GREMLIN Database
Q97U55 - Uncharacterized protein
UniProt: Q97U55 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 249 (232)
Sequences: 18953 (13242)
Seq/√Len: 869.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
139_D207_F4.6611.00
17_F21_S4.2821.00
143_L204_S3.2171.00
153_F239_L3.1411.00
11_L98_D3.0901.00
16_I109_L2.9491.00
13_A17_F2.6311.00
15_T102_G2.6201.00
95_G98_D2.6201.00
19_G103_L2.6031.00
51_D54_K2.5231.00
116_I137_L2.5061.00
190_K194_I2.4291.00
193_Y197_L2.4211.00
145_F233_S2.3681.00
16_I105_L2.3681.00
12_L105_L2.3171.00
223_L227_L2.2411.00
146_A233_S2.2301.00
79_L103_L2.1101.00
21_S24_K2.0441.00
191_S194_I1.9721.00
12_L16_I1.9651.00
238_Y242_R1.9381.00
185_Y196_L1.8911.00
227_L231_F1.8891.00
203_A225_S1.8801.00
160_H163_Y1.8611.00
224_L228_V1.8511.00
153_F243_F1.8401.00
196_L202_T1.8381.00
190_K193_Y1.7941.00
12_L98_D1.7851.00
120_I124_L1.7811.00
146_A236_F1.7491.00
194_I198_I1.7191.00
52_F55_F1.7001.00
206_I225_S1.6711.00
197_L203_A1.6651.00
228_V231_F1.6411.00
153_F236_F1.6341.00
194_I197_L1.6301.00
203_A228_V1.6141.00
24_K27_F1.5841.00
158_V167_L1.5701.00
149_S233_S1.5681.00
149_S237_F1.5641.00
135_P211_I1.5411.00
232_E236_F1.5281.00
181_V205_A1.4891.00
228_V232_E1.4881.00
139_D211_I1.4811.00
224_L227_L1.4801.00
218_S221_M1.4771.00
142_L230_L1.4751.00
143_L147_T1.4631.00
231_F235_L1.4581.00
156_S243_F1.4451.00
102_G106_A1.4261.00
12_L101_I1.4211.00
13_A16_I1.3971.00
197_L202_T1.3901.00
134_I138_I1.3811.00
121_L125_Y1.3561.00
12_L102_G1.3491.00
79_L84_R1.3481.00
59_G209_Q1.3371.00
135_P138_I1.3311.00
20_L106_A1.3251.00
112_S141_T1.3181.00
191_S195_P1.3031.00
188_I193_Y1.3031.00
142_L233_S1.3001.00
16_I102_G1.2991.00
185_Y197_L1.2501.00
57_I122_A1.2501.00
146_A229_L1.2461.00
140_I204_S1.2411.00
142_L226_F1.2401.00
97_S101_I1.2261.00
175_L199_L1.2241.00
226_F230_L1.2201.00
21_S25_R1.2141.00
154_L158_V1.1991.00
62_I201_T1.1971.00
170_L174_I1.1871.00
139_D226_F1.1751.00
233_S237_F1.1681.00
20_L24_K1.1631.00
18_Y79_L1.1561.00
185_Y193_Y1.1501.00
206_I210_G1.1471.00
52_F56_A1.1391.00
108_L141_T1.1301.00
235_L239_L1.1291.00
14_F17_F1.1281.00
159_P163_Y1.1191.00
199_L202_T1.1121.00
149_S240_S1.0971.00
108_L145_F1.0961.00
73_I164_G1.0961.00
210_G215_V1.0921.00
111_S144_L1.0891.00
239_L243_F1.0861.00
36_I40_E1.0721.00
120_I123_I1.0711.00
58_V63_S1.0691.00
206_I221_M1.0681.00
130_L134_I1.0661.00
146_A232_E1.0641.00
157_L243_F1.0541.00
158_V163_Y1.0201.00
235_L238_Y1.0171.00
203_A206_I1.0151.00
138_I142_L1.0101.00
144_L148_S0.9921.00
20_L109_L0.9901.00
242_R245_R0.9851.00
185_Y202_T0.9831.00
19_G22_S0.9791.00
203_A207_F0.9771.00
104_I149_S0.9741.00
78_F82_E0.9721.00
150_I171_L0.9701.00
189_P193_Y0.9661.00
57_I61_L0.9551.00
135_P222_L0.9501.00
131_S134_I0.9421.00
73_I76_L0.9341.00
38_L121_L0.9311.00
239_L242_R0.9311.00
72_L75_D0.9221.00
81_L161_T0.9211.00
58_V61_L0.9181.00
136_L208_S0.9181.00
74_G79_L0.9171.00
115_L140_I0.9151.00
227_L230_L0.9031.00
42_F46_I0.8991.00
149_S236_F0.8971.00
230_L234_I0.8961.00
188_I196_L0.8891.00
225_S229_L0.8881.00
94_I99_Y0.8821.00
16_I106_A0.8811.00
202_T206_I0.8771.00
57_I60_G0.8731.00
31_L35_S0.8701.00
121_L124_L0.8681.00
130_L133_F0.8681.00
129_T132_N0.8651.00
77_V81_L0.8631.00
175_L201_T0.8611.00
78_F81_L0.8501.00
153_F240_S0.8491.00
81_L84_R0.8461.00
238_Y241_V0.8451.00
180_P185_Y0.8401.00
97_S241_V0.8361.00
198_I203_A0.8331.00
88_L93_S0.8251.00
213_N217_T0.8251.00
204_S229_L0.8241.00
26_G29_Y0.8221.00
150_I236_F0.8121.00
132_N135_P0.8121.00
51_D55_F0.8051.00
112_S116_I0.8031.00
42_F45_Y0.8031.00
138_I226_F0.8001.00
151_G155_A0.8001.00
117_L120_I0.7971.00
78_F161_T0.7891.00
81_L85_L0.7851.00
221_M224_L0.7851.00
88_L92_T0.7801.00
46_I125_Y0.7791.00
19_G106_A0.7751.00
171_L174_I0.7731.00
23_I110_Y0.7731.00
222_L225_S0.7721.00
230_L233_S0.7721.00
184_P188_I0.7711.00
231_F234_I0.7651.00
221_M225_S0.7621.00
203_A232_E0.7621.00
139_D204_S0.7611.00
60_G63_S0.7601.00
55_F209_Q0.7601.00
80_R85_L0.7541.00
54_K57_I0.7531.00
205_A209_Q0.7511.00
46_I49_R0.7501.00
32_T36_I0.7481.00
169_G173_S0.7461.00
180_P184_P0.7411.00
134_I137_L0.7381.00
237_F241_V0.7371.00
11_L95_G0.7311.00
100_I241_V0.7311.00
163_Y166_G0.7301.00
45_Y126_H0.7301.00
79_L83_S0.7261.00
72_L76_L0.7211.00
183_Y187_L0.7201.00
75_D78_F0.7181.00
193_Y196_L0.7111.00
37_P41_L0.7081.00
76_L82_E0.7071.00
234_I238_Y0.7061.00
23_I33_Y0.7021.00
222_L226_F0.7001.00
98_D101_I0.6991.00
76_L84_R0.6971.00
18_Y22_S0.6961.00
156_S240_S0.6941.00
84_R89_L0.6941.00
180_P202_T0.6941.00
38_L42_F0.6931.00
179_P202_T0.6901.00
152_F156_S0.6871.00
41_L122_A0.6781.00
88_L91_A0.6761.00
210_G213_N0.6751.00
104_I237_F0.6741.00
73_I78_F0.6731.00
100_I240_S0.6731.00
18_Y84_R0.6691.00
206_I209_Q0.6691.00
73_I77_V0.6671.00
76_L80_R0.6661.00
119_I136_L0.6631.00
62_I205_A0.6591.00
136_L212_T0.6581.00
53_V57_I0.6571.00
236_F240_S0.6571.00
75_D81_L0.6511.00
40_E44_I0.6501.00
77_V80_R0.6491.00
66_A147_T0.6461.00
116_I120_I0.6451.00
43_L46_I0.6421.00
42_F121_L0.6411.00
133_F137_L0.6401.00
207_F225_S0.6391.00
152_F240_S0.6381.00
137_L141_T0.6381.00
187_L190_K0.6341.00
189_P192_L0.6331.00
80_R84_R0.6321.00
87_D90_V0.6301.00
98_D102_G0.6241.00
108_L148_S0.6231.00
76_L79_L0.6211.00
207_F222_L0.6161.00
107_N111_S0.6151.00
172_S176_T0.6121.00
59_G183_Y0.6101.00
88_L94_I0.6091.00
23_I29_Y0.6091.00
166_G169_G0.6091.00
73_I79_L0.6091.00
178_I192_L0.6071.00
84_R88_L0.6061.00
61_L64_V0.6051.00
16_I20_L0.6041.00
123_I128_L0.6021.00
186_T190_K0.6021.00
188_I192_L0.6011.00
180_P206_I0.6011.00
76_L81_L0.6001.00
90_V96_P0.5991.00
107_N148_S0.5991.00
43_L47_I0.5981.00
215_V218_S0.5941.00
104_I148_S0.5931.00
89_L94_I0.5901.00
218_S223_L0.5891.00
228_V235_L0.5891.00
154_L164_G0.5881.00
165_W169_G0.5881.00
210_G222_L0.5871.00
35_S39_A0.5871.00
199_L232_E0.5811.00
58_V62_I0.5781.00
223_L226_F0.5781.00
234_I237_F0.5771.00
168_A172_S0.5731.00
94_I98_D0.5721.00
211_I222_L0.5711.00
225_S228_V0.5711.00
152_F155_A0.5691.00
142_L229_L0.5691.00
185_Y188_I0.5681.00
101_I105_L0.5681.00
53_V58_V0.5671.00
131_S135_P0.5601.00
80_R83_S0.5591.00
210_G221_M0.5581.00
75_D82_E0.5581.00
77_V161_T0.5571.00
178_I199_L0.5541.00
24_K30_I0.5531.00
77_V164_G0.5521.00
67_N71_S0.5511.00
204_S207_F0.5511.00
103_L107_N0.5491.00
215_V221_M0.5491.00
136_L140_I0.5451.00
154_L157_L0.5441.00
11_L14_F0.5441.00
55_F61_L0.5421.00
99_Y244_S0.5411.00
153_F156_S0.5401.00
210_G225_S0.5391.00
179_P199_L0.5381.00
35_S38_L0.5301.00
12_L97_S0.5291.00
69_G147_T0.5291.00
229_L233_S0.5281.00
178_I196_L0.5281.00
173_S176_T0.5271.00
89_L99_Y0.5241.00
56_A60_G0.5231.00
155_A164_G0.5231.00
122_A126_H0.5231.00
197_L206_I0.5221.00
63_S67_N0.5221.00
75_D79_L0.5211.00
109_L112_S0.5191.00
59_G63_S0.5181.00
135_P207_F0.5171.00
89_L92_T0.5171.00
85_L99_Y0.5151.00
224_L231_F0.5151.00
174_I178_I0.5151.00
62_I143_L0.5141.00
168_A171_L0.5101.00
67_N172_S0.5101.00
114_G118_Y0.5101.00
52_F59_G0.5091.00
213_N216_S0.5081.00
158_V164_G0.5071.00
149_S152_F0.5031.00
73_I83_S0.5021.00
55_F59_G0.5021.00
80_R159_P0.5011.00
55_F183_Y0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2l6wA 2 0.1406 7 0.941 Contact Map
2a65A 2 0.3414 5.1 0.944 Contact Map
3qbgA 3 0.1888 4.2 0.947 Contact Map
2mofA 1 0.1446 3.8 0.948 Contact Map
2kluA 1 0.1325 2.7 0.951 Contact Map
2kogA 1 0.1968 1.9 0.956 Contact Map
3zuxA 1 0.8193 1.7 0.957 Contact Map
2rddB 1 0.1165 1.7 0.957 Contact Map
3j1zP 8 0.5341 1.6 0.957 Contact Map
2m20A 2 0.1205 1.6 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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