GREMLIN Database
Q97U53 - Uncharacterized protein
UniProt: Q97U53 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 124 (118)
Sequences: 1780 (1254)
Seq/√Len: 115.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
89_E101_K3.2731.00
92_E99_L3.2481.00
37_K60_L2.7341.00
12_K27_H2.6531.00
25_E97_I2.5721.00
39_L93_I2.3351.00
91_I101_K2.2411.00
12_K107_N2.1681.00
48_I83_I2.1001.00
60_L68_T2.0911.00
90_L98_V2.0331.00
69_V74_T2.0221.00
26_I100_A1.9331.00
50_H112_L1.9231.00
5_F50_H1.8971.00
39_L45_I1.8881.00
26_I47_V1.8741.00
11_I111_V1.7441.00
27_H97_I1.7351.00
13_R24_I1.7101.00
46_I87_V1.7051.00
100_A103_I1.6941.00
23_I99_L1.6571.00
94_K99_L1.6501.00
88_A100_A1.6311.00
25_E99_L1.6201.00
47_V111_V1.5871.00
24_I103_I1.5631.00
53_L106_F1.5571.00
83_I112_L1.5231.00
50_H82_P1.5221.00
23_I91_I1.5111.00
5_F82_P1.4731.00
45_I90_L1.4621.00
6_K31_E1.4151.00
34_E60_L1.3491.00
49_Y84_G1.3281.00
51_L84_G1.2921.00
39_L90_L1.2800.99
33_E96_N1.2740.99
12_K25_E1.2610.99
15_D18_T1.2520.99
10_F29_N1.2450.99
7_Y10_F1.2320.99
28_V114_I1.2050.99
47_V88_A1.1860.99
36_L96_N1.1730.99
46_I85_I1.1720.99
5_F112_L1.1540.99
48_I112_L1.1430.99
61_L74_T1.1290.99
15_D19_S1.1250.99
23_I101_K1.1230.99
62_R66_G1.0960.98
48_I85_I1.0770.98
91_I99_L1.0520.98
16_N19_S1.0350.98
24_I105_A1.0330.98
71_I76_S1.0310.98
9_G28_V0.9990.97
62_R65_K0.9820.97
38_G69_V0.9780.97
52_H106_F0.9770.97
45_I88_A0.9630.96
94_K97_I0.9460.96
56_F82_P0.9420.96
14_N22_A0.9410.96
30_K33_E0.9410.96
36_L98_V0.9380.96
84_G109_T0.9320.96
8_I35_G0.9250.95
61_L65_K0.9210.95
45_I114_I0.9170.95
69_V73_A0.9170.95
11_I24_I0.9090.95
49_Y105_A0.9040.95
49_Y86_S0.8850.94
105_A111_V0.8790.94
13_R105_A0.8780.94
47_V114_I0.8550.93
58_G78_F0.8390.92
93_I98_V0.8320.92
26_I111_V0.8160.91
47_V105_A0.8150.91
36_L90_L0.8140.91
118_S121_S0.8100.91
32_Y72_F0.7970.90
13_R103_I0.7940.90
16_N20_R0.7840.89
9_G29_N0.7720.89
34_E37_K0.7650.88
89_E102_G0.7640.88
44_H89_E0.7620.88
90_L93_I0.7600.88
54_A57_D0.7590.88
15_D20_R0.7520.87
98_V114_I0.7490.87
55_S59_R0.7400.87
100_A111_V0.7370.86
33_E95_G0.7320.86
42_F90_L0.7280.86
13_R107_N0.7230.85
22_A102_G0.7160.85
44_H87_V0.7130.85
44_H117_L0.7070.84
29_N32_Y0.7030.84
46_I117_L0.6990.83
38_G74_T0.6970.83
35_G59_R0.6950.83
56_F59_R0.6870.82
61_L64_K0.6850.82
62_R68_T0.6770.81
27_H96_N0.6770.81
51_L109_T0.6760.81
84_G110_P0.6730.81
36_L39_L0.6640.80
55_S82_P0.6640.80
87_V120_V0.6610.80
74_T77_Q0.6510.79
50_H55_S0.6490.79
45_I100_A0.6490.79
39_L98_V0.6430.78
54_A82_P0.6420.78
11_I26_I0.6340.77
23_I89_E0.6230.76
28_V111_V0.6200.75
16_N77_Q0.6190.75
49_Y87_V0.6110.74
86_S109_T0.6110.74
35_G71_I0.6090.74
26_I98_V0.6070.74
5_F83_I0.6070.74
52_H110_P0.6010.73
95_G99_L0.5990.73
17_S20_R0.5990.73
11_I100_A0.5980.73
71_I74_T0.5930.72
28_V96_N0.5920.72
38_G62_R0.5850.71
24_I88_A0.5830.71
35_G72_F0.5810.71
18_T22_A0.5810.71
86_S93_I0.5790.70
61_L76_S0.5770.70
27_H95_G0.5760.70
12_K108_N0.5760.70
23_I100_A0.5750.70
10_F27_H0.5720.69
59_R78_F0.5640.68
7_Y112_L0.5610.68
86_S104_N0.5590.68
38_G65_K0.5530.67
25_E94_K0.5530.67
17_S103_I0.5460.66
75_R85_I0.5440.66
11_I105_A0.5410.65
86_S117_L0.5400.65
94_K120_V0.5370.65
20_R87_V0.5340.64
21_N101_K0.5330.64
21_N102_G0.5300.64
75_R106_F0.5280.63
25_E92_E0.5270.63
19_S103_I0.5230.63
46_I78_F0.5210.62
41_E69_V0.5200.62
51_L71_I0.5200.62
105_A109_T0.5190.62
36_L114_I0.5170.62
28_V120_V0.5100.61
87_V121_S0.5060.60
54_A59_R0.5050.60
103_I106_F0.5050.60
16_N84_G0.5040.60
75_R84_G0.5040.60
56_F103_I0.5000.59
11_I14_N0.5000.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1xqbA 2 0.8629 100 0.094 Contact Map
2nv4A 2 0.9839 100 0.098 Contact Map
3okxA 2 1 100 0.136 Contact Map
3ut1A 2 0.8145 16 0.944 Contact Map
3a2qA 2 0.7984 10.1 0.949 Contact Map
2r58A 1 0.7742 9.1 0.95 Contact Map
4c5eA 3 0.8629 8.1 0.951 Contact Map
1oz2A 1 0.7984 7.7 0.951 Contact Map
4d9iA 2 0.4435 6.1 0.954 Contact Map
3f70A 2 0.8871 6 0.954 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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