GREMLIN Database
LIPA - Probable lipoyl synthase
UniProt: Q97U63 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 285 (272)
Sequences: 2139 (900)
Seq/√Len: 54.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
53_M74_L5.1741.00
208_M219_L4.2211.00
132_T153_F3.7971.00
162_R203_E3.6651.00
174_Y210_D3.5941.00
236_K242_E3.5851.00
209_R253_M3.4891.00
185_E217_S3.4271.00
247_E251_Y3.4221.00
244_K247_E3.2591.00
195_L221_L3.2541.00
93_Y127_I2.9661.00
161_R175_E2.9651.00
201_W245_E2.7301.00
118_T121_E2.6151.00
82_V115_V2.5521.00
205_V249_I2.5521.00
191_S211_L2.4631.00
52_I96_I2.3651.00
110_Q114_N2.3161.00
261_L264_A2.2701.00
116_V130_V2.2671.00
77_E80_K2.2661.00
123_N126_I2.2421.00
201_W242_E2.2251.00
98_S133_P2.2081.00
208_M250_A2.1821.00
167_V232_L2.1531.00
23_K32_E2.1441.00
87_K122_L2.1081.00
249_I252_S2.0211.00
201_W246_L2.0171.00
211_L216_V2.0111.00
107_G141_A1.9861.00
93_Y152_V1.9711.00
63_F172_A1.9491.00
179_N182_K1.9471.00
35_L65_Y1.9061.00
80_K118_T1.8730.99
238_Y246_L1.8100.99
30_V34_A1.8090.99
55_S67_L1.7920.99
116_V148_A1.7700.99
249_I253_M1.7680.99
153_F184_A1.7670.99
161_R164_T1.7600.99
96_I119_V1.7580.99
146_I184_A1.7560.99
181_L216_V1.7430.99
143_K147_D1.7410.99
161_R206_E1.7160.99
135_F145_V1.7140.99
120_K128_V1.6740.99
250_A258_V1.6710.99
41_E268_Y1.6160.98
14_N17_R1.6140.98
161_R207_T1.6070.98
212_R255_F1.5870.98
51_M66_V1.5760.98
80_K84_E1.5600.98
245_E249_I1.5150.98
81_R84_E1.5130.98
15_F39_I1.5100.97
138_N141_A1.4880.97
143_K183_Y1.4700.97
45_S271_K1.4430.97
242_E246_L1.4240.96
21_I88_E1.4220.96
113_A117_K1.4110.96
114_N117_K1.4100.96
62_R232_L1.3970.96
25_K85_A1.3640.95
175_E179_N1.3580.95
119_V126_I1.3540.95
7_I263_L1.3390.95
118_T122_L1.3350.95
24_K88_E1.3220.95
86_V123_N1.3210.95
109_A144_K1.3120.94
139_I183_Y1.3080.94
212_R253_M1.3020.94
75_D81_R1.3000.94
53_M111_H1.2970.94
212_R215_G1.2890.94
195_L246_L1.2850.94
248_E252_S1.2630.93
25_K88_E1.2430.93
179_N183_Y1.2360.92
56_I69_G1.2330.92
185_E189_K1.2020.91
84_E88_E1.1880.91
193_I207_T1.1840.91
77_E81_R1.1830.91
241_E244_K1.1830.91
194_L197_L1.1760.90
7_I40_M1.1570.90
84_E122_L1.1550.89
58_T71_P1.1530.89
184_A187_V1.1180.88
244_K248_E1.1130.88
33_E55_S1.1120.88
164_T173_S1.1030.87
195_L204_I1.1020.87
80_K122_L1.0950.87
100_D176_Q1.0940.87
205_V253_M1.0870.86
98_S112_F1.0670.85
211_L219_L1.0640.85
209_R213_S1.0610.85
119_V123_N1.0550.85
154_A192_S1.0540.85
26_S81_R1.0470.84
114_N118_T1.0460.84
155_H177_S1.0430.84
238_Y242_E1.0420.84
142_V183_Y1.0410.84
56_I72_S1.0220.83
247_E260_S1.0220.83
201_W205_V1.0190.83
228_S231_Q1.0190.83
52_I115_V1.0120.82
28_A55_S1.0110.82
43_W68_K1.0020.82
120_K150_V1.0020.82
139_I179_N1.0010.81
205_V209_R1.0010.81
164_T170_P0.9780.80
3_K7_I0.9740.80
56_I67_L0.9680.79
19_A32_E0.9670.79
146_I187_V0.9560.78
87_K123_N0.9490.78
145_V149_G0.9480.78
204_I236_K0.9470.78
168_R172_A0.9470.78
15_F43_W0.9450.78
140_D143_K0.9410.77
146_I153_F0.9410.77
206_E210_D0.9360.77
130_V150_V0.9350.77
166_I235_K0.9310.76
204_I238_Y0.9300.76
63_F164_T0.9250.76
17_R46_G0.9180.75
91_L94_V0.9180.75
46_G89_M0.8980.74
137_G176_Q0.8960.74
113_A145_V0.8960.74
217_S256_S0.8890.73
208_M249_I0.8890.73
259_I269_K0.8840.73
50_F82_V0.8810.72
164_T171_R0.8800.72
242_E245_E0.8770.72
130_V154_A0.8700.71
191_S221_L0.8690.71
65_Y228_S0.8610.71
139_I142_V0.8590.71
117_K147_D0.8530.70
9_V40_M0.8440.69
182_K214_V0.8420.69
68_K100_D0.8410.69
86_V126_I0.8360.68
18_V44_G0.8340.68
86_V94_V0.8330.68
209_R249_I0.8270.68
94_V126_I0.8270.68
83_A122_L0.8260.67
133_P145_V0.8250.67
110_Q144_K0.8230.67
205_V245_E0.8160.67
132_T145_V0.8150.66
80_K121_E0.8100.66
164_T172_A0.8090.66
212_R217_S0.8070.66
18_V89_M0.8030.65
86_V119_V0.8010.65
113_A144_K0.8000.65
251_Y258_V0.7990.65
74_L111_H0.7940.64
211_L214_V0.7920.64
10_Y40_M0.7880.64
208_M253_M0.7850.64
39_I43_W0.7840.63
157_V207_T0.7790.63
202_D205_V0.7770.63
49_T270_A0.7760.63
21_I25_K0.7730.62
46_G90_E0.7720.62
4_K240_L0.7720.62
115_V119_V0.7700.62
100_D164_T0.7680.62
76_D111_H0.7680.62
239_T244_K0.7630.61
33_E65_Y0.7600.61
189_K217_S0.7550.60
23_K33_E0.7520.60
65_Y100_D0.7510.60
130_V153_F0.7490.60
239_T242_E0.7490.60
257_A269_K0.7470.60
226_R237_R0.7470.60
51_M259_I0.7450.59
116_V128_V0.7440.59
182_K213_S0.7430.59
208_M212_R0.7410.59
127_I151_D0.7390.59
92_D271_K0.7390.59
164_T207_T0.7390.59
164_T175_E0.7380.59
142_V180_V0.7320.58
201_W238_Y0.7310.58
28_A72_S0.7290.58
107_G136_R0.7270.58
218_I273_A0.7220.57
5_V263_L0.7210.57
146_I185_E0.7210.57
136_R171_R0.7200.57
259_I273_A0.7180.57
206_E209_R0.7150.56
161_R165_P0.7150.56
191_S214_V0.7140.56
132_T184_A0.7120.56
22_V43_W0.7100.56
153_F180_V0.7090.56
182_K215_G0.7080.56
232_L235_K0.7070.55
164_T192_S0.7070.55
98_S135_F0.7060.55
221_L246_L0.7060.55
43_W164_T0.7040.55
208_M255_F0.7030.55
245_E248_E0.6970.54
100_D135_F0.6970.54
157_V177_S0.6960.54
197_L232_L0.6940.54
130_V148_A0.6940.54
143_K250_A0.6850.53
145_V184_A0.6840.53
178_L214_V0.6840.53
159_T195_L0.6810.53
188_I218_I0.6800.53
83_A119_V0.6800.53
32_E39_I0.6760.52
132_T135_F0.6740.52
220_V264_A0.6730.52
117_K148_A0.6730.52
204_I221_L0.6730.52
12_N15_F0.6700.52
60_G171_R0.6650.51
136_R141_A0.6650.51
139_I143_K0.6650.51
193_I204_I0.6600.50
112_F154_A0.6580.50
145_V148_A0.6570.50
20_E24_K0.6570.50
100_D216_V0.6550.50
14_N46_G0.6540.50
142_V153_F0.6520.50
6_Q261_L0.6510.50
154_A269_K0.6500.49
50_F94_V0.6490.49
200_T235_K0.6490.49
32_E100_D0.6480.49
205_V252_S0.6460.49
250_A259_I0.6460.49
257_A273_A0.6450.49
60_G68_K0.6450.49
157_V191_S0.6440.49
209_R252_S0.6430.49
13_E17_R0.6400.48
202_D212_R0.6390.48
28_A32_E0.6380.48
239_T260_S0.6360.48
84_E87_K0.6360.48
33_E112_F0.6330.48
172_A194_L0.6300.47
60_G100_D0.6290.47
174_Y206_E0.6290.47
45_S272_E0.6290.47
178_L210_D0.6260.47
8_A14_N0.6250.47
247_E250_A0.6230.47
153_F189_K0.6210.46
120_K151_D0.6200.46
96_I130_V0.6190.46
219_L250_A0.6180.46
212_R219_L0.6170.46
120_K153_F0.6160.46
159_T167_V0.6150.46
13_E16_K0.6150.46
14_N44_G0.6140.46
231_Q266_T0.6130.45
114_N119_V0.6110.45
130_V192_S0.6090.45
244_K251_Y0.6090.45
95_V222_S0.6080.45
132_T180_V0.6030.44
65_Y68_K0.6010.44
149_G184_A0.6000.44
8_A11_E0.5960.44
26_S77_E0.5940.43
200_T203_E0.5920.43
43_W173_S0.5910.43
15_F18_V0.5910.43
195_L238_Y0.5900.43
192_S269_K0.5900.43
111_H259_I0.5880.43
25_K89_M0.5880.43
108_G133_P0.5870.43
7_I10_Y0.5870.43
120_K149_G0.5870.43
51_M100_D0.5850.42
93_Y128_V0.5850.42
184_A188_I0.5840.42
248_E251_Y0.5840.42
236_K246_L0.5830.42
157_V174_Y0.5830.42
243_F260_S0.5810.42
9_V35_L0.5810.42
226_R229_R0.5790.42
171_R192_S0.5780.42
144_K149_G0.5780.42
66_V269_K0.5770.42
159_T163_L0.5710.41
50_F89_M0.5660.41
204_I208_M0.5640.40
15_F216_V0.5630.40
164_T180_V0.5620.40
13_E109_A0.5610.40
85_A88_E0.5610.40
197_L235_K0.5610.40
192_S207_T0.5590.40
168_R194_L0.5590.40
3_K241_E0.5560.39
157_V193_I0.5560.39
19_A39_I0.5560.39
130_V135_F0.5550.39
21_I81_R0.5550.39
218_I259_I0.5540.39
141_A170_P0.5530.39
180_V183_Y0.5530.39
18_V22_V0.5520.39
7_I39_I0.5510.39
162_R225_M0.5480.39
25_K84_E0.5460.38
6_Q246_L0.5460.38
80_K114_N0.5460.38
15_F22_V0.5460.38
271_K274_Y0.5440.38
62_R65_Y0.5430.38
62_R171_R0.5420.38
161_R173_S0.5410.38
69_G72_S0.5390.38
218_I226_R0.5390.38
82_V94_V0.5380.38
240_L262_P0.5370.38
25_K81_R0.5370.38
167_V194_L0.5360.37
96_I187_V0.5340.37
180_V269_K0.5340.37
63_F157_V0.5330.37
30_V170_P0.5300.37
53_M98_S0.5300.37
14_N147_D0.5300.37
87_K209_R0.5270.37
250_A273_A0.5260.36
73_P76_D0.5250.36
221_L260_S0.5230.36
112_F133_P0.5220.36
141_A144_K0.5210.36
24_K248_E0.5200.36
55_S72_S0.5200.36
103_D171_R0.5200.36
226_R232_L0.5190.36
130_V184_A0.5190.36
51_M111_H0.5190.36
145_V150_V0.5180.36
73_P111_H0.5180.36
76_D110_Q0.5170.36
20_E182_K0.5170.36
201_W249_I0.5170.36
30_V51_M0.5160.35
225_M237_R0.5160.35
150_V154_A0.5150.35
139_I176_Q0.5150.35
132_T142_V0.5140.35
30_V66_V0.5130.35
30_V33_E0.5120.35
128_V160_V0.5110.35
162_R206_E0.5110.35
206_E248_E0.5090.35
154_A220_V0.5090.35
11_E19_A0.5080.35
120_K154_A0.5080.35
56_I70_K0.5070.35
92_D119_V0.5070.35
35_L230_K0.5070.35
98_S164_T0.5050.34
226_R233_E0.5050.34
96_I115_V0.5030.34
159_T172_A0.5030.34
67_L226_R0.5020.34
14_N18_V0.5020.34
127_I274_Y0.5020.34
43_W216_V0.5010.34
192_S221_L0.5010.34
113_A147_D0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4u0oB 1 0.9193 100 0.653 Contact Map
4wcxA 1 0.9649 99.7 0.876 Contact Map
4rtbA 2 0.9579 99.6 0.881 Contact Map
3iixA 1 0.9439 99.6 0.882 Contact Map
4r33A 2 0.9719 99.6 0.882 Contact Map
1r30A 2 0.8632 99.6 0.883 Contact Map
3t7vA 1 0.9579 99.6 0.883 Contact Map
1oltA 1 0.9263 99.4 0.896 Contact Map
2qgqA 1 0.7298 99.4 0.899 Contact Map
4jc0A 1 0.9228 99.3 0.904 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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