_I152_V0.6650.81
136_Y146_G0.6640.81
28_K31_T0.6600.80
121_H125_E0.6590.80
146_G187_R0.6560.80
37_A72_A0.6560.80
157_T165_S0.6530.80
24_A34_V0.6490.79
51_F55_I0.6480.79
39_V42_Y0.6480.79
125_E129_L0.6470.79
86_M90_L0.6450.79
121_H162_Y0.6410.78
187_R191_V0.6410.78
71_W175_E0.6410.78
21_K25_E0.6400.78
141_I194_K0.6380.78
53_I56_D0.6360.78
42_Y88_G0.6330.77
179_N183_F0.6330.77
55_I59_K0.6280.77
151_E180_I0.6190.76
171_K174_D0.6190.76
23_V76_V0.6170.76
43_F53_I0.6150.75
93_F97_T0.6130.75
155_T176_N0.6120.75
69_L106_L0.6120.75
5_K64_A0.6120.75
80_P127_T0.6060.74
132_A142_I0.6020.74
56_D59_K0.6010.74
17_V54_P0.5990.73
97_T100_L0.5890.72
52_R55_I0.5880.72
79_S115_T0.5850.72
79_S85_N0.5840.72
149_I187_R0.5820.71
145_V164_A0.5810.71
27_A192_A0.5770.71
51_F56_D0.5750.70
8_V20_A0.5700.70
152_V180_I0.5690.70
10_F59_K0.5690.70
137_H162_Y0.5680.70
99_E102_I0.5680.70
6_I192_A0.5670.69
141_I144_P0.5660.69
43_F96_Q0.5620.69
104_G139_G0.5620.69
69_L93_F0.5600.68
75_I111_V0.5590.68
5_K32_K0.5590.68
38_R41_E0.5590.68
175_E182_K0.5560.68
120_M167_L0.5520.67
92_L96_Q0.5510.67
75_I110_P0.5500.67
155_T158_G0.5500.67
69_L75_I0.5500.67
23_V164_A0.5460.66
104_G148_G0.5400.66
16_I79_S0.5390.66
101_W139_G0.5310.64
147_Y161_P0.5270.64
171_K177_E0.5260.64
146_G183_F0.5220.63
94_L97_T0.5210.63
121_H157_T0.5180.62
90_L131_M0.5170.62
82_R117_A0.5160.62
91_K131_M0.5130.62
79_S113_F0.5130.62
7_L64_A0.5110.61
124_H167_L0.5110.61
94_L130_A0.5110.61
22_N173_L0.5110.61
120_M174_D0.5110.61
9_L37_A0.5080.61
129_L132_A0.5050.61
121_H165_S0.5040.60
48_V61_I0.5040.60
49_N56_D0.5030.60
141_I195_L0.5000.60
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zkiA 7 0.9898 100 0.47 Contact Map
1ydgA 4 0.9848 100 0.494 Contact Map
2a5lA 4 0.868 100 0.498 Contact Map
4lafA 4 0.9949 100 0.5 Contact Map
3d7nA 4 0.7817 100 0.513 Contact Map
3zhoA 4 0.9543 100 0.515 Contact Map
2arkA 4 0.8274 100 0.588 Contact Map
2fzvA 5 0.9086 99.9 0.618 Contact Map
2q62A 4 0.9036 99.9 0.619 Contact Map
1sqsA 2 0.8731 99.9 0.623 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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