GREMLIN Database
Q97U33 - Amino acid transporter, putative
UniProt: Q97U33 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 515 (423)
Sequences: 24642 (15922)
Seq/√Len: 774.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
174_I390_L4.4511.00
372_K384_Y4.4181.00
430_A434_K3.5341.00
60_F290_G3.2591.00
375_E384_Y3.1951.00
276_K280_W3.0711.00
20_S273_R3.0361.00
84_Y366_D2.7301.00
272_F277_T2.6751.00
364_S374_S2.6271.00
422_L453_Y2.6191.00
377_N383_V2.6051.00
100_A363_L2.5971.00
206_L299_E2.5601.00
167_A394_L2.5541.00
72_F432_G2.5191.00
372_K375_E2.5061.00
332_I336_I2.4801.00
25_V284_I2.4691.00
21_L284_I2.4551.00
204_I208_L2.4471.00
270_A365_F2.4101.00
361_F365_F2.2001.00
387_V391_S2.1981.00
88_S96_G2.1971.00
450_Y454_L2.1821.00
24_A272_F2.1611.00
21_L277_T2.1571.00
271_E358_R2.1501.00
425_S452_A2.1491.00
174_I386_H2.1361.00
175_L179_F2.1341.00
182_K186_R2.1121.00
171_V394_L2.1021.00
21_L25_V2.0751.00
178_I383_V2.0361.00
88_S93_G2.0351.00
167_A397_L2.0311.00
91_L430_A2.0271.00
367_R371_T2.0151.00
280_W284_I1.9981.00
15_L376_V1.9891.00
166_S397_L1.9771.00
104_M389_D1.9721.00
213_F216_K1.9511.00
69_I425_S1.9481.00
489_L493_I1.9471.00
193_I197_A1.9401.00
20_S23_D1.9341.00
373_F388_F1.9291.00
61_I65_P1.9081.00
283_P287_I1.8811.00
43_S52_L1.8751.00
91_L426_I1.8361.00
87_I99_M1.7981.00
274_G277_T1.7731.00
305_G308_F1.7661.00
23_D189_S1.7581.00
197_A201_L1.7571.00
377_N381_S1.7461.00
481_V485_I1.7441.00
240_S243_S1.7371.00
323_A326_A1.7281.00
483_T487_G1.7271.00
101_L487_G1.7151.00
99_M423_V1.7141.00
177_N350_A1.7091.00
308_F327_V1.6991.00
111_F393_T1.6791.00
171_V390_L1.6681.00
287_I291_I1.6491.00
444_G448_A1.6361.00
379_H383_V1.6321.00
447_S451_F1.6311.00
19_V23_D1.6261.00
430_A433_T1.6251.00
178_I387_V1.6241.00
25_V288_I1.6231.00
440_L443_A1.6191.00
28_N285_A1.6161.00
170_F393_T1.6121.00
92_N95_L1.6101.00
115_A349_L1.6021.00
482_G486_A1.5861.00
122_I165_I1.5791.00
473_N476_T1.5681.00
55_A250_L1.5641.00
454_L458_A1.5441.00
91_L95_L1.5281.00
215_S218_S1.5261.00
384_Y388_F1.5131.00
115_A170_F1.5111.00
118_T169_V1.4891.00
274_G280_W1.4661.00
493_I497_V1.4651.00
213_F217_L1.4641.00
179_F379_H1.4561.00
196_I200_I1.4511.00
371_T375_E1.4511.00
174_I387_V1.4421.00
360_V385_A1.4401.00
16_I380_G1.4391.00
216_K219_T1.4391.00
426_I430_A1.4351.00
198_T340_G1.4351.00
371_T374_S1.4341.00
216_K220_L1.4281.00
170_F390_L1.4261.00
445_I449_A1.4241.00
67_L286_L1.4051.00
335_W339_L1.4031.00
268_V354_I1.4011.00
356_F389_D1.4001.00
62_F455_T1.4001.00
167_A171_V1.3951.00
207_A299_E1.3901.00
458_A462_P1.3891.00
375_E383_V1.3721.00
80_T270_A1.3721.00
361_F376_V1.3721.00
118_T342_I1.3701.00
19_V24_A1.3691.00
23_D185_Y1.3671.00
213_F218_S1.3491.00
314_P320_F1.3451.00
485_I489_L1.3411.00
15_L361_F1.3351.00
87_I423_V1.3311.00
494_S497_V1.3261.00
446_I449_A1.3241.00
357_A386_H1.3221.00
243_S246_A1.3111.00
90_S427_A1.3011.00
326_A334_Q1.2991.00
68_L283_P1.2991.00
59_G254_F1.2981.00
77_I89_R1.2981.00
94_G494_S1.2891.00
21_L280_W1.2841.00
67_L282_L1.2711.00
492_I496_I1.2701.00
277_T280_W1.2671.00
452_A456_Y1.2661.00
53_W298_L1.2651.00
66_Q425_S1.2621.00
488_A492_I1.2611.00
360_V369_L1.2561.00
202_A206_L1.2521.00
217_L220_L1.2491.00
61_I451_F1.2471.00
19_V185_Y1.2411.00
173_I349_L1.2371.00
215_S220_L1.2341.00
85_V89_R1.2321.00
291_I295_L1.2291.00
51_V240_S1.2251.00
29_I288_I1.2241.00
114_V348_I1.2231.00
38_L117_F1.2121.00
51_V247_T1.1981.00
306_Y309_N1.1981.00
490_A494_S1.1951.00
203_M295_L1.1931.00
210_S302_L1.1891.00
453_Y457_V1.1871.00
448_A452_A1.1811.00
176_L187_V1.1791.00
24_A281_N1.1751.00
164_G168_L1.1751.00
217_L221_I1.1751.00
433_T436_R1.1741.00
22_W26_A1.1631.00
31_N289_T1.1611.00
384_Y387_V1.1591.00
28_N265_G1.1591.00
163_Y167_A1.1561.00
214_Y218_S1.1551.00
477_T480_V1.1511.00
218_S221_I1.1491.00
44_P52_L1.1491.00
215_S219_T1.1451.00
215_S221_I1.1391.00
480_V484_F1.1301.00
474_L477_T1.1291.00
426_I453_Y1.1281.00
365_F374_S1.1221.00
70_Y83_D1.1211.00
27_L268_V1.1211.00
311_E314_P1.1201.00
200_I204_I1.1191.00
79_R85_V1.1111.00
429_I450_Y1.1111.00
446_I450_Y1.1081.00
74_T86_W1.1031.00
457_V461_N1.0951.00
323_A327_V1.0931.00
493_I496_I1.0821.00
273_R277_T1.0751.00
187_V191_L1.0751.00
168_L172_V1.0731.00
69_I449_A1.0711.00
18_N273_R1.0691.00
206_L303_I1.0651.00
476_T480_V1.0641.00
97_S101_L1.0631.00
487_G490_A1.0611.00
376_V380_G1.0581.00
84_Y362_A1.0571.00
214_Y220_L1.0521.00
447_S450_Y1.0501.00
188_V350_A1.0471.00
174_I178_I1.0471.00
456_Y459_A1.0461.00
490_A493_I1.0461.00
119_S165_I1.0441.00
326_A331_P1.0421.00
486_A489_L1.0421.00
87_I95_L1.0411.00
391_S395_L1.0351.00
178_I381_S1.0331.00
104_M360_V1.0331.00
445_I448_A1.0311.00
57_L294_T1.0311.00
122_I342_I1.0291.00
201_L205_V1.0271.00
478_I482_G1.0271.00
432_G436_R1.0251.00
89_R435_D1.0231.00
186_R190_V1.0181.00
458_A461_N1.0161.00
474_L478_I1.0041.00
487_G491_Y1.0041.00
213_F220_L1.0011.00
214_Y217_L0.9951.00
72_F75_E0.9891.00
422_L457_V0.9861.00
171_V175_L0.9751.00
260_P417_G0.9691.00
191_L347_Y0.9611.00
79_R89_R0.9591.00
181_A354_I0.9581.00
442_I445_I0.9541.00
60_F259_Y0.9531.00
113_L257_Y0.9501.00
248_L458_A0.9491.00
244_W247_T0.9461.00
422_L426_I0.9361.00
178_I377_N0.9341.00
26_A189_S0.9291.00
172_V346_I0.9291.00
196_I292_L0.9221.00
476_T479_F0.9211.00
65_P451_F0.9201.00
449_A452_A0.9201.00
75_E439_V0.9171.00
122_I126_L0.9141.00
119_S166_S0.9141.00
217_L302_L0.9121.00
29_I289_T0.9091.00
263_Q267_A0.9061.00
18_N182_K0.9061.00
353_V390_L0.9061.00
373_F384_Y0.9031.00
383_V387_V0.9031.00
329_S333_L0.9021.00
459_A463_D0.9011.00
269_A278_V0.8931.00
32_M35_G0.8931.00
88_S366_D0.8911.00
15_L358_R0.8901.00
249_F253_F0.8891.00
173_I350_A0.8881.00
444_G447_S0.8881.00
482_G485_I0.8861.00
298_L302_L0.8851.00
101_L369_L0.8841.00
113_L410_L0.8811.00
290_G294_T0.8791.00
477_T481_V0.8671.00
127_T130_G0.8661.00
377_N380_G0.8661.00
240_S247_T0.8651.00
170_F397_L0.8641.00
443_A446_I0.8641.00
390_L394_L0.8631.00
320_F323_A0.8611.00
331_P335_W0.8611.00
23_D186_R0.8591.00
203_M207_A0.8581.00
369_L373_F0.8571.00
284_I288_I0.8551.00
81_G85_V0.8521.00
57_L61_I0.8491.00
448_A462_P0.8471.00
53_W301_D0.8451.00
449_A453_Y0.8401.00
308_F311_E0.8391.00
54_L58_I0.8381.00
48_Q51_V0.8381.00
15_L271_E0.8371.00
274_G279_K0.8341.00
95_L423_V0.8341.00
203_M299_E0.8311.00
452_A455_T0.8301.00
92_N495_K0.8291.00
94_G98_I0.8281.00
22_W189_S0.8281.00
175_L178_I0.8271.00
264_A355_V0.8271.00
76_K438_Y0.8261.00
486_A490_A0.8221.00
483_T490_A0.8221.00
103_L107_S0.8211.00
325_I330_N0.8211.00
165_I168_L0.8201.00
483_T486_A0.8201.00
119_S162_I0.8131.00
118_T345_N0.8121.00
482_G489_L0.8121.00
491_Y495_K0.8101.00
126_L129_I0.8091.00
87_I427_A0.8061.00
321_W325_I0.8061.00
108_T392_L0.8061.00
76_K436_R0.8051.00
440_L446_I0.8041.00
428_G449_A0.8011.00
475_I479_F0.8001.00
475_I478_I0.7971.00
412_G416_L0.7961.00
65_P69_I0.7961.00
330_N333_L0.7951.00
441_S446_I0.7951.00
64_I68_L0.7931.00
64_I283_P0.7931.00
210_S299_E0.7911.00
173_I353_V0.7871.00
491_Y497_V0.7851.00
186_R189_S0.7781.00
195_S344_W0.7761.00
54_L57_L0.7751.00
459_A462_P0.7691.00
451_F454_L0.7691.00
36_V296_A0.7681.00
50_G301_D0.7661.00
305_G327_V0.7621.00
449_A462_P0.7551.00
94_G488_A0.7541.00
163_Y397_L0.7541.00
320_F325_I0.7531.00
53_W294_T0.7521.00
81_G84_Y0.7521.00
73_L428_G0.7511.00
214_Y219_T0.7491.00
491_Y494_S0.7491.00
353_V357_A0.7471.00
360_V388_F0.7471.00
444_G449_A0.7451.00
260_P421_F0.7421.00
21_L281_N0.7421.00
429_I433_T0.7421.00
279_K282_L0.7411.00
65_P448_A0.7341.00
118_T346_I0.7311.00
54_L247_T0.7311.00
73_L86_W0.7311.00
458_A463_D0.7221.00
456_Y460_T0.7221.00
207_A295_L0.7211.00
322_T326_A0.7191.00
452_A463_D0.7181.00
479_F482_G0.7181.00
18_N181_A0.7181.00
25_V281_N0.7171.00
415_I480_V0.7151.00
473_N477_T0.7141.00
177_N386_H0.7131.00
332_I335_W0.7111.00
179_F183_W0.7091.00
446_I463_D0.7091.00
107_S352_G0.7091.00
481_V484_F0.7071.00
126_L130_G0.7071.00
63_A262_M0.7051.00
449_A456_Y0.7031.00
52_L297_F0.7021.00
278_V282_L0.6991.00
449_A463_D0.6991.00
442_I446_I0.6961.00
22_W186_R0.6961.00
238_L241_S0.6931.00
378_K383_V0.6911.00
205_V330_N0.6901.00
266_P282_L0.6891.00
303_I324_A0.6881.00
372_K388_F0.6861.00
185_Y189_S0.6861.00
80_T361_F0.6851.00
70_Y424_V0.6831.00
442_I449_A0.6821.00
91_L427_A0.6801.00
112_A396_L0.6781.00
284_I287_I0.6751.00
427_A431_F0.6731.00
185_Y350_A0.6711.00
110_Y413_A0.6701.00
178_I386_H0.6691.00
391_S394_L0.6691.00
307_N311_E0.6681.00
178_I379_H0.6681.00
76_K439_V0.6671.00
56_S258_T0.6671.00
433_T446_I0.6661.00
121_A341_L0.6661.00
244_W248_L0.6651.00
478_I481_V0.6641.00
205_V325_I0.6621.00
490_A496_I0.6601.00
116_F409_S0.6601.00
32_M37_A0.6561.00
288_I292_L0.6521.00
425_S453_Y0.6521.00
373_F385_A0.6471.00
102_A420_Y0.6461.00
40_E297_F0.6451.00
429_I449_A0.6431.00
32_M195_S0.6431.00
310_L313_Y0.6421.00
484_F487_G0.6411.00
357_A385_A0.6401.00
295_L299_E0.6401.00
122_I169_V0.6401.00
90_S430_A0.6391.00
306_Y310_L0.6391.00
480_V485_I0.6391.00
325_I328_A0.6381.00
336_I340_G0.6371.00
246_A249_F0.6361.00
33_S293_V0.6341.00
106_E417_G0.6341.00
84_Y88_S0.6341.00
177_N354_I0.6331.00
216_K221_I0.6311.00
183_W186_R0.6311.00
299_E302_L0.6311.00
206_L210_S0.6291.00
67_L262_M0.6291.00
489_L494_S0.6271.00
445_I463_D0.6271.00
173_I346_I0.6261.00
18_N22_W0.6261.00
482_G487_G0.6251.00
119_S122_I0.6251.00
90_S431_F0.6251.00
59_G259_Y0.6241.00
110_Y113_L0.6231.00
167_A398_L0.6221.00
169_V349_L0.6211.00
488_A491_Y0.6201.00
74_T266_P0.6191.00
456_Y463_D0.6191.00
460_T463_D0.6191.00
170_F394_L0.6191.00
163_Y166_S0.6171.00
445_I450_Y0.6171.00
84_Y100_A0.6171.00
32_M292_L0.6171.00
489_L492_I0.6161.00
454_L457_V0.6161.00
112_A409_S0.6161.00
461_N464_F0.6151.00
194_F198_T0.6141.00
25_V28_N0.6141.00
53_W57_L0.6141.00
30_G192_G0.6141.00
109_A412_G0.6121.00
312_A323_A0.6121.00
358_R361_F0.6111.00
92_N96_G0.6091.00
440_L444_G0.6091.00
491_Y496_I0.6081.00
183_W187_V0.6061.00
205_V209_N0.6051.00
181_A268_V0.6051.00
296_A300_M0.6041.00
203_M296_A0.6041.00
429_I453_Y0.6031.00
237_F241_S0.6021.00
22_W25_V0.6011.00
248_L252_P0.6001.00
364_S373_F0.6001.00
455_T458_A0.5981.00
415_I460_T0.5971.00
270_A361_F0.5961.00
451_F455_T0.5951.00
307_N310_L0.5951.00
431_F436_R0.5941.00
171_V174_I0.5931.00
114_V349_L0.5931.00
382_P385_A0.5921.00
210_S303_I0.5921.00
240_S244_W0.5911.00
83_D263_Q0.5911.00
213_F221_I0.5891.00
442_I448_A0.5891.00
124_T338_A0.5881.00
344_W347_Y0.5881.00
474_L481_V0.5861.00
476_T487_G0.5851.00
194_F340_G0.5841.00
202_A325_I0.5841.00
356_F360_V0.5831.00
276_K279_K0.5821.00
293_V297_F0.5801.00
431_F435_D0.5791.00
448_A451_F0.5781.00
388_F392_L0.5781.00
353_V386_H0.5781.00
40_E43_S0.5761.00
123_N127_T0.5751.00
296_A321_W0.5721.00
125_A339_L0.5721.00
214_Y221_I0.5711.00
247_T251_L0.5711.00
428_G432_G0.5711.00
71_V75_E0.5701.00
474_L487_G0.5701.00
451_F462_P0.5691.00
267_A355_V0.5691.00
83_D267_A0.5691.00
29_I192_G0.5691.00
106_E416_L0.5681.00
484_F488_A0.5681.00
260_P263_Q0.5671.00
84_Y96_G0.5661.00
455_T462_P0.5631.00
123_N131_E0.5631.00
37_A199_L0.5631.00
169_V346_I0.5621.00
168_L171_V0.5611.00
476_T483_T0.5601.00
15_L80_T0.5601.00
74_T278_V0.5601.00
220_L239_P0.5591.00
180_R183_W0.5581.00
239_P243_S0.5571.00
114_V117_F0.5561.00
73_L90_S0.5561.00
288_I295_L0.5561.00
69_I442_I0.5561.00
24_A268_V0.5551.00
439_V443_A0.5541.00
480_V483_T0.5531.00
288_I291_I0.5501.00
376_V379_H0.5491.00
184_G354_I0.5481.00
480_V487_G0.5481.00
172_V176_L0.5481.00
339_L343_V0.5471.00
486_A494_S0.5471.00
480_V490_A0.5451.00
42_I407_A0.5451.00
395_L398_L0.5421.00
485_I488_A0.5421.00
108_T396_L0.5401.00
171_V387_V0.5401.00
481_V487_G0.5401.00
275_R439_V0.5391.00
67_L71_V0.5391.00
490_A495_K0.5381.00
452_A462_P0.5381.00
82_G266_P0.5371.00
272_F278_V0.5371.00
453_Y461_N0.5361.00
310_L314_P0.5361.00
128_V131_E0.5341.00
28_N281_N0.5341.00
416_L420_Y0.5341.00
443_A447_S0.5331.00
263_Q421_F0.5331.00
441_S445_I0.5321.00
260_P413_A0.5291.00
213_F219_T0.5291.00
108_T389_D0.5291.00
476_T490_A0.5281.00
407_A410_L0.5281.00
24_A277_T0.5281.00
473_N480_V0.5271.00
417_G420_Y0.5271.00
192_G195_S0.5261.00
66_Q452_A0.5241.00
251_L255_A0.5241.00
53_W56_S0.5231.00
34_A37_A0.5231.00
477_T483_T0.5221.00
237_F240_S0.5211.00
189_S193_I0.5211.00
174_I353_V0.5211.00
372_K376_V0.5201.00
50_G53_W0.5191.00
50_G306_Y0.5171.00
247_T250_L0.5171.00
492_I495_K0.5171.00
116_F400_P0.5151.00
474_L483_T0.5151.00
39_F410_L0.5151.00
358_R382_P0.5141.00
460_T477_T0.5131.00
255_A418_S0.5131.00
474_L480_V0.5121.00
42_I46_V0.5121.00
439_V444_G0.5121.00
66_Q456_Y0.5111.00
56_S297_F0.5101.00
422_L456_Y0.5101.00
40_E300_M0.5091.00
36_V39_F0.5091.00
312_A320_F0.5091.00
36_V199_L0.5081.00
479_F483_T0.5071.00
20_S182_K0.5061.00
83_D424_V0.5051.00
169_V173_I0.5051.00
473_N483_T0.5051.00
271_E382_P0.5051.00
449_A464_F0.5041.00
42_I45_Y0.5031.00
68_L443_A0.5031.00
321_W324_A0.5031.00
236_S241_S0.5031.00
27_L30_G0.5031.00
275_R280_W0.5021.00
72_F76_K0.5011.00
490_A497_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.8117 100 0.37 Contact Map
3giaA 1 0.8272 100 0.408 Contact Map
4djkA 2 0.8272 100 0.423 Contact Map
3dh4A 3 0.8408 98.7 0.876 Contact Map
2jlnA 1 0.8039 98.7 0.878 Contact Map
2xq2A 2 0.8427 98.5 0.883 Contact Map
4xp4A 1 0.9068 98.2 0.893 Contact Map
2a65A 2 0.8874 98.1 0.896 Contact Map
4us3A 1 0.8117 97.8 0.903 Contact Map
4wgvA 2 0.7146 97 0.916 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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