GREMLIN Database
Q97U48 - Uncharacterized protein
UniProt: Q97U48 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 122 (100)
Sequences: 9833 (6082)
Seq/√Len: 608.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
45_Q52_S2.9271.00
69_E83_E2.8141.00
90_D104_K2.7291.00
53_K57_K2.6751.00
35_L92_K2.5941.00
71_K83_E2.5571.00
75_S79_V2.5271.00
34_L68_V2.3391.00
69_E85_T2.1941.00
73_I81_V1.9681.00
87_K105_F1.8321.00
34_L44_L1.8161.00
97_E100_R1.7811.00
94_V97_E1.7481.00
73_I79_V1.7321.00
93_R97_E1.7091.00
84_L88_G1.6691.00
30_T58_T1.6031.00
38_P83_E1.6011.00
60_K63_E1.5981.00
38_P81_V1.5951.00
54_T57_K1.4831.00
27_K61_E1.4461.00
89_K92_K1.3821.00
67_I88_G1.3731.00
70_R80_A1.3641.00
86_D89_K1.3401.00
18_A98_L1.3361.00
27_K58_T1.3161.00
90_D101_W1.2981.00
87_K90_D1.2821.00
24_S61_E1.2311.00
21_I65_H1.2211.00
52_S56_S1.2031.00
73_I77_P1.1711.00
99_R103_E1.1661.00
63_E68_V1.1491.00
39_K43_E1.1421.00
42_N46_R1.1411.00
34_L39_K1.1351.00
17_S106_A1.1241.00
24_S58_T1.1191.00
18_A102_G1.1171.00
27_K62_L1.1021.00
87_K108_T1.0741.00
72_I77_P1.0681.00
71_K81_V1.0591.00
31_I84_L1.0591.00
67_I91_L1.0541.00
41_F56_S1.0511.00
56_S60_K1.0451.00
90_D105_F1.0451.00
83_E89_K1.0271.00
74_N77_P1.0241.00
40_R81_V1.0231.00
72_I80_A1.0201.00
73_I78_I0.9981.00
72_I78_I0.9981.00
73_I76_H0.9821.00
28_L95_F0.9751.00
24_S27_K0.9651.00
54_T58_T0.9611.00
92_K96_D0.9561.00
21_I67_I0.9461.00
91_L101_W0.9381.00
35_L84_L0.9311.00
50_L55_L0.9041.00
66_G87_K0.8921.00
30_T47_L0.8911.00
36_D39_K0.8901.00
43_E46_R0.8831.00
100_R104_K0.8801.00
41_F52_S0.8691.00
42_N45_Q0.8671.00
51_S54_T0.8601.00
16_V20_A0.8581.00
93_R100_R0.8511.00
32_R99_R0.8361.00
27_K65_H0.8221.00
61_E65_H0.8121.00
39_K44_L0.8001.00
35_L96_D0.8001.00
33_Y44_L0.7981.00
30_T50_L0.7951.00
96_D100_R0.7931.00
33_Y47_L0.7591.00
72_I76_H0.7571.00
94_V98_L0.7531.00
76_H80_A0.7301.00
26_P50_L0.7261.00
72_I75_S0.7191.00
32_R35_L0.7171.00
14_P103_E0.7101.00
11_E16_V0.6931.00
57_K61_E0.6891.00
11_E20_A0.6791.00
40_R73_I0.6781.00
102_G106_A0.6701.00
33_Y36_D0.6681.00
91_L94_V0.6631.00
29_L33_Y0.6601.00
17_S105_F0.6561.00
96_D99_R0.6541.00
19_I98_L0.6521.00
33_Y39_K0.6321.00
103_E106_A0.6311.00
105_F108_T0.6191.00
34_L38_P0.6151.00
42_N52_S0.6121.00
45_Q55_L0.6091.00
17_S109_K0.6071.00
15_I106_A0.6051.00
31_I91_L0.6041.00
40_R43_E0.6011.00
19_I28_L0.6001.00
50_L80_A0.5981.00
75_S78_I0.5981.00
63_E72_I0.5811.00
86_D90_D0.5811.00
100_R103_E0.5751.00
19_I91_L0.5741.00
75_S81_V0.5731.00
93_R96_D0.5691.00
90_D93_R0.5691.00
17_S20_A0.5671.00
62_L67_I0.5661.00
38_P44_L0.5631.00
52_S58_T0.5601.00
15_I32_R0.5581.00
34_L84_L0.5520.99
34_L63_E0.5520.99
63_E70_R0.5510.99
77_P80_A0.5480.99
87_K109_K0.5460.99
41_F45_Q0.5400.99
101_W105_F0.5370.99
105_F109_K0.5340.99
38_P47_L0.5320.99
11_E17_S0.5300.99
83_E86_D0.5240.99
94_V102_G0.5170.99
93_R104_K0.5160.99
38_P71_K0.5150.99
16_V28_L0.5150.99
44_L47_L0.5140.99
87_K106_A0.5140.99
37_G89_K0.5080.99
104_K107_L0.5020.99
99_R102_G0.5010.99
13_C41_F0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4gcvA 3 0.9016 99.9 0.418 Contact Map
4a5nA 2 0.8525 99.7 0.511 Contact Map
1yyvA 2 0.8934 99.7 0.513 Contact Map
2hztA 2 0.7705 99.7 0.521 Contact Map
1z7uA 2 0.9016 99.7 0.523 Contact Map
2fswA 2 0.8361 99.6 0.539 Contact Map
2f2eA 4 0.9508 99.6 0.541 Contact Map
4hw0A 2 0.8033 99.6 0.558 Contact Map
3df8A 2 0.8279 99.5 0.586 Contact Map
4hqeA 2 0.8607 99.3 0.618 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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