GREMLIN Database
Q97U56 - MutT-like protein
UniProt: Q97U56 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 159 (140)
Sequences: 3062 (2205)
Seq/√Len: 186.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
55_R64_A4.8531.00
33_L148_L3.4371.00
62_F98_Y2.8131.00
22_V69_C2.4821.00
59_E63_Q2.4791.00
80_R100_A2.4731.00
70_E77_P2.4091.00
34_I49_A2.2221.00
55_R61_A2.2161.00
60_T63_Q2.1881.00
117_K138_Y2.1601.00
30_Y120_W2.1551.00
110_P118_V2.0291.00
81_S103_D1.9391.00
22_V100_A1.9311.00
23_V147_I1.8681.00
143_M147_I1.8011.00
62_F82_S1.7751.00
62_F85_V1.7321.00
38_S116_D1.6611.00
61_A98_Y1.6471.00
23_V151_L1.6431.00
35_K38_S1.6241.00
69_C75_I1.6101.00
95_V143_M1.5961.00
31_I148_L1.5941.00
69_C80_R1.5771.00
149_S153_E1.5681.00
63_Q77_P1.5601.00
87_S150_K1.5441.00
24_L102_L1.4431.00
48_M138_Y1.4251.00
56_E111_N1.4081.00
44_W47_Q1.3991.00
18_D55_R1.3991.00
35_K117_K1.3921.00
140_I148_L1.3801.00
35_K138_Y1.3651.00
28_G120_W1.3591.00
33_L144_T1.3561.00
76_R79_I1.3531.00
61_A64_A1.3481.00
58_N63_Q1.3291.00
40_P45_S1.3261.00
35_K116_D1.3221.00
39_N113_V1.3211.00
119_F138_Y1.3041.00
32_L73_V1.3021.00
48_M119_F1.2931.00
54_H93_I1.2901.00
74_G110_P1.2891.00
26_A120_W1.2721.00
82_S100_A1.2501.00
132_A139_R1.2441.00
127_V152_F1.2391.00
85_V98_Y1.2251.00
66_I70_E1.2241.00
126_L152_F1.1981.00
122_H125_E1.1841.00
91_I143_M1.1681.00
89_N146_R1.1591.00
70_E76_R1.1581.00
26_A30_Y1.1451.00
88_P96_R1.1421.00
18_D94_K1.1241.00
34_I40_P1.1111.00
17_S54_H1.0961.00
125_E131_N1.0941.00
128_R131_N1.0921.00
34_I44_W1.0601.00
34_I115_V1.0571.00
135_Y140_I1.0481.00
58_N64_A1.0401.00
88_P94_K1.0271.00
99_I151_L1.0100.99
95_V147_I0.9910.99
24_L100_A0.9880.99
61_A96_R0.9700.99
20_A61_A0.9680.99
33_L48_M0.9610.99
19_A93_I0.9550.99
27_K101_L0.9350.99
38_S45_S0.9340.99
48_M140_I0.9150.99
121_V140_I0.9020.99
50_L147_I0.8980.99
69_C98_Y0.8820.99
79_I103_D0.8760.99
37_V40_P0.8760.99
93_I143_M0.8720.99
108_P118_V0.8680.98
16_E90_N0.8530.98
17_S93_I0.8490.98
90_N94_K0.8450.98
134_Y137_Q0.8400.98
125_E136_K0.8310.98
146_R150_K0.8310.98
103_D106_I0.8270.98
82_S98_Y0.8250.98
77_P80_R0.8200.98
66_I82_S0.8170.98
86_F97_A0.8110.98
47_Q93_I0.7970.97
33_L50_L0.7920.97
21_V147_I0.7840.97
23_V31_I0.7810.97
32_L102_L0.7810.97
22_V82_S0.7800.97
34_I43_P0.7770.97
40_P44_W0.7590.96
28_G105_L0.7580.96
33_L152_F0.7560.96
25_I123_E0.7500.96
70_E109_R0.7490.96
37_V45_S0.7490.96
124_S128_R0.7440.96
81_S101_L0.7340.96
125_E135_Y0.7310.96
79_I106_I0.7260.95
66_I80_R0.7230.95
23_V50_L0.7190.95
25_I99_I0.7160.95
18_D61_A0.7130.95
25_I30_Y0.7070.95
22_V65_A0.7050.95
18_D88_P0.7020.95
38_S46_G0.7010.94
125_E140_I0.6990.94
60_T64_A0.6950.94
126_L148_L0.6950.94
135_Y138_Y0.6940.94
123_E127_V0.6900.94
85_V96_R0.6900.94
73_V115_V0.6870.94
86_F99_I0.6830.94
28_G104_E0.6780.93
69_C73_V0.6760.93
134_Y139_R0.6730.93
62_F66_I0.6730.93
73_V110_P0.6680.93
43_P93_I0.6650.93
85_V88_P0.6650.93
66_I77_P0.6640.93
70_E78_N0.6610.93
143_M150_K0.6490.92
25_I151_L0.6490.92
44_W145_Y0.6470.92
40_P43_P0.6390.91
132_A135_Y0.6360.91
34_I73_V0.6330.91
22_V80_R0.6320.91
77_P100_A0.6320.91
149_S152_F0.6300.91
40_P113_V0.6290.91
129_G152_F0.6280.91
31_I123_E0.6280.91
24_L50_L0.6150.90
24_L51_P0.6140.90
80_R102_L0.6040.89
73_V118_V0.6020.89
131_N144_T0.6010.89
50_L89_N0.5940.88
68_E114_E0.5930.88
43_P91_I0.5920.88
86_F154_I0.5920.88
40_P49_A0.5910.88
89_N152_F0.5910.88
109_R130_D0.5900.88
74_G111_N0.5870.87
36_R115_V0.5870.87
20_A97_A0.5870.87
35_K48_M0.5800.87
25_I31_I0.5780.87
133_F137_Q0.5760.86
65_A69_C0.5720.86
48_M135_Y0.5710.86
150_K154_I0.5640.85
48_M141_W0.5620.85
86_F150_K0.5610.85
151_L154_I0.5610.85
44_W91_I0.5610.85
133_F152_F0.5590.85
133_F140_I0.5500.84
69_C74_G0.5500.84
83_L101_L0.5490.84
97_A147_I0.5450.83
19_A117_K0.5410.83
122_H135_Y0.5400.83
66_I100_A0.5390.83
45_S150_K0.5380.83
33_L119_F0.5360.82
89_N150_K0.5340.82
16_E117_K0.5340.82
15_N29_Q0.5290.81
123_E152_F0.5280.81
45_S49_A0.5260.81
84_G99_I0.5260.81
19_A48_M0.5240.81
37_V113_V0.5210.81
26_A147_I0.5190.80
20_A23_V0.5150.80
20_A28_G0.5110.79
115_V145_Y0.5090.79
24_L33_L0.5080.79
78_N107_E0.5060.79
74_G86_F0.5050.78
34_I37_V0.5030.78
14_D29_Q0.5030.78
41_K48_M0.5020.78
45_S146_R0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nqzA 1 0.8491 99.9 0.51 Contact Map
3h95A 2 0.8302 99.8 0.62 Contact Map
4c9xA 2 0.8176 99.7 0.635 Contact Map
1u20A 2 0.9748 99.7 0.638 Contact Map
3kvhA 2 0.9057 99.7 0.638 Contact Map
3qsjA 1 0.9057 99.7 0.641 Contact Map
2w4eA 2 0.8365 99.7 0.645 Contact Map
5bonA 4 0.8302 99.7 0.648 Contact Map
4nfwA 6 0.8239 99.7 0.65 Contact Map
2fkbA 1 0.9245 99.7 0.653 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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