GREMLIN Database
Q97U39 - Uncharacterized protein
UniProt: Q97U39 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 407 (358)
Sequences: 25079 (16948)
Seq/√Len: 895.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
256_I268_V4.6891.00
82_T274_G4.6891.00
318_I322_R3.5461.00
259_K268_V3.4151.00
161_K164_E2.9871.00
159_T165_N2.8371.00
164_E168_K2.7871.00
256_I259_K2.7641.00
261_N267_L2.7621.00
32_A247_L2.6941.00
248_A258_T2.6861.00
75_G278_A2.5551.00
15_Y250_E2.4661.00
115_S187_A2.4161.00
208_V211_I2.3321.00
333_I337_A2.3261.00
86_F267_L2.2751.00
83_L87_T2.2421.00
329_G332_V2.1931.00
245_F249_R2.1661.00
158_E242_R2.1421.00
168_K172_L2.1361.00
79_A278_A2.1351.00
82_T270_T2.1321.00
341_N344_G2.0811.00
334_P338_T2.0721.00
74_I281_T2.0701.00
75_G281_T2.0671.00
216_I220_I2.0481.00
19_Y28_A2.0481.00
19_Y24_S2.0131.00
22_W318_I2.0011.00
271_A275_I1.9841.00
90_K94_G1.9791.00
102_T106_A1.9731.00
3_M320_Y1.9701.00
329_G333_I1.9451.00
369_S373_L1.9391.00
22_W314_F1.9381.00
79_A274_G1.9311.00
157_E249_R1.9211.00
368_V372_V1.9091.00
36_L273_I1.9021.00
208_V212_Q1.9011.00
330_N333_I1.8941.00
257_F272_V1.8861.00
121_H124_Y1.8631.00
161_K165_N1.8581.00
211_I218_L1.8451.00
330_N337_A1.8181.00
18_N31_E1.7861.00
367_V370_W1.7371.00
370_W374_K1.7361.00
251_N255_K1.7311.00
106_A110_S1.7281.00
318_I321_W1.7061.00
86_F271_A1.6471.00
263_S267_L1.6461.00
240_A273_I1.6311.00
85_S234_I1.6231.00
31_E311_L1.6221.00
155_L238_I1.6191.00
78_I277_T1.6111.00
361_T365_S1.5971.00
112_F183_L1.5811.00
33_L367_V1.5731.00
259_K267_L1.5731.00
261_N265_E1.5661.00
171_W175_I1.5651.00
82_T271_A1.5631.00
334_P337_A1.5601.00
344_G347_Q1.5571.00
87_T263_S1.5541.00
245_F260_V1.5531.00
120_I123_D1.5381.00
337_A340_I1.5331.00
244_L269_A1.5261.00
255_K258_T1.5171.00
22_W27_L1.5141.00
337_A341_N1.5101.00
335_L339_I1.4991.00
349_I352_M1.4941.00
346_A350_L1.4911.00
23_R27_L1.4831.00
363_F367_V1.4661.00
107_L224_L1.4641.00
329_G334_P1.4611.00
310_I338_T1.4561.00
165_N168_K1.4541.00
43_N277_T1.4491.00
330_N334_P1.4281.00
18_N311_L1.4231.00
219_Y223_T1.4181.00
175_I179_V1.4151.00
116_L187_A1.4141.00
8_L20_G1.4121.00
359_M362_V1.4041.00
332_V336_I1.3911.00
342_S346_A1.3891.00
120_I124_Y1.3891.00
338_T342_S1.3791.00
211_I215_I1.3771.00
21_A315_G1.3711.00
81_P233_N1.3701.00
241_A270_T1.3661.00
78_I274_G1.3531.00
198_G212_Q1.3471.00
161_K168_K1.3421.00
47_V233_N1.3371.00
314_F318_I1.3271.00
66_P69_V1.3261.00
115_S191_L1.3211.00
193_P197_S1.3181.00
47_V78_I1.3151.00
338_T341_N1.3021.00
362_V365_S1.2941.00
249_R258_T1.2871.00
268_V272_V1.2741.00
179_V183_L1.2721.00
198_G201_N1.2611.00
111_L115_S1.2551.00
344_G348_S1.2461.00
10_S16_N1.2441.00
196_I199_L1.2401.00
197_S200_A1.2391.00
82_T86_F1.2321.00
268_V271_A1.2281.00
16_N20_G1.2281.00
193_P198_G1.2181.00
334_P340_I1.2141.00
36_L244_L1.2131.00
160_K165_N1.2061.00
162_P167_S1.2051.00
202_S205_P1.2031.00
255_K259_K1.1991.00
54_L73_V1.1981.00
330_N336_I1.1901.00
75_G79_A1.1841.00
358_L362_V1.1821.00
313_G340_I1.1751.00
122_F127_P1.1731.00
69_V72_F1.1691.00
94_G98_T1.1671.00
345_D348_S1.1661.00
71_Y75_G1.1551.00
341_N345_D1.1531.00
11_A157_E1.1471.00
362_V366_I1.1451.00
340_I344_G1.1431.00
186_Y190_V1.1421.00
18_N27_L1.1381.00
96_V234_I1.1261.00
50_V77_S1.1221.00
10_S20_G1.1211.00
332_V335_L1.1141.00
345_D349_I1.1051.00
121_H127_P1.1011.00
105_A109_I1.0971.00
68_Y72_F1.0961.00
80_Y230_L1.0781.00
51_Y54_L1.0761.00
89_V238_I1.0751.00
371_Y375_A1.0691.00
128_K131_N1.0691.00
355_V358_L1.0681.00
125_F128_K1.0671.00
95_Y99_I1.0621.00
121_H126_V1.0621.00
358_L361_T1.0601.00
372_V376_R1.0551.00
348_S351_Q1.0541.00
329_G338_T1.0541.00
348_S352_M1.0451.00
99_I231_A1.0431.00
197_S201_N1.0411.00
374_K377_K1.0391.00
137_T141_L1.0361.00
366_I370_W1.0301.00
202_S208_V1.0261.00
244_L253_A1.0251.00
50_V226_I1.0231.00
94_G97_V1.0221.00
330_N340_I1.0201.00
110_S114_L1.0191.00
331_V334_P1.0161.00
54_L58_S1.0061.00
365_S369_S1.0051.00
204_Q208_V1.0041.00
339_I343_W1.0031.00
275_I279_I1.0011.00
147_S305_W1.0001.00
121_H125_F0.9961.00
343_W347_Q0.9941.00
5_T17_L0.9921.00
193_P212_Q0.9881.00
193_P196_I0.9801.00
46_N232_S0.9791.00
370_W373_L0.9731.00
109_I113_F0.9721.00
62_G65_I0.9631.00
215_I219_Y0.9611.00
132_F135_L0.9581.00
79_A83_L0.9481.00
355_V359_M0.9481.00
50_V53_I0.9481.00
124_Y127_P0.9471.00
49_A53_I0.9461.00
237_T274_G0.9451.00
112_F187_A0.9441.00
127_P131_N0.9401.00
84_I95_Y0.9301.00
328_I334_P0.9281.00
178_G182_F0.9271.00
76_F80_Y0.9261.00
33_L253_A0.9241.00
29_F33_L0.9221.00
347_Q351_Q0.9201.00
260_V264_G0.9161.00
151_A239_G0.9151.00
354_I358_L0.9121.00
44_V47_V0.9101.00
332_V337_A0.9101.00
172_L176_I0.9091.00
123_D127_P0.9091.00
156_G166_I0.9091.00
81_P234_I0.9091.00
274_G278_A0.9041.00
124_Y128_K0.9031.00
19_Y250_E0.9021.00
4_Y316_A0.8991.00
364_A368_V0.8971.00
331_V335_L0.8941.00
333_I336_I0.8921.00
12_G15_Y0.8851.00
257_F268_V0.8801.00
22_W315_G0.8781.00
357_L361_T0.8771.00
349_I353_D0.8751.00
176_I180_S0.8751.00
132_F136_A0.8741.00
324_N328_I0.8721.00
214_G217_A0.8681.00
45_V144_V0.8621.00
27_L311_L0.8621.00
310_I314_F0.8621.00
191_L209_E0.8611.00
87_T91_K0.8601.00
356_Q364_A0.8591.00
150_G154_Y0.8581.00
333_I340_I0.8521.00
373_L376_R0.8481.00
73_V76_F0.8451.00
267_L271_A0.8451.00
167_S170_M0.8411.00
373_L377_K0.8411.00
321_W331_V0.8391.00
335_L338_T0.8361.00
334_P349_I0.8331.00
131_N134_D0.8311.00
216_I219_Y0.8291.00
112_F184_G0.8261.00
350_L353_D0.8241.00
75_G282_V0.8231.00
346_A349_I0.8211.00
122_F125_F0.8211.00
93_L97_V0.8181.00
347_Q352_M0.8181.00
343_W346_A0.8171.00
18_N315_G0.8091.00
357_L360_I0.8061.00
15_Y246_N0.8001.00
342_S345_D0.7991.00
317_P321_W0.7971.00
303_V360_I0.7961.00
329_G340_I0.7941.00
369_S372_V0.7931.00
12_G16_N0.7891.00
184_G188_M0.7891.00
310_I341_N0.7881.00
51_Y73_V0.7851.00
315_G319_F0.7831.00
340_I343_W0.7811.00
354_I357_L0.7801.00
334_P351_Q0.7801.00
360_I364_A0.7791.00
86_F265_E0.7761.00
11_A245_F0.7761.00
103_A107_L0.7761.00
293_A296_E0.7761.00
248_A257_F0.7741.00
52_T55_S0.7741.00
367_V371_Y0.7731.00
83_L86_F0.7711.00
196_I200_A0.7701.00
348_S353_D0.7641.00
355_V360_I0.7641.00
198_G202_S0.7631.00
366_I369_S0.7601.00
329_G348_S0.7601.00
372_V377_K0.7581.00
53_I56_A0.7551.00
333_I341_N0.7541.00
126_V135_L0.7531.00
71_Y74_I0.7521.00
363_F366_I0.7481.00
362_V369_S0.7471.00
200_A203_N0.7471.00
72_F76_F0.7451.00
241_A269_A0.7451.00
316_A320_Y0.7441.00
122_F126_V0.7441.00
356_Q360_I0.7441.00
314_F338_T0.7431.00
86_F261_N0.7421.00
261_N264_G0.7411.00
329_G352_M0.7391.00
104_E228_S0.7361.00
23_R372_V0.7361.00
275_I278_A0.7361.00
329_G337_A0.7321.00
357_L363_F0.7311.00
253_A257_F0.7291.00
88_H91_K0.7281.00
46_N49_A0.7251.00
166_I170_M0.7251.00
42_L301_E0.7241.00
344_G349_I0.7231.00
242_R245_F0.7211.00
3_M6_K0.7211.00
112_F116_L0.7201.00
184_G206_L0.7181.00
44_V280_I0.7181.00
172_L175_I0.7171.00
300_V304_L0.7171.00
321_W324_N0.7161.00
262_R267_L0.7131.00
333_I344_G0.7091.00
333_I338_T0.7051.00
5_T153_T0.7041.00
347_Q350_L0.7011.00
205_P210_M0.6961.00
51_Y56_A0.6951.00
86_F270_T0.6921.00
123_D126_V0.6921.00
360_I371_Y0.6911.00
77_S233_N0.6901.00
48_I297_V0.6871.00
71_Y281_T0.6861.00
48_I52_T0.6851.00
134_D137_T0.6801.00
78_I281_T0.6781.00
340_I349_I0.6781.00
106_A109_I0.6771.00
337_A352_M0.6711.00
105_A180_S0.6711.00
91_K94_G0.6681.00
329_G336_I0.6671.00
53_I225_S0.6641.00
120_I125_F0.6641.00
347_Q353_D0.6621.00
49_A52_T0.6611.00
121_H128_K0.6611.00
47_V50_V0.6571.00
43_N47_V0.6541.00
161_K167_S0.6541.00
120_I128_K0.6501.00
361_T364_A0.6481.00
85_S270_T0.6451.00
154_Y239_G0.6421.00
43_N46_N0.6421.00
15_Y32_A0.6411.00
295_T298_A0.6401.00
257_F269_A0.6401.00
279_I282_V0.6401.00
52_T56_A0.6391.00
181_M185_T0.6371.00
40_T276_S0.6371.00
198_G208_V0.6361.00
100_S104_E0.6361.00
40_T44_V0.6351.00
21_A319_F0.6351.00
78_I278_A0.6351.00
183_L187_A0.6341.00
39_Y236_T0.6331.00
242_R260_V0.6321.00
7_K326_L0.6301.00
341_N347_Q0.6281.00
42_L45_V0.6281.00
157_E245_F0.6271.00
332_V338_T0.6231.00
337_A344_G0.6231.00
256_I260_V0.6221.00
153_T170_M0.6221.00
158_E260_V0.6211.00
215_I218_L0.6201.00
50_V54_L0.6201.00
147_S309_R0.6191.00
81_P237_T0.6191.00
85_S238_I0.6191.00
207_F211_I0.6181.00
359_M363_F0.6161.00
372_V375_A0.6151.00
122_F128_K0.6141.00
56_A222_L0.6131.00
92_L238_I0.6091.00
147_S150_G0.6081.00
36_L40_T0.6061.00
196_I201_N0.6051.00
15_Y19_Y0.6041.00
334_P348_S0.6031.00
123_D128_K0.6011.00
50_V229_L0.6001.00
337_A348_S0.5991.00
40_T273_I0.5991.00
340_I348_S0.5991.00
210_M217_A0.5981.00
187_A190_V0.5981.00
58_S63_V0.5971.00
341_N349_I0.5971.00
14_Y312_D0.5961.00
45_V298_A0.5961.00
356_Q363_F0.5951.00
304_L308_G0.5951.00
313_G337_A0.5941.00
20_G323_I0.5911.00
356_Q367_V0.5901.00
38_A305_W0.5901.00
360_I367_V0.5901.00
86_F263_S0.5901.00
341_N348_S0.5881.00
244_L272_V0.5871.00
176_I179_V0.5851.00
54_L77_S0.5791.00
111_L210_M0.5781.00
147_S301_E0.5771.00
331_V351_Q0.5761.00
97_V102_T0.5761.00
15_Y28_A0.5761.00
305_W308_G0.5741.00
34_T308_G0.5741.00
70_I73_V0.5741.00
114_L214_G0.5711.00
51_Y55_S0.5701.00
170_M173_A0.5701.00
41_L300_V0.5691.00
133_G136_A0.5691.00
82_T237_T0.5681.00
79_A82_T0.5681.00
27_L30_L0.5681.00
34_T307_L0.5681.00
77_S81_P0.5681.00
333_I352_M0.5671.00
358_L372_V0.5671.00
357_L362_V0.5671.00
357_L371_Y0.5651.00
330_N351_Q0.5631.00
359_M364_A0.5601.00
343_W348_S0.5591.00
330_N338_T0.5581.00
223_T227_N0.5581.00
334_P341_N0.5581.00
44_V297_V0.5581.00
116_L183_L0.5571.00
356_Q359_M0.5571.00
316_A334_P0.5571.00
4_Y319_F0.5551.00
256_I272_V0.5551.00
337_A347_Q0.5531.00
267_L270_T0.5521.00
358_L363_F0.5511.00
237_T273_I0.5511.00
364_A367_V0.5501.00
175_I178_G0.5501.00
4_Y21_A0.5491.00
358_L367_V0.5471.00
360_I370_W0.5451.00
310_I345_D0.5451.00
328_I333_I0.5441.00
5_T166_I0.5441.00
240_A244_L0.5431.00
251_N258_T0.5431.00
278_A281_T0.5421.00
107_L110_S0.5411.00
46_N50_V0.5411.00
68_Y71_Y0.5411.00
21_A318_I0.5401.00
126_V131_N0.5371.00
292_G296_E0.5371.00
14_Y150_G0.5361.00
333_I351_Q0.5361.00
358_L364_A0.5361.00
31_E308_G0.5351.00
220_I224_L0.5351.00
50_V230_L0.5331.00
176_I183_L0.5321.00
370_W377_K0.5321.00
7_K324_N0.5311.00
103_A224_L0.5311.00
91_K95_Y0.5291.00
81_P230_L0.5291.00
355_V362_V0.5291.00
87_T90_K0.5281.00
98_T102_T0.5281.00
72_F75_G0.5271.00
266_P269_A0.5261.00
196_I203_N0.5261.00
80_Y83_L0.5241.00
349_I357_L0.5241.00
323_I326_L0.5231.00
361_T371_Y0.5231.00
204_Q207_F0.5231.00
96_V104_E0.5231.00
159_T169_G0.5221.00
313_G341_N0.5171.00
330_N348_S0.5151.00
337_A345_D0.5151.00
14_Y154_Y0.5151.00
6_K163_H0.5141.00
162_P165_N0.5141.00
137_T140_V0.5131.00
35_E39_Y0.5121.00
233_N236_T0.5111.00
23_R377_K0.5091.00
62_G66_P0.5091.00
7_K319_F0.5081.00
35_E308_G0.5081.00
205_P209_E0.5071.00
359_M371_Y0.5071.00
210_M213_Y0.5071.00
41_L44_V0.5061.00
96_V235_G0.5041.00
241_A273_I0.5031.00
43_N48_I0.5031.00
328_I331_V0.5021.00
237_T241_A0.5011.00
329_G335_L0.5011.00
93_L234_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.8993 100 0.332 Contact Map
4djkA 2 0.8943 100 0.36 Contact Map
3giaA 1 0.9091 100 0.373 Contact Map
2jlnA 1 0.8722 98.6 0.858 Contact Map
3dh4A 3 0.9263 98.1 0.877 Contact Map
2xq2A 2 0.9238 97.9 0.882 Contact Map
4xp4A 1 0.9312 96.5 0.907 Contact Map
2a65A 2 0.8968 96 0.911 Contact Map
4wgvA 2 0.7985 95.7 0.913 Contact Map
4c7rA 3 0.8231 92.1 0.926 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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