GREMLIN Database
Q97U40 - Uncharacterized protein
UniProt: Q97U40 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 130 (125)
Sequences: 19074 (15639)
Seq/√Len: 1398.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
4_V93_C3.0121.00
81_A117_A2.8501.00
19_F127_L2.8381.00
95_L127_L2.5271.00
98_T118_L2.1031.00
31_H74_I2.0881.00
96_I124_V2.0511.00
31_H93_C2.0221.00
29_E71_V1.9981.00
116_S120_S1.9861.00
78_N83_S1.9421.00
31_H87_Y1.9421.00
18_F64_E1.8911.00
6_G98_T1.8751.00
5_I20_T1.8671.00
88_C96_I1.8581.00
31_H73_K1.8561.00
35_I83_S1.8381.00
33_V87_Y1.8111.00
76_E83_S1.6511.00
83_S86_Q1.6111.00
6_G84_I1.5991.00
23_L27_E1.5881.00
20_T24_I1.5711.00
62_V66_G1.5111.00
96_I122_S1.4971.00
5_I17_L1.4911.00
34_T54_A1.4551.00
85_L121_K1.4541.00
89_N123_N1.4491.00
117_A121_K1.4461.00
55_K59_D1.4141.00
14_K64_E1.4091.00
54_A58_Q1.3991.00
74_I87_Y1.3911.00
88_C123_N1.3701.00
29_E73_K1.3671.00
51_E55_K1.3641.00
96_I118_L1.2751.00
47_I51_E1.2731.00
122_S126_V1.2501.00
57_M61_V1.2281.00
76_E87_Y1.2051.00
35_I80_V1.2011.00
87_Y93_C1.1821.00
100_S128_V1.1811.00
80_V114_V1.1771.00
108_K116_S1.1551.00
14_K60_E1.1251.00
106_I110_I1.1241.00
88_C124_V1.1161.00
57_M60_E1.1081.00
19_F23_L1.1051.00
50_S53_R1.0981.00
33_V84_I1.0931.00
9_G34_T1.0791.00
59_D62_V1.0671.00
53_R57_M1.0281.00
52_Q56_Q1.0261.00
27_E94_G1.0231.00
61_V65_L1.0231.00
98_T115_S1.0231.00
25_K68_Y1.0011.00
85_L88_C1.0001.00
7_Y32_L0.9951.00
119_V128_V0.9921.00
54_A57_M0.9911.00
33_V76_E0.9721.00
17_L32_L0.9621.00
21_L68_Y0.9611.00
62_V72_Q0.9571.00
13_A16_A0.9491.00
17_L61_V0.9421.00
3_V95_L0.9311.00
88_C93_C0.9291.00
59_D63_N0.9291.00
20_T97_V0.9261.00
24_I30_I0.9161.00
22_N26_K0.9091.00
100_S115_S0.8741.00
85_L118_L0.8721.00
49_Q53_R0.8721.00
103_L107_K0.8641.00
115_S128_V0.8621.00
10_S13_A0.8571.00
105_G108_K0.8571.00
14_K18_F0.8491.00
36_V77_S0.8481.00
7_Y16_A0.8461.00
17_L21_L0.8441.00
53_R56_Q0.8441.00
32_L65_L0.8441.00
19_F22_N0.8431.00
48_I52_Q0.8411.00
79_E82_D0.8371.00
60_E63_N0.8311.00
19_F129_V0.8281.00
21_L65_L0.8241.00
20_T30_I0.8221.00
85_L122_S0.8201.00
24_I27_E0.8181.00
83_S87_Y0.8151.00
50_S54_A0.8151.00
4_V87_Y0.8091.00
4_V96_I0.8081.00
61_V64_E0.8081.00
44_E48_I0.8071.00
15_K18_F0.8061.00
66_G69_K0.8041.00
10_S102_G0.8031.00
73_K87_Y0.8031.00
52_Q55_K0.7961.00
19_F125_P0.7951.00
49_Q52_Q0.7821.00
92_G124_V0.7761.00
4_V33_V0.7701.00
7_Y61_V0.7681.00
7_Y17_L0.7631.00
60_E64_E0.7591.00
97_V127_L0.7581.00
106_I109_A0.7551.00
65_L68_Y0.7481.00
111_L115_S0.7421.00
21_L25_K0.7401.00
45_Q48_I0.7351.00
7_Y14_K0.7331.00
5_I30_I0.7241.00
105_G109_A0.7171.00
102_G111_L0.7161.00
84_I118_L0.7161.00
6_G99_G0.7041.00
81_A114_V0.7031.00
64_E68_Y0.6981.00
98_T128_V0.6931.00
63_N66_G0.6821.00
44_E47_I0.6781.00
77_S83_S0.6731.00
23_L127_L0.6721.00
64_E67_D0.6681.00
23_L26_K0.6671.00
81_A85_L0.6621.00
32_L72_Q0.6601.00
100_S110_I0.6571.00
69_K72_Q0.6521.00
32_L61_V0.6511.00
45_Q49_Q0.6431.00
46_V49_Q0.6421.00
46_V50_S0.6301.00
7_Y13_A0.6291.00
21_L64_E0.6161.00
3_V97_V0.6151.00
89_N124_V0.6131.00
97_V129_V0.6131.00
36_V54_A0.6131.00
8_D13_A0.6121.00
56_Q59_D0.6101.00
35_I78_N0.6071.00
12_H15_K0.6051.00
34_T57_M0.6031.00
63_N67_D0.6021.00
118_L126_V0.6021.00
101_R115_S0.6021.00
81_A118_L0.6011.00
29_E94_G0.6011.00
11_D14_K0.6011.00
29_E69_K0.5981.00
119_V126_V0.5951.00
3_V24_I0.5931.00
54_A75_L0.5811.00
5_I16_A0.5791.00
56_Q60_E0.5791.00
33_V83_S0.5751.00
9_G61_V0.5731.00
99_G129_V0.5701.00
14_K61_V0.5681.00
22_N25_K0.5681.00
25_K28_D0.5661.00
9_G57_M0.5661.00
82_D86_Q0.5621.00
51_E54_A0.5601.00
23_L97_V0.5461.00
48_I51_E0.5431.00
85_L117_A0.5401.00
47_I77_S0.5241.00
31_H71_V0.5181.00
58_Q62_V0.5131.00
111_L119_V0.5121.00
14_K57_M0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2gm3A 2 0.8923 99.9 0.19 Contact Map
2dumA 2 0.9923 99.8 0.204 Contact Map
3s3tA 4 1 99.8 0.205 Contact Map
5ahwA 4 1 99.8 0.206 Contact Map
4wnyA 2 0.8846 99.8 0.208 Contact Map
1mjhA 2 0.9923 99.8 0.209 Contact Map
3hgmA 2 0.9923 99.8 0.211 Contact Map
3dloA 2 0.9692 99.8 0.221 Contact Map
3loqA 1 0.9846 99.8 0.23 Contact Map
1tq8A 4 0.9 99.8 0.236 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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