GREMLIN Database
Q97U51 - Second ORF in transposon ISC1904
UniProt: Q97U51 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 422 (343)
Sequences: 4356 (2762)
Seq/√Len: 149.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
264_D268_K5.2961.00
288_N291_S4.3201.00
340_P367_N4.1311.00
320_A327_V3.6891.00
206_L312_I2.9901.00
313_H329_E2.9661.00
284_V316_L2.9401.00
283_A376_M2.9141.00
19_F322_L2.8741.00
347_R350_G2.8281.00
311_S315_V2.7751.00
271_N275_D2.7301.00
312_I316_L2.4341.00
338_S345_V2.4251.00
311_S314_R2.3931.00
226_K302_R2.3731.00
334_L337_R2.3241.00
317_K329_E2.3231.00
173_P182_L2.3231.00
330_V372_I2.2541.00
274_L320_A2.2531.00
293_F305_S2.2101.00
375_K378_G2.1481.00
282_F320_A2.1161.00
171_G187_K2.1131.00
54_K120_K2.1051.00
225_L261_R2.1051.00
337_R346_S2.1031.00
267_H315_V2.0801.00
335_T372_I2.0681.00
284_V327_V2.0031.00
28_R31_S1.9941.00
354_E361_K1.9911.00
232_K247_G1.9901.00
51_N55_I1.9861.00
267_H318_Y1.9731.00
263_L311_S1.9461.00
342_C358_C1.9311.00
36_K180_V1.8991.00
49_L97_I1.8781.00
270_V315_V1.8751.00
206_L265_F1.8741.00
298_G301_S1.8561.00
341_R360_F1.8391.00
266_V315_V1.8211.00
351_K364_R1.7671.00
342_C355_C1.7661.00
37_E87_H1.7601.00
353_F362_L1.7541.00
339_C342_C1.7481.00
242_K245_K1.7411.00
317_K321_P1.7341.00
247_G251_M1.7301.00
50_W100_A1.7291.00
355_C358_C1.7181.00
339_C358_C1.7151.00
267_H319_K1.6971.00
267_H270_V1.6791.00
245_K248_R1.6311.00
284_V329_E1.6311.00
266_V311_S1.6231.00
232_K235_K1.6111.00
35_I180_V1.5961.00
44_K84_K1.5951.00
144_I182_L1.5841.00
20_T183_P1.5841.00
352_T361_K1.5501.00
33_E37_E1.5481.00
339_C355_C1.5401.00
199_I207_D1.5221.00
286_K329_E1.5171.00
278_P325_S1.5161.00
284_V313_H1.5141.00
208_A366_L1.5051.00
346_S350_G1.4881.00
177_E256_H1.4881.00
344_F356_E1.4821.00
196_F373_Y1.4761.00
68_L72_K1.4751.00
69_P72_K1.4711.00
106_S118_I1.4381.00
39_R180_V1.4141.00
205_T208_A1.4121.00
101_F105_K1.4091.00
353_F360_F1.4091.00
110_R118_I1.4041.00
32_K36_K1.4021.00
111_A118_I1.3841.00
236_V248_R1.3661.00
49_L100_A1.3661.00
179_K256_H1.3651.00
270_V318_Y1.3621.00
348_K351_K1.3571.00
240_A244_T1.3521.00
145_T151_Y1.3511.00
136_K145_T1.3381.00
209_Y213_K1.3361.00
317_K327_V1.3331.00
270_V319_K1.3241.00
232_K254_Y1.3231.00
285_E332_P1.3211.00
197_L209_Y1.3201.00
295_D301_S1.3041.00
370_L374_L1.3011.00
256_H260_N1.2981.00
304_I309_W1.2881.00
105_K109_K1.2751.00
196_F281_F1.2631.00
24_K179_K1.2621.00
91_H131_K1.2311.00
104_L120_K1.2251.00
68_L98_N1.2201.00
102_S106_S1.2151.00
66_I71_K1.2021.00
272_T276_L1.1961.00
54_K58_R1.1921.00
29_E32_K1.1911.00
229_M255_S1.1851.00
239_F247_G1.1841.00
197_L277_Y1.1721.00
366_L370_L1.1681.00
340_P370_L1.1651.00
274_L323_Y1.1641.00
99_D129_R1.1571.00
229_M251_M1.1521.00
27_E31_S1.1511.00
225_L258_E1.1491.00
91_H133_T1.1481.00
340_P362_L1.1461.00
95_K98_N1.1331.00
199_I209_Y1.1280.99
69_P73_E1.1280.99
288_N332_P1.1280.99
338_S375_K1.1220.99
362_L370_L1.1160.99
266_V312_I1.1160.99
201_S309_W1.1090.99
70_K73_E1.1070.99
76_K79_R1.1050.99
263_L315_V1.1020.99
55_I59_K1.1010.99
270_V316_L1.0980.99
42_L96_A1.0910.99
259_R263_L1.0900.99
233_R237_Q1.0890.99
203_L307_T1.0880.99
347_R351_K1.0790.99
228_S232_K1.0710.99
270_V312_I1.0660.99
198_A373_Y1.0600.99
348_K364_R1.0570.99
214_F363_D1.0540.99
233_R251_M1.0530.99
235_K239_F1.0480.99
275_D323_Y1.0420.99
89_A92_Y1.0420.99
134_L147_R1.0410.99
77_P81_E1.0390.99
271_N323_Y1.0380.99
315_V318_Y1.0380.99
319_K322_L1.0370.99
156_W159_S1.0370.99
128_V132_T1.0370.99
335_T375_K1.0370.99
110_R119_E1.0310.99
128_V131_K1.0250.99
27_E35_I1.0240.99
146_V175_I1.0200.99
106_S111_A1.0190.99
52_L74_V1.0150.99
106_S110_R1.0140.99
201_S313_H1.0130.99
274_L325_S1.0120.99
266_V270_V1.0100.99
236_V251_M1.0090.99
21_Y186_Y1.0060.99
344_F357_R1.0010.99
46_I96_A0.9910.99
232_K250_L0.9890.99
337_R345_V0.9850.99
289_K310_R0.9830.99
347_R364_R0.9800.99
362_L366_L0.9790.99
79_R93_V0.9730.98
196_F377_C0.9710.98
205_T216_T0.9710.98
286_K332_P0.9680.98
41_L84_K0.9680.98
330_V375_K0.9680.98
208_A214_F0.9670.98
274_L282_F0.9640.98
54_K104_L0.9480.98
295_D298_G0.9480.98
330_V376_M0.9470.98
50_W104_L0.9460.98
32_K180_V0.9460.98
295_D299_S0.9450.98
341_R370_L0.9450.98
106_S109_K0.9360.98
351_K363_D0.9360.98
281_F326_F0.9330.98
232_K251_M0.9270.98
273_L282_F0.9270.98
193_P278_P0.9240.98
244_T248_R0.9220.98
366_L369_S0.9210.98
218_S307_T0.9190.98
44_K48_Y0.9160.98
197_L210_D0.9100.98
95_K129_R0.9060.98
283_A372_I0.9060.98
346_S353_F0.9030.98
281_F328_K0.9000.97
91_H95_K0.8960.97
138_V141_S0.8950.97
207_D269_F0.8950.97
320_A325_S0.8920.97
350_G364_R0.8910.97
75_Y79_R0.8890.97
229_M258_E0.8870.97
52_L56_Q0.8820.97
107_W121_P0.8790.97
340_P360_F0.8780.97
221_Q261_R0.8770.97
314_R317_K0.8730.97
352_T362_L0.8690.97
332_P335_T0.8660.97
46_I103_I0.8650.97
266_V308_V0.8630.97
154_F158_K0.8630.97
67_T70_K0.8620.97
334_L375_K0.8600.97
196_F283_A0.8600.97
40_T43_Q0.8570.97
68_L97_I0.8550.97
230_E234_A0.8530.96
250_L253_K0.8500.96
18_H185_R0.8500.96
257_R261_R0.8480.96
73_E76_K0.8440.96
46_I100_A0.8440.96
230_E233_R0.8410.96
99_D174_I0.8400.96
85_I93_V0.8330.96
129_R172_E0.8320.96
236_V247_G0.8290.96
71_K74_V0.8290.96
56_Q60_K0.8280.96
143_R151_Y0.8280.96
229_M237_Q0.8230.96
271_N319_K0.8190.96
254_Y258_E0.8190.96
241_S244_T0.8150.95
130_I146_V0.8130.95
18_H187_K0.8120.95
201_S207_D0.8120.95
25_N182_L0.8110.95
94_D98_N0.8110.95
95_K99_D0.8090.95
107_W120_K0.8090.95
265_F269_F0.8040.95
213_K272_T0.8040.95
136_K139_G0.8000.95
53_T101_F0.7980.95
203_L303_K0.7970.95
57_V61_N0.7940.95
91_H132_T0.7930.95
72_K97_I0.7920.95
48_Y52_L0.7910.95
289_K309_W0.7900.95
221_Q225_L0.7900.95
367_N371_N0.7890.95
291_S332_P0.7890.95
248_R252_R0.7880.95
229_M233_R0.7860.94
233_R255_S0.7830.94
368_A371_N0.7820.94
269_F272_T0.7800.94
72_K76_K0.7770.94
300_L304_I0.7750.94
293_F301_S0.7740.94
24_K181_Y0.7730.94
174_I183_P0.7730.94
370_L373_Y0.7720.94
328_K376_M0.7690.94
175_I182_L0.7660.94
344_F353_F0.7650.94
338_S371_N0.7640.94
350_G353_F0.7620.94
41_L88_L0.7620.94
197_L282_F0.7590.93
154_F157_S0.7560.93
88_L91_H0.7550.93
230_E237_Q0.7540.93
215_V265_F0.7530.93
340_P374_L0.7530.93
205_T214_F0.7510.93
340_P368_A0.7470.93
65_K70_K0.7470.93
129_R132_T0.7430.93
192_T195_N0.7420.93
23_I182_L0.7410.93
134_L137_V0.7380.92
45_A96_A0.7370.92
53_T71_K0.7330.92
334_L338_S0.7310.92
214_F366_L0.7270.92
95_K131_K0.7240.92
34_L38_Y0.7240.92
282_F316_L0.7230.92
91_H94_D0.7230.92
61_N65_K0.7210.92
40_T44_K0.7200.91
204_Y208_A0.7170.91
375_K379_F0.7150.91
44_K82_L0.7150.91
353_F364_R0.7120.91
283_A373_Y0.7110.91
231_V235_K0.7080.91
29_E33_E0.7040.91
53_T104_L0.7010.90
291_S304_I0.7000.90
57_V104_L0.6980.90
262_V306_R0.6980.90
200_D365_Q0.6950.90
286_K313_H0.6930.90
202_N208_A0.6920.90
232_K236_V0.6890.90
287_L332_P0.6860.89
236_V244_T0.6830.89
38_Y42_L0.6820.89
91_H134_L0.6820.89
129_R174_I0.6810.89
76_K80_E0.6810.89
258_E306_R0.6760.89
97_I101_F0.6740.89
71_K75_Y0.6730.89
206_L307_T0.6730.89
283_A328_K0.6710.88
169_E187_K0.6700.88
334_L345_V0.6700.88
20_T185_R0.6680.88
138_V145_T0.6670.88
225_L257_R0.6660.88
96_A100_A0.6650.88
104_L108_R0.6650.88
377_C380_P0.6640.88
127_Y131_K0.6600.88
346_S364_R0.6600.88
135_R170_L0.6600.88
156_W160_W0.6590.87
75_Y97_I0.6580.87
18_H171_G0.6580.87
190_W325_S0.6570.87
131_K134_L0.6570.87
66_I70_K0.6570.87
41_L44_K0.6550.87
60_K65_K0.6550.87
144_I173_P0.6540.87
133_T136_K0.6540.87
310_R314_R0.6520.87
76_K97_I0.6520.87
376_M380_P0.6510.87
35_I39_R0.6500.87
30_K33_E0.6490.87
210_D216_T0.6470.86
23_I158_K0.6470.86
235_K247_G0.6450.86
263_L267_H0.6440.86
172_E185_R0.6440.86
209_Y215_V0.6430.86
295_D304_I0.6420.86
218_S221_Q0.6420.86
237_Q251_M0.6420.86
146_V149_Y0.6410.86
346_S351_K0.6390.86
27_E32_K0.6380.86
66_I74_V0.6370.86
26_S155_S0.6350.85
100_A104_L0.6350.85
206_L270_V0.6340.85
157_S160_W0.6340.85
154_F159_S0.6330.85
149_Y152_I0.6310.85
341_R362_L0.6280.85
17_V187_K0.6280.85
273_L277_Y0.6280.85
92_Y128_V0.6270.85
275_D281_F0.6260.85
207_D312_I0.6260.85
37_E41_L0.6250.85
234_A238_S0.6210.84
52_L78_L0.6190.84
93_V96_A0.6190.84
48_Y78_L0.6190.84
41_L85_I0.6180.84
195_N211_G0.6150.84
67_T71_K0.6150.84
225_L229_M0.6140.84
90_S131_K0.6130.83
313_H317_K0.6100.83
200_D336_S0.6090.83
75_Y78_L0.6080.83
190_W193_P0.6050.83
127_Y130_I0.6040.83
107_W110_R0.6010.82
316_L327_V0.6010.82
104_L107_W0.6000.82
204_Y351_K0.6000.82
88_L93_V0.5980.82
338_S343_G0.5980.82
22_S183_P0.5980.82
103_I121_P0.5970.82
52_L55_I0.5950.82
255_S259_R0.5950.82
283_A375_K0.5940.81
203_L294_K0.5940.81
195_N277_Y0.5940.81
362_L367_N0.5930.81
74_V77_P0.5920.81
338_S353_F0.5910.81
350_G356_E0.5890.81
298_G305_S0.5880.81
225_L254_Y0.5870.81
38_Y88_L0.5820.80
356_E364_R0.5820.80
374_L379_F0.5810.80
318_Y322_L0.5790.80
203_L293_F0.5790.80
75_Y94_D0.5770.80
372_I375_K0.5770.80
109_K118_I0.5760.79
201_S284_V0.5730.79
34_L37_E0.5730.79
51_N123_L0.5720.79
331_N334_L0.5710.79
39_R128_V0.5710.79
244_T247_G0.5700.79
38_Y89_A0.5680.79
245_K249_E0.5660.78
76_K81_E0.5660.78
222_L225_L0.5630.78
244_T251_M0.5630.78
51_N54_K0.5610.78
68_L76_K0.5610.78
49_L74_V0.5610.78
25_N154_F0.5600.78
255_S262_V0.5570.77
348_K352_T0.5570.77
320_A323_Y0.5570.77
74_V78_L0.5560.77
289_K292_M0.5550.77
145_T148_P0.5530.77
235_K250_L0.5510.76
123_L126_A0.5500.76
206_L266_V0.5480.76
21_Y158_K0.5480.76
138_V143_R0.5480.76
208_A216_T0.5470.76
347_R363_D0.5470.76
310_R313_H0.5460.76
72_K98_N0.5450.76
289_K304_I0.5440.76
57_V108_R0.5440.76
41_L93_V0.5400.75
96_A99_D0.5390.75
223_Y302_R0.5350.74
38_Y130_I0.5340.74
283_A377_C0.5340.74
269_F312_I0.5310.74
68_L71_K0.5280.73
92_Y130_I0.5280.73
176_K179_K0.5280.73
179_K260_N0.5280.73
65_K71_K0.5280.73
90_S134_L0.5280.73
137_V141_S0.5260.73
57_V107_W0.5260.73
74_V79_R0.5250.73
140_E143_R0.5240.73
260_N263_L0.5240.73
22_S263_L0.5230.73
348_K363_D0.5230.73
56_Q59_K0.5210.72
315_V319_K0.5190.72
277_Y282_F0.5180.72
90_S133_T0.5170.72
266_V269_F0.5170.72
39_R42_L0.5170.72
70_K75_Y0.5160.72
292_M304_I0.5150.72
97_I100_A0.5150.72
235_K238_S0.5150.72
27_E152_I0.5150.72
49_L78_L0.5140.71
271_N274_L0.5140.71
68_L75_Y0.5140.71
300_L303_K0.5140.71
333_H337_R0.5130.71
198_A283_A0.5130.71
181_Y256_H0.5120.71
228_S254_Y0.5110.71
48_Y84_K0.5100.71
53_T57_V0.5090.71
230_E238_S0.5070.70
53_T56_Q0.5040.70
230_E298_G0.5030.70
37_E40_T0.5020.70
223_Y226_K0.5020.70
145_T149_Y0.5010.69
236_V239_F0.5010.69
239_F243_H0.5000.69
248_R251_M0.5000.69
363_D368_A0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nu0A 1 0.3081 95.4 0.932 Contact Map
1vhxA 2 0.3246 94.3 0.936 Contact Map
1iv0A 1 0.2299 92.4 0.94 Contact Map
1qypA 1 0.1019 86.4 0.947 Contact Map
4aybP 1 0.0948 83.4 0.949 Contact Map
2k4xA 1 0.1256 78.4 0.952 Contact Map
1ffkW 1 0.1659 77.8 0.952 Contact Map
3j20Y 1 0.1137 76.9 0.952 Contact Map
1vd4A 1 0.1256 72.7 0.954 Contact Map
3j3w0 1 0.1303 65.7 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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