GREMLIN Database
Q97U62 - Lipoate-protein ligase A (LplA-2)
UniProt: Q97U62 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 264 (227)
Sequences: 2666 (1851)
Seq/√Len: 122.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
177_R205_F4.2931.00
247_K251_E4.0271.00
202_V207_F3.4681.00
113_K117_Y2.8381.00
61_N65_L2.7561.00
22_E26_L2.7221.00
120_Q125_N2.7161.00
62_I69_L2.6221.00
211_E214_Q2.6131.00
65_L186_V2.4691.00
60_D64_E2.4641.00
121_I225_K2.4251.00
22_E252_K2.1701.00
238_T241_E2.1361.00
249_Y254_S2.1311.00
117_Y225_K2.1211.00
121_I222_G2.0921.00
89_Y172_G2.0661.00
244_L247_K2.0311.00
39_Y90_S2.0121.00
61_N64_E1.9821.00
179_E182_I1.9201.00
26_L244_L1.8761.00
13_D16_Y1.8461.00
43_P68_K1.8371.00
122_L218_A1.8281.00
74_T162_V1.8101.00
65_L185_K1.8041.00
70_V259_N1.8001.00
202_V206_E1.7971.00
248_L253_Y1.7751.00
149_V156_I1.7451.00
125_N152_A1.7401.00
217_D221_K1.7291.00
8_V216_F1.7261.00
81_H88_T1.7171.00
240_K243_K1.6811.00
22_E253_Y1.6721.00
87_I212_I1.6681.00
117_Y120_Q1.6441.00
48_L54_A1.6271.00
118_T222_G1.6181.00
117_Y222_G1.6111.00
16_Y242_I1.5851.00
26_L164_D1.5741.00
154_R202_V1.5661.00
87_I215_I1.5501.00
21_D171_H1.5231.00
61_N186_V1.5211.00
81_H86_E1.5151.00
47_S81_H1.5131.00
151_V156_I1.5111.00
241_E244_L1.5041.00
235_G241_E1.4821.00
27_T244_L1.4671.00
248_L252_K1.4561.00
95_A166_K1.4191.00
18_M21_D1.4181.00
36_L223_F1.4121.00
157_S173_T1.4121.00
23_A27_T1.3821.00
46_V62_I1.3761.00
65_L182_I1.3631.00
129_R150_I1.3621.00
59_L63_K1.3611.00
116_L126_V1.3571.00
54_A260_L1.3551.00
24_I35_T1.3481.00
147_S200_R1.3261.00
78_A187_I1.3181.00
154_R206_E1.3081.00
126_V151_V1.2901.00
118_T219_M1.2871.00
6_I220_I1.2871.00
176_L215_I1.2851.00
86_E173_T1.2591.00
59_L69_L1.2571.00
18_M47_S1.2561.00
34_D94_S1.2410.99
160_A171_H1.2300.99
185_K188_R1.2270.99
156_I204_L1.2160.99
213_D217_D1.2100.99
109_V113_K1.2040.99
74_T171_H1.2010.99
121_I218_A1.1920.99
16_Y20_I1.1890.99
60_D63_K1.1650.99
126_V149_V1.1640.99
182_I185_K1.1600.99
17_N42_S1.1580.99
21_D37_R1.1560.99
150_I153_G1.1530.99
42_S81_H1.1450.99
220_I224_S1.1440.99
39_Y47_S1.1430.99
157_S172_G1.1430.99
17_N81_H1.1380.99
151_V207_F1.1320.99
43_P84_D1.1270.99
47_S79_L1.1090.99
109_V128_I1.1050.99
28_R94_S1.0950.99
40_M212_I1.0900.99
147_S192_V1.0820.99
111_I114_G1.0770.98
159_S170_Q1.0760.98
73_P252_K1.0730.98
237_L245_S1.0670.98
159_S172_G1.0630.98
118_T218_A1.0610.98
256_E259_N1.0570.98
87_I216_F1.0510.98
61_N67_F1.0500.98
57_A62_I1.0450.98
243_K247_K1.0450.98
58_Y188_R1.0400.98
14_P70_V1.0310.98
246_N249_Y1.0290.98
48_L78_A1.0280.98
73_P162_V1.0250.98
58_Y61_N1.0170.98
161_Q170_Q1.0050.98
39_Y170_Q1.0030.98
117_Y226_A0.9970.98
80_L186_V0.9800.97
24_I28_R0.9740.97
18_M81_H0.9740.97
126_V130_G0.9690.97
67_F186_V0.9660.97
235_G238_T0.9620.97
222_G225_K0.9510.97
77_G157_S0.9480.97
23_A245_S0.9480.97
49_G148_D0.9460.97
47_S86_E0.9420.96
176_L212_I0.9370.96
61_N185_K0.9360.96
28_R33_Y0.9360.96
46_V187_I0.9270.96
73_P253_Y0.9240.96
112_A159_S0.9120.96
8_V220_I0.9070.96
240_K244_L0.9060.96
18_M88_T0.9040.96
81_H171_H0.8970.95
47_S88_T0.8910.95
90_S170_Q0.8890.95
183_W201_I0.8730.95
95_A163_R0.8680.94
42_S86_E0.8670.94
95_A168_L0.8650.94
205_F209_E0.8610.94
18_M86_E0.8480.94
20_I245_S0.8470.94
119_L215_I0.8400.93
127_D153_G0.8340.93
121_I221_K0.8320.93
239_P243_K0.8300.93
242_I246_N0.8290.93
79_L88_T0.8290.93
108_A146_S0.8220.93
181_E198_K0.8210.93
243_K246_N0.8180.93
180_P184_L0.8180.93
197_L200_R0.8170.92
16_Y249_Y0.8100.92
62_I67_F0.8020.92
13_D254_S0.8020.92
44_S182_I0.8000.92
218_A221_K0.8000.92
257_K260_L0.7990.92
38_L216_F0.7980.92
126_V129_R0.7960.91
121_I214_Q0.7930.91
28_R31_V0.7930.91
210_V218_A0.7920.91
47_S170_Q0.7920.91
93_L168_L0.7900.91
182_I186_V0.7770.91
24_I92_V0.7750.90
152_A207_F0.7730.90
85_N203_G0.7720.90
94_S167_A0.7610.90
13_D68_K0.7560.89
224_S231_D0.7550.89
181_E184_L0.7540.89
224_S232_V0.7480.89
107_S163_R0.7410.88
20_I237_L0.7410.88
175_L178_F0.7360.88
156_I202_V0.7290.87
90_S161_Q0.7270.87
56_A195_E0.7230.87
40_M84_D0.7160.87
130_G147_S0.7150.86
47_S173_T0.7140.86
34_D93_L0.7140.86
215_I219_M0.7080.86
245_S248_L0.7020.85
45_G68_K0.6990.85
57_A69_L0.6990.85
77_G148_D0.6920.85
249_Y255_N0.6910.85
90_S169_L0.6900.84
120_Q124_E0.6890.84
194_E200_R0.6890.84
159_S171_H0.6890.84
214_Q217_D0.6880.84
77_G173_T0.6870.84
79_L173_T0.6870.84
119_L156_I0.6860.84
179_E203_G0.6850.84
54_A59_L0.6840.84
40_M216_F0.6810.84
39_Y81_H0.6800.84
54_A259_N0.6790.84
180_P183_W0.6780.83
222_G226_A0.6780.83
116_L149_V0.6780.83
25_M164_D0.6760.83
90_S171_H0.6740.83
90_S160_A0.6720.83
75_G158_G0.6640.82
58_Y64_E0.6630.82
221_K231_D0.6550.81
39_Y86_E0.6500.81
77_G147_S0.6490.81
78_A200_R0.6470.81
221_K224_S0.6470.81
157_S175_L0.6470.81
59_L260_L0.6460.80
61_N182_I0.6420.80
147_S189_A0.6410.80
46_V80_L0.6410.80
180_P203_G0.6400.80
12_R84_D0.6380.80
14_P259_N0.6360.79
161_Q168_L0.6360.79
127_D130_G0.6350.79
148_D157_S0.6350.79
25_M169_L0.6310.79
253_Y259_N0.6290.79
148_D192_V0.6280.79
55_N256_E0.6250.78
212_I216_F0.6250.78
26_L30_S0.6240.78
89_Y130_G0.6220.78
63_K256_E0.6210.78
175_L203_G0.6190.78
256_E260_L0.6190.78
214_Q218_A0.6190.78
39_Y88_T0.6170.77
233_F236_S0.6150.77
88_T159_S0.6110.77
24_I34_D0.6100.77
114_G119_L0.6100.77
146_S187_I0.6080.76
79_L85_N0.6070.76
85_N177_R0.6060.76
196_F199_S0.6050.76
217_D233_F0.6030.76
81_H178_F0.6030.76
181_E185_K0.6020.76
25_M162_V0.5990.75
81_H172_G0.5980.75
175_L201_I0.5970.75
59_L62_I0.5960.75
17_N172_G0.5960.75
20_I46_V0.5920.74
163_R168_L0.5920.74
85_N178_F0.5910.74
89_Y170_Q0.5910.74
9_D12_R0.5910.74
63_K236_S0.5900.74
203_G206_E0.5890.74
108_A111_I0.5880.74
18_M253_Y0.5840.73
21_D81_H0.5830.73
149_V157_S0.5830.73
14_P47_S0.5830.73
239_P242_I0.5820.73
82_P85_N0.5810.73
176_L210_V0.5800.73
176_L205_F0.5790.73
235_G245_S0.5770.72
79_L86_E0.5770.72
237_L242_I0.5770.72
235_G239_P0.5770.72
245_S249_Y0.5750.72
80_L182_I0.5740.72
52_Q71_R0.5740.72
78_A197_L0.5710.72
6_I232_V0.5710.72
130_G200_R0.5690.71
38_L118_T0.5670.71
14_P18_M0.5670.71
33_Y233_F0.5640.71
120_Q126_V0.5620.71
21_D47_S0.5620.71
177_R203_G0.5590.70
42_S88_T0.5550.70
220_I234_M0.5490.69
25_M167_A0.5490.69
22_E162_V0.5480.69
115_I219_M0.5470.68
47_S74_T0.5470.68
46_V227_L0.5470.68
112_A149_V0.5430.68
44_S67_F0.5400.67
231_D240_K0.5390.67
73_P78_A0.5390.67
114_G222_G0.5370.67
25_M51_G0.5330.66
159_S162_V0.5320.66
127_D150_I0.5280.66
156_I223_F0.5260.65
175_L183_W0.5250.65
148_D170_Q0.5240.65
239_P244_L0.5230.65
29_N238_T0.5230.65
241_E245_S0.5220.65
73_P169_L0.5210.65
8_V40_M0.5210.65
86_E175_L0.5160.64
17_N21_D0.5160.64
149_V168_L0.5160.64
27_T30_S0.5150.64
51_G162_V0.5140.64
15_Y259_N0.5120.63
67_F80_L0.5120.63
221_K236_S0.5110.63
37_R90_S0.5060.63
189_A197_L0.5050.62
18_M45_G0.5030.62
96_S166_K0.5030.62
148_D201_I0.5020.62
180_P206_E0.5010.62
118_T215_I0.5010.62
9_D237_L0.5000.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2c8mA 1 0.9129 100 0.255 Contact Map
3a7rA 1 0.8939 100 0.257 Contact Map
2e5aA 1 0.8864 100 0.294 Contact Map
1vqzA 1 0.8977 100 0.327 Contact Map
2p0lA 1 0.9091 100 0.374 Contact Map
2p5iA 1 0.9129 100 0.389 Contact Map
2qhsA 1 0.7727 100 0.47 Contact Map
1w66A 1 0.7614 100 0.486 Contact Map
2dxuA 2 0.7045 98 0.88 Contact Map
2eayA 2 0.6477 97.5 0.892 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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