Q97U35 - SULSO - GREMLIN Contacts

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Q97U35 - D-3-phosphoglycerate dehydrogenase, putative (SerA-2)

UniProt:	Q97U35	Sequences: MKIISTEKVPDECKNIISVKDENITEEDYKNAEILLTWPGRVNNDLIGKMPNLKVIQTFSAGVDDLDFSIIPSHVKVFSNAGAYSLSVAEHAWALILASAKGVGTKKRTIVYDVSEKTLLILGGGGIGSEVARIGKTAFRNYVIGISRSFKKPEWFDERHGMTMLREKIGEADIIVDTLPLNKQTRGLLSYDLLKDIRRNAIIVNVGRGETVDEEGIYKLLKERQDVRFGTDVFWRKNGKEDFYNTKLWELDNFTGTLHTAGAYGNESIMKRAMLIACLNVKKYIDRGIADNEVRREDYV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	300 (264)
Sequences:	19526 (13342)
Seq/√Len:	821.1

ECOLI - SERA GHRB GHRA PDXB LDHD
BACSU - SERA YOAD TKRA
HALSA - Q9HMR0 Q9HSS1 Q9HPW9
SULSO - Q97U35 Q97ZK1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
190_S	193_L	4.219	1.00
191_Y	219_K	3.095	1.00
213_D	216_G	2.965	1.00
106_K	109_T	2.672	1.00
119_L	135_G	2.653	1.00
222_K	251_L	2.429	1.00
181_L	210_E	2.388	1.00
118_T	142_Y	2.376	1.00
33_E	54_K	2.268	1.00
166_R	196_D	2.249	1.00
118_T	144_I	2.172	1.00
120_L	168_K	2.141	1.00
199_R	225_Q	2.133	1.00
169_I	193_L	2.130	1.00
124_G	145_G	2.029	1.00
170_G	196_D	1.982	1.00
187_G	235_W	1.981	1.00
144_I	171_E	1.979	1.00
164_M	167_E	1.943	1.00
93_W	135_G	1.905	1.00
44_N	73_S	1.875	1.00
283_K	288_G	1.867	1.00
102_G	105_T	1.849	1.00
195_K	225_Q	1.819	1.00
120_L	172_A	1.816	1.00
100_A	174_I	1.814	1.00
219_K	223_E	1.783	1.00
55_V	78_F	1.776	1.00
130_E	133_R	1.776	1.00
94_A	103_V	1.762	1.00
189_L	194_L	1.750	1.00
44_N	48_G	1.717	1.00
187_G	213_D	1.716	1.00
201_A	226_D	1.706	1.00
202_I	228_R	1.682	1.00
222_K	247_K	1.675	1.00
203_I	212_V	1.669	1.00
96_I	174_I	1.664	1.00
218_Y	251_L	1.661	1.00
166_R	193_L	1.650	1.00
93_W	139_F	1.646	1.00
31_N	52_N	1.644	1.00
191_Y	195_K	1.605	1.00
95_L	230_G	1.586	1.00
121_I	128_G	1.586	1.00
251_L	254_F	1.580	1.00
194_L	220_L	1.570	1.00
76_K	293_E	1.568	1.00
98_A	104_G	1.561	1.00
173_D	198_R	1.559	1.00
91_H	261_A	1.545	1.00
22_E	45_D	1.543	1.00
167_E	171_E	1.543	1.00
183_K	186_R	1.525	1.00
119_L	141_N	1.523	1.00
70_I	73_S	1.515	1.00
48_G	74_H	1.505	1.00
112_Y	117_K	1.489	1.00
214_E	235_W	1.480	1.00
189_L	193_L	1.479	1.00
217_I	229_F	1.474	1.00
117_K	268_S	1.457	1.00
181_L	186_R	1.450	1.00
192_D	196_D	1.439	1.00
135_G	141_N	1.427	1.00
22_E	43_N	1.422	1.00
21_D	24_I	1.422	1.00
197_I	201_A	1.421	1.00
131_V	178_T	1.416	1.00
90_E	134_I	1.410	1.00
282_K	286_D	1.407	1.00
86_L	115_S	1.403	1.00
169_I	189_L	1.401	1.00
218_Y	222_K	1.399	1.00
142_Y	161_G	1.396	1.00
113_D	272_R	1.388	1.00
99_S	228_R	1.380	1.00
177_D	211_T	1.375	1.00
191_Y	216_G	1.375	1.00
29_Y	50_M	1.372	1.00
202_I	227_V	1.365	1.00
71_I	77_V	1.344	1.00
193_L	196_D	1.338	1.00
130_E	134_I	1.333	1.00
92_A	131_V	1.327	1.00
178_T	206_V	1.315	1.00
283_K	291_D	1.313	1.00
121_I	176_V	1.308	1.00
186_R	210_E	1.299	1.00
142_Y	171_E	1.288	1.00
47_I	74_H	1.281	1.00
207_G	211_T	1.272	1.00
26_E	49_K	1.261	1.00
34_I	55_V	1.257	1.00
86_L	130_E	1.257	1.00
179_L	211_T	1.236	1.00
121_I	132_A	1.229	1.00
177_D	203_I	1.223	1.00
234_F	256_G	1.213	1.00
279_L	283_K	1.211	1.00
168_K	172_A	1.206	1.00
275_L	279_L	1.198	1.00
91_H	95_L	1.187	1.00
44_N	70_I	1.184	1.00
92_A	206_V	1.182	1.00
43_N	46_L	1.174	1.00
70_I	74_H	1.165	1.00
99_S	202_I	1.161	1.00
84_Y	262_G	1.149	1.00
284_Y	290_A	1.143	1.00
122_L	179_L	1.143	1.00
144_I	163_T	1.140	1.00
166_R	192_D	1.139	1.00
33_E	52_N	1.136	1.00
97_L	139_F	1.130	1.00
133_R	140_R	1.129	1.00
131_V	176_V	1.127	1.00
69_S	73_S	1.120	1.00
124_G	129_S	1.113	1.00
99_S	230_G	1.105	1.00
122_L	188_L	1.104	1.00
89_A	134_I	1.099	1.00
55_V	284_Y	1.098	1.00
279_L	291_D	1.095	1.00
192_D	195_K	1.094	1.00
176_V	206_V	1.094	1.00
122_L	189_L	1.093	1.00
144_I	172_A	1.082	1.00
86_L	134_I	1.082	1.00
58_T	66_L	1.076	1.00
198_R	201_A	1.075	1.00
276_I	292_N	1.075	1.00
94_A	97_L	1.073	1.00
188_L	211_T	1.071	1.00
99_S	255_T	1.066	1.00
66_L	71_I	1.066	1.00
47_I	71_I	1.065	1.00
118_T	171_E	1.059	1.00
215_E	247_K	1.058	1.00
175_I	197_I	1.051	1.00
200_N	225_Q	1.040	1.00
174_I	202_I	1.040	1.00
214_E	236_R	1.039	1.00
57_Q	280_N	1.038	1.00
165_L	193_L	1.029	1.00
194_L	203_I	1.028	1.00
91_H	257_T	1.016	1.00
96_I	119_L	1.013	1.00
69_S	72_P	1.009	1.00
161_G	171_E	1.008	1.00
48_G	70_I	1.007	1.00
147_S	151_K	1.005	1.00
91_H	230_G	0.991	1.00
122_L	175_I	0.990	1.00
221_L	254_F	0.978	1.00
190_S	216_G	0.973	1.00
57_Q	277_A	0.972	1.00
163_T	167_E	0.971	1.00
218_Y	247_K	0.969	1.00
222_K	250_E	0.968	1.00
239_G	246_T	0.968	1.00
122_L	165_L	0.967	1.00
96_I	135_G	0.966	1.00
236_R	240_K	0.965	1.00
214_E	246_T	0.964	1.00
148_R	184_Q	0.956	1.00
220_L	225_Q	0.947	1.00
76_K	290_A	0.944	1.00
220_L	226_D	0.936	1.00
271_K	275_L	0.936	1.00
165_L	169_I	0.931	1.00
133_R	136_K	0.928	1.00
58_T	65_D	0.923	1.00
34_I	281_V	0.920	1.00
22_E	26_E	0.913	1.00
68_F	72_P	0.911	1.00
24_I	27_E	0.910	1.00
95_L	255_T	0.908	1.00
180_P	185_T	0.904	1.00
190_S	213_D	0.903	1.00
66_L	77_V	0.902	1.00
93_W	134_I	0.893	1.00
131_V	135_G	0.888	1.00
100_A	112_Y	0.887	1.00
189_L	203_I	0.882	1.00
27_E	30_K	0.878	1.00
100_A	117_K	0.878	1.00
98_A	103_V	0.872	1.00
172_A	175_I	0.871	1.00
145_G	160_H	0.868	1.00
179_L	188_L	0.867	1.00
26_E	46_L	0.863	1.00
87_S	113_D	0.861	1.00
129_S	151_K	0.860	1.00
67_D	70_I	0.857	1.00
122_L	177_D	0.852	1.00
57_Q	78_F	0.845	1.00
113_D	264_Y	0.844	1.00
177_D	189_L	0.839	1.00
34_I	285_I	0.837	1.00
194_L	225_Q	0.836	1.00
121_I	131_V	0.829	1.00
60_S	65_D	0.826	1.00
119_L	176_V	0.823	1.00
115_S	140_R	0.821	1.00
136_K	159_R	0.819	1.00
280_N	283_K	0.819	1.00
98_A	255_T	0.813	1.00
24_I	28_D	0.813	1.00
212_V	217_I	0.811	1.00
88_V	261_A	0.810	1.00
114_V	141_N	0.809	1.00
200_N	227_V	0.807	1.00
100_A	202_I	0.807	1.00
132_A	143_V	0.802	1.00
29_Y	35_L	0.802	1.00
194_L	197_I	0.801	1.00
112_Y	268_S	0.792	1.00
124_G	132_A	0.788	1.00
56_I	71_I	0.788	1.00
85_S	130_E	0.782	1.00
152_K	156_F	0.780	1.00
86_L	90_E	0.780	1.00
219_K	222_K	0.780	1.00
93_W	131_V	0.779	1.00
55_V	281_V	0.779	1.00
45_D	48_G	0.778	1.00
47_I	56_I	0.774	1.00
169_I	175_I	0.772	1.00
214_E	248_L	0.768	1.00
175_I	201_A	0.767	1.00
30_K	49_K	0.767	1.00
163_T	168_K	0.760	1.00
181_L	185_T	0.759	1.00
236_R	239_G	0.759	1.00
215_E	219_K	0.759	1.00
228_R	255_T	0.751	1.00
217_I	226_D	0.751	1.00
112_Y	267_E	0.748	1.00
35_L	42_V	0.746	1.00
94_A	98_A	0.745	1.00
36_L	277_A	0.745	1.00
166_R	170_G	0.743	1.00
85_S	126_G	0.743	1.00
195_K	223_E	0.741	1.00
92_A	178_T	0.736	1.00
231_T	254_F	0.735	1.00
153_P	157_D	0.729	1.00
169_I	196_D	0.728	1.00
100_A	104_G	0.727	1.00
234_F	239_G	0.724	1.00
215_E	235_W	0.722	1.00
145_G	162_M	0.719	1.00
90_E	101_K	0.719	1.00
167_E	170_G	0.716	1.00
221_L	253_N	0.714	1.00
86_L	113_D	0.713	1.00
92_A	176_V	0.711	1.00
87_S	269_I	0.709	1.00
272_R	275_L	0.708	1.00
118_T	172_A	0.705	1.00
93_W	96_I	0.702	1.00
229_F	254_F	0.702	1.00
249_W	256_G	0.699	1.00
82_G	126_G	0.699	1.00
191_Y	225_Q	0.696	1.00
96_I	131_V	0.691	1.00
44_N	74_H	0.689	1.00
141_N	174_I	0.688	1.00
278_C	282_K	0.686	1.00
134_I	139_F	0.685	1.00
146_I	165_L	0.680	1.00
147_S	150_F	0.676	1.00
63_V	68_F	0.676	1.00
175_I	198_R	0.675	1.00
202_I	230_G	0.675	1.00
58_T	63_V	0.674	1.00
150_F	162_M	0.672	1.00
80_N	276_I	0.671	1.00
112_Y	200_N	0.670	1.00
200_N	226_D	0.668	1.00
177_D	207_G	0.666	1.00
165_L	188_L	0.665	1.00
115_S	272_R	0.662	1.00
82_G	276_I	0.661	1.00
96_I	114_V	0.658	1.00
44_N	67_D	0.655	1.00
87_S	90_E	0.655	1.00
117_K	174_I	0.652	1.00
179_L	207_G	0.652	1.00
92_A	95_L	0.652	1.00
89_A	130_E	0.651	1.00
51_P	74_H	0.651	1.00
57_Q	281_V	0.647	1.00
212_V	229_F	0.647	1.00
169_I	197_I	0.646	1.00
217_I	231_T	0.640	1.00
283_K	289_I	0.640	1.00
23_N	27_E	0.639	1.00
129_S	133_R	0.638	1.00
219_K	225_Q	0.634	1.00
240_K	246_T	0.633	1.00
289_I	293_E	0.631	1.00
37_T	42_V	0.629	1.00
54_K	284_Y	0.628	1.00
279_L	282_K	0.627	1.00
163_T	171_E	0.627	1.00
221_L	229_F	0.626	1.00
230_G	255_T	0.624	1.00
63_V	79_S	0.623	1.00
182_N	185_T	0.621	1.00
186_R	235_W	0.620	1.00
118_T	198_R	0.617	1.00
118_T	173_D	0.617	1.00
283_K	290_A	0.617	1.00
155_W	158_E	0.615	1.00
120_L	146_I	0.614	1.00
187_G	210_E	0.611	1.00
83_A	262_G	0.610	1.00
191_Y	223_E	0.608	1.00
57_Q	80_N	0.608	1.00
26_E	50_M	0.607	1.00
246_T	250_E	0.605	1.00
87_S	264_Y	0.602	1.00
30_K	51_P	0.601	1.00
95_L	98_A	0.601	1.00
50_M	53_L	0.600	1.00
96_I	204_V	0.598	1.00
119_L	131_V	0.597	1.00
96_I	176_V	0.597	1.00
64_D	181_L	0.595	1.00
31_N	51_P	0.589	1.00
34_I	57_Q	0.588	1.00
59_F	273_A	0.588	1.00
267_E	271_K	0.587	1.00
45_D	49_K	0.586	1.00
83_A	273_A	0.583	1.00
91_H	94_A	0.583	1.00
222_K	252_D	0.583	1.00
42_V	47_I	0.582	1.00
210_E	235_W	0.578	1.00
91_H	101_K	0.576	1.00
28_D	32_A	0.575	1.00
136_K	143_V	0.575	1.00
214_E	218_Y	0.575	1.00
100_A	141_N	0.575	1.00
153_P	156_F	0.574	1.00
82_G	85_S	0.573	1.00
117_K	141_N	0.573	1.00
80_N	273_A	0.572	1.00
263_A	270_M	0.569	1.00
26_E	45_D	0.568	1.00
187_G	190_S	0.567	1.00
191_Y	220_L	0.564	1.00
134_I	138_A	0.563	1.00
290_A	293_E	0.563	1.00
76_K	79_S	0.563	1.00
95_L	99_S	0.562	1.00
88_V	92_A	0.559	1.00
239_G	249_W	0.559	1.00
114_V	139_F	0.559	1.00
86_L	140_R	0.557	1.00
104_G	255_T	0.556	1.00
179_L	185_T	0.556	1.00
144_I	162_M	0.554	1.00
247_K	251_L	0.553	1.00
100_A	114_V	0.551	1.00
144_I	168_K	0.549	1.00
275_L	278_C	0.543	1.00
148_R	151_K	0.542	1.00
80_N	83_A	0.539	1.00
220_L	223_E	0.538	1.00
200_N	223_E	0.537	1.00
84_Y	87_S	0.536	1.00
215_E	246_T	0.535	1.00
47_I	75_V	0.531	1.00
37_T	58_T	0.531	1.00
78_F	280_N	0.531	1.00
133_R	138_A	0.531	1.00
208_R	259_H	0.527	1.00
175_I	189_L	0.526	1.00
218_Y	254_F	0.522	1.00
34_I	37_T	0.522	1.00
132_A	145_G	0.520	1.00
277_A	280_N	0.518	1.00
117_K	173_D	0.516	1.00
83_A	276_I	0.514	1.00
124_G	147_S	0.513	1.00
122_L	168_K	0.509	1.00
276_I	280_N	0.508	1.00
169_I	188_L	0.507	1.00
246_T	249_W	0.507	1.00
138_A	141_N	0.505	1.00
257_T	260_T	0.503	1.00
199_R	220_L	0.501	1.00
55_V	76_K	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2j6iA	2	0.9733	100	0.243	Contact Map
3hg7A	2	0.96	100	0.244	Contact Map
4g2nA	3	0.9567	100	0.245	Contact Map
2g76A	2	0.9233	100	0.246	Contact Map
3jtmA	2	0.9733	100	0.247	Contact Map
1sc6A	4	0.9467	100	0.248	Contact Map
1mx3A	3	0.96	100	0.249	Contact Map
3ba1A	2	0.95	100	0.25	Contact Map
1dxyA	5	0.9633	100	0.251	Contact Map
4hy3A	3	0.96	100	0.251	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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