GREMLIN Database
Q97U65 - Lipoate-protein ligase A (LplA-1)
UniProt: Q97U65 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 247 (234)
Sequences: 2213 (1533)
Seq/√Len: 100.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
155_S188_S4.3991.00
232_R236_E4.1481.00
185_S190_L3.3211.00
60_I67_L3.0641.00
22_E26_L2.9791.00
63_Y164_V2.8551.00
59_M63_Y2.8371.00
112_E118_R2.7461.00
105_R109_S2.6291.00
113_N207_G2.4471.00
113_N210_S2.4221.00
118_R130_K2.3711.00
196_T199_E2.2781.00
223_S226_E2.2731.00
229_L232_R2.2291.00
58_E62_K2.2241.00
22_E237_K2.1831.00
86_Y150_G2.1541.00
234_A239_S2.1241.00
79_H85_N2.0661.00
109_S210_S1.9621.00
63_Y163_K1.9501.00
37_W87_T1.9491.00
59_M164_V1.9381.00
8_T201_I1.8821.00
45_L51_I1.8631.00
125_T171_N1.8581.00
157_N160_I1.8521.00
72_S140_Y1.8451.00
231_M235_N1.8221.00
16_L227_L1.8101.00
59_M62_K1.7461.00
132_Y185_S1.7291.00
138_A149_H1.7251.00
68_A244_I1.7201.00
27_H229_L1.7011.00
233_L238_Y1.6931.00
22_E238_Y1.6761.00
114_L203_A1.6661.00
127_I134_I1.6541.00
43_V60_I1.6331.00
172_Y176_D1.6221.00
26_L142_N1.6031.00
122_Y128_A1.5791.00
185_S189_N1.5781.00
57_L61_K1.5781.00
135_S151_T1.5491.00
108_I119_V1.5321.00
56_N166_I1.5131.00
220_D226_E1.5011.00
222_I230_A1.5001.00
84_I197_Y1.4831.00
235_N239_S1.4801.00
171_N183_R1.4751.00
233_L237_K1.4691.00
59_M65_V1.4521.00
169_P173_R1.4451.00
134_I185_S1.4421.00
225_E228_K1.4421.00
226_E229_L1.4191.00
109_S112_E1.3891.00
119_V129_F1.3780.99
26_L229_L1.3730.99
39_N85_N1.3390.99
49_S54_E1.3380.99
101_G105_R1.3070.99
51_I245_Y1.3060.99
45_L76_S1.3020.99
79_H83_N1.3010.99
202_E206_R1.3010.99
110_A207_G1.2950.99
18_V21_D1.2910.99
172_Y177_I1.2840.99
129_F134_I1.2740.99
139_G148_L1.2670.99
63_Y160_I1.2630.99
125_T183_R1.2610.99
32_P91_S1.2580.99
40_E81_M1.2470.99
20_M230_A1.2450.99
129_F190_L1.2370.99
55_V60_I1.2350.99
44_V83_N1.2270.99
16_L20_M1.2190.99
132_Y189_N1.2170.99
44_V79_H1.2120.99
18_V44_V1.2080.99
92_G144_D1.1970.99
103_L106_G1.1820.98
135_S150_G1.1810.98
39_N79_H1.1650.98
59_M163_K1.1620.98
13_D16_L1.1600.98
40_E66_K1.1520.98
6_L205_I1.1430.98
17_N39_N1.1400.98
24_L33_I1.1380.98
109_S207_G1.1320.98
137_N150_G1.1310.98
23_A27_H1.1290.98
231_M234_A1.1230.98
83_N151_T1.1180.98
171_N175_K1.1150.98
193_G199_E1.1140.98
154_V200_A1.0940.97
119_V127_I1.0940.97
128_A131_G1.0930.97
17_N79_H1.0850.97
241_K244_I1.0770.97
56_N59_M1.0760.97
125_T175_K1.0760.97
44_V77_V1.0740.97
71_I238_Y1.0730.97
232_R235_N1.0710.97
71_I237_K1.0610.97
113_N206_R1.0540.97
18_V79_H1.0380.96
41_K160_I1.0260.96
160_I163_K1.0260.96
37_W148_L1.0240.96
57_L67_L1.0230.96
65_V164_V1.0230.96
58_E61_K1.0160.96
38_R197_Y1.0160.96
153_L156_S0.9980.95
198_D202_E0.9940.95
205_I209_S0.9900.95
24_L28_S0.9860.95
84_I200_A0.9850.95
21_D149_H0.9830.95
51_I57_L0.9750.95
120_E131_G0.9730.95
80_D160_I0.9710.95
87_T148_L0.9630.94
84_I201_I0.9450.94
34_L208_F0.9440.94
104_L137_N0.9430.94
123_N171_N0.9400.94
78_F160_I0.9390.94
37_W44_V0.9350.94
87_T149_H0.9280.93
13_D239_S0.9280.93
44_V148_L0.9180.93
154_V195_I0.9150.93
53_D174_K0.9030.92
161_L184_V0.9000.92
225_E229_L0.8950.92
108_I127_I0.8940.92
228_K232_R0.8910.92
18_V85_N0.8850.92
110_A203_A0.8850.92
8_T205_I0.8830.91
200_A204_F0.8630.90
188_S194_D0.8610.90
209_S215_D0.8560.90
18_V39_N0.8550.90
75_G135_S0.8530.90
158_L162_H0.8530.90
24_L32_P0.8510.90
104_L121_V0.8440.89
54_E153_L0.8430.89
227_L231_M0.8300.89
71_I140_Y0.8300.89
167_I171_N0.8300.89
179_M182_Y0.8290.89
53_D178_N0.8280.89
226_E230_A0.8260.88
45_L67_L0.8260.88
111_I134_I0.8220.88
20_M35_R0.8220.88
123_N183_R0.8210.88
76_S165_L0.8200.88
159_D181_K0.8190.88
112_E117_D0.8190.88
92_G146_Y0.8190.88
43_V55_V0.8170.88
87_T138_A0.8160.88
55_V67_L0.8090.87
195_I203_A0.8080.87
21_D35_R0.8020.87
12_N81_M0.8010.87
100_Y103_L0.8000.87
92_G141_I0.7940.86
130_K190_L0.7890.86
30_Y33_I0.7850.86
60_I65_V0.7760.85
242_E245_Y0.7740.85
28_S91_S0.7730.85
14_P68_A0.7730.85
79_H156_S0.7720.85
137_N148_L0.7690.85
207_G210_S0.7680.85
39_N44_V0.7670.84
44_V85_N0.7660.84
39_N68_A0.7620.84
82_G186_N0.7570.84
203_A206_R0.7570.84
72_S149_H0.7490.83
39_N83_N0.7450.83
90_T146_Y0.7440.83
220_D230_A0.7420.82
13_D66_K0.7400.82
77_V85_N0.7400.82
153_L186_N0.7330.82
222_I227_L0.7310.82
53_D172_Y0.7290.81
57_L245_Y0.7290.81
234_A240_K0.7260.81
73_G136_G0.7220.81
75_G126_D0.7190.80
77_V83_N0.7190.80
23_A230_A0.7190.80
31_V91_S0.7190.80
229_L233_L0.7170.80
160_I164_V0.7080.79
89_I147_L0.7050.79
43_V164_V0.7040.79
25_L142_N0.6980.78
193_G196_T0.6980.78
228_K235_N0.6930.78
137_N149_H0.6920.78
77_V151_T0.6890.78
59_M160_I0.6870.77
110_A204_F0.6830.77
42_S79_H0.6820.77
159_D162_H0.6820.77
176_D183_R0.6810.77
197_Y201_I0.6760.76
224_D227_L0.6730.76
163_K166_I0.6720.76
48_L140_Y0.6660.75
174_K178_N0.6650.75
134_I187_L0.6640.75
25_L147_L0.6620.75
51_I244_I0.6610.75
38_R201_I0.6610.75
16_L234_A0.6600.75
158_L161_L0.6590.74
65_V160_I0.6560.74
170_K173_R0.6560.74
28_S31_V0.6520.74
55_V164_V0.6490.73
111_I119_V0.6450.73
14_P66_K0.6410.72
109_S211_L0.6390.72
61_K241_K0.6380.72
56_N163_K0.6370.72
9_E20_M0.6350.72
8_T38_R0.6340.72
9_E16_L0.6330.71
54_E165_L0.6330.71
153_L184_V0.6320.71
87_T147_L0.6310.71
228_K231_M0.6300.71
44_V151_T0.6270.71
120_E128_A0.6230.70
154_V197_Y0.6160.69
137_N140_Y0.6160.69
135_S153_L0.6110.69
22_E140_Y0.6110.69
14_P244_I0.6100.69
139_G146_Y0.6100.69
225_E242_E0.6090.69
177_I183_R0.6080.68
17_N150_G0.6070.68
9_E35_R0.6060.68
18_V238_Y0.6060.68
214_C236_E0.6040.68
14_P18_V0.6030.68
8_T36_I0.6010.68
154_V188_S0.5990.67
199_E202_E0.5960.67
18_V83_N0.5950.67
37_W154_V0.5940.67
220_D223_S0.5930.66
177_I180_I0.5920.66
187_L200_A0.5890.66
108_I121_V0.5870.66
57_L60_I0.5850.65
52_S241_K0.5850.65
112_E119_V0.5840.65
126_D184_V0.5840.65
162_H180_I0.5790.65
188_S198_D0.5790.65
106_G207_G0.5780.65
24_L30_Y0.5780.65
37_W83_N0.5750.64
207_G211_L0.5740.64
224_D228_K0.5740.64
96_I177_I0.5730.64
42_S66_K0.5730.64
93_Q144_D0.5720.64
125_T167_I0.5710.64
51_I60_I0.5710.64
153_L161_L0.5700.63
172_Y175_K0.5670.63
99_L141_I0.5650.63
191_V194_D0.5650.63
141_I146_Y0.5600.62
172_Y180_I0.5590.62
140_Y147_L0.5570.62
36_I201_I0.5570.62
104_L127_I0.5540.61
205_I219_F0.5520.61
71_I147_L0.5490.61
29_K223_S0.5490.61
211_L214_C0.5480.60
86_Y148_L0.5460.60
79_H150_G0.5450.60
209_S220_D0.5440.60
6_L34_L0.5400.59
15_Y66_K0.5390.59
124_E174_K0.5390.59
200_A203_A0.5390.59
158_L186_N0.5360.59
71_I76_S0.5360.59
25_L140_Y0.5340.58
23_A226_E0.5330.58
110_A200_A0.5330.58
118_R190_L0.5320.58
36_I110_A0.5300.58
143_E163_K0.5290.58
36_I87_T0.5290.58
79_H149_H0.5280.58
126_D183_R0.5280.58
77_V153_L0.5270.57
156_S186_N0.5260.57
87_T139_G0.5260.57
40_E202_E0.5230.57
88_F103_L0.5230.57
30_Y91_S0.5220.57
213_R232_R0.5220.57
167_I180_I0.5210.57
15_Y244_I0.5200.56
20_M222_I0.5190.56
223_S231_M0.5160.56
86_Y137_N0.5160.56
35_R103_L0.5160.56
99_L102_Y0.5150.56
238_Y244_I0.5120.55
37_W79_H0.5110.55
16_L230_A0.5110.55
76_S180_I0.5100.55
104_L139_G0.5100.55
167_I204_F0.5070.55
114_L187_L0.5070.55
86_Y123_N0.5050.54
56_N62_K0.5020.54
9_E17_N0.5020.54
75_G184_V0.5010.54
14_P85_N0.5000.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3a7rA 1 0.9717 100 0.191 Contact Map
2c8mA 1 0.9312 100 0.217 Contact Map
2e5aA 1 0.9595 100 0.218 Contact Map
1vqzA 1 0.9798 100 0.251 Contact Map
2p0lA 1 0.9514 100 0.353 Contact Map
2p5iA 1 0.9514 100 0.377 Contact Map
2qhsA 1 0.8259 100 0.438 Contact Map
1w66A 1 0.8057 100 0.465 Contact Map
2dxuA 2 0.7085 97.8 0.886 Contact Map
2eayA 2 0.6802 97.5 0.892 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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