GREMLIN Database
Q97U52 - First ORF in transposon ISC1904
UniProt: Q97U52 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 192 (181)
Sequences: 478 (335)
Seq/√Len: 24.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
60_A78_L4.1881.00
56_V117_R4.1831.00
82_V119_V3.5361.00
117_R144_E3.4191.00
7_A11_L2.8731.00
110_I138_C2.6200.99
103_F126_L2.5550.99
91_D102_G2.5400.99
58_L148_L2.4650.99
17_T21_Y2.4240.98
13_I21_Y2.4150.98
5_K9_Q2.3450.98
135_E139_K2.2070.97
85_Y146_V2.2000.97
106_L115_V2.1920.97
16_A19_R2.1700.97
111_L141_H2.0730.96
75_V88_V2.0020.95
22_V37_W1.9610.94
58_L78_L1.9310.94
18_L39_F1.9290.94
98_M132_E1.9010.93
55_K109_M1.8180.92
77_Y121_A1.7980.91
96_L129_F1.7750.91
131_F145_I1.7700.90
3_R34_S1.6830.88
110_I115_V1.6740.88
119_V132_E1.6720.88
75_V90_T1.6660.88
89_I102_G1.6210.86
127_V131_F1.6150.86
16_A24_K1.5990.85
110_I118_V1.5870.85
27_I30_V1.5760.84
109_M114_E1.5640.84
4_P19_R1.5550.84
58_L88_V1.5310.83
131_F147_V1.5230.82
166_V177_S1.5200.82
138_C143_C1.5190.82
98_M167_S1.4710.80
40_R43_D1.4360.78
26_Y33_Q1.4310.78
12_G142_N1.4170.77
72_V76_K1.3870.76
70_E73_N1.3700.75
17_T20_E1.3600.74
22_V29_P1.3380.73
167_S170_G1.3320.73
96_L130_G1.3200.72
155_E159_E1.3180.72
14_S20_E1.3160.72
119_V146_V1.3150.72
31_I37_W1.3000.71
89_I118_V1.2930.70
122_Y159_E1.2910.70
56_V144_E1.2900.70
7_A27_I1.2650.69
22_V27_I1.2560.68
4_P18_L1.2450.67
7_A44_V1.2450.67
20_E23_K1.2420.67
8_C15_Y1.2330.67
64_S67_Q1.2330.67
166_V170_G1.1990.64
138_C172_L1.1890.64
62_V67_Q1.1870.64
8_C13_I1.1870.64
15_Y19_R1.1840.63
121_A178_H1.1740.63
22_V39_F1.1390.60
107_L111_L1.1370.60
131_F134_L1.1220.59
170_G175_M1.1080.58
110_I120_V1.0990.58
78_L148_L1.0830.56
4_P29_P1.0800.56
67_Q70_E1.0780.56
58_L82_V1.0710.56
164_V174_G1.0620.55
91_D167_S1.0600.55
91_D121_A1.0510.54
3_R38_R1.0490.54
62_V71_L1.0360.53
57_I75_V1.0300.53
159_E170_G1.0110.51
117_R146_V1.0090.51
11_L18_L1.0090.51
89_I106_L1.0050.51
56_V93_G1.0040.51
57_I89_I1.0000.51
173_Y176_R0.9860.49
56_V119_V0.9790.49
95_G126_L0.9770.49
156_E168_F0.9770.49
98_M127_V0.9630.48
75_V107_L0.9570.47
4_P7_A0.9520.47
27_I134_L0.9450.47
76_K79_E0.9450.47
26_Y34_S0.9380.46
161_L165_L0.9360.46
72_V75_V0.9230.45
127_V134_L0.9160.44
170_G177_S0.9140.44
138_C169_S0.9090.44
54_R142_N0.9080.44
43_D46_R0.8960.43
157_L166_V0.8850.42
7_A18_L0.8820.42
81_Q85_Y0.8800.42
148_L154_E0.8790.42
8_C18_L0.8770.42
19_R22_V0.8730.41
7_A38_R0.8730.41
28_K43_D0.8670.41
4_P15_Y0.8640.41
129_F160_D0.8610.41
22_V31_I0.8590.40
158_V161_L0.8550.40
110_I143_C0.8530.40
134_L138_C0.8500.40
166_V178_H0.8500.40
8_C171_K0.8480.40
13_I20_E0.8460.40
18_L22_V0.8460.40
77_Y149_N0.8430.39
78_L143_C0.8420.39
171_K175_M0.8360.39
85_Y148_L0.8320.39
79_E88_V0.8310.38
63_S67_Q0.8290.38
155_E158_V0.8240.38
39_F43_D0.8230.38
42_E73_N0.8220.38
161_L174_G0.8210.38
81_Q146_V0.8190.38
67_Q73_N0.8150.37
3_R33_Q0.8130.37
5_K34_S0.8130.37
27_I43_D0.8120.37
19_R39_F0.8060.37
160_D174_G0.7870.36
9_Q68_K0.7840.35
30_V38_R0.7800.35
118_V145_I0.7740.35
153_K175_M0.7690.34
73_N162_M0.7580.34
97_N141_H0.7560.33
157_L160_D0.7360.32
14_S22_V0.7360.32
108_R140_A0.7350.32
76_K80_E0.7310.32
139_K171_K0.7300.32
121_A166_V0.7300.32
84_E119_V0.7290.32
175_M182_K0.7230.31
19_R31_I0.7200.31
91_D145_I0.7200.31
10_R90_T0.7190.31
70_E121_A0.7160.31
14_S172_L0.7100.31
87_L100_R0.7050.30
81_Q149_N0.6990.30
63_S128_R0.6990.30
95_G103_F0.6980.30
82_V85_Y0.6960.30
54_R143_C0.6950.30
19_R36_K0.6920.29
100_R127_V0.6910.29
6_E43_D0.6890.29
147_V165_L0.6800.29
6_E157_L0.6750.28
160_D164_V0.6750.28
64_S73_N0.6690.28
57_I150_Q0.6680.28
45_E48_M0.6680.28
30_V43_D0.6670.28
44_V118_V0.6670.28
51_I147_V0.6670.28
93_G163_S0.6600.28
120_V147_V0.6560.27
19_R37_W0.6520.27
137_T140_A0.6510.27
135_E145_I0.6490.27
107_L146_V0.6460.27
15_Y37_W0.6450.27
120_V143_C0.6400.26
178_H182_K0.6360.26
56_V116_S0.6270.26
85_Y96_L0.6260.26
129_F164_V0.6200.25
33_Q113_N0.6200.25
48_M51_I0.6170.25
26_Y165_L0.6160.25
120_V145_I0.6130.25
129_F174_G0.6120.25
57_I106_L0.6110.25
99_K171_K0.6090.25
57_I115_V0.6070.25
177_S180_Y0.6050.25
118_V171_K0.6040.24
29_P39_F0.6030.24
161_L164_V0.5980.24
119_V134_L0.5950.24
157_L168_F0.5950.24
92_I101_K0.5930.24
77_Y91_D0.5920.24
4_P8_C0.5920.24
103_F167_S0.5890.24
54_R112_N0.5890.24
77_Y163_S0.5880.24
53_K57_I0.5850.23
34_S113_N0.5840.23
12_G129_F0.5840.23
13_I16_A0.5820.23
119_V136_E0.5820.23
110_I147_V0.5820.23
92_I145_I0.5810.23
103_F127_V0.5770.23
85_Y103_F0.5760.23
3_R36_K0.5750.23
130_G169_S0.5740.23
110_I145_I0.5740.23
73_N76_K0.5740.23
85_Y121_A0.5710.23
96_L133_I0.5690.23
8_C12_G0.5690.23
5_K25_G0.5690.23
99_K141_H0.5670.23
111_L137_T0.5670.23
92_I100_R0.5660.23
13_I31_I0.5630.22
181_E184_K0.5620.22
31_I36_K0.5620.22
169_S175_M0.5600.22
123_P165_L0.5580.22
16_A26_Y0.5570.22
103_F116_S0.5490.22
90_T137_T0.5460.22
66_T121_A0.5450.21
6_E146_V0.5410.21
115_V143_C0.5390.21
63_S129_F0.5390.21
130_G146_V0.5390.21
55_K116_S0.5390.21
64_S174_G0.5360.21
20_E29_P0.5340.21
14_S24_K0.5300.21
22_V32_L0.5250.21
8_C103_F0.5230.20
165_L169_S0.5220.20
5_K19_R0.5210.20
77_Y178_H0.5210.20
107_L114_E0.5210.20
16_A20_E0.5180.20
93_G97_N0.5180.20
46_R122_Y0.5140.20
66_T122_Y0.5130.20
99_K162_M0.5120.20
6_E10_R0.5120.20
4_P21_Y0.5100.20
137_T141_H0.5100.20
21_Y157_L0.5100.20
134_L157_L0.5070.20
51_I116_S0.5070.20
23_K101_K0.5050.20
6_E120_V0.5050.20
3_R37_W0.5020.19
81_Q148_L0.5020.19
29_P70_E0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ilxA 2 0.7188 100 0.647 Contact Map
3lhkA 2 0.7292 99.9 0.656 Contact Map
3g13A 2 0.7135 99.8 0.737 Contact Map
3bvpA 4 0.625 99.8 0.746 Contact Map
4bqqA 2 0.6979 99.8 0.747 Contact Map
3guvA 2 0.6875 99.8 0.748 Contact Map
2mhcA 1 0.5625 99.8 0.749 Contact Map
2gm5A 4 0.6146 99.7 0.757 Contact Map
3pkzA 4 0.5833 99.7 0.763 Contact Map
1gdtA 2 0.6875 99.7 0.763 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0077 seconds.