Q97U62 - SULSO - GREMLIN Contacts

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Q97U62 - Lipoate-protein ligase A (LplA-2)

UniProt:	Q97U62	Sequences: MKMLRIIVDGPRDPYYNMAIDEAIMLTRNSVNYDTLRLYMWSPSGVSLGRGQNANAAYLDNIKELGFKLVRRPTGGGALLHPEDNEITYSVVLSASNTIAKLSVDESAVEIAKGILYTLQILGENVDIRGLGDMKKHDLCYLRSGSSDVIVAGRKISGSAQVRDDKALLQHGTLLLRFEPEIWLKVIRAPGVTEEFLKSRIVGLFEFMEVEIDQIFDAMIKGFSKALNEIDVFMGSLTPKEIKLSNKLYKEKYSNEKWNLLGIQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	264 (227)
Sequences:	2666 (1851)
Seq/√Len:	122.9

ECOLI - LPLA
BACSU - LIPM LPLJ LIPL
HALSA - Q9HSK8 Q9HMH8 Q9HHS2
SULSO - Q97U62 Q97U65 Q97Z28 Q97Z70

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
177_R	205_F	4.293	1.00
247_K	251_E	4.027	1.00
202_V	207_F	3.468	1.00
113_K	117_Y	2.838	1.00
61_N	65_L	2.756	1.00
22_E	26_L	2.722	1.00
120_Q	125_N	2.716	1.00
62_I	69_L	2.622	1.00
211_E	214_Q	2.613	1.00
65_L	186_V	2.469	1.00
60_D	64_E	2.464	1.00
121_I	225_K	2.425	1.00
22_E	252_K	2.170	1.00
238_T	241_E	2.136	1.00
249_Y	254_S	2.131	1.00
117_Y	225_K	2.121	1.00
121_I	222_G	2.092	1.00
89_Y	172_G	2.066	1.00
244_L	247_K	2.031	1.00
39_Y	90_S	2.012	1.00
61_N	64_E	1.982	1.00
179_E	182_I	1.920	1.00
26_L	244_L	1.876	1.00
13_D	16_Y	1.846	1.00
43_P	68_K	1.837	1.00
122_L	218_A	1.828	1.00
74_T	162_V	1.810	1.00
65_L	185_K	1.804	1.00
70_V	259_N	1.800	1.00
202_V	206_E	1.797	1.00
248_L	253_Y	1.775	1.00
149_V	156_I	1.745	1.00
125_N	152_A	1.740	1.00
217_D	221_K	1.729	1.00
8_V	216_F	1.726	1.00
81_H	88_T	1.717	1.00
240_K	243_K	1.681	1.00
22_E	253_Y	1.672	1.00
87_I	212_I	1.668	1.00
117_Y	120_Q	1.644	1.00
48_L	54_A	1.627	1.00
118_T	222_G	1.618	1.00
117_Y	222_G	1.611	1.00
16_Y	242_I	1.585	1.00
26_L	164_D	1.574	1.00
154_R	202_V	1.566	1.00
87_I	215_I	1.550	1.00
21_D	171_H	1.523	1.00
61_N	186_V	1.521	1.00
81_H	86_E	1.515	1.00
47_S	81_H	1.513	1.00
151_V	156_I	1.511	1.00
241_E	244_L	1.504	1.00
235_G	241_E	1.482	1.00
27_T	244_L	1.467	1.00
248_L	252_K	1.456	1.00
95_A	166_K	1.419	1.00
18_M	21_D	1.418	1.00
36_L	223_F	1.412	1.00
157_S	173_T	1.412	1.00
23_A	27_T	1.382	1.00
46_V	62_I	1.376	1.00
65_L	182_I	1.363	1.00
129_R	150_I	1.362	1.00
59_L	63_K	1.361	1.00
116_L	126_V	1.357	1.00
54_A	260_L	1.355	1.00
24_I	35_T	1.348	1.00
147_S	200_R	1.326	1.00
78_A	187_I	1.318	1.00
154_R	206_E	1.308	1.00
126_V	151_V	1.290	1.00
118_T	219_M	1.287	1.00
6_I	220_I	1.287	1.00
176_L	215_I	1.285	1.00
86_E	173_T	1.259	1.00
59_L	69_L	1.257	1.00
18_M	47_S	1.256	1.00
34_D	94_S	1.241	0.99
160_A	171_H	1.230	0.99
185_K	188_R	1.227	0.99
156_I	204_L	1.216	0.99
213_D	217_D	1.210	0.99
109_V	113_K	1.204	0.99
74_T	171_H	1.201	0.99
121_I	218_A	1.192	0.99
16_Y	20_I	1.189	0.99
60_D	63_K	1.165	0.99
126_V	149_V	1.164	0.99
182_I	185_K	1.160	0.99
17_N	42_S	1.158	0.99
21_D	37_R	1.156	0.99
150_I	153_G	1.153	0.99
42_S	81_H	1.145	0.99
220_I	224_S	1.144	0.99
39_Y	47_S	1.143	0.99
157_S	172_G	1.143	0.99
17_N	81_H	1.138	0.99
151_V	207_F	1.132	0.99
43_P	84_D	1.127	0.99
47_S	79_L	1.109	0.99
109_V	128_I	1.105	0.99
28_R	94_S	1.095	0.99
40_M	212_I	1.090	0.99
147_S	192_V	1.082	0.99
111_I	114_G	1.077	0.98
159_S	170_Q	1.076	0.98
73_P	252_K	1.073	0.98
237_L	245_S	1.067	0.98
159_S	172_G	1.063	0.98
118_T	218_A	1.061	0.98
256_E	259_N	1.057	0.98
87_I	216_F	1.051	0.98
61_N	67_F	1.050	0.98
57_A	62_I	1.045	0.98
243_K	247_K	1.045	0.98
58_Y	188_R	1.040	0.98
14_P	70_V	1.031	0.98
246_N	249_Y	1.029	0.98
48_L	78_A	1.028	0.98
73_P	162_V	1.025	0.98
58_Y	61_N	1.017	0.98
161_Q	170_Q	1.005	0.98
39_Y	170_Q	1.003	0.98
117_Y	226_A	0.997	0.98
80_L	186_V	0.980	0.97
24_I	28_R	0.974	0.97
18_M	81_H	0.974	0.97
126_V	130_G	0.969	0.97
67_F	186_V	0.966	0.97
235_G	238_T	0.962	0.97
222_G	225_K	0.951	0.97
77_G	157_S	0.948	0.97
23_A	245_S	0.948	0.97
49_G	148_D	0.946	0.97
47_S	86_E	0.942	0.96
176_L	212_I	0.937	0.96
61_N	185_K	0.936	0.96
28_R	33_Y	0.936	0.96
46_V	187_I	0.927	0.96
73_P	253_Y	0.924	0.96
112_A	159_S	0.912	0.96
8_V	220_I	0.907	0.96
240_K	244_L	0.906	0.96
18_M	88_T	0.904	0.96
81_H	171_H	0.897	0.95
47_S	88_T	0.891	0.95
90_S	170_Q	0.889	0.95
183_W	201_I	0.873	0.95
95_A	163_R	0.868	0.94
42_S	86_E	0.867	0.94
95_A	168_L	0.865	0.94
205_F	209_E	0.861	0.94
18_M	86_E	0.848	0.94
20_I	245_S	0.847	0.94
119_L	215_I	0.840	0.93
127_D	153_G	0.834	0.93
121_I	221_K	0.832	0.93
239_P	243_K	0.830	0.93
242_I	246_N	0.829	0.93
79_L	88_T	0.829	0.93
108_A	146_S	0.822	0.93
181_E	198_K	0.821	0.93
243_K	246_N	0.818	0.93
180_P	184_L	0.818	0.93
197_L	200_R	0.817	0.92
16_Y	249_Y	0.810	0.92
62_I	67_F	0.802	0.92
13_D	254_S	0.802	0.92
44_S	182_I	0.800	0.92
218_A	221_K	0.800	0.92
257_K	260_L	0.799	0.92
38_L	216_F	0.798	0.92
126_V	129_R	0.796	0.91
121_I	214_Q	0.793	0.91
28_R	31_V	0.793	0.91
210_V	218_A	0.792	0.91
47_S	170_Q	0.792	0.91
93_L	168_L	0.790	0.91
182_I	186_V	0.777	0.91
24_I	92_V	0.775	0.90
152_A	207_F	0.773	0.90
85_N	203_G	0.772	0.90
94_S	167_A	0.761	0.90
13_D	68_K	0.756	0.89
224_S	231_D	0.755	0.89
181_E	184_L	0.754	0.89
224_S	232_V	0.748	0.89
107_S	163_R	0.741	0.88
20_I	237_L	0.741	0.88
175_L	178_F	0.736	0.88
156_I	202_V	0.729	0.87
90_S	161_Q	0.727	0.87
56_A	195_E	0.723	0.87
40_M	84_D	0.716	0.87
130_G	147_S	0.715	0.86
47_S	173_T	0.714	0.86
34_D	93_L	0.714	0.86
215_I	219_M	0.708	0.86
245_S	248_L	0.702	0.85
45_G	68_K	0.699	0.85
57_A	69_L	0.699	0.85
77_G	148_D	0.692	0.85
249_Y	255_N	0.691	0.85
90_S	169_L	0.690	0.84
120_Q	124_E	0.689	0.84
194_E	200_R	0.689	0.84
159_S	171_H	0.689	0.84
214_Q	217_D	0.688	0.84
77_G	173_T	0.687	0.84
79_L	173_T	0.687	0.84
119_L	156_I	0.686	0.84
179_E	203_G	0.685	0.84
54_A	59_L	0.684	0.84
40_M	216_F	0.681	0.84
39_Y	81_H	0.680	0.84
54_A	259_N	0.679	0.84
180_P	183_W	0.678	0.83
222_G	226_A	0.678	0.83
116_L	149_V	0.678	0.83
25_M	164_D	0.676	0.83
90_S	171_H	0.674	0.83
90_S	160_A	0.672	0.83
75_G	158_G	0.664	0.82
58_Y	64_E	0.663	0.82
221_K	231_D	0.655	0.81
39_Y	86_E	0.650	0.81
77_G	147_S	0.649	0.81
78_A	200_R	0.647	0.81
221_K	224_S	0.647	0.81
157_S	175_L	0.647	0.81
59_L	260_L	0.646	0.80
61_N	182_I	0.642	0.80
147_S	189_A	0.641	0.80
46_V	80_L	0.641	0.80
180_P	203_G	0.640	0.80
12_R	84_D	0.638	0.80
14_P	259_N	0.636	0.79
161_Q	168_L	0.636	0.79
127_D	130_G	0.635	0.79
148_D	157_S	0.635	0.79
25_M	169_L	0.631	0.79
253_Y	259_N	0.629	0.79
148_D	192_V	0.628	0.79
55_N	256_E	0.625	0.78
212_I	216_F	0.625	0.78
26_L	30_S	0.624	0.78
89_Y	130_G	0.622	0.78
63_K	256_E	0.621	0.78
175_L	203_G	0.619	0.78
256_E	260_L	0.619	0.78
214_Q	218_A	0.619	0.78
39_Y	88_T	0.617	0.77
233_F	236_S	0.615	0.77
88_T	159_S	0.611	0.77
24_I	34_D	0.610	0.77
114_G	119_L	0.610	0.77
146_S	187_I	0.608	0.76
79_L	85_N	0.607	0.76
85_N	177_R	0.606	0.76
196_F	199_S	0.605	0.76
217_D	233_F	0.603	0.76
81_H	178_F	0.603	0.76
181_E	185_K	0.602	0.76
25_M	162_V	0.599	0.75
81_H	172_G	0.598	0.75
175_L	201_I	0.597	0.75
59_L	62_I	0.596	0.75
17_N	172_G	0.596	0.75
20_I	46_V	0.592	0.74
163_R	168_L	0.592	0.74
85_N	178_F	0.591	0.74
89_Y	170_Q	0.591	0.74
9_D	12_R	0.591	0.74
63_K	236_S	0.590	0.74
203_G	206_E	0.589	0.74
108_A	111_I	0.588	0.74
18_M	253_Y	0.584	0.73
21_D	81_H	0.583	0.73
149_V	157_S	0.583	0.73
14_P	47_S	0.583	0.73
239_P	242_I	0.582	0.73
82_P	85_N	0.581	0.73
176_L	210_V	0.580	0.73
176_L	205_F	0.579	0.73
235_G	245_S	0.577	0.72
79_L	86_E	0.577	0.72
237_L	242_I	0.577	0.72
235_G	239_P	0.577	0.72
245_S	249_Y	0.575	0.72
80_L	182_I	0.574	0.72
52_Q	71_R	0.574	0.72
78_A	197_L	0.571	0.72
6_I	232_V	0.571	0.72
130_G	200_R	0.569	0.71
38_L	118_T	0.567	0.71
14_P	18_M	0.567	0.71
33_Y	233_F	0.564	0.71
120_Q	126_V	0.562	0.71
21_D	47_S	0.562	0.71
177_R	203_G	0.559	0.70
42_S	88_T	0.555	0.70
220_I	234_M	0.549	0.69
25_M	167_A	0.549	0.69
22_E	162_V	0.548	0.69
115_I	219_M	0.547	0.68
47_S	74_T	0.547	0.68
46_V	227_L	0.547	0.68
112_A	149_V	0.543	0.68
44_S	67_F	0.540	0.67
231_D	240_K	0.539	0.67
73_P	78_A	0.539	0.67
114_G	222_G	0.537	0.67
25_M	51_G	0.533	0.66
159_S	162_V	0.532	0.66
127_D	150_I	0.528	0.66
156_I	223_F	0.526	0.65
175_L	183_W	0.525	0.65
148_D	170_Q	0.524	0.65
239_P	244_L	0.523	0.65
29_N	238_T	0.523	0.65
241_E	245_S	0.522	0.65
73_P	169_L	0.521	0.65
8_V	40_M	0.521	0.65
86_E	175_L	0.516	0.64
17_N	21_D	0.516	0.64
149_V	168_L	0.516	0.64
27_T	30_S	0.515	0.64
51_G	162_V	0.514	0.64
15_Y	259_N	0.512	0.63
67_F	80_L	0.512	0.63
221_K	236_S	0.511	0.63
37_R	90_S	0.506	0.63
189_A	197_L	0.505	0.62
18_M	45_G	0.503	0.62
96_S	166_K	0.503	0.62
148_D	201_I	0.502	0.62
180_P	206_E	0.501	0.62
118_T	215_I	0.501	0.62
9_D	237_L	0.500	0.62

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2c8mA	1	0.9129	100	0.255	Contact Map
3a7rA	1	0.8939	100	0.257	Contact Map
2e5aA	1	0.8864	100	0.294	Contact Map
1vqzA	1	0.8977	100	0.327	Contact Map
2p0lA	1	0.9091	100	0.374	Contact Map
2p5iA	1	0.9129	100	0.389	Contact Map
2qhsA	1	0.7727	100	0.47	Contact Map
1w66A	1	0.7614	100	0.486	Contact Map
2dxuA	2	0.7045	98	0.88	Contact Map
2eayA	2	0.6477	97.5	0.892	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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