GREMLIN Database
Q97U59 - Glycolate oxidase glcE subunit. (GlcE)
UniProt: Q97U59 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 382 (341)
Sequences: 18668 (14263)
Seq/√Len: 772.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
168_K208_E3.7271.00
67_N373_N3.5621.00
56_Y168_K3.5531.00
145_L209_A3.1921.00
100_N114_Q3.0261.00
165_L212_K2.9141.00
70_K373_N2.8971.00
296_K299_D2.7091.00
99_N121_D2.6881.00
112_T208_E2.6751.00
112_T210_T2.6611.00
168_K178_K2.6341.00
105_S108_D2.5931.00
125_I128_A2.5861.00
51_A62_V2.5461.00
54_Q97_Q2.5401.00
229_N232_S2.4941.00
169_V196_L2.4261.00
131_L213_I2.3571.00
59_L207_L2.3161.00
171_T175_I2.2991.00
114_Q208_E2.1811.00
60_R176_I2.1511.00
166_M178_K2.1371.00
65_F69_K2.0731.00
117_V122_L2.0531.00
127_K216_F2.0521.00
166_M210_T2.0441.00
63_I73_I1.9581.00
120_S124_E1.9481.00
172_G376_L1.9481.00
101_V117_V1.9251.00
106_D129_K1.9141.00
334_V338_E1.9031.00
38_N41_D1.8931.00
118_R121_D1.8601.00
39_G42_E1.8581.00
56_Y176_I1.8371.00
171_T177_A1.8341.00
168_K176_I1.8081.00
111_V122_L1.8001.00
167_A196_L1.7821.00
52_I97_Q1.7751.00
103_E112_T1.7701.00
56_Y207_L1.7671.00
169_V204_G1.7661.00
57_A60_R1.7661.00
166_M180_G1.7501.00
335_L338_E1.7431.00
57_A61_D1.7331.00
56_Y60_R1.7131.00
59_L205_I1.7131.00
33_I36_V1.6951.00
60_R64_K1.6891.00
98_F114_Q1.6481.00
303_K338_E1.6421.00
126_I213_I1.6341.00
110_Y210_T1.6331.00
75_P205_I1.6161.00
76_F79_N1.6161.00
95_L205_I1.6041.00
93_V205_I1.6041.00
110_Y165_L1.6001.00
109_L131_L1.5881.00
54_Q58_E1.5841.00
55_T58_E1.5701.00
125_I129_K1.5671.00
231_T302_R1.5611.00
61_D64_K1.5571.00
368_E374_N1.5471.00
266_E270_A1.5341.00
63_I376_L1.5341.00
163_L214_Y1.5201.00
365_M369_A1.5191.00
113_S141_L1.5121.00
104_I125_I1.5121.00
330_D334_V1.5061.00
101_V125_I1.5061.00
145_L164_I1.4991.00
258_R262_E1.4891.00
286_K290_I1.4681.00
146_A199_M1.4631.00
361_E365_M1.4611.00
144_L160_P1.4411.00
66_A91_I1.4351.00
303_K306_S1.4281.00
111_V211_L1.4231.00
64_K67_N1.4131.00
344_V347_R1.4101.00
109_L215_P1.4091.00
146_A206_Y1.4021.00
121_D124_E1.3891.00
168_K207_L1.3861.00
170_I207_L1.3811.00
39_G43_G1.3791.00
195_I366_L1.3721.00
319_T323_R1.3601.00
364_Q368_E1.3591.00
145_L211_L1.3581.00
231_T235_R1.3351.00
51_A91_I1.3221.00
105_S110_Y1.3221.00
245_E249_K1.3201.00
95_L98_F1.3141.00
328_S331_N1.3101.00
310_V331_N1.3101.00
343_V346_E1.3101.00
361_E364_Q1.3101.00
356_G359_D1.3091.00
59_L170_I1.3041.00
306_S310_V1.3001.00
246_K249_K1.2971.00
65_F71_L1.2841.00
196_L204_G1.2801.00
114_Q117_V1.2791.00
262_E266_E1.2781.00
113_S211_L1.2501.00
172_G370_F1.2401.00
179_G193_H1.2391.00
164_I167_A1.2221.00
63_I67_N1.2151.00
180_G188_S1.2101.00
139_G144_L1.2101.00
362_T365_M1.2081.00
235_R239_I1.2041.00
242_E251_Y1.1941.00
281_Y285_E1.1931.00
176_I207_L1.1871.00
59_L93_V1.1831.00
342_Q345_V1.1771.00
331_N334_V1.1741.00
113_S122_L1.1691.00
63_I205_I1.1611.00
357_I361_E1.1591.00
52_I94_K1.1571.00
283_S288_I1.1511.00
232_S235_R1.1491.00
66_A73_I1.1481.00
100_N117_V1.1271.00
367_K374_N1.1231.00
334_V353_D1.1181.00
60_R170_I1.1181.00
260_A263_K1.1181.00
64_K68_E1.1181.00
287_V290_I1.1131.00
245_E248_D1.1061.00
305_K309_R1.0981.00
53_P62_V1.0941.00
283_S287_V1.0931.00
99_N114_Q1.0911.00
320_G323_R1.0861.00
40_K43_G1.0821.00
63_I170_I1.0781.00
38_N43_G1.0731.00
179_G189_G1.0681.00
124_E128_A1.0681.00
327_A331_N1.0671.00
37_S41_D1.0621.00
303_K335_L1.0611.00
170_I176_I1.0581.00
326_V330_D1.0521.00
335_L339_I1.0511.00
38_N42_E1.0441.00
53_P58_E1.0441.00
283_S286_K1.0371.00
164_I197_S1.0351.00
58_E61_D1.0321.00
62_V91_I1.0301.00
365_M368_E1.0261.00
299_D303_K1.0171.00
247_G250_T1.0141.00
336_R339_I1.0141.00
158_G162_N1.0131.00
360_K364_Q1.0121.00
76_F92_G1.0111.00
359_D362_T1.0071.00
145_L160_P1.0011.00
67_N375_I1.0001.00
267_E270_A0.9961.00
111_V126_I0.9921.00
307_I310_V0.9911.00
246_K250_T0.9861.00
236_P239_I0.9851.00
279_I283_S0.9841.00
284_D288_I0.9811.00
286_K289_S0.9811.00
104_I111_V0.9801.00
62_V93_V0.9791.00
52_I96_S0.9771.00
248_D251_Y0.9761.00
111_V213_I0.9721.00
329_F333_E0.9681.00
331_N335_L0.9671.00
343_V347_R0.9661.00
260_A264_I0.9621.00
277_Y283_S0.9611.00
169_V177_A0.9551.00
196_L206_Y0.9551.00
37_S40_K0.9541.00
77_S140_S0.9521.00
228_V232_S0.9511.00
171_T370_F0.9481.00
104_I131_L0.9461.00
280_D283_S0.9451.00
167_A193_H0.9371.00
32_K35_K0.9341.00
244_D250_T0.9331.00
277_Y280_D0.9231.00
244_D247_G0.9201.00
194_K362_T0.9201.00
70_K375_I0.9171.00
312_R315_G0.9151.00
177_A189_G0.9131.00
49_I91_I0.9111.00
277_Y290_I0.9071.00
141_L211_L0.9041.00
73_I93_V0.9031.00
345_V348_G0.9001.00
30_L34_V0.8991.00
121_D125_I0.8961.00
95_L115_V0.8951.00
142_G209_A0.8891.00
245_E250_T0.8851.00
344_V349_Y0.8821.00
35_K38_N0.8811.00
235_R238_S0.8771.00
238_S241_Y0.8761.00
48_K89_I0.8721.00
347_R350_Y0.8681.00
77_S95_L0.8671.00
71_L91_I0.8641.00
244_D248_D0.8641.00
307_I335_L0.8641.00
59_L98_F0.8621.00
293_V296_K0.8591.00
263_K266_E0.8561.00
76_F94_K0.8511.00
306_S309_R0.8421.00
268_I272_G0.8401.00
261_I265_G0.8391.00
81_H85_P0.8361.00
120_S138_D0.8291.00
333_E337_R0.8281.00
303_K339_I0.8271.00
283_S290_I0.8251.00
56_Y170_I0.8251.00
61_D65_F0.8231.00
167_A209_A0.8211.00
234_Y238_S0.8211.00
56_Y114_Q0.8201.00
302_R306_S0.8191.00
318_G324_L0.8191.00
131_L215_P0.8191.00
341_E347_R0.8171.00
180_G187_S0.8171.00
120_S137_Y0.8151.00
164_I209_A0.8131.00
298_V302_R0.8131.00
344_V348_G0.8121.00
181_G187_S0.8121.00
119_V144_L0.8101.00
72_S377_Q0.8081.00
178_K208_E0.8061.00
191_K194_K0.8061.00
284_D290_I0.8031.00
247_G251_Y0.7991.00
73_I375_I0.7991.00
264_I267_E0.7991.00
178_K210_T0.7941.00
199_M203_L0.7921.00
331_N336_R0.7921.00
285_E288_I0.7911.00
303_K307_I0.7881.00
190_Y202_W0.7861.00
64_K175_I0.7811.00
187_S190_Y0.7811.00
242_E246_K0.7791.00
346_E350_Y0.7751.00
32_K36_V0.7751.00
346_E349_Y0.7751.00
278_S290_I0.7741.00
343_V348_G0.7741.00
195_I203_L0.7731.00
233_K237_I0.7731.00
353_D356_G0.7701.00
245_E251_Y0.7691.00
30_L33_I0.7681.00
59_L95_L0.7661.00
301_I304_A0.7641.00
282_T286_K0.7641.00
318_G323_R0.7631.00
266_E269_G0.7631.00
244_D251_Y0.7631.00
252_V255_I0.7581.00
78_F140_S0.7581.00
72_S90_D0.7541.00
277_Y286_K0.7531.00
206_Y209_A0.7531.00
31_G34_V0.7481.00
99_N117_V0.7461.00
117_V121_D0.7421.00
280_D288_I0.7381.00
307_I331_N0.7361.00
282_T287_V0.7341.00
333_E336_R0.7341.00
110_Y212_K0.7331.00
264_I272_G0.7301.00
299_D302_R0.7271.00
173_D177_A0.7271.00
334_V337_R0.7261.00
301_I305_K0.7251.00
280_D284_D0.7241.00
341_E344_V0.7231.00
172_G375_I0.7221.00
254_F261_I0.7211.00
244_D249_K0.7201.00
130_G216_F0.7181.00
304_A307_I0.7171.00
96_S140_S0.7151.00
237_I241_Y0.7131.00
36_V39_G0.7121.00
331_N339_I0.7091.00
302_R305_K0.7071.00
265_G269_G0.7071.00
34_V38_N0.7071.00
163_L212_K0.7051.00
300_V304_A0.7051.00
53_P95_L0.7021.00
341_E345_V0.7011.00
279_I287_V0.7011.00
115_V209_A0.7001.00
75_P95_L0.6991.00
53_P97_Q0.6971.00
278_S283_S0.6951.00
325_E329_F0.6931.00
296_K339_I0.6911.00
191_K369_A0.6901.00
281_Y284_D0.6891.00
179_G196_L0.6881.00
237_I240_I0.6871.00
63_I172_G0.6811.00
292_T300_V0.6791.00
313_G316_I0.6781.00
301_I310_V0.6771.00
136_Y139_G0.6761.00
134_P163_L0.6741.00
132_F216_F0.6731.00
341_E346_E0.6711.00
254_F268_I0.6701.00
67_N173_D0.6691.00
355_W359_D0.6691.00
312_R316_I0.6681.00
327_A330_D0.6681.00
280_D289_S0.6671.00
282_T285_E0.6661.00
56_Y59_L0.6641.00
253_T256_G0.6641.00
280_D287_V0.6641.00
263_K267_E0.6621.00
342_Q347_R0.6621.00
242_E245_E0.6611.00
284_D289_S0.6601.00
134_P214_Y0.6591.00
325_E328_S0.6581.00
343_V349_Y0.6571.00
105_S112_T0.6561.00
267_E271_K0.6541.00
167_A206_Y0.6541.00
304_A308_M0.6531.00
257_F260_A0.6531.00
165_L210_T0.6521.00
98_F207_L0.6491.00
141_L209_A0.6491.00
48_K90_D0.6481.00
291_H294_R0.6481.00
50_T92_G0.6461.00
111_V125_I0.6461.00
326_V329_F0.6441.00
77_S115_V0.6431.00
374_N377_Q0.6431.00
159_Y162_N0.6431.00
305_K310_V0.6421.00
242_E249_K0.6391.00
342_Q346_E0.6371.00
96_S118_R0.6361.00
28_D31_G0.6301.00
47_W92_G0.6301.00
279_I282_T0.6291.00
328_S336_R0.6291.00
193_H197_S0.6271.00
269_G272_G0.6271.00
119_V139_G0.6261.00
37_S42_E0.6261.00
291_H342_Q0.6251.00
332_L336_R0.6241.00
330_D333_E0.6181.00
329_F332_L0.6171.00
167_A179_G0.6161.00
360_K363_L0.6161.00
122_L141_L0.6151.00
56_Y98_F0.6151.00
328_S332_L0.6141.00
299_D339_I0.6121.00
227_K236_P0.6091.00
345_V349_Y0.6071.00
281_Y287_V0.6061.00
124_E127_K0.6021.00
300_V339_I0.6021.00
203_L366_L0.6011.00
221_V262_E0.6011.00
366_L370_F0.6001.00
278_S284_D0.5991.00
254_F265_G0.5951.00
312_R317_V0.5951.00
147_T345_V0.5941.00
166_M208_E0.5941.00
279_I284_D0.5931.00
108_D295_G0.5911.00
367_K377_Q0.5881.00
101_V114_Q0.5861.00
285_E289_S0.5861.00
142_G146_A0.5861.00
259_R263_K0.5851.00
36_V41_D0.5831.00
278_S282_T0.5821.00
279_I288_I0.5811.00
242_E250_T0.5801.00
119_V122_L0.5791.00
305_K308_M0.5791.00
281_Y288_I0.5781.00
56_Y208_E0.5771.00
294_R301_I0.5761.00
28_D34_V0.5741.00
30_L35_K0.5731.00
145_L206_Y0.5731.00
57_A176_I0.5691.00
361_E368_E0.5691.00
328_S333_E0.5691.00
303_K310_V0.5681.00
58_E62_V0.5661.00
246_K251_Y0.5651.00
277_Y282_T0.5651.00
123_F216_F0.5641.00
292_T295_G0.5591.00
278_S287_V0.5571.00
278_S281_Y0.5551.00
191_K366_L0.5541.00
279_I290_I0.5521.00
34_V40_K0.5511.00
53_P59_L0.5491.00
106_D109_L0.5491.00
123_F132_F0.5481.00
278_S288_I0.5451.00
126_I129_K0.5451.00
313_G317_V0.5431.00
300_V303_K0.5411.00
318_G322_C0.5381.00
328_S335_L0.5371.00
120_S136_Y0.5351.00
280_D286_K0.5351.00
53_P98_F0.5341.00
273_E277_Y0.5331.00
281_Y286_K0.5331.00
234_Y237_I0.5331.00
236_P241_Y0.5321.00
122_L133_L0.5311.00
277_Y284_D0.5291.00
345_V350_Y0.5291.00
314_I317_V0.5291.00
60_R63_I0.5291.00
285_E290_I0.5271.00
154_S159_Y0.5241.00
342_Q348_G0.5241.00
104_I129_K0.5231.00
333_E339_I0.5231.00
261_I268_I0.5231.00
340_D346_E0.5221.00
259_R262_E0.5201.00
294_R298_V0.5201.00
280_D290_I0.5181.00
295_G298_V0.5181.00
277_Y287_V0.5171.00
254_F257_F0.5171.00
168_K210_T0.5161.00
358_R361_E0.5151.00
178_K188_S0.5151.00
321_Y324_L0.5151.00
74_Y90_D0.5151.00
328_S339_I0.5121.00
105_S109_L0.5101.00
228_V231_T0.5091.00
189_G370_F0.5091.00
292_T298_V0.5081.00
72_S378_P0.5081.00
101_V113_S0.5081.00
281_Y289_S0.5071.00
221_V265_G0.5071.00
34_V42_E0.5071.00
320_G324_L0.5061.00
78_F118_R0.5051.00
180_G189_G0.5051.00
202_W367_K0.5041.00
148_N159_Y0.5041.00
277_Y289_S0.5041.00
33_I37_S0.5031.00
31_G35_K0.5021.00
65_F91_I0.5021.00
165_L181_G0.5011.00
151_T154_S0.5011.00
283_S289_S0.5001.00
233_K238_S0.5001.00
169_V179_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pm9A 5 0.9791 100 0.276 Contact Map
2uuuA 2 0.9555 100 0.313 Contact Map
1f0xA 1 0.9503 100 0.336 Contact Map
4bbyA 2 0.9948 100 0.347 Contact Map
1w1oA 1 0.9241 100 0.352 Contact Map
4o95A 1 0.9267 100 0.36 Contact Map
4xloA 2 0.9686 100 0.362 Contact Map
4mlaA 1 0.9162 100 0.366 Contact Map
1wvfA 2 0.9791 100 0.368 Contact Map
2exrA 1 0.9136 100 0.37 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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