GREMLIN Database
Q97U35 - D-3-phosphoglycerate dehydrogenase, putative (SerA-2)
UniProt: Q97U35 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 300 (264)
Sequences: 19526 (13342)
Seq/√Len: 821.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
190_S193_L4.2191.00
191_Y219_K3.0951.00
213_D216_G2.9651.00
106_K109_T2.6721.00
119_L135_G2.6531.00
222_K251_L2.4291.00
181_L210_E2.3881.00
118_T142_Y2.3761.00
33_E54_K2.2681.00
166_R196_D2.2491.00
118_T144_I2.1721.00
120_L168_K2.1411.00
199_R225_Q2.1331.00
169_I193_L2.1301.00
124_G145_G2.0291.00
170_G196_D1.9821.00
187_G235_W1.9811.00
144_I171_E1.9791.00
164_M167_E1.9431.00
93_W135_G1.9051.00
44_N73_S1.8751.00
283_K288_G1.8671.00
102_G105_T1.8491.00
195_K225_Q1.8191.00
120_L172_A1.8161.00
100_A174_I1.8141.00
219_K223_E1.7831.00
55_V78_F1.7761.00
130_E133_R1.7761.00
94_A103_V1.7621.00
189_L194_L1.7501.00
44_N48_G1.7171.00
187_G213_D1.7161.00
201_A226_D1.7061.00
202_I228_R1.6821.00
222_K247_K1.6751.00
203_I212_V1.6691.00
96_I174_I1.6641.00
218_Y251_L1.6611.00
166_R193_L1.6501.00
93_W139_F1.6461.00
31_N52_N1.6441.00
191_Y195_K1.6051.00
95_L230_G1.5861.00
121_I128_G1.5861.00
251_L254_F1.5801.00
194_L220_L1.5701.00
76_K293_E1.5681.00
98_A104_G1.5611.00
173_D198_R1.5591.00
91_H261_A1.5451.00
22_E45_D1.5431.00
167_E171_E1.5431.00
183_K186_R1.5251.00
119_L141_N1.5231.00
70_I73_S1.5151.00
48_G74_H1.5051.00
112_Y117_K1.4891.00
214_E235_W1.4801.00
189_L193_L1.4791.00
217_I229_F1.4741.00
117_K268_S1.4571.00
181_L186_R1.4501.00
192_D196_D1.4391.00
135_G141_N1.4271.00
22_E43_N1.4221.00
21_D24_I1.4221.00
197_I201_A1.4211.00
131_V178_T1.4161.00
90_E134_I1.4101.00
282_K286_D1.4071.00
86_L115_S1.4031.00
169_I189_L1.4011.00
218_Y222_K1.3991.00
142_Y161_G1.3961.00
113_D272_R1.3881.00
99_S228_R1.3801.00
177_D211_T1.3751.00
191_Y216_G1.3751.00
29_Y50_M1.3721.00
202_I227_V1.3651.00
71_I77_V1.3441.00
193_L196_D1.3381.00
130_E134_I1.3331.00
92_A131_V1.3271.00
178_T206_V1.3151.00
283_K291_D1.3131.00
121_I176_V1.3081.00
186_R210_E1.2991.00
142_Y171_E1.2881.00
47_I74_H1.2811.00
207_G211_T1.2721.00
26_E49_K1.2611.00
34_I55_V1.2571.00
86_L130_E1.2571.00
179_L211_T1.2361.00
121_I132_A1.2291.00
177_D203_I1.2231.00
234_F256_G1.2131.00
279_L283_K1.2111.00
168_K172_A1.2061.00
275_L279_L1.1981.00
91_H95_L1.1871.00
44_N70_I1.1841.00
92_A206_V1.1821.00
43_N46_L1.1741.00
70_I74_H1.1651.00
99_S202_I1.1611.00
84_Y262_G1.1491.00
284_Y290_A1.1431.00
122_L179_L1.1431.00
144_I163_T1.1401.00
166_R192_D1.1391.00
33_E52_N1.1361.00
97_L139_F1.1301.00
133_R140_R1.1291.00
131_V176_V1.1271.00
69_S73_S1.1201.00
124_G129_S1.1131.00
99_S230_G1.1051.00
122_L188_L1.1041.00
89_A134_I1.0991.00
55_V284_Y1.0981.00
279_L291_D1.0951.00
192_D195_K1.0941.00
176_V206_V1.0941.00
122_L189_L1.0931.00
144_I172_A1.0821.00
86_L134_I1.0821.00
58_T66_L1.0761.00
198_R201_A1.0751.00
276_I292_N1.0751.00
94_A97_L1.0731.00
188_L211_T1.0711.00
99_S255_T1.0661.00
66_L71_I1.0661.00
47_I71_I1.0651.00
118_T171_E1.0591.00
215_E247_K1.0581.00
175_I197_I1.0511.00
200_N225_Q1.0401.00
174_I202_I1.0401.00
214_E236_R1.0391.00
57_Q280_N1.0381.00
165_L193_L1.0291.00
194_L203_I1.0281.00
91_H257_T1.0161.00
96_I119_L1.0131.00
69_S72_P1.0091.00
161_G171_E1.0081.00
48_G70_I1.0071.00
147_S151_K1.0051.00
91_H230_G0.9911.00
122_L175_I0.9901.00
221_L254_F0.9781.00
190_S216_G0.9731.00
57_Q277_A0.9721.00
163_T167_E0.9711.00
218_Y247_K0.9691.00
222_K250_E0.9681.00
239_G246_T0.9681.00
122_L165_L0.9671.00
96_I135_G0.9661.00
236_R240_K0.9651.00
214_E246_T0.9641.00
148_R184_Q0.9561.00
220_L225_Q0.9471.00
76_K290_A0.9441.00
220_L226_D0.9361.00
271_K275_L0.9361.00
165_L169_I0.9311.00
133_R136_K0.9281.00
58_T65_D0.9231.00
34_I281_V0.9201.00
22_E26_E0.9131.00
68_F72_P0.9111.00
24_I27_E0.9101.00
95_L255_T0.9081.00
180_P185_T0.9041.00
190_S213_D0.9031.00
66_L77_V0.9021.00
93_W134_I0.8931.00
131_V135_G0.8881.00
100_A112_Y0.8871.00
189_L203_I0.8821.00
27_E30_K0.8781.00
100_A117_K0.8781.00
98_A103_V0.8721.00
172_A175_I0.8711.00
145_G160_H0.8681.00
179_L188_L0.8671.00
26_E46_L0.8631.00
87_S113_D0.8611.00
129_S151_K0.8601.00
67_D70_I0.8571.00
122_L177_D0.8521.00
57_Q78_F0.8451.00
113_D264_Y0.8441.00
177_D189_L0.8391.00
34_I285_I0.8371.00
194_L225_Q0.8361.00
121_I131_V0.8291.00
60_S65_D0.8261.00
119_L176_V0.8231.00
115_S140_R0.8211.00
136_K159_R0.8191.00
280_N283_K0.8191.00
98_A255_T0.8131.00
24_I28_D0.8131.00
212_V217_I0.8111.00
88_V261_A0.8101.00
114_V141_N0.8091.00
200_N227_V0.8071.00
100_A202_I0.8071.00
132_A143_V0.8021.00
29_Y35_L0.8021.00
194_L197_I0.8011.00
112_Y268_S0.7921.00
124_G132_A0.7881.00
56_I71_I0.7881.00
85_S130_E0.7821.00
152_K156_F0.7801.00
86_L90_E0.7801.00
219_K222_K0.7801.00
93_W131_V0.7791.00
55_V281_V0.7791.00
45_D48_G0.7781.00
47_I56_I0.7741.00
169_I175_I0.7721.00
214_E248_L0.7681.00
175_I201_A0.7671.00
30_K49_K0.7671.00
163_T168_K0.7601.00
181_L185_T0.7591.00
236_R239_G0.7591.00
215_E219_K0.7591.00
228_R255_T0.7511.00
217_I226_D0.7511.00
112_Y267_E0.7481.00
35_L42_V0.7461.00
94_A98_A0.7451.00
36_L277_A0.7451.00
166_R170_G0.7431.00
85_S126_G0.7431.00
195_K223_E0.7411.00
92_A178_T0.7361.00
231_T254_F0.7351.00
153_P157_D0.7291.00
169_I196_D0.7281.00
100_A104_G0.7271.00
234_F239_G0.7241.00
215_E235_W0.7221.00
145_G162_M0.7191.00
90_E101_K0.7191.00
167_E170_G0.7161.00
221_L253_N0.7141.00
86_L113_D0.7131.00
92_A176_V0.7111.00
87_S269_I0.7091.00
272_R275_L0.7081.00
118_T172_A0.7051.00
93_W96_I0.7021.00
229_F254_F0.7021.00
249_W256_G0.6991.00
82_G126_G0.6991.00
191_Y225_Q0.6961.00
96_I131_V0.6911.00
44_N74_H0.6891.00
141_N174_I0.6881.00
278_C282_K0.6861.00
134_I139_F0.6851.00
146_I165_L0.6801.00
147_S150_F0.6761.00
63_V68_F0.6761.00
175_I198_R0.6751.00
202_I230_G0.6751.00
58_T63_V0.6741.00
150_F162_M0.6721.00
80_N276_I0.6711.00
112_Y200_N0.6701.00
200_N226_D0.6681.00
177_D207_G0.6661.00
165_L188_L0.6651.00
115_S272_R0.6621.00
82_G276_I0.6611.00
96_I114_V0.6581.00
44_N67_D0.6551.00
87_S90_E0.6551.00
117_K174_I0.6521.00
179_L207_G0.6521.00
92_A95_L0.6521.00
89_A130_E0.6511.00
51_P74_H0.6511.00
57_Q281_V0.6471.00
212_V229_F0.6471.00
169_I197_I0.6461.00
217_I231_T0.6401.00
283_K289_I0.6401.00
23_N27_E0.6391.00
129_S133_R0.6381.00
219_K225_Q0.6341.00
240_K246_T0.6331.00
289_I293_E0.6311.00
37_T42_V0.6291.00
54_K284_Y0.6281.00
279_L282_K0.6271.00
163_T171_E0.6271.00
221_L229_F0.6261.00
230_G255_T0.6241.00
63_V79_S0.6231.00
182_N185_T0.6211.00
186_R235_W0.6201.00
118_T198_R0.6171.00
118_T173_D0.6171.00
283_K290_A0.6171.00
155_W158_E0.6151.00
120_L146_I0.6141.00
187_G210_E0.6111.00
83_A262_G0.6101.00
191_Y223_E0.6081.00
57_Q80_N0.6081.00
26_E50_M0.6071.00
246_T250_E0.6051.00
87_S264_Y0.6021.00
30_K51_P0.6011.00
95_L98_A0.6011.00
50_M53_L0.6001.00
96_I204_V0.5981.00
119_L131_V0.5971.00
96_I176_V0.5971.00
64_D181_L0.5951.00
31_N51_P0.5891.00
34_I57_Q0.5881.00
59_F273_A0.5881.00
267_E271_K0.5871.00
45_D49_K0.5861.00
83_A273_A0.5831.00
91_H94_A0.5831.00
222_K252_D0.5831.00
42_V47_I0.5821.00
210_E235_W0.5781.00
91_H101_K0.5761.00
28_D32_A0.5751.00
136_K143_V0.5751.00
214_E218_Y0.5751.00
100_A141_N0.5751.00
153_P156_F0.5741.00
82_G85_S0.5731.00
117_K141_N0.5731.00
80_N273_A0.5721.00
263_A270_M0.5691.00
26_E45_D0.5681.00
187_G190_S0.5671.00
191_Y220_L0.5641.00
134_I138_A0.5631.00
290_A293_E0.5631.00
76_K79_S0.5631.00
95_L99_S0.5621.00
88_V92_A0.5591.00
239_G249_W0.5591.00
114_V139_F0.5591.00
86_L140_R0.5571.00
104_G255_T0.5561.00
179_L185_T0.5561.00
144_I162_M0.5541.00
247_K251_L0.5531.00
100_A114_V0.5511.00
144_I168_K0.5491.00
275_L278_C0.5431.00
148_R151_K0.5421.00
80_N83_A0.5391.00
220_L223_E0.5381.00
200_N223_E0.5371.00
84_Y87_S0.5361.00
215_E246_T0.5351.00
47_I75_V0.5311.00
37_T58_T0.5311.00
78_F280_N0.5311.00
133_R138_A0.5311.00
208_R259_H0.5271.00
175_I189_L0.5261.00
218_Y254_F0.5221.00
34_I37_T0.5221.00
132_A145_G0.5201.00
277_A280_N0.5181.00
117_K173_D0.5161.00
83_A276_I0.5141.00
124_G147_S0.5131.00
122_L168_K0.5091.00
276_I280_N0.5081.00
169_I188_L0.5071.00
246_T249_W0.5071.00
138_A141_N0.5051.00
257_T260_T0.5031.00
199_R220_L0.5011.00
55_V76_K0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2j6iA 2 0.9733 100 0.243 Contact Map
3hg7A 2 0.96 100 0.244 Contact Map
4g2nA 3 0.9567 100 0.245 Contact Map
2g76A 2 0.9233 100 0.246 Contact Map
3jtmA 2 0.9733 100 0.247 Contact Map
1sc6A 4 0.9467 100 0.248 Contact Map
1mx3A 3 0.96 100 0.249 Contact Map
3ba1A 2 0.95 100 0.25 Contact Map
1dxyA 5 0.9633 100 0.251 Contact Map
4hy3A 3 0.96 100 0.251 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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