Q97U65 - SULSO - GREMLIN Contacts

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Q97U65 - Lipoate-protein ligase A (LplA-1)

UniProt:	Q97U65	Sequences: MKLRVLLTEYPNDPYLNVAMDEALLLHSKYVPILRIWRNEKSVVLGILSSISDEVNLEMIKKYDVKLARRISGGGSVFHDMGNINYTFITSGQGGIDYLYGYLLRGTISAIENLVNDRVEVYNETDIAFKGYKISGNAGYINEDKYLLHGTLLVSSNLDILHKVLIIPPKNYRKKDINMIKYRVSNLSNLVKGDITYDEAIEAFIRGFSSLLRCDDYFFDDISDEELKLAMRLANEKYSKKEFIYKR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	247 (234)
Sequences:	2213 (1533)
Seq/√Len:	100.2

ECOLI - LPLA
BACSU - LPLJ LIPM LIPL
HALSA - Q9HSK8 Q9HMH8 Q9HHS2
SULSO - Q97U65 Q97Z28 Q97Z70 Q97U62

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
155_S	188_S	4.399	1.00
232_R	236_E	4.148	1.00
185_S	190_L	3.321	1.00
60_I	67_L	3.064	1.00
22_E	26_L	2.979	1.00
63_Y	164_V	2.855	1.00
59_M	63_Y	2.837	1.00
112_E	118_R	2.746	1.00
105_R	109_S	2.629	1.00
113_N	207_G	2.447	1.00
113_N	210_S	2.422	1.00
118_R	130_K	2.371	1.00
196_T	199_E	2.278	1.00
223_S	226_E	2.273	1.00
229_L	232_R	2.229	1.00
58_E	62_K	2.224	1.00
22_E	237_K	2.183	1.00
86_Y	150_G	2.154	1.00
234_A	239_S	2.124	1.00
79_H	85_N	2.066	1.00
109_S	210_S	1.962	1.00
63_Y	163_K	1.950	1.00
37_W	87_T	1.949	1.00
59_M	164_V	1.938	1.00
8_T	201_I	1.882	1.00
45_L	51_I	1.863	1.00
125_T	171_N	1.858	1.00
157_N	160_I	1.852	1.00
72_S	140_Y	1.845	1.00
231_M	235_N	1.822	1.00
16_L	227_L	1.810	1.00
59_M	62_K	1.746	1.00
132_Y	185_S	1.729	1.00
138_A	149_H	1.725	1.00
68_A	244_I	1.720	1.00
27_H	229_L	1.701	1.00
233_L	238_Y	1.693	1.00
22_E	238_Y	1.676	1.00
114_L	203_A	1.666	1.00
127_I	134_I	1.654	1.00
43_V	60_I	1.633	1.00
172_Y	176_D	1.622	1.00
26_L	142_N	1.603	1.00
122_Y	128_A	1.579	1.00
185_S	189_N	1.578	1.00
57_L	61_K	1.578	1.00
135_S	151_T	1.549	1.00
108_I	119_V	1.532	1.00
56_N	166_I	1.513	1.00
220_D	226_E	1.501	1.00
222_I	230_A	1.500	1.00
84_I	197_Y	1.483	1.00
235_N	239_S	1.480	1.00
171_N	183_R	1.475	1.00
233_L	237_K	1.469	1.00
59_M	65_V	1.452	1.00
169_P	173_R	1.445	1.00
134_I	185_S	1.442	1.00
225_E	228_K	1.442	1.00
226_E	229_L	1.419	1.00
109_S	112_E	1.389	1.00
119_V	129_F	1.378	0.99
26_L	229_L	1.373	0.99
39_N	85_N	1.339	0.99
49_S	54_E	1.338	0.99
101_G	105_R	1.307	0.99
51_I	245_Y	1.306	0.99
45_L	76_S	1.302	0.99
79_H	83_N	1.301	0.99
202_E	206_R	1.301	0.99
110_A	207_G	1.295	0.99
18_V	21_D	1.291	0.99
172_Y	177_I	1.284	0.99
129_F	134_I	1.274	0.99
139_G	148_L	1.267	0.99
63_Y	160_I	1.263	0.99
125_T	183_R	1.261	0.99
32_P	91_S	1.258	0.99
40_E	81_M	1.247	0.99
20_M	230_A	1.245	0.99
129_F	190_L	1.237	0.99
55_V	60_I	1.235	0.99
44_V	83_N	1.227	0.99
16_L	20_M	1.219	0.99
132_Y	189_N	1.217	0.99
44_V	79_H	1.212	0.99
18_V	44_V	1.208	0.99
92_G	144_D	1.197	0.99
103_L	106_G	1.182	0.98
135_S	150_G	1.181	0.98
39_N	79_H	1.165	0.98
59_M	163_K	1.162	0.98
13_D	16_L	1.160	0.98
40_E	66_K	1.152	0.98
6_L	205_I	1.143	0.98
17_N	39_N	1.140	0.98
24_L	33_I	1.138	0.98
109_S	207_G	1.132	0.98
137_N	150_G	1.131	0.98
23_A	27_H	1.129	0.98
231_M	234_A	1.123	0.98
83_N	151_T	1.118	0.98
171_N	175_K	1.115	0.98
193_G	199_E	1.114	0.98
154_V	200_A	1.094	0.97
119_V	127_I	1.094	0.97
128_A	131_G	1.093	0.97
17_N	79_H	1.085	0.97
241_K	244_I	1.077	0.97
56_N	59_M	1.076	0.97
125_T	175_K	1.076	0.97
44_V	77_V	1.074	0.97
71_I	238_Y	1.073	0.97
232_R	235_N	1.071	0.97
71_I	237_K	1.061	0.97
113_N	206_R	1.054	0.97
18_V	79_H	1.038	0.96
41_K	160_I	1.026	0.96
160_I	163_K	1.026	0.96
37_W	148_L	1.024	0.96
57_L	67_L	1.023	0.96
65_V	164_V	1.023	0.96
58_E	61_K	1.016	0.96
38_R	197_Y	1.016	0.96
153_L	156_S	0.998	0.95
198_D	202_E	0.994	0.95
205_I	209_S	0.990	0.95
24_L	28_S	0.986	0.95
84_I	200_A	0.985	0.95
21_D	149_H	0.983	0.95
51_I	57_L	0.975	0.95
120_E	131_G	0.973	0.95
80_D	160_I	0.971	0.95
87_T	148_L	0.963	0.94
84_I	201_I	0.945	0.94
34_L	208_F	0.944	0.94
104_L	137_N	0.943	0.94
123_N	171_N	0.940	0.94
78_F	160_I	0.939	0.94
37_W	44_V	0.935	0.94
87_T	149_H	0.928	0.93
13_D	239_S	0.928	0.93
44_V	148_L	0.918	0.93
154_V	195_I	0.915	0.93
53_D	174_K	0.903	0.92
161_L	184_V	0.900	0.92
225_E	229_L	0.895	0.92
108_I	127_I	0.894	0.92
228_K	232_R	0.891	0.92
18_V	85_N	0.885	0.92
110_A	203_A	0.885	0.92
8_T	205_I	0.883	0.91
200_A	204_F	0.863	0.90
188_S	194_D	0.861	0.90
209_S	215_D	0.856	0.90
18_V	39_N	0.855	0.90
75_G	135_S	0.853	0.90
158_L	162_H	0.853	0.90
24_L	32_P	0.851	0.90
104_L	121_V	0.844	0.89
54_E	153_L	0.843	0.89
227_L	231_M	0.830	0.89
71_I	140_Y	0.830	0.89
167_I	171_N	0.830	0.89
179_M	182_Y	0.829	0.89
53_D	178_N	0.828	0.89
226_E	230_A	0.826	0.88
45_L	67_L	0.826	0.88
111_I	134_I	0.822	0.88
20_M	35_R	0.822	0.88
123_N	183_R	0.821	0.88
76_S	165_L	0.820	0.88
159_D	181_K	0.819	0.88
112_E	117_D	0.819	0.88
92_G	146_Y	0.819	0.88
43_V	55_V	0.817	0.88
87_T	138_A	0.816	0.88
55_V	67_L	0.809	0.87
195_I	203_A	0.808	0.87
21_D	35_R	0.802	0.87
12_N	81_M	0.801	0.87
100_Y	103_L	0.800	0.87
92_G	141_I	0.794	0.86
130_K	190_L	0.789	0.86
30_Y	33_I	0.785	0.86
60_I	65_V	0.776	0.85
242_E	245_Y	0.774	0.85
28_S	91_S	0.773	0.85
14_P	68_A	0.773	0.85
79_H	156_S	0.772	0.85
137_N	148_L	0.769	0.85
207_G	210_S	0.768	0.85
39_N	44_V	0.767	0.84
44_V	85_N	0.766	0.84
39_N	68_A	0.762	0.84
82_G	186_N	0.757	0.84
203_A	206_R	0.757	0.84
72_S	149_H	0.749	0.83
39_N	83_N	0.745	0.83
90_T	146_Y	0.744	0.83
220_D	230_A	0.742	0.82
13_D	66_K	0.740	0.82
77_V	85_N	0.740	0.82
153_L	186_N	0.733	0.82
222_I	227_L	0.731	0.82
53_D	172_Y	0.729	0.81
57_L	245_Y	0.729	0.81
234_A	240_K	0.726	0.81
73_G	136_G	0.722	0.81
75_G	126_D	0.719	0.80
77_V	83_N	0.719	0.80
23_A	230_A	0.719	0.80
31_V	91_S	0.719	0.80
229_L	233_L	0.717	0.80
160_I	164_V	0.708	0.79
89_I	147_L	0.705	0.79
43_V	164_V	0.704	0.79
25_L	142_N	0.698	0.78
193_G	196_T	0.698	0.78
228_K	235_N	0.693	0.78
137_N	149_H	0.692	0.78
77_V	151_T	0.689	0.78
59_M	160_I	0.687	0.77
110_A	204_F	0.683	0.77
42_S	79_H	0.682	0.77
159_D	162_H	0.682	0.77
176_D	183_R	0.681	0.77
197_Y	201_I	0.676	0.76
224_D	227_L	0.673	0.76
163_K	166_I	0.672	0.76
48_L	140_Y	0.666	0.75
174_K	178_N	0.665	0.75
134_I	187_L	0.664	0.75
25_L	147_L	0.662	0.75
51_I	244_I	0.661	0.75
38_R	201_I	0.661	0.75
16_L	234_A	0.660	0.75
158_L	161_L	0.659	0.74
65_V	160_I	0.656	0.74
170_K	173_R	0.656	0.74
28_S	31_V	0.652	0.74
55_V	164_V	0.649	0.73
111_I	119_V	0.645	0.73
14_P	66_K	0.641	0.72
109_S	211_L	0.639	0.72
61_K	241_K	0.638	0.72
56_N	163_K	0.637	0.72
9_E	20_M	0.635	0.72
8_T	38_R	0.634	0.72
9_E	16_L	0.633	0.71
54_E	165_L	0.633	0.71
153_L	184_V	0.632	0.71
87_T	147_L	0.631	0.71
228_K	231_M	0.630	0.71
44_V	151_T	0.627	0.71
120_E	128_A	0.623	0.70
154_V	197_Y	0.616	0.69
137_N	140_Y	0.616	0.69
135_S	153_L	0.611	0.69
22_E	140_Y	0.611	0.69
14_P	244_I	0.610	0.69
139_G	146_Y	0.610	0.69
225_E	242_E	0.609	0.69
177_I	183_R	0.608	0.68
17_N	150_G	0.607	0.68
9_E	35_R	0.606	0.68
18_V	238_Y	0.606	0.68
214_C	236_E	0.604	0.68
14_P	18_V	0.603	0.68
8_T	36_I	0.601	0.68
154_V	188_S	0.599	0.67
199_E	202_E	0.596	0.67
18_V	83_N	0.595	0.67
37_W	154_V	0.594	0.67
220_D	223_S	0.593	0.66
177_I	180_I	0.592	0.66
187_L	200_A	0.589	0.66
108_I	121_V	0.587	0.66
57_L	60_I	0.585	0.65
52_S	241_K	0.585	0.65
112_E	119_V	0.584	0.65
126_D	184_V	0.584	0.65
162_H	180_I	0.579	0.65
188_S	198_D	0.579	0.65
106_G	207_G	0.578	0.65
24_L	30_Y	0.578	0.65
37_W	83_N	0.575	0.64
207_G	211_L	0.574	0.64
224_D	228_K	0.574	0.64
96_I	177_I	0.573	0.64
42_S	66_K	0.573	0.64
93_Q	144_D	0.572	0.64
125_T	167_I	0.571	0.64
51_I	60_I	0.571	0.64
153_L	161_L	0.570	0.63
172_Y	175_K	0.567	0.63
99_L	141_I	0.565	0.63
191_V	194_D	0.565	0.63
141_I	146_Y	0.560	0.62
172_Y	180_I	0.559	0.62
140_Y	147_L	0.557	0.62
36_I	201_I	0.557	0.62
104_L	127_I	0.554	0.61
205_I	219_F	0.552	0.61
71_I	147_L	0.549	0.61
29_K	223_S	0.549	0.61
211_L	214_C	0.548	0.60
86_Y	148_L	0.546	0.60
79_H	150_G	0.545	0.60
209_S	220_D	0.544	0.60
6_L	34_L	0.540	0.59
15_Y	66_K	0.539	0.59
124_E	174_K	0.539	0.59
200_A	203_A	0.539	0.59
158_L	186_N	0.536	0.59
71_I	76_S	0.536	0.59
25_L	140_Y	0.534	0.58
23_A	226_E	0.533	0.58
110_A	200_A	0.533	0.58
118_R	190_L	0.532	0.58
36_I	110_A	0.530	0.58
143_E	163_K	0.529	0.58
36_I	87_T	0.529	0.58
79_H	149_H	0.528	0.58
126_D	183_R	0.528	0.58
77_V	153_L	0.527	0.57
156_S	186_N	0.526	0.57
87_T	139_G	0.526	0.57
40_E	202_E	0.523	0.57
88_F	103_L	0.523	0.57
30_Y	91_S	0.522	0.57
213_R	232_R	0.522	0.57
167_I	180_I	0.521	0.57
15_Y	244_I	0.520	0.56
20_M	222_I	0.519	0.56
223_S	231_M	0.516	0.56
86_Y	137_N	0.516	0.56
35_R	103_L	0.516	0.56
99_L	102_Y	0.515	0.56
238_Y	244_I	0.512	0.55
37_W	79_H	0.511	0.55
16_L	230_A	0.511	0.55
76_S	180_I	0.510	0.55
104_L	139_G	0.510	0.55
167_I	204_F	0.507	0.55
114_L	187_L	0.507	0.55
86_Y	123_N	0.505	0.54
56_N	62_K	0.502	0.54
9_E	17_N	0.502	0.54
75_G	184_V	0.501	0.54
14_P	85_N	0.500	0.54

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3a7rA	1	0.9717	100	0.191	Contact Map
2c8mA	1	0.9312	100	0.217	Contact Map
2e5aA	1	0.9595	100	0.218	Contact Map
1vqzA	1	0.9798	100	0.251	Contact Map
2p0lA	1	0.9514	100	0.353	Contact Map
2p5iA	1	0.9514	100	0.377	Contact Map
2qhsA	1	0.8259	100	0.438	Contact Map
1w66A	1	0.8057	100	0.465	Contact Map
2dxuA	2	0.7085	97.8	0.886	Contact Map
2eayA	2	0.6802	97.5	0.892	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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